Prostaglandin H2
Prostaglandin D2 synthase to create prostaglandin D2 Prostaglandin E synthase to create prostaglandin E2 It rearranges non- ... Prostaglandin H2 is a type of prostaglandin and a precursor for many other biologically significant molecules. It is ... "Showing metabocard for Prostaglandin H2 (HMDB0001381)". Human Metabolome Database, HMDB. 5.0. van der Donk WA, Tsai AL, Kulmacz ... The conversion from Arachidonic acid to Prostaglandin H2 is a two step process. First, COX-1 catalyzes the addition of two free ...
Prostaglandin E synthase
It generates prostaglandin E (PGE) from prostaglandin H2. The synthase generating PGE2 is a membrane-associated protein. Humans ... Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). "Prostaglandin E synthase". Prostaglandins Other Lipid Mediat. 68-69: ... prostaglandin-E+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 5.3.99.3 Portal: Biology v ... Prostaglandin E synthase (EC 5.3.99.3, or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a ...
Aldrin
PGG2 is reduced to prostaglandin H2 (PGH2) by hydroperoxidase. Dieldrin can then be directly oxidized by cytochrome oxidases, ... Lang, B.; Frei, K.; Maier, P. (1986-10-15). "Prostaglandin synthase dependent aldrin epoxidation in hepatic and extrahepatic ... Tissues with low CYP-450 expression use the prostaglandin endoperoxide synthase (PES) instead. This oxidative pathway ... bisdioxygenises the arachidonic acid to prostaglandin G2 (PGG2). Subsequently, ...
Prostaglandin-endoperoxide synthase 2
Picot D, Loll PJ, Garavito RM (January 1994). "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1 ... It is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin, which is ... PTGS2 (COX-2), converts arachidonic acid (AA) to prostaglandin endoperoxide H2. PTGSs are targets for NSAIDs and PTGS2 (COX-2) ... Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (The HUGO official symbol is PTGS2; HGNC ...
Prostaglandin F synthase
"Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F ... "Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing ... prostaglandin F synthase, prostaglandin F synthetase, synthetase, prostaglandin F2α, prostaglandin-D2 11-reductase, PGF ... In general, prostaglandins are molecules that are used for inflammation, muscle contraction and blood clotting. Prostaglandin F ...
Prostaglandin G2
It quickly converts into prostaglandin H2, a process catalyzed by the enzyme COX. Prostaglandin G2 is produced from the fatty ... Prostaglandin G2 is an organic peroxide belonging to the family of prostaglandins. The compound has been isolated as a solid, ... "Prostaglandin G2". Santa cruz biotechnology, inc. Retrieved 27 April 2015. v t e (Articles containing unverified chemical ... infoboxes, Articles with short description, Short description matches Wikidata, Prostaglandins, All stub articles, Organic ...
Cyclooxygenase
The specific reaction catalyzed is the conversion from arachidonic acid to prostaglandin H2 via a short-living prostaglandin G2 ... The names "prostaglandin synthase (PHS)", "prostaglandin synthetase (PHS)", and "prostaglandin-endoperoxide synthetase (PES)" ... Nina M, Bernèche S, Roux B (2000). "Anchoring of a monotopic membrane protein: the binding of prostaglandin H2 synthase-1 to ... "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1". Nature. 367 (6460): 243-9. Bibcode:1994Natur. ...
Levuglandin
"Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway". Biochemistry. 38 (29): 9389-96 ... Though spontaneous rearrangements of PGH2 are known to generate prostaglandins (PG) PGD2 and PGE2. Prof. Robert Salomon at Case ... Salomon R.G.; Miller D.B.; Zagorski M.G.; Coughlin D.J. (1984). "Prostaglandin endoperoxides. 14. Solvent-induced fragmentation ... Levuglandins are reactive aldehydes formed by the spontaneous rearrangement of prostaglandin H (PGH). Enantiomerically pure ...
PTGS1
Cyclooxygenase 1 (COX-1), also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 ... Picot D, Loll PJ, Garavito RM (January 1994). "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1 ... Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase (COX), is the key enzyme in prostaglandin biosynthesis ... "Entrez Gene: PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)". Chandrasekharan NV, ...
Prostacyclin
... is produced in endothelial cells, which line the walls of arteries and veins, from prostaglandin H2 (PGH2) by the ... These convert arachidonic acid to prostaglandin H2 (PGH2), the immediate precursor of prostacyclin. Since thromboxane (an ... Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules. It ... prostaglandin I1, and prostaglandin I3". Journal of the American Chemical Society. 100 (24): 7690-7705. doi:10.1021/ja00492a043 ...
