Of these, the alkyl and alkenyl moiety in each case form an ether bond, which makes for two types of ether phospholipids, ... Hardeman D, van den Bosch H (November 1989). "Topography of ether phospholipid biosynthesis". Biochim Biophys Acta. 1006 (1): 1 ... Ether lipid Yamashita S, Honjo A, Aruga M, Nakagawa K, Miyazawa T (2014). "Preparation of marine plasmalogen and selective ... The lipid attached to the vinyl ether at sn-1 can be C16:0, C18:0, or C18:1 (saturated and monounsaturated), and the lipid ...

Fleer EA, Unger C, Kim DJ, Eibl H (November 1987). "Metabolism of ether phospholipids and analogs in neoplastic cells". Lipids ... In 1987 the phospholipids were found to be potent toxins on leukemic cell culture. Initial in vivo investigation on the ... Phospholipid group alkylphosphocholine were known since the early 1980s, particularly in terms of their binding affinity with ... demonstrated that the antineoplastic activity of the phospholipid analogue miltefosine (at the time known as ...

"Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic". The Journal of Lipid Research. 48 (4 ... Initially, a lens is formed by accumulation of TAGs between the two layers of its phospholipid membrane. Nascent lipid droplets ... Analysis of the lipid composition of lipid droplets has revealed the presence of a diverse set of phospholipid species; ... The budding of lipid droplets is promoted by an asymmetric accumulation of phospholipids that decrease surface tension towards ...

The phospholipids of archaea are unusual in four ways: They have membranes composed of glycerol-ether lipids, whereas bacteria ... Balleza D, Garcia-Arribas AB, Sot J, Ruiz-Mirazo K, Goñi FM (September 2014). "Ether- versus ester-linked phospholipid bilayers ... In ester lipids this is an ester bond, whereas in ether lipids this is an ether bond. The stereochemistry of the archaeal ... One property unique to archaea is the abundant use of ether-linked lipids in their cell membranes. Ether linkages are more ...

Plasmanyl-phospholipids have an ether bond in position sn-1 to an alkyl group. Plasmenyl-phospholipids have an ether bond in ... Ether+phospholipids at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Lipids). ... Lux H, Heise N, Klenner T, Hart D, Opperdoes FR (November 2000). "Ether--lipid (alkyl-phospholipid) metabolism and the ... In a biochemical sense, an ether lipid usually implies glycerophospholipids of various type, also called phospholipids, in ...

This lets the ether-linked phospholipid be more stable and less susceptible to breakdown from large amounts of increased ... Bacteria and eukaryotic cells contain phospholipid bilayers containing ester linkages, while archaea contain ether linkages. ... A phospholipid molecule is composed of a long fatty acid, often called the tail of the molecule, and a phosphate group, which ... Phospholipid membranes can range widely in the structure of the fatty acid tail, which is composed of mostly hydrocarbons. ...

In addition, PBD-ZSD patients show deficient levels of plasmalogens, ether-phospholipids necessary for normal brain and lung ...

In addition, these individuals can show deficient levels of plasmalogens, ether-phospholipids that are especially important for ...

... key enzyme in biosynthesis of the enantiomeric glycerophosphate backbone of ether phospholipids of archaebacteria". J. Biochem ... NAD(P)H + H+ → + NAD(P)+ Glycerol 1-phosphate is a starting material for de novo synthesis of ether lipids, such as those ... It is a component of ether lipids, which are common for archaea. Glycerol 1-phosphate is synthesized by reducing ... Koga & Morii (2007). "Biosynthesis of ether-type polar lipids in archaea and evolutionary considerations". Microbiol. Mol. Biol ...

In addition, these individuals can show deficient levels of plasmalogens, ether-phospholipids that are especially important for ...

Mechanisms of Action and Biomedical Prospect of the Antitumor Ether Phospholipid ET-18-OCH3 (Edelfosine), A Proapoptotic Agent ... "The antitumor ether lipid Edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by ... Berdel, WE (1990). "Ether lipids and derivatives as investigational anticancer drugs. A brief review". Onkologie. 13 (4): 245- ... 2009). "Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing ...

... glyceryl ethers MeSH D02.033.800.421.400.750 - phospholipid ethers MeSH D02.033.800.421.560 - nitroglycerin MeSH D02.033. ... phospholipid ethers MeSH D02.355.601.200 - anisoles MeSH D02.355.601.200.100 - anethole trithione MeSH D02.355.601.200.324 - ... crown ethers MeSH D02.355.291.411 - epoxy compounds MeSH D02.355.291.411.400 - epichlorohydrin MeSH D02.355.291.411.417 - ... ether, ethyl MeSH D02.355.417.515 - flurothyl MeSH D02.355.417.600 - methoxyflurane MeSH D02.355.417.650 - phenetidine MeSH ...

... phospholipid ethers MeSH D10.570.755.375.760.400.985.820 - plasmalogens MeSH D10.570.755.375.760.400.985.910 - platelet ...

... ether phospholipids critical for the normal function of mammalian brains and lungs. They also contain approximately 10% of the ... Peroxisomes also interact with the endoplasmic reticulum (ER) and cooperate in the synthesis of ether lipids (plasmalogens) ... Plasmalogen is the most abundant phospholipid in myelin. Deficiency of plasmalogens causes profound abnormalities in the ...

... ether phospholipids, which are found in mammalian brains and lungs. They produce hydrogen peroxide in s process catalyzed by ...

