Organic Cation Transporter Like-3 (ORCTL3) was first discovered as a result of a large-scale DNA sequencing project in search ... bearing homology to organic-cation transporters". Cytogenetic and Genome Research. 83 (3-4): 251-255. doi:10.1159/000015197. ... "Identification of a kidney-specific mouse organic cation transporter like-1 (mOCTL1)". Experimental & Molecular Medicine. 39 (6 ... ORCTL3 was decided upon because of its structural homology to proteins belonging to the family of organic cation transporters. ...

... serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in ... Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many ... Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 ... "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1". Pryor, R; Cabreiro, F; Haberland, G (16 ...

... serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in ... Organic cation transporter 3 is a polyspecific transporter whose transport is independent of sodium. Known substrates for ... 2007). "The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show ... 1999). "Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for ...

Thiamine transport is not inhibited by other organic cations nor affected by sodium ion concentration; it is stimulated by a ... The thiamine transporter protein encoded by SLC19A2 has a 40% shared amino acid identity with the folate transporter SLC19A1. ... "Cloning of the human thiamine transporter, a member of the folate transporter family". The Journal of Biological Chemistry. 274 ... Thiamine transporter 1, also known as thiamine carrier 1 (TC1) or solute carrier family 19 member 2 (SLC19A2) is a protein that ...

2006). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U ... Chen Y, Zhang S, Sorani M, Giacomini KM (2007). "Transport of paraquat by human organic cation transporters and multidrug and ... 2007). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends Pharmacol. Sci. 27 ( ... "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U.S.A. ...

The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. The Journal of Biological Chemistry ... Assessment of substrate-dependent ligand interactions at the organic cation transporter OCT2 using six model substrates. ... and organic cation transporter (OCT) 2 in rabbit renal proximal tubules. Journal of Pharmacology and Experimental Therapeutics ... Sex differences in the mRNA, protein, and functional expression of organic anion transporter (OAT) 1, OAT3, ...

Eraly SA, Hamilton BA, Nigam SK (Jan 2003). "Organic anion and cation transporters occur in pairs of similar and similarly ... Xuan W, Lamhonwah AM, Librach C, Jarvi K, Tein I (Jun 2003). "Characterization of organic cation/carnitine transporter family ... Kawasaki Y, Kato Y, Sai Y, Tsuji A (Dec 2004). "Functional characterization of human organic cation transporter OCTN1 single ... The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of ...

Roth B., M; Obaidat, A; Hagenbuch, B (March 2012). "OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO ... Organic cation transport proteins Organic anion-transporting polypeptide Solute carrier family Osmoregulation Organic anion ... "Transporter Classification Database: 2.A.82 The Organic Solute Transporter (OST) Family". tcdb.org. Ballatori, Nazzareno; ... "The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter". J Biol ...

Zhu HJ, Appel DI, Gründemann D, Markowitz JS (July 2010). "Interaction of organic cation transporter 3 (SLC22A3) and ... Rytting E, Audus KL (January 2005). "Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma ... The human serotonin transporter and norepinephrine transporter do not contain zinc binding sites. 4-Hydroxyamphetamine has been ... SLC1A1 is excitatory amino acid transporter 3 (EAAT3), a glutamate transporter located in neurons, SLC22A3 is an extraneuronal ...

Hsyu PH, Gisclon LG, Hui AC, Giacomini KM (January 1988). "Interactions of organic anions with the organic cation transporter ... Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in ... "Entrez Gene: SLC22A12 solute carrier family 22 (organic anion/cation transporter), member 12". Enomoto A, Kimura H, ... "A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout". ...

... such as being a transcriptional regulator of bile acid transporters in the intestine and kidneys. HNF-1α is involved in the ... promotion of hepatic organic cation transporters, which uptake certain classes of pharmaceuticals; hence, the loss of its ... including the involvement in GLUT1 and GLUT2 transporter expression in pancreatic β-cells and angiotensin-converting enzyme 2 ... HNF-1 protein is present in ovarian clear-cell carcinoma. In humans, mutations in HNF1A cause diabetes that responds to low ...

Human MATE1 (hMATE1) is an electroneutral H+/organic cation (OC) exchanger responsible for the final excretion step of ... These transporters may function together with auxiliary proteins that allow passage across just the cytoplasmic membrane or ... "Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter". American Journal ... structurally unrelated toxic organic cations in kidney and liver. Glu273, Glu278, Glu300 and Glu389 are conserved in the ...

2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. ... "Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11". Maruyama K, Sugano S (1994). " ... 2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. ... "Human renal organic anion transporter 4 operates as an asymmetric urate transporter". J Am Soc Nephrol. 18 (2): 430-9. doi: ...

Lamhonwah, A. M.; Skaug, J.; Scherer, S. W.; Tein, I. (2003). "A third human carnitine/organic cation transporter (OCTN3) as a ... Solute carrier family 22 (organic cation transporter), member 21 is a protein that in the house mouse is encoded by the ... "Solute carrier family 22 (organic cation transporter), member 21". Retrieved 2011-12-11. "Indirect calorimetry data for ... "Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice". Journal of Biological ...

... and human clarify the phylogeny of organic anion and cation transporters". Physiol. Genomics. 18 (1): 12-24. doi:10.1152/ ... Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is ... "Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family". Genomics. ... Eraly SA; Monte JC; Nigam SK (2004). "Novel slc22 transporter homologs in fly, worm, ...

... organic cation transport proteins MeSH D12.776.157.530.450.250.812.500 - organic cation transporter 1 MeSH D12.776.157.530. ... organic anion transporters, sodium-dependent MeSH D12.776.157.530.450.074.500.781 - organic anion transporters, sodium- ... organic anion transporters MeSH D12.776.157.530.450.074.500.199 - dicarboxylic acid transporters MeSH D12.776.157.530.450.074. ... 500.400 - monocarboxylic acid transporters MeSH D12.776.157.530.450.074.500.500 - organic anion transporters, atp-dependent ...