Animal heme-dependent peroxidases
Picot D, Loll PJ, Garavito RM (1994). "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1". Nature ... The cyclooxygenase active site, which catalyzes the formation of prostaglandin G2 (PGG2) from arachidonic acid, resides at the ... prostaglandin H synthase (PGHS); and peroxidasin. Myeloperoxidase (MPO) plays a major role in the oxygen-dependent microbicidal ...
U46619
"Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets". Prostaglandins. 33 (6): 789-797. ... U46619 is a stable synthetic analog of the endoperoxide prostaglandin PGH2 first prepared in 1975, and acts as a thromboxane A2 ... It potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro ... Bundy, G. L. (1975). "Synthesis of prostaglandin endoperoxide analogs". Tetrahedron Letters. 16 (24): 1957-1960. doi:10.1016/ ...
Neuroinflammation
NSAIDs function by blocking conversion of prostaglandin H2 into other prostaglandins (PGs) and thromboxane (TX). Prostoglandins ...
Thromboxane A2
TXA2 is generated from prostaglandin H2 by thromboxane-A synthase in a metabolic reaction which generates approximately equal ... Aspirin irreversibly inhibits platelet cyclooxygenase 1 preventing the formation of prostaglandin H2, and therefore thromboxane ...
Prostaglandin D2 synthase
Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme that in humans is encoded by the PTGDS gene. The protein encoded by this gene ... is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin ... Overview of all the structural information available in the PDB for UniProt: P41222 (Human Prostaglandin-H2 D-isomerase) at the ... Overview of all the structural information available in the PDB for UniProt: O09114 (Mouse Prostaglandin-H2 D-isomerase) at the ...
Prostaglandin
... is generated from the action of prostaglandin E synthases on prostaglandin H2 (prostaglandin H2, PGH2). Several prostaglandin E ... "Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing ... prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α). Examples of prostaglandin antagonists are: ... prostaglandin E1 is abbreviated PGE1, and prostaglandin I2 is abbreviated PGI2. Systematic studies of prostaglandins began in ...
Integral monotopic protein
... prostaglandin H2 syntheses 1 and 2 (cyclooxygenases) lanosterol synthase and squalene-hopene cyclase microsomal prostaglandin E ... "A Computational Protocol for the Integration of the Monotopic Protein Prostaglandin H2 Synthase into a Phospholipid Bilayer". ...
Thromboxane
... converts the arachidonic acid derivative prostaglandin H2 to thromboxane. People with asthma tend to have increased thromboxane ... Cavar I (2010). "The role of prostaglandin E2 in acute acetaminophen hepatotoxicity in mice". Histol Histopathol. 25 (7): 819- ... with the prostaglandin I2 synthesis being little affected; however, higher doses of aspirin are required to attain further ...
Ménétrier's disease
Such medications include: anticholinergic agents, prostaglandins, proton pump inhibitors, prednisone, and H2 receptor ...
Furegrelate
In platelets this fatty acid is metabolized to an endoperoxide called prostaglandin H2 by the enzyme cyclooxygenase 1. This ... It does this presumably by enhancing the formation of vasodilator prostaglandins. Inhibition of furegrelate induced a ... Prostaglandins. 26 (2): 311-24. doi:10.1016/0090-6980(83)90098-9. PMID 6685888. Gorman RR, Johnson RA, Spilman CH, Aiken JW ( ... Prostaglandins. 26 (2): 325-42. doi:10.1016/0090-6980(83)90099-0. PMID 6316421. Sidonio RF (2017). "Thromboxane Synthetase ...
Medication
... prostaglandin agonists/prostaglandin inhibitors, nitroglycerin. Anti-inflammatory: NSAIDs, corticosteroids. Antibacterial: ... Upper digestive tract: antacids, reflux suppressants, antiflatulents, antidopaminergics, proton pump inhibitors (PPIs), H2- ... receptor antagonists, cytoprotectants, prostaglandin analogues. Affecting blood pressure/(antihypertensive drugs): ACE ... prostaglandins, gonadorelin, clomiphene, tamoxifen, diethylstilbestrol. Emollients, anti-pruritics, antifungals, antiseptics, ...
