The GEF SOS1 activates Ras, whose target is the kinase Raf. Raf is a proto-oncogene because mutations in this protein have been ... GEFs are multi-domain proteins and interact with other proteins inside the cell through these domains. Adaptor proteins can ... G protein-coupled receptors are trans-membrane receptors that act as GEFs for their cognate G proteins upon binding of a ligand ... This 200 amino acid region is homologous to the yeast Sec7p protein. GEFs are often recruited by adaptor proteins in response ...

PI3K Akt IKK NFkB Caspase 9 STAT3 p38 MAPK VEGF IL-8 Shc Grb2/SOS Ras Raf MEK1 / MEK2 Erk1/2 FAK p190Rho/GAP Paxillin p130CAS ... Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc ... Proto-oncogene tyrosine-protein kinase Src) at the PDBe-KB. Portal: Biology (Articles with short description, Short description ... This proto-oncogene may play a role in the regulation of embryonic development and cell growth. When src is activated, it ...

RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an ... Raf kinases A-Raf kinase B-Raf kinase KSR1 protein KSR2 protein GRCm38: Ensembl release 89: ENSMUSG00000000441 - Ensembl, May ... RAF proto-oncogene serine/threonine-protein kinase) at the PDBe-KB. Portal: Biology (Articles with short description, Short ... A-Raf and B-Raf. Drosophila pole hole - The Interactive Fly c-raf+Proteins at the U.S. National Library of Medicine Medical ...

... the BRAF and ROS1 genes code for serine/threonine-protein kinase B-Raf and proto-oncogene tyrosine-protein kinase, respectively ... and RET proto-oncogene receptor, respectively, all of which activate the PI3K/AKT/mTOR pathway; 2) ... "RBM27 RNA binding motif protein 27 [Homo sapiens (Human)] - Gene - NCBI". "TPR translocated promoter region, nuclear basket ... LPF tumor tissues also contain scattered foci of cells that express the tumor marker proteins CD99, SMA (i.e. smooth muscle ...

AMP-activated protein kinase (AMPK) RAF proto-oncogene serine/threonine-protein kinase (C-Raf) mammalian Target of Rapamycin ... Yee WM, Worley PF (Feb 1997). "Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase ... 5' adenosine-monophosphate-activated protein kinase (AMPK) has also been found to be an effector for RHEB. AMPK is a protein ... The protein is a lipid-anchored, cell-membrane protein with five repeats of the RAS-related GTP-binding region. Also present ...

"Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product". Immunity. 5 (6): 591-604. doi: ... Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex". The Journal of ... Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene. SYK ... Without Syk, the protein it makes, and genetic disruption in a panel of 55 genes thought also to be controlled by Syk, breast ...

B-Raf proto-oncogene, casein kinase 2-interacting protein 1, and filamin A. Functions of PAK1 are regulated by its ability to ... ARG-binding protein 2γ, hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl ... These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of ... "Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1". The Journal of Biological ...

"Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf ... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ... "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". ... He was the first to fully clone the focal adhesion protein paxillin (human and chicken) and demonstrate its role in oncogenic ...

The downstream target of Elk1 is the serum response element (SRE) of the c-fos proto-oncogene. To produce c-fos, a protein ... However, Raf activation does not exclusively depend on Ras. Protein kinase C, which is activated by phorbol esters, can fulfill ... The binding of Elk1 to SRF happens due to protein-protein interaction between the B domain of Elk1 and SRF and the protein-DNA ... Elk1 can, thus, independently interact with an ETS binding site, as in the case of the lck proto-oncogene in Figure 2. Moreover ...

... proto-oncogene proteins b-raf MeSH D08.811.913.696.620.682.700.559.842.500 - proto-oncogene proteins c-raf MeSH D08.811.913.696 ... proto-oncogene proteins c-cbl MeSH D08.811.464.938.750.562 - proto-oncogene proteins c-mdm2 MeSH D08.811.464.938.750.750 - skp ... proto-oncogene proteins c-akt MeSH D08.811.913.696.620.682.700.759 - proto-oncogene proteins c-bcr MeSH D08.811.913.696.620.682 ... proto-oncogene proteins c-kit MeSH D08.811.913.696.620.682.725.400.075 - proto-oncogene proteins c-met MeSH D08.811.913.696. ...

BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine ... while the protein is more formally known as serine/threonine-protein kinase B-Raf. The B-Raf protein is involved in sending ... B-Raf is a member of the Raf kinase family of growth signal transduction protein kinases. This protein plays a role in ... "Serine/threonine protein kinase B-rAF". Retrieved 4 Mar 2013. Morrison DK, Cutler RE (April 1997). "The complexity of Raf-1 ...

The Kit proto-oncogene encodes a tyrosine kinase receptor whose ligand is a paracrine protein called stem cell factor (SCF), ... Kolch, Walter (2000). "Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions". The ... Then active Smoothened protein is able to inhibit PKA and Slimb, so that the Ci protein is not cleaved. This intact Ci protein ... The binding of Wnt to a Frizzled protein activates the Dishevelled protein. In its active state the Dishevelled protein ...

... proto-oncogene proteins a-raf MeSH D12.776.476.400.842.437 - proto-oncogene proteins b-raf MeSH D12.776.476.400.842.500 - proto ... oncogene protein p21(ras) MeSH D12.776.476.525.500.600 - proto-oncogene proteins p21(ras) MeSH D12.776.476.525.700.050 - cdc42 ... oncogene proteins c-raf MeSH D12.776.476.450.169.500 - mitogen-activated protein kinase 1 MeSH D12.776.476.450.169.750 - ... proto-oncogene proteins c-vav MeSH D12.776.476.325.300.600 - ral guanine nucleotide exchange factor MeSH D12.776.476.325. ...

... proto-oncogene proteins b-raf MeSH D12.776.624.664.700.204.500 - proto-oncogene proteins c-raf MeSH D12.776.624.664.700.205 - ... proto-oncogene proteins c-abl MeSH D12.776.624.664.700.168 - proto-oncogene proteins c-akt MeSH D12.776.624.664.700.169 - proto ... proto-oncogene proteins c-bcr MeSH D12.776.624.664.700.172 - proto-oncogene proteins c-cbl MeSH D12.776.624.664.700.174 - proto ... proto-oncogene proteins c-fes MeSH D12.776.624.664.700.179 - proto-oncogene proteins c-fos MeSH D12.776.624.664.700.180 - proto ...

... is called a proto-oncogene. The K-Ras protein is a GTPase, a class of enzymes which convert the nucleotide guanosine ... "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes & Development ... This proto-oncogene is a Kirsten ras oncogene homolog from the mammalian Ras gene family. A single amino acid substitution, and ... The K-Ras protein is turned off (inactivated) when it converts the GTP to GDP. When the protein is bound to GDP, it does not ...

Proto-oncogenes code for proteins that help to regulate the cell growth and differentiation. Proto-oncogenes are often involved ... Garnett MJ, Marais R (October 2004). "Guilty as charged: B-RAF is a human oncogene". Cancer Cell. 6 (4): 313-319. doi:10.1016/j ... a proto-oncogene becomes a tumor-inducing agent, an oncogene. Examples of proto-oncogenes include RAS, WNT, MYC, ERK, and TRK. ... Wikimedia Commons has media related to Proto-oncogene proteins. Drosophila Oncogenes and Tumor Suppressors - The Interactive ...

1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941-8. doi:10.1038/sj.onc.1202024. ... and RET proto-oncogene. GRCh38: Ensembl release 89: ENSG00000106070 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... GRB10 has been shown to interact with Abl gene, BCR gene, C-Raf, c-Kit, Insulin receptor,> Insulin-like growth factor 1 ... Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is ...

More specifically, he focuses on "the roles of proto-oncogene proteins as elements of signal transduction pathways that control ... B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. ... Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800. Erhardt, ... Regulation of neuronal survival by the Ser/Thr protein kinase Akt. Science 275:661-665. Erhardt, P., Tomaselli, K.J., and ...

