VEGFD Platelet-activating factor Platelet-derived growth factor receptor atheroma platelet involvement in smooth muscle ... Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In ... "Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family". Biochemical and ... Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF ...
"Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". ... Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet- ... Platelet-Derived+Growth+Factor+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... Heldin CH, Ostman A, Eriksson A, Siegbahn A, Claesson-Welsh L, Westermark B (March 1992). "Platelet-derived growth factor: ...
Platelet-activating factor Platelet-derived growth factor GRCh38: Ensembl release 89: ENSG00000163737 - Ensembl, May 2017 ... "The control of angiogenesis and tumor invasion by platelet factor-4 and platelet factor-4-derived molecules". Seminars in ... Maurer AM, Zhou B, Han ZC (December 2006). "Roles of platelet factor 4 in hematopoiesis and angiogenesis". Growth Factors. 24 ( ... Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with ...
... receptor Platelet-derived growth factor Zimmerman GA, McIntyre TM, Prescott SM, Stafforini DM (May ... Platelet Activating Factor) Platelet+Activating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH ... cytoplasmic platelet-activating factor acetylhydrolase 2, and platelet-activating factor acetylhydrolase 1b. Cations are one ... an enzyme that catabolizes platelet-activating factor. It is an important mediator of bronchoconstriction. It causes platelets ...
The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. It is ... "Entrez Gene: PTAFR platelet-activating factor receptor". Correa-Costa M (Apr 2014). "Activation of platelet-activating factor ... Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl- ... platelet+activating+factor+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article ...
Platelet-activating factor (PAF) is an ether lipid which has an acetyl group instead of an acyl chain at the second position ( ... Ether lipids can also act directly in cell signaling, as the platelet-activating factor is an ether lipid signaling molecule ... Demopoulos CA, Pinckard RN, Hanahan DJ (October 1979). "Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl ... 2014). Omega 3 fatty acids in brain and neurological health. Elsevier Academic Press. doi:10.1016/C2012-0-06006-1. ISBN 978-0- ...
Platelets also secrete platelet-derived growth factor (PDGF). Platelets modulate neutrophils by forming platelet-leukocyte ... platelet factor 4, transforming growth factor-β1, platelet-derived growth factor, fibronectin, B-thromboglobulin, vWF, ... platelet-derived epidermal growth factor, and vascular endothelial growth factor. Local application of these factors in ... "Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in ...
... platelet‑derived growth factor (PGDF), transforming growth factors‑β (TGF‑β), vascular endothelial growth factor (VEGF), and ... Platelet derived growth factor along with bone morphogenetic proteins are among the most researched growth factors in ... Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a derivative of PRP where autologous platelets and ... Dohan, DM; Choukroun, J (2006). "Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet- ...
PAF-AH inactivates platelet-activating factor, a phospholipid that plays a role in the inflammation seen in sepsis. The enzyme ... Pafase is the recombinant form of platelet-activating factor acetylhydrolase (PAF-AH, also known as lipoprotein-associated ... Stafforini DM, McIntyre TM, Carter ME, Prescott SM (March 25, 1987). "Human Plasma Platelet-activating Factor Acetylhydrolase ... April 6, 1995). "Anti-inflammatory properties of a platelet-activating factor acetylhydrolase". Nature. 374 (6522): 549-53. ...
"The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel ... 554 (3): 381-8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. S2CID 11563502. "Entrez Gene: GPR135 G protein-coupled ...
Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene. It is one ... "Entrez Gene: PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa". Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM ... This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes ... Min JH, Wilder C, Aoki J, Arai H, Inoue K, Paul L, Gelb MH (Apr 2001). "Platelet-activating factor acetylhydrolases: broad ...
Kato K, Clark GD, Bazan NG, Zorumski CF (January 1994). "Platelet-activating factor as a potential retrograde messenger in CA1 ... Kato K, Zorumski CF (September 1996). "Platelet-activating factor as a potential retrograde messenger". Journal of Lipid ... platelet-activating factor, arachidonic acid, and nitric oxide. Nitric oxide has received a great deal of attention in the past ... pairing the other factors with the retrograde signal should mimic the phenomenon The most prevalent endogenous retrograde ...