Prostaglandin-D synthase
Other names in common use include prostaglandin-H2 Delta-isomerase, prostaglandin-R-prostaglandin D isomerase, and PGH-PGD ... Prostaglandin D2 synthase Hematopoietic prostaglandin D synthase Garza, L. A.; Liu, Y.; Yang, Z.; Alagesan, B.; Lawson, J. A.; ... In enzymology, a prostaglandin-D synthase (EC 5.3.99.2) is an enzyme that catalyzes the chemical reaction (5Z,13E)-(15S)-9alpha ... Shimizu T, Yamamoto S, Hayaishi O (1979). "Purification and properties of prostaglandin D synthetase from rat brain". J. Biol. ...
Ibuprofen
... which convert arachidonic acid to prostaglandin H2 (PGH2). PGH2, in turn, is converted by other enzymes to several other ... Like other NSAIDs, it works by inhibiting the production of prostaglandins by decreasing the activity of the enzyme ... which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever, and swelling. Antipyretic ... prostaglandins (which are mediators of pain, inflammation, and fever) and to thromboxane A2 (which stimulates platelet ...
Fatty acid metabolism
... which is converted by the hydroperoxidase component of the enzyme complex into prostaglandin H2. This highly unstable compound ... The prostaglandins made from arachidonic acid stored in the cell membrane are probably the best-known of these local hormones. ... The prostaglandins are synthesized in the cell membrane by the cleavage of arachidonate from the phospholipids that make up the ... Every prostaglandin therefore contains 20 carbon atoms, including a 5-carbon ring. They are a subclass of eicosanoids and form ...
Discovery and development of cyclooxygenase 2 inhibitors
Their main role is to catalyze the transformation of arachidonic acid into the intermediate prostaglandin H2, which is the ... COX-2 plays a major role in prostaglandin biosynthesis in inflammatory cells and in the central nervous system. Prostaglandin ... All of the coxibs achieve sufficient brain concentrations to have a central analgesic effect, and all reduce prostaglandin ... have analgesic and anti-inflammatory activity by blocking the transformation of arachidonic acid into prostaglandin H2 ...
12-Hydroxyeicosatetraenoic acid
... a product made when prostaglandin H2 is metabolized to Thromboxane A2 by Thromboxane synthase or spontaneously rearranges non- ... 12-diHETE at the human platelet thromboxane A2/prostaglandin H2 receptor". Eicosanoids. 3 (2): 121-4. PMID 2169775. Fonlupt, P ... act as Competitive antagonists of the Thromboxane receptor which mediates the actions of Thromboxane A2 and Prostaglandin H2. ... Yoshimoto, T; Takahashi, Y (2002). "Arachidonate 12-lipoxygenases". Prostaglandins & Other Lipid Mediators. 68-69: 245-62. doi: ...
AKR1C3
... prostaglandin H2, and phenanthrenequinone, and the oxidation of prostaglandin F2α to prostaglandin D2. It is also capable of ... This enzyme catalyzes the reduction of prostaglandin D2, ... that exhibits high prostaglandin D2 11-ketoreductase activity ... expression and characterization of human prostaglandin F synthase". FEBS Letters. 462 (3): 335-40. doi:10.1016/S0014-5793(99) ...
Thromboxane-A synthase
The heme was found to be sandwiched between helices I and L. Thromboxane A (TXA) is derived from the prostaglandin H2 (PGH2) ... This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H2 to thromboxane A2, a potent ... Wang LH, Kulmacz RJ (August 2002). "Thromboxane synthase: structure and function of protein and gene". Prostaglandins & Other ... Wang LH, Kulmacz RJ (August 2002). "Thromboxane synthase: structure and function of protein and gene". Prostaglandins & Other ...
Prostacyclin synthase
Instead it uses its heme cofactor to catalyze the isomerization of prostaglandin H2 to prostacyclin. Prostaglandin H2 is ... This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H2 to prostacyclin (prostaglandin I2), a ... Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme ... 2009). "Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and ...
Prostaglandin F2alpha
... or PGH synthase to form Prostaglandin H2, an intermediate. Lastly, the compound reacts with Aldose Reductase (AKR1B1) or PGF ... Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed carboprost is a naturally occurring prostaglandin ... Kerekes L, Domokos N (July 1979). "The effect of prostaglandin F2 alpha on third stage labor". Prostaglandins. 18 (1): 161-166 ... Prostaglandin is also used to treat uterine infections in domestic animals. In domestic mammals, it is produced by the uterus ...