2004). "Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9". J. Biol. Chem. ... Neuronal+Apoptosis-Inhibitory+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all ... 2002). "Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF- ... 2007). "Distribution of neuronal apoptosis inhibitory protein in human tissues". J. Histochem. Cytochem. 55 (9): 911-23. doi: ...
Davoodi J, Lin L, Kelly J, Liston P, MacKenzie AE (September 2004). "Neuronal apoptosis-inhibitory protein does not interact ... This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic ... a group of proteins that negatively regulate apoptosis, or programmed cell death. SMAC is normally a mitochondrial protein ... a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". Cell. 102 (1): 43-53. doi:10.1016/ ...
Davoodi J, Lin L, Kelly J, Liston P, MacKenzie AE (September 2004). "Neuronal apoptosis-inhibitory protein does not interact ... X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP ... XIAP is the most potent human IAP protein currently identified. Neuronal apoptosis inhibitor protein (NAIP) was the first ... Suzuki Y, Nakabayashi Y, Takahashi R (July 2001). "Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein ...
Davoodi J, Lin L, Kelly J, Liston P, MacKenzie AE (September 2004). "Neuronal apoptosis-inhibitory protein does not interact ... Deveraux QL, Reed JC (February 1999). "IAP family proteins--suppressors of apoptosis". Genes & Development. 13 (3): 239-52. doi ... two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins". The Journal of Biological Chemistry. 276 ( ... a novel member of the inhibitor of apoptosis protein family". Molecular and Cellular Biology. 21 (13): 4292-301. doi:10.1128/ ...
Neuronal Apoptosis-Inhibitory Protein Neuronal Calcium-Sensor Proteins Neuropeptides Olfactory Marker Protein S100 Proteins ... Neuronal apoptosis inhibitory protein (NAIP) belongs to the family of proteins called the inhibiter of apoptosis family (IAP), ... "Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent ... Hippocalcin is a neuronal calcium-sensor protein which has two to three regions that can bind with calcium ions. The X-linked ...
Furthermore, the neuronal apoptosis inhibitory protein (NAIP), normally widespread, has an LTR of the HERV-P family acting as a ... and the proteins can interfere with active retroviruses. A gag protein from HERV-K(HML2) is shown to mix with HIV Gag, ... On a protein level, a direct interaction between TLRs and certain HERV proteins has been shown. For example, the surface unit ... encodes for coat proteins for the virus's exterior). These viral proteins are encoded as polyproteins. In order to carry out ...
Neuronal apoptosis inhibitory protein (NAIP) Mixed lineage kinase 2 (MLK2) - MLK2 is myosin light chain kinase 2 The b2 adaptin ... Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 ... Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It is expressed ... "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203-9. doi:10.1016/j. ...
... neuronal apoptosis-inhibitory protein MeSH D12.644.360.075.437.750 - x-linked inhibitor of apoptosis protein MeSH D12.644. ... proto-oncogene proteins c-vav MeSH D12.644.360.024.334 - smad proteins MeSH D12.644.360.024.334.200 - smad proteins, inhibitory ... apoptosis regulatory proteins MeSH D12.644.360.075.311 - apoptosis inducing factor MeSH D12.644.360.075.405 - caspases MeSH ... neuronal calcium-sensor proteins MeSH D12.644.360.381.500.124 - guanylate cyclase-activating proteins MeSH D12.644.360.381. ...
... in neuronal injury through apoptosis inducing factor and activation of nuclease activity of macrophage migration inhibitory ... The Dawsons have also been at the forefront of research into the biology and pathobiology of the proteins and mutant proteins ... 2006). "Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death". J ... protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1". Proc Natl Acad Sci U S A. 97 ...
... activity of proto-oncogenic proteins, apoptosis, centrosome duplication, and organization of neuronal dendrites. In unicellular ... Most NDR kinase catalytic domains also contain an extended insert region that may function as an auto-inhibitory element. The ... Pearce, Laura R.; David Komander; Dario R. Allesi (January 2010). "The nuts and bolts of AGC protein kinases". Nature Reviews ... NDR (nuclear dbf2-related) kinases, are an ancient and highly conserved subclass of AGC protein kinases that control diverse ...
