This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates ... Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene. ... "Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2". Meier PJ, Eckhardt U, Schroeder A, et al. ( ... 2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". ...

Scharschmidt, B. F.; Waggoner, J. G.; Berk, P. D. (1 November 1975). "Hepatic organic anion uptake in the rat". J. Clin. Invest ... identified of the presence on the basolateral hepatocyte membrane of a sodium-coupled bicarbonate transporter critical to ... While at UCSF, for two decades Scharschmidt led an independent NIH-funded research laboratory focused on liver physiology and ... including characterization of the hepatic uptake of organic anions such as bilirubin, demonstrated that hepatic update of bile ...

... organic anion transporters, sodium-independent MeSH D12.776.157.530.450.074.500.781.500 - organic anion transport polypeptide c ... organic anion transporters, sodium-dependent MeSH D12.776.157.530.450.074.500.781 - ... organic anion transporters MeSH D12.776.157.530.450.074.500.199 - dicarboxylic acid transporters MeSH D12.776.157.530.450.074. ... 500.400 - monocarboxylic acid transporters MeSH D12.776.157.530.450.074.500.500 - organic anion transporters, atp-dependent ...

... organic anion transporters, sodium-independent MeSH D12.776.543.585.450.074.500.875.500 - organic anion transport polypeptide c ... organic anion transporters, sodium-dependent MeSH D12.776.543.585.450.074.500.875 - ... organic anion transporters MeSH D12.776.543.585.450.074.500.149 - dicarboxylic acid transporters MeSH D12.776.543.585.450.074. ... 500.300 - monocarboxylic acid transporters MeSH D12.776.543.585.450.074.500.500 - organic anion transporters, atp-dependent ...

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which ... 2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. ... 2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. ... "Human renal organic anion transporter 4 operates as an asymmetric urate transporter". J Am Soc Nephrol. 18 (2): 430-9. doi: ...

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which ... organic anion transporter), member 7". Cropp CD, Komori T, Shima JE, et al. (2008). "Organic anion transporter 2 (SLC22A7) is a ... 2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. ... 2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. ...

AE1 in human red blood cells has been shown to transport a variety of inorganic and organic anions. Divalent anions may be ... The anion exchanger family (TC# 2.A.31, also named bicarbonate transporter family) is a member of the large APC superfamily of ... In addition to the Na+-independent anion exchangers (AE1-3) and the Na+:HCO− 3 cotransporters (NBCs) (which may be either ... Additionally, it catalyzes flipping of several anionic amphipathic molecules such as sodium dodecyl sulfate (SDS) and ...

"Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflügers Archiv. 447 (5): ... Ammonia transporter (RHAG(SLC42A1), RHBG(SLC42A2), RHCG(SLC42A3)) Na+-independent, system-L like amino acid transporter ( ... Mackenzie B, Erickson JD (February 2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family ... the organic anion transporting polypeptide transporters), which for historical reasons have names in the format SLCOnXm where n ...

Transporter (Nramp) Family 2.A.56 The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family 2.A.57 The ... Family 2.A.82 The Organic Solute Transporter (OST) Family 2.A.83 The Na+-dependent Bicarbonate Transporter (SBT) Family 2.A.84 ... Family 2.A.60 Organo Anion Transporter (OAT) Family 2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family 2.A.62 The NhaD Na+:H+ ... Family 2.A.20 The Inorganic Phosphate Transporter (PiT) Family 2.A.21 Solute:Sodium Symporter Family 2.A.22 The ...

In the 1st phase, organic solutes (such as phosphates, amino acids, glucose and anions), sodium ions, and hydronium ions are ... These proteins may include sodium-potassium-2 chloride co-transporter, chloride anion exchangers, and chloride channels. ... researchers found that there seems to be an independent association between ill patients with hyperchloremia and mortality. ... due to increased sodium chloride intake Edema - due to influx in sodium in the body Weakness - due to loss of fluids Thirst - ...