... organic cation transport proteins MeSH D12.776.543.585.450.250.812.500 - organic cation transporter 1 MeSH D12.776.543.585. ... organic anion transporters, sodium-dependent MeSH D12.776.543.585.450.074.500.875 - organic anion transporters, sodium- ... organic anion transporters MeSH D12.776.543.585.450.074.500.149 - dicarboxylic acid transporters MeSH D12.776.543.585.450.074. ... 500.300 - monocarboxylic acid transporters MeSH D12.776.543.585.450.074.500.500 - organic anion transporters, atp-dependent ...

2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. ... organic anion transporter), member 7". Cropp CD, Komori T, Shima JE, et al. (2008). "Organic anion transporter 2 (SLC22A7) is a ... 2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. ... Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney ...

"A human transporter protein that mediates the final excretion step for toxic organic cations". Proceedings of the National ... "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends in Pharmacological Sciences ... "Entrez Gene: MATE2 H+/organic cation antiporter". Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T, Tsuchiya T ( ... organic cation antiporters". Biochemical Pharmacology. 74 (2): 359-71. doi:10.1016/j.bcp.2007.04.010. hdl:2433/124277. PMID ...

2006). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends in Pharmacological ... archaea and eukaryotes function as fundamental transporters of metabolic and xenobiotic organic cations. These proteins are ... NorM is nicknamed "Last of the multidrug transporters" because it is the last multidrug transporter discovered functionally as ... "Structure of a Cation-bound Multidrug and Toxic Compound Extrusion Transporter". Nature. 467 (7318): 991-994. Bibcode:2010Natur ...

hENT4 is uniquely selective for adenosine, and also transports a variety of organic cations. The generalized transport reaction ... Concentrative nucleoside transporter Nucleoside transporter Molina-Arcas M, Trigueros-Motos L, Casado FJ, Pastor-Anglada M (Jun ... Young, J. D.; Yao, S. Y. M.; Sun, L.; Cass, C. E.; Baldwin, S. A. (2008-07-01). "Human equilibrative nucleoside transporter ( ... Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (Feb 2004). "The equilibrative nucleoside transporter family, SLC29". ...

"Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18". Akiyama S (December 2001). "[ ... an organic cation transporter expressed in the renal proximal tubules". FEBS Letters. 433 (3): 245-50. doi:10.1016/S0014-5793( ... an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Human Molecular Genetics. 7 (4): 597- ... 49 (1): 38-51. doi:10.1006/geno.1998.5221. PMID 9570947. Reece M, Prawitt D, Landers J, Kast C, Gros P, Housman D, Zabel BU, ...

... serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in ... Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many ... Solute carrier family 22 member 2 (also termed OCT2 or organic cation transporter-2) is a protein that in humans is encoded by ... Barendt WM, Wright SH (2002). "The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization". J. ...

These transporters generally catalyze the export of cations. A representative list of proteins belonging to the PCC family can ... Anyatonwu GI, Ehrlich BE (August 2005). "Organic cation permeation through the channel formed by polycystin-2". The Journal of ... Polycystin-2 transports a variety of organic cations (dimethylamine, tetraethylammonium, tetrabutylammonium, ... The Polycystin Cation Channel (PCC) Family (TC# 1.A.5) consists of several transporters ranging in size from 500 to over 4000 ...

Decynium has been shown to have a very high affinity to organic cation transporters in a variety of species, including human, ... Hayer-Zillgen M, Brüss M, Bönisch H (2002). "Expression and pharmacological profile of the human organic cation transporters ... as well as all members of the organic cation transporter (OCT) family in both human and rat cells. However, it has little ... "Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells". J ...

... organic cation transporter), member 5 SLC26A2: solute carrier family 26 (sulfate transporter), member 2 SH3TC2: domain and ... Solute carrier organic anion transporter family member 4c1 SLU7: pre-mRNA-splicing factor SLU7 SMN1: survival motor neuron 1, ... diastrophic dysplasia sulfate transporter EIF4E1B: encoding protein Eukaryotic translation initiation factor 4E family member ... 103 (1): 63-8. doi:10.1002/ajmg.1513. PMID 11562936. Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, et al. ( ...

... organic anion/cation transporter), member 9". Zhou F, Hong M, You G (2007). "Regulation of human organic anion transporter 4 by ... 2005). "Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules". J. ... Shin HJ, Anzai N, Enomoto A, He X, Kim do K, Endou H, Kanai Y (Apr 2007). "Novel liver-specific organic anion transporter OAT7 ... Sun W, Wu RR, van Poelje PD, Erion MD (Apr 2001). "Isolation of a family of organic anion transporters from human liver and ...

"Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential effects on ... "Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine ... Such polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for the ... The SLC22A5 gene codes for a plasma integral membrane protein which functions as both an organic cation transporter and a ...

... sodium-independent organic cation transport proteins (OCTs) and/or carnitine/organic cation transporters (OCTNs), and do not ... Lastly, choline may enter the cell through intermediate-affinity transporters, which include the choline transporter-like ... The uptake of choline is accomplished predominantly by the high-affinity, sodium dependent choline transporter (CHT) and ... 222 (1): 193-214. doi:10.1016/S0021-9258(19)50785-2. PMID 13366993. Michel V, Yuan Z, Ramsubir S, Bakovic M (May 2006). " ...

Along with the organic cation transporters and the ATP-binding cassette transporters, the OATPs play an important role in the ... Members of the Organo Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport ... "Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity ... proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs are ...