JNK activation is required for apoptosis but c-jun, a protein in the JNK signaling pathway, is not always required. LNGFR also ... p75NTR is involved in pathways that promote neuronal survival and neuronal death. p75NTR is a member of the tumor necrosis ... to mediate RhoA-dependent inhibition of growth of regenerating axons exposed to inhibitory proteins of CNS myelin, such as Nogo ... October 1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". The ...
The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor ... Castro-Rivera E, Ran S, Thorpe P, Minna JD (August 2004). "Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, ... The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development ... "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron ...
... leading to a neuronal cell death pathway known as apoptosis. Apoptosis occurs primarily via the increased intracellular ... This protein interacts with other proteins called SNAREs in order to induce vesicle fusion with the presynaptic membrane. As a ... These electrical signals may be excitatory or inhibitory, and, if the total of excitatory influences exceeds that of the ... Additional sources of neuronal cell death related to excitotoxicity involve energy rundown in the mitochondria and increased ...
... neuronal apoptosis-inhibitory protein MeSH D12.776.476.075.437.750 - x-linked inhibitor of apoptosis protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.476.024.417.249.600 - smad6 protein MeSH D12.776.476.024.417.249.700 - smad7 protein ... smad1 protein MeSH D12.776.476.024.417.500.200 - smad2 protein MeSH D12.776.476.024.417.500.300 - smad3 protein MeSH D12.776. ... rhoa gtp-binding protein MeSH D12.776.476.525.700.300 - rhob gtp-binding protein The list continues at List of MeSH codes ( ...
The axon hillock is a specialized domain of the neuronal cell body from which the axon originates. A high amount of protein ... In case of neurons, the soma receives a large number of inhibitory synapses, which can regulate the activity of these cells. It ... of some sensory neurons depends on axon terminals making contact with sources of survival factors that prevent apoptosis. The ... Axons contain microtubule-associated motor proteins that transport protein-containing vesicles between the soma and the ...
... binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase". J. ... Another important function of the developing mammalian nervous system is neuronal apoptosis. The absence of DLK also protects ... neuronal migration and axon growth are critical components of neuronal development. DLK null mice have defects in neuronal ... Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene. The protein encoded by this ...
HGE was shown to exhibit selective osteoclast inhibitory activity by inducing osteoclast apoptosis and inhibiting their ... The resulting isocyanates could then react with skin proteins. In the liver of humans and rats, HGE can be metabolized via ... HGE increases the affinity of GABA binding to its receptor, thus decreasing the neuronal excitability. Flumazenil, a selective ... Studies have found that HGE plays a role in antitumor activity by inducing apoptosis in cancer cells. It is also shown to have ...
Sun X, Wu Y, Herculano B, Song W (2014-04-21). "RCAN1 overexpression exacerbates calcium overloading-induced neuronal apoptosis ... SH3 domains or PRD are very important to allow the binding of the protein to endocytosis-related proteins such as ITSN1 and ... Ermak G, Morgan TE, Davies KJ (October 2001). "Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is ... Down syndrome critical region gene 1, also known as DSCR1, is a protein that in humans is encoded by the RCAN1 gene. DSCR1 in ...
... has also been found to promote apoptosis within neuronal cells. It is currently believed that KCNB1-induced apoptosis ... Another proposed mechanism for regulation of apoptosis is oligomerization, or the process of forming multi-protein complexes ... a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". The EMBO Journal ... and apoptosis. Voltage-gated potassium channels are essential in regulating neuronal membrane potential, and in contributing to ...
GnIH binds to the Gαi protein coupled receptor GPR147 to suppress adenylyl cyclase formation of cAMP and inhibit protein kinase ... Furthermore, GnIH neuronal cell counts in multiple vertebrates fluctuate with an organism's parental status. GnIH cell count ... In male vertebrates, GnIH reduces testis size, lowers testosterone secretion, and increases the incidence of apoptosis in germ ... Gonadotropin-inhibitory hormone (GnIH) is a RFamide-related peptide coded by the NPVF gene in mammals. GnIH was discovered in ...
