Iron-sulfur proteins, including those that are enzymes, are not included in this definition. Some non-heme iron proteins ... In biochemistry, non-heme iron proteins describe families of enzymes that utilize iron at the active site but lack heme ... Que, Lawrence; Ho, Raymond Y. N. (1996). "Dioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active Sites". Chemical ... Abu-Omar, Mahdi M.; Loaiza, Aristobulo; Hontzeas, Nikos (2005). "Reaction Mechanisms of Mononuclear Non-Heme Iron Oxygenases". ...

... non-heme mono-iron, non-heme diiron , or heme centers. A well-known family of iron-dependent enzymes include oxygenases that ... Iron-sulfur proteins are those with an iron structure that includes sulfur. There are a variety of forms iron and sulfur can ... Iron Iron-binding+proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Brock JH (1989). "Iron- ... Iron-binding proteins are carrier proteins and metalloproteins that are important in iron metabolism and the immune response. ...

... mu-aqua-mu-hydroxo model for non-heme iron sites in proteins". Inorg Chem. 44 (24): 8656-8. doi:10.1021/ic051739i. PMID ... the dinuclear non-heme iron protein, ribonucleotide reductase; leucine aminopeptidase; urease; arginase; several phosphatases ... a protein that is necessary for protein synthesis in vivo. Specifically, MetAP2 protects eIF-2α from inhibitory phosphorylation ... For proteins with small, uncharged penultimate N-terminal residues, a methionine aminopeptidase can cleave the methionine ...

In 2010, Lippard received the Ronald Breslow Award for his work on nonheme iron proteins. Also exciting was the synthesis of a ... "How iron-containing proteins control dioxygen chemistry: a detailed atomic level description via accurate quantum chemical and ... Another novel complex was a "ferric triple-decker", containing three parallel triangular iron units and a triple bridge of six ... Purely inorganic substances such as iron are often required in essential organic reactions, e.g. oxygen binding in the ...

"The influence of different protein sources on phytate inhibition of nonheme-iron absorption in humans". The American Journal of ... Iron supplements, also known as iron salts and iron pills, are a number of iron formulations used to treat and prevent iron ... Injectable forms include iron dextran and iron sucrose. They work by providing the iron needed for making red blood cells. Iron ... Iron supplements are used to treat iron deficiency and iron-deficiency anemia; parenteral irons can also be used to treat ...

Examples include superoxide dismutase, urease, nickel-iron hydrogenase. Many Non-heme iron proteins have diiron active sites, e ...

"Azurin as a protein scaffold for a low-coordinate nonheme iron site with a small-molecule binding pocket". Journal of the ... Protein-protein interactions and cancer therapy". Protein Science. 26 (12): 2334-2341. doi:10.1002/pro.3310. PMC 5699490. PMID ... "Blue copper proteins: a comparative analysis of their molecular interaction properties". Protein Science. 9 (8): 1439-54. doi: ... Azurin from P aeruginosa is a type I blue copper protein (cupredoxin), while cytochrome c551 (9 kDa) is a haem-containing ...

... which are non-heme iron-containing proteins. Recombinant FTO protein was first discovered to catalyze demethylation of 3- ... FTO protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Catharine Paddock (2007-04-13). " ... RPGRIP1L is a protein found in primary cilia that are cellular organelles important for body weight regulation. Decreased ... As one homolog in the AlkB family proteins, it is the first mRNA demethylase that has been identified. Certain alleles of the ...

The body more easily absorbs heme iron than non-heme iron, which is found in plant-based foods. This is because heme iron is ... v t e (Protein pages needing a picture, Human proteins, All stub articles, Protein stubs). ... HCP1 is a protein found in the small intestine that plays a role in the absorption of dietary heme, a form of iron that is only ... Haem Carrier Protein 1 (HCP1) is a membrane-bound protein that is embedded in the cell membrane. As such, it is not freely ...

... are a major class of non-heme iron proteins that catalyse a wide range of reactions ... Solomon EI, Decker A, Lehnert N (April 2003). "Non-heme iron enzymes: contrasts to heme catalysis". Proc. Natl. Acad. Sci. U.S. ... You, Z.; Omura, S.; Ikeda, H.; Cane, D.E.; Jogl, G. (2007). "Crystal structure of the non-heme iron dioxygenase PtlH in ... an emerging structural motif in mononuclear non-heme iron(II) enzymes". Eur. J. Biochem. 250 (3): 625-629. doi:10.1111/j.1432- ...