1988). "Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human ... 1986). "Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta- ... "Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets". J. Clin. ... Tunnacliffe A, Majumdar S, Yan B, Poncz M (1992). "Genes for beta-thromboglobulin and platelet factor 4 are closely linked and ...
1997). Platelets and their factors. K.S. Authi (contributor). Berlin: Springer. ISBN 3-642-60639-3. List of Streptomyces ...
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood, The Journal of the American Society ... Aslan, J. E.; Mccarty, O. J. T. (2013). "Rho GTPases in platelet function". Journal of Thrombosis and Haemostasis. 11 (1): 35- ... "A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo". Blood. 116 (19): 3981-3989. doi:10.1182/ ... Aslan, J. E., & McCarty, O. J. (2013). Rho GTPases in platelet function. Journal of Thrombosis and Haemostasis, 11(1), 35-46. ...
Farooque SP, Arm JP, Lee TH (2008). "Lipid Mediators: Leukotrienes, Prostanoids, Lipoxins, and Platelet-Activating Factor". In ... and platelet-induced blood clotting-responses in vitro and in vivo. The platelet-directed functions of TP are in many respects ... and/or platelet functional responses not only to TP agonists but also to agents that stimulate platelets by TP-independent ... For example, platelets express high concentrations of the α isoform (and possess residual RNA for the β isoform), while ...
Alpha-granules contain various factors which contribute to blood clotting and other functions. In their absence, platelets are ... transcription factor regulating cell cycle progression), TAL1 (a transcription factor), FOG2 (a transcription factor regulator ... GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of ... excessive numbers of malformed platelet-precursor cells, and an absence of platelets. These defects reflect the essential role ...
... lack of platelet aggregatory response to adrenaline and lack of secondary aggregation to ADP and platelet activating factor ( ... Day, HJ; Stormorken, H; Holmsen, H (1973). "Subcellular localization of platelet factor 3 and platelet factor 4". Scandinavian ... Gogstad, GO; Stormorken, H; Solum, NO (15 July 1983). "Platelet alpha 2-antiplasmin is located in the platelet alpha-granules ... "Characterization of a factor VII molecule carrying a mutation in the second epidermal growth factor-like domain". Thrombosis ...
The TYMP gene is also known as ECGF1 (endothelial cell growth factor 1, platelet-derived) and MNGIE due to its role in MNGIE ... Identity of gliostatin and platelet-derived endothelial cell growth factor". J. Biol. Chem. 267 (28): 20311-6. doi:10.1016/ ... 1987). "Purification and properties of an endothelial cell growth factor from human platelets". J. Biol. Chem. 262 (9): 4098- ... 1992). "Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13". ...
Bioactive molecules extracted from its bark and roots have been reported to inhibit platelet-activating factor receptor binding ... and Goniothalamus uvaroides King on Platelet-Activating Factor Receptor Binding". Phytotherapy Research. 26 (5): 687-691. doi: ... "Antiplatelet Aggregation and Platelet Activating Factor (PAF) Receptor Antagonistic Activities of the Essential Oils of Five ... The pedicels are hairless to slightly hairy and have 2-3 bracts. Its oval to triangular, pink to red sepals are 3.5-10 by 3-6.5 ...
Appiah-Kubi K, Lan T, Wang Y, Qian H, Wu M, Yao X, Wu Y, Chen Y (2017). "Platelet-derived growth factor receptors (PDGFRs) ... The PDGFRA gene encodes the platelet-derived growth factor receptor A (PDGFRA) which is a cell surface, RTK class III Receptor ... The PDGFRB gene encodes the platelet-derived growth factor receptor B (PDGFRB) which, like PDGFRA, is a cell surface, RTK class ... Songdej N, Rao AK (2017). "Hematopoietic Transcription Factors Mutations - Important Players in Inherited Platelet Defects". ...