PKR also mediates ethanol-induced protein synthesis inhibition and apoptosis which is linked to fetal alcohol syndrome. Protein ... 2006). "Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease". ... However, BACE1 expression can be activated by phosphorylation of eIF2a, which reverses the inhibitory effect exerted by BACE1 5 ... Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein ...
The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in ... Insulin stimulation of neuronal cells also antagonizes PAK2 kinase activity, leading to an increased glucose uptake. PAK2- ... Similar to PAK1, PAK2 contains a p21-binding domain (PBD) and an auto-inhibitory domain (AID) and exists in an inactive ... The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in ...
All three RGM proteins appear capable of binding selected BMPs (bone morphogenetic proteins). RGMs may play inhibitory roles in ... Neogenin overexpression and RGM downexpression in the developing embryonic neural tube induces apoptosis. The apoptotic ... "RGM and its receptor neogenin regulate neuronal survival". Nat. Cell Biol. 6 (8): 749-55. doi:10.1038/ncb1157. PMID 15258591. ... linked cell-membrane-associated proteins. The three proteins, RGMa (this protein), RGMb and RGMc are 40-50% identical to each ...
The increase in LRRK2 kinase activity leads to enhanced protein translation via the phosphorylation of the ribosomal protein ... They defined the role for NO generated from neuronal NO synthase or immunologic NO synthase leads in models of HIV dementia and ... Her research team discovered that PAR leads to cell death by facilitating the release of apoptosis inducing factor (AIF) factor ... Parsylated AIF then recruits macrophage migration inhibitory factor (MIF) and the complex translocates to the nucleus where the ...
Current research suggests that genes that increase susceptibility to ASD are ones that control protein synthesis in neuronal ... Some of these genes are known to modulate production of the GABA neurotransmitter, the nervous system's main inhibitory ... February 2009). "CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis". Nature Cell ... The gene CHD8 encodes the protein chromodomain helicase DNA binding protein 8, which is a chromatin regulator enzyme that is ...
Manipulation of apoptosis regulator proteins Bcl-2 and Bax (overexpression of Bcl-2 or deletion of Bax) produces an increase in ... Lossi, L; Merighi, A (April 2003). "In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS". ... In the neocortex, a 4:1 ratio of excitatory to inhibitory interneurons is maintained by apoptotic machinery that appears to be ... It is hypothesized that necroptosis can serve as a cell-death backup to apoptosis when the apoptosis signaling is blocked by ...
"Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis". Nature Cell Biology. 4 (1): 11-9 ... The auto-inhibitory domain, which contains an ubiquitylation site at the K1182 residue is located at the C-terminus. HIPK2 has ... HIPK2 has been shown to be expressed at the highest levels in the brain and neuronal tissues. In addition to adult tissues, ... HIPK2 interacts with several other proteins: CREB binding protein p53 p300 SKI protein TP53INP1 ATM kinase PIN1 HMGA1 SIAH1 ...
This family is also known as inhibitors of DNA binding protein family and are composed of transcription inhibitory proteins ... "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation". J. Biol. ... This is inclusive of embryonic cellular growth, senescence, cellular differentiation, apoptosis, and as an oncogene in ... ID4 is a protein coding gene. In humans, it encodes for the protein known as DNA-binding protein inhibitor ID-4. This protein ...
After natural apoptosis is suppressed, abnormal tumor growth can be observed through the loss of polarity in which Rho proteins ... genetic malfunctions of a rho protein could explain the irregular morphology of neuronal dendrites seen in some cases of mental ... Following injury to the spinal cord, the extracellular space becomes inhibitory to the natural efforts neurons undergo to ... A second target to explain the role of the Rho proteins in cancer is their regulatory proteins. Rho proteins are very tightly ...
In both cases, the protein is vital for normal neuronal pattern development. Semaphorin-3A is secreted by neurons and ... "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron ... it potentially holds a causal relationship to synaptic weakening and denervation that precedes motor neuron apoptosis in ALS. ... Semaphorin-3A is a protein that in humans is encoded by the SEMA3A gene. The SEMA3A gene is a member of the semaphorin family ...