... (IPNS) is a non-heme iron protein belonging to the 2-oxoglutarate (2OG)-dependent dioxygenases ... Kovacs JA, Brines, LM (July 2007). "Understanding How the Thiolate Sulfur Contributes to the Function of the Non-Heme Iron ... This causes the hydrogen atom at the C-3 of the valine residue to come closer to the iron(IV) oxo ligand which is highly ... This ligation of the thiolate to the iron center anchors the ACV within the active site. The ligation of ACV results in a ...

the MIOX protein fold diverges from that of other non-heme di-iron oxygenases including ribonucleotide reductase and soluble ... Like other di-iron oxygenases, the iron coordination centers are buried deep inside the protein presumably to protect the cell ... Inositol oxygenase, also commonly referred to as myo-inositol oxygenase (MIOX), is a non-heme di-iron enzyme that oxidizes myo- ... The two iron centers are coordinated by various amino acids and water molecules as shown in complex with the myo-inositol ...

"Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine ...

Omura T, Sanders E, Estabrook RW, Cooper DY, Rosenthal O (1966). "Isolation from adrenal cortex of a nonheme iron protein and a ... and iron-sulfur protein biogenesis. FNR is a soluble protein that is found both free in the chloroplast stroma and bound to the ... This enzyme belongs to the family of oxidoreductases, that use iron-sulfur proteins as electron donors and NAD+ or NADP+ as ... However, these proteins belong to two unrelated protein families and are an example of convergent evolution. The plant-type ...

"Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine ... The name of the enzyme was coined based on its function to reduce a [2Fe-2S] (2 iron, 2 sulfur) electron-transfer protein that ... With more proteins with a ferroxodin-reducing activity discovered in both families as well as novel families, this enzyme ... The FAD coenzyme receives two electrons from NADPH and transfers them one at a time to the electron transfer protein ...

... which function as ligands for iron in nonheme iron proteins, such as hemerythrin. transition metal oxalate complex Brignole, ... Jasniewski, Andrew J.; Que, Lawrence (2018). "Dioxygen Activation by Nonheme Diiron Enzymes: Diverse Dioxygen Adducts, High- ... an O2-carrying iron-carboxylate A commercially important family of metal carboxylates are derived from aminopolycarboxylates, e ...

Hemerythrin Some marine invertebrates and a few species of annelid use this iron-containing non-heme protein to carry oxygen in ... Each subunit is composed of a protein chain tightly associated with a non-protein prosthetic heme group. Each protein chain ... it is a giant free-floating blood protein containing many dozens-possibly hundreds-of iron- and heme-bearing protein subunits ... the iron in oxyhemoglobin is seen as existing in the iron(II) oxidation state. However, the complex of oxygen with heme iron is ...

Non-heme iron is mainly derived from plants and exist as iron(II) or iron(III) ions. Iron is essential for more than 500 ... The other 20% is present in ferritin, hemosiderin, iron-sulfur (Fe/S) proteins, such as ferrochelatase, and more. A relatively ... It is absorbed in the intestine as heme or non-heme iron depending on the food source. Heme iron is derived from the digestion ... Iron physiology and pathophysiology in humans. Gregory J. Anderson, Gordon D. McLaren. New York: Humana Press. 2012. ISBN 978-1 ...

While most iron-dependent dioxygenases utilize a non-heme iron cofactor, the oxidation of L-(and D-)tryptophan to N- ... The active ferric center is coordinated by four protein ligands-two histidine and two tyrosinate residues-in a trigonal ... The mononuclear iron dioxygenases, or non-heme iron-dependent dioxygenases as they are also termed, all utilize a single ... Abu-Omar MM, Loaiza A, Hontzeas N (June 2005). "Reaction mechanisms of mononuclear non-heme iron oxygenases". Chemical Reviews ...

Iron in the form of non-heme iron in beans, sea vegetables and leafy greens is sufficient for good health; detailed information ... Adequate protein is available from grains, nuts, seeds, beans, and bean products. Sources of Omega-3 fatty acids are discussed ... USDA National Nutrient Database for Standard Reference, Release 20: Iron, Fe (mg) Content of Selected Foods per Common Measure ...

