"Entrez Gene: PLCB4 phospholipase C, beta 4". Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 ... "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4)". Genomics. 29 (1): ... Lyu MS, Park DJ, Rhee SG, Kozak CA (1996). "Genetic mapping of the human and mouse phospholipase C genes". Mamm. Genome. 7 (7 ... 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 is an enzyme that in humans is encoded by the PLCB4 gene. The ...

Maheswaran SK, Lindorfer RK (November 1967). "Staphylococcal beta-hemolysin. II. Phospholipase C activity of purified beta- ... At the moment, apiegnin and beta-cyclodextrin are thought to alleviate S.aureus pneumonia, whereas the antibodies of anti alpha ... β-hemolysin (hlb; Q2FWP1) is a Phospholipase C toxin secreted by S. aureus. Upon investigating sheep erythrocytes, its toxic ... Compared to beta-hemolysin, it has a higher affinity for phosphocholines with short saturated acyl chains, especially if they ...

"Entrez Gene: PLCB2 phospholipase C, beta 2". Barr AJ, Marjoram R, Xu J, Snyderman R (Apr 2002). "Phospholipase C-beta 2 ... "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. ... Singer AU, Waldo GL, Harden TK, Sondek J (2002). "A unique fold of phospholipase C-beta mediates dimerization and interaction ... Barr AJ, Marjoram R, Xu J, Snyderman R (2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3 ...

The metallo beta-lactamase protein fold is adapted to associate with membrane phospholipids. A hydrophobic cavity provides an ... NAPE-PLD was found to have no homology to the known phospholipase D genes, but can be classed by homology to fall into the zinc ... N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) is an enzyme that catalyzes the release of N-acylethanolamine (NAE) ... NAPE-PLD is an enzyme activity - a phospholipase, acting on phospholipids found in the cell membrane. It is not homology but ...

1999). "Molecular characterization of cytosolic phospholipase A2-beta". J. Biol. Chem. 274 (24): 17063-7. doi:10.1074/jbc. ... "Entrez Gene: PLA2G4B phospholipase A2, group IVB (cytosolic)". Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of ... Phospholipase A2, group IVB (cytosolic), also known as PLA2G4B, is a human gene. GRCh38: Ensembl release 89: ENSG00000168970 - ... 2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial ...

"Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. ... "Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)". Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 ... Singer AU, Waldo GL, Harden TK, Sondek J (2002). "A unique fold of phospholipase C-beta mediates dimerization and interaction ... 1-Phosphatidylinositol-4,5-bisphosphate phospholipase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene. The ...

"Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. ... "Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)". Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, ... Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG (2000). "Regulation of phospholipase C-beta 3 activity by Na+/ ... Xia C, Bao Z, Yue C, Sanborn BM, Liu M (2001). "Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by ...

The active site His and Ser residues are located at the exterior of the beta-barrel, at the outer leaflet side of the membrane ... Outer membrane phospholipase A1 (OMPLA) is an acyl hydrolase with a broad substrate specificity (EC:3.1.1.32.) from the ... The active site residues are exposed on the exterior of the flat face of the beta-barrel. The activity of the enzyme is ... It has been proposed that Ser164 is the active site of the protein (UniProt P00631) This integral membrane phospholipase was ...

Barr, Alastair J; Marjoram Robin; Xu Jing; Snyderman Ralph (Apr 2002). "Phospholipase C-beta 2 interacts with mitogen-activated ...

Dowal L, Provitera P, Scarlata S (August 2006). "Stable association between G alpha(q) and phospholipase C beta 1 in living ...

Hwang, J I; Heo K; Shin K J; Kim E; Yun C; Ryu S H; Shin H S; Suh P G (June 2000). "Regulation of phospholipase C-beta 3 ... 2000). "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. 275 (22): 16632- ...

Additionally, Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and it has been found ... Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase ... "Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy". ... "Entrez Gene: PLCE1 phospholipase C, epsilon 1". This article incorporates text from this source, which is in the public domain ...

These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, ... Beta-synuclein is a synuclein protein found primarily in brain tissue and is seen mainly in presynaptic terminals. Beta- ... Beta-synuclein is a protein that in humans is encoded by the SNCB gene. The protein encoded by this gene is highly homologous ... Thus, beta-synuclein may protect the central nervous system from the neurotoxic effects of alpha-synuclein and provide a novel ...

Ueno, E; Rosenberg, P (1996). "Mechanism of action of beta-bungarotoxin, a presynaptically acting phospholipase A2 neurotoxin: ... beta 3-, beta 4-, and beta 5- bungarotoxins) from Bungarus multicinctus venom. Amino acid substitutions in the A chains". ... The A chain confers phospholipase A2 (PLP A2) activity, and the B chain, like dendrotoxins, have a Kunitz domain. There are ... Cheng YC, Wang JJ, Chang LS (February 2008). "B chain is a functional subunit of beta-bungarotoxin for inducing apoptotic death ...

It migrates in beta-alanine-acetate-urea gel electrophoresis as a single compound. The phospholipase activity can be separated ... It has been seen that the 16-kDa subunit exhibits phospholipase activity, inducing a release of acyl CoA and acyl carnitine, ... Universal protein resource accession number Q7LZG2 for "Phospholipase A2 taicatoxin" at UniProt. Universal protein resource ... a neurotoxic phospholipase (16 kDa;) and a serine protease inhibitor (7 kDa;). The active complex was isolated by ion exchange ...