Some genes are oncogenes: they are overexpressed in colorectal cancer. For example, genes encoding the proteins KRAS, RAF, and ... and activates the transcription of proto-oncogenes. These genes are normally important for stem cell renewal and ... The APC protein prevents the accumulation of β-catenin protein. Without APC, β-catenin accumulates to high levels and ... Sometimes the gene encoding p53 is not mutated, but another protective protein named BAX is mutated instead. Other proteins ...

The proto-oncogene MYC is also found to induce HSP90AA1 gene expression and binds proximally to the TSS as verified by ChIP-SEQ ... Heat shock protein 90kDa alpha (cytosolic), member A1 has been shown to interact with: AHSA1, AKT1, AR, C-Raf, CDC37, DAP3, ... Kang J, Kim T, Ko YG, Rho SB, Park SG, Kim MJ, Kwon HJ, Kim S (Oct 2000). "Heat shock protein 90 mediates protein-protein ... Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene. The gene, HSP90AA1, encodes the ...

Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded ... FYN has been shown to interact with: ADD2, BCAR1, C-Raf, CBLC, CD36, CD44, CDH1, CHRNA7, CTNND1, CBL, CSF1R, DLG4, Dystroglycan ... By definition as a proto-oncogene, Fyn codes for proteins that help regulate cell growth. Changes in its DNA sequence transform ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ...

In many types of cancers, the proto-oncogene c-Raf binds to the SARAH domain of MST2 and prevents RASSF1A-mediated MST2 ... Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene. Protein kinase activation is a ... "Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1". Science. 306 (5705): 2267-70. doi: ... This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' ( ...

... raf kinases MeSH D12.644.360.400.842.249 - oncogene proteins v-raf MeSH D12.644.360.400.842.374 - proto-oncogene proteins b-raf ... 14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ... ras proteins MeSH D12.644.360.525.500.300 - oncogene protein p21(ras) MeSH D12.644.360.525.500.600 - proto-oncogene proteins ... proto-oncogene proteins c-raf MeSH D12.644.360.440 - mitogen-activated protein kinase kinases MeSH D12.644.360.440.100 - map ...

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. The protein encoded by this proto-oncogene is a ... Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex". J. Biol. Chem. 271 (43 ... Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in ... Adams JM, Houston H, Allen J, Lints T, Harvey R (1992). "The hematopoietically expressed vav proto-oncogene shares homology ...

... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, Abl). The UPS is also involved in the regulation of ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ... The human protein proteasome subunit beta type-6 is 22 kDa in size and composed of 205 amino acids. The calculated theoretical ... This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits ...

... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ... "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ... The human protein proteasome subunit beta type-2 is 23 kDa in size and composed of 201 amino acids. The calculated theoretical ...

... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ... The PSMA5 protein has further been associated with the biosynthesis of conjugated linoleic acid (CLA) in mammary tissue. PSMD13 ... Lecossier D, Bouchonnet F, Clavel F, Hance AJ (May 2003). "Hypermutation of HIV-1 DNA in the absence of the Vif protein". ...

... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ... The human protein proteasome subunit beta type-1 is 26.5 kDa in size and composed of 241 amino acids. The calculated ... Overall, the PSMB1 protein has been described in several forms of malignancies such as follicular lymphoma with an important ...

"Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog". Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein ... novel genes closely related to ras proto-oncogenes". Cell. 48 (1): 137-46. doi:10.1016/0092-8674(87)90364-3. PMID 3098437. ... Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene. RRAS has been shown to interact with: ARAF, ... "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 ( ...

Mdm2 is a proto-oncogene that directly antagonizes p53 to ubiquitination (Figure 1). The p53 protein is known as the "guardian ... The kinase inhibitor blocks serine-threonine kinase RAF-1 as well as FLT-ITD (Kindler, 2010). The drug has been proven to be ... The fusion protein AML1-ETO is commonly found in acute myeloid leukemia patients. p14ARF is a well known tumor suppressor that ... ETO is a protein with transcriptional repressing abilities located at the 8q22. Less than 1% of acute myeloid leukemia patients ...