Poly (ADP-ribose) polymerase
ADP-ribose) polymerase at inotekcorp.com The PARP Link Homepage at parplink.u-strasbg.fr Poly+ADP+Ribose+Polymerase at the U.S ... Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, ... the PAR chains are degraded via Poly(ADP-ribose) glycohydrolase (PARG). NAD+ is required as substrate for generating ADP-ribose ... 2008). "Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice". Current ...
Poly(adp-ribose) polymerase family member 14
... is a protein that, in humans, is encoded by the PARP14 gene. Poly(ADP-ribosyl) ... "Entrez Gene: Poly(ADP-ribose) polymerase family member 14". Retrieved 2016-03-02. This article incorporates text from the ...
Bradley J. Monk
"Poly (ADP-ribose) polymerase". September 13, 2022 - via Wikipedia. Mirza, Mansoor R.; Monk, Bradley J.; Herrstedt, Jørn; Oza, ... Monk has also been a leader in the field of inhibition of Poly (ADP-ribose) polymerase (PARP) in advanced and recurrent ovarian ... Eakin, C., Ewongwo, A., Pendleton, L., Monk, B., & Chase, D. (2020). Real world experience of poly (ADP-ribose) polymerase ... Eakin, C., Ewongwo, A., Pendleton, L., Monk, B., & Chase, D. (2020). Real world experience of poly (ADP-ribose) polymerase ...
PARP inhibitor
... s are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed ... Banasik M, Stedeford T, Strosznajder RP (August 2012). "Natural inhibitors of poly(ADP-ribose) polymerase-1". Molecular ... Patel AG, De Lorenzo SB, Flatten KS, Poirier GG, Kaufmann SH (March 2012). "Failure of iniparib to inhibit poly(ADP-Ribose) ... Tattersall, Abigail; Ryan, Neil; Wiggans, Alison J.; Rogozińska, Ewelina; Morrison, Jo (2022-02-16). "Poly(ADP-ribose) ...
Talazoparib
... acts as an inhibitor of poly ADP ribose polymerase (PARP) which aids in single strand DNA repair. Cells that have ... Talazoparib, sold under the brand name Talzenna, is an orally available poly ADP ribose polymerase (PARP) inhibitor developed ... Talzenna FDA Professional Drug Information Shen Y, Aoyagi-Scharber M, Wang B (June 2015). "Trapping Poly(ADP-Ribose) Polymerase ...
MYBL2
PARP16
Poly (ADP-ribose) polymerase family, member 16 is a protein in humans that is encoded by the PARP16 gene. GRCh38: Ensembl ... "Entrez Gene: Poly (ADP-ribose) polymerase family, member 16". Retrieved 2013-04-03. PDBe-KB provides an overview of all the ... structure information available in the PDB for Human Protein mono-ADP-ribosyltransferase PARP16 v t e (Articles with short ...
PARP8
Poly [ADP-ribose] polymerase 8 is an enzyme that in humans is encoded by the PARP8 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: PARP8 poly (ADP-ribose) polymerase family, member 8". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method ...
Minocycline
Alano CC, Kauppinen TM, Valls AV, Swanson RA (June 2006). "Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar ...
PARP3
Johansson M (Aug 1999). "A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) ... Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene. The protein encoded by this gene ... "Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3". Bashford CL, Chance B, Lloyd D, Poole RK (1981). " ... 2009). "Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3". J. Med. Chem. 52 (9): 3108-3111. ...
DNA polymerase alpha catalytic subunit
January 1993). "Poly(ADP-ribose) polymerase stimulates DNA polymerase alpha by physical association". The Journal of Biological ... ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication ... DNA Polymerase DNA polymerase alpha subunit 2 GRCh38: Ensembl release 89: ENSG00000101868 - Ensembl, May 2017 GRCm38: Ensembl ... interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity". FEBS Letters. 475 (3): 209- ...
DNA damage theory of aging
studied the level of a particular enzyme, Poly ADP ribose polymerase, which is involved in repair of single-strand breaks in ... Bürkle, A; Brabeck, C; Diefenbach, J; Beneke, S (May 2005). "The emerging role of poly(ADP-ribose) polymerase-1 in longevity". ... Muiras ML, Müller M, Schächter F, Bürkle A (1998). "Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines ... Grube K, Bürkle A (Dec 1992). "Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species ...
Iniparib
Patel AG, De Lorenzo SB, Flatten KS, Poirier GG, Kaufmann SH (March 2012). "Failure of iniparib to inhibit poly(ADP-Ribose) ... polymerase in vitro". Clinical Cancer Research. 18 (6): 1655-62. doi:10.1158/1078-0432.CCR-11-2890. PMC 3306513. PMID 22291137 ...