Other factors that will influence the survival rate are the severity of proteinuria, blood urea nitrogen levels, serum creatine ... Mesangial proliferation is caused by activated platelets. Another mechanism involves antibodies formed against alpha-3 chain of ... Males are at a higher risk factor than females. Overall, about 50% of patients with DPGN require daily dialysis within 6-12 ... C3a, C5a, IL-8 are all chemotactic factors of the activated complement system. Part of their role is to recruit ...
... which produce platelets and platelet-derived factor V, and hepatocytes, which produce plasma-derived factor V. The molecule ... All prothrombotic factor V mutations (factor V Leiden, factor V Cambridge, factor V Hong Kong) make it resistant to cleavage by ... Factor V is able to bind to activated platelets and is activated by thrombin. On activation, factor V is spliced in two chains ... Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. ...
Cochran BH, Reffel AC, Stiles CD (July 1983). "Molecular cloning of gene sequences regulated by platelet-derived growth factor ... CXCL1 was first cloned from a cDNA library of genes induced by platelet-derived growth factor (PDGF) stimulation of BALB/c-3T3 ... July 1988). "Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor ... 266 (3 Pt 1): L278-L286. doi:10.1152/ajplung.1994.266.3.L278. PMID 8166297. Ma K, Yang L, Shen R, Kong B, Chen W, Liang J, et ...
... insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet- ... A bone growth factor is a growth factor that stimulates the growth of bone tissue. Known bone growth factors include insulin- ... and induces the STAT pathway which activates transcription factors. Platelet-derived growth factors (PDGF) are polypeptides ... SMADS are transcription factors that will induce osteoblast growth. The majority of the substrates of platelet-derived growth ...
"The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating ... and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa. Factor IX is inhibited by ... Zhong D, Bajaj MS, Schmidt AE, Bajaj SP (Feb 2002). "The N-terminal epidermal growth factor-like domain in factor IX and factor ... conclude that residues 88 to 109 of the second EGF domain mediate binding to platelets and assembly of the factor X activating ...
A number of cytokines such as tumor necrosis factor alpha (TNFα), transforming growth factor beta 2 (TGFβ2), platelet derived ... Andrews A, Balciunaite E, Leong FL, Tallquist M, Soriano P, Refojo M, Kazlauskas A (1999). "Platelet-derived growth factor ... 1 is added if the risk factor is present and 0 if the risk factor is absent. A patient is at a high risk for developing PVR if ... Predisposing factors for Postoperative PVR are preoperative PVR, aphakia, high levels of vitreous proteins, duration of retinal ...
2. Interaction with platelets and plasma-clotting factors". Biochemistry. 18 (16): 3570-7. doi:10.1021/bi00583a021. PMID 476069 ... by inducing it to bind to platelet glycoprotein Ib (GPIb) thereby providing the surface for initial platelet aggregation. In ... in cerastocytin has no effect on fibrin clot formation or platelet aggregation. Cerastotin is a more potent platelet ... Since this exosite was shown to be involved in the platelet aggregating activity of thrombin, a similar function could be ...
He has discovered the anti-platelet factors from tomatoes. This discovery made by him is now widely known as Fruitflow. In 2009 ... Duttaroy serves as Editor-In-Chief of the peer-reviewed journal Food & Nutrition Research, which has an Impact factor of 3.89 ( ... "Water-soluble tomato concentrate (WSTC I and II) and platelet aggregation [1] , EFSA". www.efsa.europa.eu. 28 May 2009. doi: ... "Water-soluble tomato concentrate (WSTC I and II) and platelet aggregation [1] , EFSA". www.efsa.europa.eu. 28 May 2009. doi: ...
In enzymology, a platelet-activating factor acetyltransferase (EC 2.3.1.149) is an enzyme that catalyzes the chemical reaction ... "A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor ( ... The systematic name of this enzyme class is 1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glyce ro-3- ... 1-alkyl-2-acetyl-sn-glycero-3-phospholipid Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3- ...