The structure of the sperm head is also related to protamine levels. The ratio of protamine 2 to protamine 1 and transition ... Protamine may be used as a drug to prevent obesity. Protamine has been shown to deter increases in body weight and low-density ... Protamine and protamine-like (PL) proteins are collectively known as the sperm-specific nuclear basic proteins (SNBPs). The PL ... Human and chimp protamine has undergone rapid evolution. When mixed with insulin, protamines slow down the onset and increase ...

Protamine is used in insulin aspart protamine and NPH insulin. Dosage for heparin reversal is 0.5mg to 1.0 mg mg protamine ... Protamine works by binding with heparin. Protamine sulfate was approved for medical use in the United States in 1969. It is on ... Protamine+Sulfate at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "Protamine Sulfate". Drug ... In large doses, protamine sulfate may also have an independent - however weak - anticoagulant effect. Protamine sulfate ...

Protamines replace histones during spermatogenesis. The most widespread deoxyribonucleoproteins are nucleosomes, in which the ... The proteins combined with DNA are histones and protamines; the resulting nucleoproteins are located in chromosomes. Thus, the ...

Kerr, R. B.; Best, C. H.; Campbell, W. R.; Fletcher, A. A. (1936). "Protamine Insulin". Canadian Medical Association Journal. ...

Kerr, R. B.; Best, C. H.; Campbell, W. R.; Fletcher, A. A. (1936). "Protamine Insulin". Canadian Medical Association Journal. ...

Aoki VW, Liu L, Jones KP, Hatasaka HH, Gibson M, Peterson CM, Carrell DT (November 2006). "Sperm protamine 1/protamine 2 ratios ... non-coding regions of the protamine genes in patients with protamine deregulation". Archives of Andrology. 53 (5): 267-74. doi: ... Protamine 1 is a protein that in humans is encoded by the PRM1 gene. GRCh38: Ensembl release 89: ENSG00000175646 - Ensembl, May ... "Entrez Gene: Protamine 1". Retrieved 2020-03-17. Tanaka H, Miyagawa Y, Tsujimura A, Matsumiya K, Okuyama A, Nishimune Y ( ...

Protamine 2 is a protein that in humans is encoded by the PRM2 gene. Protamines substitute for histones in the chromatin of ... This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced ... Aoki VW, Liu L, Jones KP, Hatasaka HH, Gibson M, Peterson CM, Carrell DT (November 2006). "Sperm protamine 1/protamine 2 ratios ... Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. ...

The chromatin in mammalian sperm is the most condensed form of eukaryotic DNA, it is packaged by protamines rather than ... Braun, Robert E. (1 May 2001). "Packaging paternal chromosomes with protamine". Nature Genetics. 28 (1): 10-12. doi:10.1038/ ...

Sprague, R.G.; Blum, B.B.; Osterberg, A.E.; Kepler, E.J.; Wilder, R.M. (1936). "Clinical Observations with Insulin Protamine ...

They take the place of histones associated with the sperm DNA, and are subsequently themselves replaced by protamines. TNPs in ... Chromatin Histone Protamine Sperm Spermatogenesis Spermiogenesis Meistrich, ML; Mohapatra, B; Shirley, CR; Zhao, M (May 2003 ...

NPH stands for neutral protamine Hagedorn, and the words refer to neutral pH (pH = 7), protamine (a protein), and Hans ... Protamine insulin was first created in 1936 and NPH insulin in 1946. It is on the World Health Organization's List of Essential ... The effects of PZI lasted for 24-36 h. In 1946, Nordisk was able to form crystals of protamine and insulin and marketed it in ... Neutral Protamine Hagedorn (NPH) insulin, also known as isophane insulin, is an intermediate-acting insulin given to help ...

Male protamines are replaced with histones and the male DNA is demethylated. Chromosomes then orientate on the metaphase ...