Eser BE, Das D, Han J, Jones PR, Marsh EN (Dec 2013). "Oxygen-independent alkane formation by non-heme iron-dependent ... H2O2 is an inhibitor of cADO, and an ADO-catalase fusion protein exhibits improved turnover. Short-chain aldehydes are also ... Cyanobacterial aldehyde deformylating oxygenases are cytosolic nonheme di-iron oxygenases, but are much smaller (29 kDa) than ... Two electron transfers restore the reduced state of di-iron and release a molecule of water. Non-specific formation of alcohols ...

Iron poisoning is a fatal medical condition. Due to the saturation of iron-binding protein ferritin, iron in the plasma becomes ... Non-heme and heme oral iron preparations are absorbed into the systemic circulation via different mechanisms. Non-heme iron is ... Iron supplement Human iron metabolism Iron poisoning "Iron supplementation - WikEM". www.wikem.org. Iron Supplementation., ... The absorption of heme iron is 2-3 times faster than non-heme iron. After absorption, the iron from preparation becomes part of ...

... binding proteins PCBP1 and PCBP2 appear to mediate transfer of free iron to ferritin (for storage) and non-heme iron enzymes ( ... 4H+ outside Although the heme proteins are the most important class of iron-containing proteins, the iron-sulfur proteins are ... Iron proteins are involved in electron transfer. The ubiquity of Iron in life has led to the Iron-sulfur world hypothesis that ... To be absorbed, dietary iron can be absorbed as part of a protein such as heme protein or iron must be in its ferrous Fe2+ form ...

... binding proteins PCBP1 and PCBP2 appear to mediate transfer of free iron to ferritin (for storage) and non-heme iron enzymes ( ... To be absorbed, dietary iron can be absorbed as part of a protein such as heme protein or iron must be in its ferrous Fe2+ form ... Muckenthaler MU, Galy B, Hentze MW (2008). "Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein ( ... However, some of the intracellular iron is bound to low-affinity complexes, and is termed labile iron or "free" iron. Iron in ...

The oxygen incorporated need not be derived from O2 with reduced iron-sulfur protein as one donor, and incorporation of one ... It contains a diiron non-heme active site. Recently two crystal structures of the enzyme have appeared that provide much more ... Both structures show an unusual diiron active site where the two iron ions are separated by more than 5 angstroms. Neither ... structure shows evidence for a ligand that would bridge the two iron ions. McKenna EJ, Coon MJ (1970). "Enzymatic omega- ...

NovR is a non-heme iron oxygenase with a unique bifunctional catalysis. In the first stage both oxygens are incorporated from ... Novobiocin bound to proteins in the PDB (Articles with short description, Short description matches Wikidata, ECHA InfoCard ID ... Pojer F, Kahlich R, Kammerer B, Li SM, Heide L (August 2003). "CloR, a bifunctional non-heme iron oxygenase involved in ... This is then adenylated and thioesterified onto the peptidyl carrier protein (PCP) of NovH by ATP and NovH itself. NovI then ...

... designed numerous proteins that mimic many of the catalytic and electron relay properties of heme and non-heme iron proteins, ... "The Protein Society : Protein Society Awards". The Protein Society. Retrieved February 8, 2023. "Recipients , ACS Division of ... The protein, alpha3D, was notable at the time, because it was the premier example of a de novo protein, which was biologically ... As an early pioneer of protein design, he coined the term de novo protein design. He is also active in discovery of small ...

... a nonheme, iron and α-ketoglutarate dependent oxygenase (αKG, FrzG), two short-chain dehydrogenase/reductases (SDRs, FrzB, and ... FrzI), and a hypothetical protein (HP, FrzH). By heterologous expression of these genes in the organism Aspergillus nidulans, ...

Domains and protein flexibility), and a relatively large C-terminal catalytic domain which contains the non-heme iron critical ... Cavity III, the iron site and cavity II form a continuous passage throughout the protein molecule. The active site iron is ... possesses proteins with a slight (~20%) amino acid sequence similarity to lipoxygenases, these proteins lack iron-binding ... Lipoxygenases (EC 1.13.11.-) are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of ...

Fe2+ and 2-oxoglytarate dependent non-heme-ferrous iron hydrolase localized to the mitochondrial matrix. The trimethyllysine ... TMLHE has been shown to have 14 binary protein-protein interactions including 12 co-complex interactions. TMLHE appears to ... and requires iron and L-ascorbate as co-factors. Mutations in the TMLHE gene cause epsilon-trimethyllysine hydroxylase ... The encoded protein converts trimethyllysine into hydroxytrimethyllysine with the reaction (EC 1.14.11.8): N6,N6,N(6)-trimethyl ...