Its alkyl group is connected by an ether linkage at the C1 carbon to a 16-carbon chain. The acyl group at the C2 carbon is an ... PAF was the first phospholipid known to have messenger functions. Benveniste made significant contributions in the role and ... Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent ... The precursor to the remodeling pathway is a phospholipid, which is typically phosphatidylcholine (PC). The fatty acid is ...

... of prodan is sensitive to whether the linkage between phospholipid hydrocarbon tails and the glycerol backbone is of ether or ... including the physical state of surrounding phospholipids). Usually it is concentrated at the surface of the membrane, with ...

Coleman R, Bell RM (1977). "Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol ... This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid ...

However, as the phospholipids of archaea are not ester linked as in bacteria, but are ether linked, they are not significantly ... Phospholipids can be saponified, which releases the fatty acids contained in their diglyceride tail. Once the phospholipids of ... phospholipids are rapidly degraded and the remaining phospholipid content of the sample is assumed to be from living organisms ... Phospholipids can occur in many biological classes (such as in plant roots, fungi, as well as in soil bacteria), so care has to ...

Phospholipids consist of two non-polar hydrocarbon chains with ester or ether bonds to the phosphate group which is also linked ... The phospholipid membrane systems are comparable to the model membranes above but it only consists of one phospholipid which is ... The phospholipid bilayer is a two-layer structure mainly composed of phospholipids, which are amphiphilic molecules that have ... by ester or ether bonds to the polar hydrophilic region. The phospholipid carries a negative charge due to the presence of the ...

The presence of these ether linkages in Archaea adds to their ability to withstand extreme temperatures and highly acidic ... Even though bacteria are prokaryotic cells just like Archaea, their cell membranes are instead made of phospholipid bilayers. ... Bacteria cell membranes are distinct from Archean membranes: They characteristically have none of the ether linkages that ... typically characterized by membrane lipids that are branched hydrocarbon chains attached to glycerol by ether linkages. ...

The SN-1 position can contain either an ester bond or an ether bond, with ether LPA being found at elevated levels in certain ... It is similar to the ubiquitous membrane phospholipid phosphatidylcholine except that it contains an acetyl-group in the SN-2 ... 2005). "Rapid transbilayer movement of ceramides in phospholipid vesicles and in human erythrocytes". J. Biol. Chem. 280 (27): ... position and the SN-1 position contains an ether-linkage. PAF signals through a dedicated G-protein coupled receptor, PAFR and ...

Dimethyl ethers of PEG are the key ingredient of Selexol, a solvent used by coal-burning, integrated gasification combined ... PEG and related polymers (PEG phospholipid constructs) are often sonicated when used in biomedical applications. However, as ... PEG is soluble in water, methanol, ethanol, acetonitrile, benzene, and dichloromethane, and is insoluble in diethyl ether and ... Ethylene glycol and its ethers are nephrotoxic if applied to damaged skin. Ethylene Propylene glycol Monoethylene glycol ...

Hoefs M, Schouten S, De Leeuw JW, King LL, Wakeham SG, Damste J (August 1997). "Ether lipids of planktonic archaea in the ... In most organisms, the cell membrane consists of a lipid bilayer in which phospholipids arrange with their hydrophobic, ... DeLong EF, King LL, Massana R, Cittone H, Murray A, Schleper C, Wakeham SG (March 1998). "Dibiphytanyl ether lipids in ... The long, nonpolar hydrocarbon chains are hydrophobic while the ether-linked glycerol head groups are polar and hydrophilic. ...

... to glycerol molecules via ether linkage. It's highly notable that these lipids are only different from archaea ether lipids in ... Archaeol in the sediments typically originates from the hydrolysis of archaea membrane phospholipids during diagenesis. Due to ... The 2,3-sn-glycerol structure and ether bond linkage are two key differences between lipids found in archaea vs those of ... Though archaeol, featuring the ether linkage between isoprenoid chain to glycerol, has been considered as a biomarker for ...

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic ... Ellingson JS; Lands WEM (1968). "Phospholipid reactivation of plasmalogen metabolism". Lipids. 3 (2): 111-120. doi:10.1007/ ... This enzyme participates in ether lipid metabolism. Arthur G, Page L, Mock T, Choy PC (1986). "The catabolism of ... Warner HR; Lands WEM (1961). "The metabolism of plasmalogen: enzymatic hydrolysis of the vinyl ether" (PDF). J. Biol. Chem. 236 ...

It has been found that the basic nitrogen atoms in pyrido[3,4-b]pyridine do have an anchoring function in the phospholipid ... In the development of MK-869, it was discovered that 3,5-disubstitution of the benzyl ring in the ether series gave greater ...

Egg-derived phospholipids as an ingredient in term and preterm infant formula, Food and Drug Administration, USA Unisci.com, ... Egg lecithin is usually extracted chemically using ethanol, acetone, petroleum ether but not benzene or hexane due to ... Egg lecithin is a type of lecithin, a group of compounds primarily containing phospholipids, that is derived from eggs. Egg ... In aqueous solution, its phospholipids can form either liposomes, bilayer sheets, micelles, or lamellar structures, depending ...

The differing cell membranes in archaea compared to the bacteria may hold part of the explanation; ether lipids that link ... Thermoplasma acidophilum also uses these bulky isoprenoid cores in its phospholipid bilayer. It is possible that the family ...

2-Arachidonoyl glyceryl ether Endocannabinoid transporters Stella N, Schweitzer P, Piomelli D (August 1997). "A second ... which is derived from the increase of inositol phospholipid metabolism by the action of diacylglycerol lipase. The molecule can ... Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds". The Journal of ...