Parthanatos
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci U S A 96: 13978-13982 ... Berger, NA; Sims, JL; Catino, DM; Berger, SJ (1983). "Poly(ADP-ribose) polymerase mediates the suicide response to massive DNA ... Berger, Nathan A.; Berger, Sosamma J. (1986). "Metabolic Consequences of DNA Damage: The Role of Poly (ADP-Ribose) Polymerase ... "Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA ...
7-Methylguanine
... is a natural inhibitor of poly (ADP-ribose) polymerase (PARP) and tRNA guanine transglycosylase (TGT) - and ... "Inhibition of poly(ADP-ribose) polymerase by nucleic acid metabolite 7-methylguanine". Int. J. Mol. Sci. 21 (6): 2159. doi: ... "Inhibition of poly(ADP-ribose) polymerase by nucleic acid metabolite 7-methylguanine". Acta Naturae. 8 (2): 108-115. doi: ... "Bioinformatic analysis of the nicotinamide binding site in poly(ADP-ribose) polymerase family proteins". Cancers. 13 (6): 1201 ...
Institute of Cancer Research
"Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers". New England Journal of Medicine. 361 (2): 123 ...
Tankyrase
"TNKS - Poly [ADP-ribose] polymerase tankyrase-1 - Homo sapiens (Human) - TNKS gene & protein". Voges D, Zwickl P, Baumeister W ... Cook BD, Dynek JN, Chang W, Shostak G, Smith S (2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at ... Cook BD, Dynek JN, Chang W, Shostak G, Smith S (Jan 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 ... Smith S, Giriat I, Schmitt A, de Lange T (Dec 1998). "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres". Science. ...
Diamond
Mohammad G, Siddiquei MM, Abu El-Asrar AM (2006). "Poly (ADP-ribose) polymerase mediates diabetes-induced retinal neuropathy". ...
Telomeric repeat-binding factor 1
Cook BD, Dynek JN, Chang W, Shostak G, Smith S (January 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 ... Smith S, Giriat I, Schmitt A, de Lange T (1998). "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres". Science. 282 ( ... Smith S, Giriat I, Schmitt A, de Lange T (November 1998). "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres". ... Seimiya H, Smith S (April 2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for ...
TIPARP
TCDD-inducible poly [ADP-ribose] polymerase is an enzyme that in humans is encoded by the TIPARP gene. TCDD, or 2,3,7,8- ... "Entrez Gene: TIPARP TCDD-inducible poly(ADP-ribose) polymerase". Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in ...
Adenosine thiamine triphosphate
... inhibits poly(ADP-ribose) polymerase-1(PARP-1) activity". J Nutr Sci Vitaminol (Tokyo). 57 (2): 192-6. doi:10.3177/jnsv.57.192 ... ADP) ↔ AThTP + PPi (Pi) The molecule is made up of thiamine and adenosine joined together with phosphate groups. It is similar ...
P21
... poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners". J. Biol. Chem. 278 (41): 39265-8. doi:10.1074 ... p21 interacts with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in ... leading to the proposal that p21 acts to preferentially select polymerase processivity factors depending on the context of DNA ... protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase ...
Bill Earnshaw
Lazebnik, Y. A.; Kaufmann, S. H.; Desnoyers, S; Poirier, G. G.; Earnshaw, W. C. (1994). "Cleavage of poly(ADP-ribose) ... polymerase by a proteinase with properties like ICE". Nature. 371 (6495): 346-7. Bibcode:1994Natur.371..346L. doi:10.1038/ ...
Ted M. Dawson
They identified the mechanisms by which NO kills neurons through poly (ADP-ribose) polymerase. They discovered that poly (ADP- ... 2011). "Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death ( ... 1997). "Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia". Nat Med. 3 (10): 1089-95. doi ... 2002). "Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor". Science. 297 (5579): 259 ...
UBE2I
Masson M, Menissier-de Murcia J, Mattei MG, de Murcia G, Niedergang CP (1997). "Poly(ADP-ribose) polymerase interacts with a ...
ZNF423
Ku MC, Stewart S, Hata A (November 2003). "Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes". ...
Nicola Curtin
"Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase". Nature. 434 (7035): 913-917. ... "Anticancer Chemosensitization and Radiosensitization by the Novel Poly(ADP-ribose) Polymerase-1 Inhibitor AG14361". JNCI ...
PARP12
Poly [ADP-ribose] polymerase 12 is an enzyme that in humans is encoded by the PARP12 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: PARP12 poly (ADP-ribose) polymerase family, member 12". Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The ...
PARP4
Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene. This gene encodes poly(ADP-ribosyl) ... "Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4". van Zon, Arend; Mossink Marieke H; Schoester Martijn; ... 2004). "Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function ... 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. 146 (5): 917-28. doi:10.1083/ ...
Gianluca Tognon
Poly(ADP-ribose) Polymerase Cleavage During Apoptosis: When and Where?. Experimental Cell Research (2001) 269:193-201. Tognon G ...