A key candidate transporter is INDY (I'm not dead yet), a sodium-independent anion exchanger, which moves both dicarboxylate ... Fieser, Louis F.; Martin, E. L. (1932). "Succinic Anhydride". Organic Syntheses. 12: 66. doi:10.15227/orgsyn.012.0066. "Top ... Both anions are colorless and can be isolated as the salts, e.g., Na(CH2)2(CO2H)(CO2) and Na2(CH2)2(CO2)2. In living organisms ... Succinate requires specific transporters to move through both the mitochondrial and plasma membrane. Succinate exits the ...

... as well as by the sodium-dependent organic anion transporter (SOAT; SLC10A6). E1S, serving as a precursor and intermediate for ... "Metabolism and biologic response of estrogen sulfates in hormone-dependent and hormone-independent mammary cancer cell lines. ... Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter ... Instead, estrone sulfate is transported into cells in a tissue-specific manner by active transport via organic-anion- ...

Loop and thiazide diuretics are secreted from the proximal tubule via the organic anion transporter-1 and exert their diuretic ... This is large in comparison to normal renal sodium reabsorption which leaves only about 0.4% of filtered sodium in the urine. ... are independent of their diuretic effect. That is, the reduction in blood pressure is not due to decreased blood volume ... Aldosterone normally adds sodium channels in the principal cells of the collecting duct and late distal tubule of the nephron. ...

Proteins of the OAT family catalyze the Na+-independent facilitated transport of fairly large amphipathic organic anions (and ... De Bruyn T, Fattah S, Stieger B, Augustijns P, Annaert P (November 2011). "Sodium fluorescein is a probe substrate for hepatic ... Members of the Organo Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport ... Along with the organic cation transporters and the ATP-binding cassette transporters, the OATPs play an important role in the ...

"The permeability of the sodium channel to organic cations in myelinated nerve". The Journal of General Physiology. 58 (6): 599- ... These channels are non-selective for small anions; however chloride is the most abundant anion, and hence they are known as ... Ion channels are one of the two classes of ionophoric proteins, the other being ion transporters. The study of ion channels ... This suggests Kv could be opened by lipid hydrolysis independent of voltage and may qualify this channel as dual lipid and ...

... and serotonin sodium dependent transport area as targets as separate mechanisms from its reuptake of those transporters; unique ... The first addition is a Mannich-like reaction with the enolate anion from acetyl-CoA acting as a nucleophile towards the ... Cocaine crosses the blood-brain barrier via a proton-coupled organic cation antiporter and (to a lesser extent) via passive ... "Drug that spans the ages: The history of cocaine". London: The Independent (UK). 2006. Archived from the original on 28 ...

A major trafficking protein is the pore-forming voltage-dependent anion channel (VDAC). The VDAC is the primary transporter of ... Release of this calcium back into the cell's interior can occur via a sodium-calcium exchange protein or via "calcium-induced- ... When oxygen is limited, the glycolytic products will be metabolized by anaerobic fermentation, a process that is independent of ... releasing a lot of free energy from the reactants without breaking bonds of an organic fuel. The free energy put in to remove ...

Sodium pumps in the renal tubules operate to reabsorb sodium. Potassium must be conserved, but because the amount of potassium ... When ions move through ion transporters (pumps) there is a gate in the pumps on both sides of the cell membrane and only one ... It was suspected in 1702 that they were distinct elements that combine with the same anions to make similar salts, and this was ... Deposits of niter (potassium nitrate) are formed by decomposition of organic material in contact with atmosphere, mostly in ...

"Man makes deadly snakes bite him 160 times in hunt for human antidote , Americas , News , The Independent". Independent.co.uk. ... The recovered purified material is formulated with combinations of sodium octanoate and sodium N-acetyl tryptophanate and then ... Postsynaptic density Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter Receptor Neurotransmitter Axon ... International Journal of Organic Evolution. 75 (6): 1377-1394. doi:10.1111/evo.14239. PMID 33904594. S2CID 233411378. Martin CJ ...

... anion, H 2W 12O10− 42. Further acidification produces the very soluble metatungstate anion, H 2W 12O6− 40, after which ... Sodium tungstate and lead have been studied for their effect on earthworms. Lead was found to be lethal at low levels and ... The tungsten industry often uses independent pricing references such as Argus Media or Metal Bulletin as a basis for contracts ... 5 March 1993). "Identification of molybdopterin as the organic component of the tungsten cofactor in four enzymes from ...