"GPIIb/IIIa Antagonist Reagent". Haemoview Diagnostics. Retrieved 17 February 2016. Hechler, B; Gachet, C (1988). "P2 receptors ... and platelet function". Purinergic Signalling. 27 (2011 September, 7(3)): 293-303. doi:10.1007/s11302-011-9247-6. PMC 3166986. ... Thrombin receptor activating peptide-6 (TRAP-6) activates platelets through the thrombin receptor protease activated receptor-1 ... The GPIIb/IIIa antagonist blocks the binding of fibrinogen to the GPIIb/IIIa receptors, preventing the formation of platelet- ...

... is classified as a purinergic P2 receptor (P2Y12) antagonist. Other compounds in the same mechanistic class include ... August 2007). "Rapid and reversible modulation of platelet function in man by a novel P2Y(12) ADP-receptor antagonist, INS50589 ... It is characterized as a reversible, competitive receptor antagonist. The IC50 for antagonism of ADP-induced (P2Y12-mediated) ... modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor ...

All of these are antiplatelet agents that block P2Y12 receptors. Data obtained from using P2 receptor-selective antagonists has ... P2 receptors) or adenosine (P1 receptors). P2 receptors have further been divided into five subclasses: P2X, P2Y, P2Z, P2U, and ... IUPHAR GPCR Database - Adenosine receptors IUPHAR GPCR Database - P2Y receptors Purinergic+Receptors at the U.S. National ... the first purinergic receptor in plants, DORN1, was discovered. There are three known distinct classes of purinergic receptors ...

There are various types of purinergic receptors, the most common expressed in the Hensen's cells is the P2 subtype. Another ... Other chemicals such as Calmodulin antagonists W7 and trifluoperazine (TFP) could also induce the gap junctions uncoupling. ... Purinergic receptors have been found in the cells of the Organ of Corti, which are able to mediate physiological and ... and the purinergic receptors that found in the Hensen's cells are all important in providing a suitable electrical and micro ...

GABAA receptor involvement was demonstrated by intrathecal administration of gabazine, a GABAA antagonist, in animals receiving ... Histological staining by another research group examined the distribution of purinergic receptor subtypes throughout the RVM. ... Activation of on cells by ATP was reversed by using the P2 antagonists suramin and pyridoxal-phosphate-6-azophenyl-2′,4′ ... Intra-RVM administration of AP5 or MK-801, NMDA receptor antagonists, resulted in a reversal of the mechanical sensitivity ...

Jacob F, Pérez Novo C, Bachert C, Van Crombruggen K (September 2013). "Purinergic signaling in inflammatory cells: P2 receptor ... receptor inhibitors. Before the expiry of its patent, the P2Y12 receptor antagonist Clopidogrel (trade name: Plavix) was the ... The purinergic signalling complex of a cell is sometimes referred to as the "purinome". Purinergic receptors, represented by ... Purinergic receptors are specific classes of membrane receptors that mediate various physiological functions such as the ...

... purinergic P1 receptor - purinergic P2 receptor - purinergic receptor - pyridine - pyrimidine - pyruvate - pyruvate oxidation ... receptor (biochemistry) - receptor antagonist - receptor protein-tyrosine kinase - recombinant fusion protein - recombinant ... interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - interleukin-3 receptor - intermediate ... G protein-coupled receptor - G3P - GABA - GABA receptor - GABA-A receptor - gag-onc fusion protein - galanin - gamete - gamma- ...

The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as the ... The adenosine receptors are commonly known for their antagonists caffeine, theobromine, and theophylline, whose action on the ... "Towards a revised nomenclature for P1 and P2 receptors". Trends Pharmacol. Sci. 18 (3): 79-82. doi:10.1016/S0165-6147(96)01038- ... Newer adenosine receptor agonists and antagonists are much more potent and subtype-selective, and have allowed extensive ...

... (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergic P2X antagonist. It is able to block ... Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses". European ... It appears to be relatively selective for P2X receptors, having no appreciable activity at α1 adrenergic, muscarinic M2 and M3 ... histamine H1, and adenosine A1 receptors. PPADS tetrasodium salt, Santa Cruz Biotechnology Ziganshin, AU (December 1993). " ...

One study in mice showed that blockade of P2X7 receptors attenuates onset of liver fibrosis. Purinergic receptor P2X receptor ... Gartland A, Buckley KA, Hipskind RA, Bowler WB, Gallagher JA (2003). "P2 receptors in bone--modulation of osteoclast formation ... July 2009). "Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord ... The P2X7 subunits can form homomeric receptors only with a typical P2X receptor structure. The P2X7 receptor is a ligand-gated ...

... purinergic receptor P2X, ligand-gated ion channel, 1". North RA (2002). "Molecular physiology of P2X receptors". Physiol ... It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male ... 2004). "Increased mitogenic and decreased contractile P2 receptors in smooth muscle cells by shear stress in human vessels with ... "A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors". Br. J. ...