Clostridium perfringens beta toxin Awad, M.M.; Bryant, A.E.; Stevens, D.L. & Rood, J.I. (1995). "Virulence studies on ... The N-terminal domain has phospholipase activity. This property allows hydrolysis of phospholipids such as phosphatidyl choline ... There is significant homology with phospholipase C enzymes from Bacillus cereus, C. bifermentans, and Listeria monocytogenes. ... mimicking endogenous phospholipase C. The hydrolysis of phosphatidyl choline produces diacylglycerol, which activates a variety ...

... 's IUPAC chemical name is "N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L ... Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it may cause ...

"Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to ... Group VI phospholipase A2, Intracellular membrane-associated calcium-independent phospholipase A2 beta, or Patatin-like ... 85 kDa calcium-independent phospholipase A2, also known as 85/88 kDa calcium-independent phospholipase A2, ... Specifically, the A2 phospholipase produced from the PLA2G6 gene, sometimes called PLA2 group VI, helps to regulate the levels ...

February 2006). "Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation". Proceedings of the ... Amyloid beta is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid-beta precursor ... Amyloid beta monomers are soluble and contain short regions of beta sheet and polyproline II helix secondary structures in ... October 2007). "Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain". ...

This calcium signaling is dependent on Gq-11 protein signaling and phospholipase C, as well as on the influx of extracellular ... It has been shown that M1-Muscarinic receptors cooperate with D5 receptors and beta-2 adrenergic receptors to consolidate cued ... One effect of the activation of phospholipase C is deactivation of KCNQ channels. Since KCNQ channels conduct M current that ... Young MB, Thomas SA (2014). "M1-muscarinic receptors promote fear memory consolidation via phospholipase C and the M-current". ...

Gq proteins couple to G protein-coupled receptors to activate beta-type phospholipase C (PLC-β) enzymes. PLC-β in turn ... Gq/11/14/15 proteins all activate beta-type phospholipase C (PLC-β) to signal through calcium and PKC signaling pathways. PLC-β ... Second messenger system G protein-coupled receptor Heterotrimeric G protein Phospholipase C Calcium signaling Protein kinase C ...

Hauptmann R, Maurer-Fogy I, Krystek E, Bodo G, Andree H, Reutelingsperger CP (Oct 1989). "Vascular anticoagulant beta: a novel ... and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in ... "Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family". Behring Institute ... "Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against ...

1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and ... phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". Eur. J. Biochem. 185 (1): 63-71. ...

Phospholipase D is an ester bond-cleaving exotoxin that provides the bacterium with the ability to cleave sphingomyelin, which ... Media containing serum or whole blood improve bacterial growth, and a band of beta-hemolysis tends to forms around bacterial ... This phospholipase encoding gene has been isolated to pathogenicity island 1. At least seven pathogenicity islands have been ... A vaccine using a recombinant form of the phospholipase D exotoxin is now in widespread use, and has been shown to decrease the ...

This is true in the case of phospholipase C-beta, which possesses GAP activity within its C-terminal region. This is an ... e.g. somatostatin, prostaglandins Gαq/11 stimulates the membrane-bound phospholipase C beta, which then cleaves PIP2 (a minor ... In addition, the beta and gamma subunits can form a stable dimeric complex referred to as the beta-gamma complex . ... Clapham DE, Neer EJ (1997). "G protein beta gamma subunits". Annual Review of Pharmacology and Toxicology. 37: 167-203. doi: ...

Guo Y, Philip F, Scarlata S (2003). "The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation ... "Entrez Gene: PLCD1 phospholipase C, delta 1". Yagisawa H (2006). "Nucleocytoplasmic shuttling of phospholipase C-delta1: a link ... 1998). "Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector". Biochem. J. 331 (1): 283 ... 2003). "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site". Biochem. Biophys. Res ...

Harris JB, Grubb BD, Maltin CA, Dixon R (February 2000). "The neurotoxicity of the venom phospholipases A(2), notexin and ... Hyatt MC, Russell JA (October 1981). "Effects of beta-bungarotoxin and taipoxin on contractions of canine airways caused by ... Lomonte B, Tarkowski A, Hanson LA (November 1994). "Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of ... Harris JB, MacDonell CA (1981-01-01). "Phospholipase A2 activity of notexin and its role in muscle damage". Toxicon. 19 (3): ...

SH3 domains are constituted by a beta barrel formed by two orthogonal beta sheets and three anti-parallel beta strands. These ... Growth factor receptor binding proteins and phospholipase Cγ are examples of proteins that have SH2 domains. Src homology 3 ( ... domain SH2 domains are structurally composed by three-stranded twisted beta sheet sandwiched flanked by two alpha-helices. The ...

The cleavage of PIP2 by PLC-beta can result in disinhibition of TRPV1 and, as a consequence, contribute to the sensitivity of ... Most sensitizing pro-inflammatory agents activate the phospholipase C pathway. Phosphorylation of TRPV1 by protein kinase C ...

PKR2 is a Gq-coupled protein, so when the ligand binds, beta-type phospholipase C is activated which creates inositol ...