This allows protamine to displace Azure A. Once the dye is liberated it displays a purple color. The degree to which the dye is ... For example, protamine is a coagulant that is routinely administered after cardiopulmonary surgery that counter acts the anti- ... In order to quantify the protamine in plasma samples, a colorimetric displacement assay is used. Azure A dye is blue when it is ... Yang, V.; Fu, Y.; Teng, C.; Ma, S.; Shanberge, J. (1994). "A method for the quantitation of protamine in plasma" (PDF). ...

Protamine sulfate has been given to counteract the anticoagulant effect of heparin (1 mg per 100 units of heparin that had been ... Internal medicine, Jay H. Stein, p. 635 "Protamine Sulfate". The American Society of Health-System Pharmacists. Archived from ...

It has been used to reverse pulmonary hypertension caused by protamine (which in turn was administered to reverse the effects ... "Ketanserin in the treatment of protamine-induced pulmonary hypertension". Texas Heart Institute Journal. 23 (4): 301-304. PMC ...

The testis-specific proteins that show the highest level of expression are protamines. There are two phases in which the testes ...

The histones are mostly displaced, and replaced by protamines (small, arginine-rich proteins). It is proposed that in yeast, ...

ISBN 978-953-307-613-3. Gupta R, Kim ST (2015). "Depletion of RuBisCO protein using the protamine sulfate precipitation method ... Recently, one efficient method for precipitating out RuBisCO involves the usage of protamine sulfate solution. Other existing ... though these methods are more time-consuming and less efficient when compared to protamine sulfate precipitation. The ...

This complex of protamine and insulin is known as NPH (neutral protamine Hagedorn) insulin. It is one of the earliest example ... He came upon protamine, a protein isolated from fish sperm. Hagedorn discovered that the addition of protamine to insulin ...

"Prm2 - Protamine-2 - Rattus tunneyi (Tunney's rat) - Prm2 gene & protein". Musser, G.G.; Carleton, M.D. (2005). "Superfamily ...

Protamine sulfate will reverse tinzaparin by 85% per package insert. Cheer S.M. et al. Drugs 2004; 64 (13): 1479-1502 Pedersen ...

In contrast to prokaryotes, NAGS in mammals is enhanced by arginine, along with protamines. It is inhibited by N-acetylglutamic ...

Protamine is administered to reverse the effect of the anticoagulant heparin. After possible bleeding sites are checked, chest ...

Engel W, Keime S, Kremling H, Hameister H, Schluter G (Nov 1992). "The genes for protamine 1 and 2 (PRM1 and PRM2) and ... "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)". Schlüter G, Kremling H, Engel W (1992). "The ... gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low ...

Other relatively common causes include chemotherapy, vaccines, protamine and herbal preparations. Some medications (vancomycin ...

He also identified protamine and made a number of other discoveries. Miescher had isolated various phosphate-rich chemicals, ... It later found use, as protamine sulfate, in the stabilization of insulin (NPH insulin) and also as a reversal agent for the ... Boer, C.; Meesters, M.I.; Veerhoek, D.; Vonk, A.B.A. (May 2018). "Anticoagulant and side-effects of protamine in cardiac ... While analyzing the composition of salmon sperm, Miescher also discovered the alkaline substance protamine, which he published ...

... protamine is contained in neutral protamine hagedorn (NPH) insulin formulations), are at an increased risk of type II protamine ... The first step in management of a protamine reaction is to immediately stop the protamine infusion. Corticosteroids are used ... Patients with prior exposure to protamine, such as those who have had a previous vasectomy (protamine is contained in sperm) or ... Because protamine is a fast-acting drug, it is typically given slowly to allow for monitoring of possible reactions. ...

"Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)". Meistrich ML, Mohapatra B, Shirley CR, Zhao ...

Protamine is used to reverse heparin and low-molecular-weight heparin. Vitamin K is a reversal agent for warfarin. It is ...

... bonds are also formed within and between protamines in the sperm chromatin of many mammalian species. As disulfide ...