The main receptor neurokinin B interacts with is the neurokinin 3 receptor (NK3R). The Neurokinin 3 receptor is a part of a ... While neurokinin B has the ability to bind to other Neurokinin receptors, the highest affinity lies in that of the NK3R ... Neurokinin B (NKB) belongs in the family of tachykinin peptides. Neurokinin B is implicated in a variety of human functions and ... Much like the neurokinin B peptide, the NK3R receptor that it binds to is encoded within five exons of the TACR3 gene in humans ...

Modified from: Sun J, Ramnath RD, Tamizhselvi R, Bhatia M."Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB- ... Sun, J; Ramnath, RD; Tamizhselvi, R; Bhatia, M (Sep 2008). "Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB- ... The molecular mechanism behind neurokinin's role as a chemoattractor is currently unclear. Neurokinin A has an inhibitory ... Neurokinin A is ubiquitous in both the central and peripheral mammalian nervous systems, and seems to be involved in reactions ...

Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". The Journal ... Gerard NP, Eddy RL, Shows TB, Gerard C (Jan 1991). "The human neurokinin A (substance K) receptor. Molecular cloning of the ... Gerard NP, Eddy RL, Shows TB, Gerard C (Nov 1990). "The human neurokinin A (substance K) receptor. Molecular cloning of the ... Bandari PS, Qian J, Oh HS, Potian JA, Yehia G, Harrison JS, Rameshwar P (May 2003). "Crosstalk between neurokinin receptors is ...

... neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior". Physiol. Behav. 54 (2): 249- ... TAC1 encodes neurokinin A (formerly known as substance K), neuropeptide K (which has also been called neurokinin K), ... NK1, NK2 and NK3 selectively bind to substance P, neurokinin A, and neurokinin B, respectively. Whilst the receptors are not ... TAC3 encodes neurokinin B. The best known tachykinin is Substance P. There are three known mammalian tachykinin receptors ...

Receptors,+Neurokinin-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural ... The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein ... Fong TM, Yu H, Huang RR, Strader CD (December 1992). "The extracellular domain of the neurokinin-1 receptor is required for ... Ho WZ, Douglas SD (December 2004). "Substance P and neurokinin-1 receptor modulation of HIV". Journal of Neuroimmunology. 157 ( ...

Giardina GA, Gagliardi S, Martinelli M (August 2003). "Antagonists at the neurokinin receptors--recent patent literature". ...

Bang R, Sass G, Kiemer AK, Vollmar AM, Neuhuber WL, Tiegs G (April 2003). "Neurokinin-1 receptor antagonists CP-96,345 and L- ... Rittner HL, Lux C, Labuz D, Mousa SA, Schäfer M, Stein C, Brack A (December 2007). "Neurokinin-1 receptor antagonists inhibit ... Muñoz M, Rosso M, Coveñas R, Montero I, González-Moles MA, Robles MJ (June 2007). "Neurokinin-1 receptors located in human ... Yu J, Allison S, Ibrahim D, Cadet JL, Angulo JA (June 2002). "Ontogeny of neurokinin-1 receptor mediation of methamphetamine ...

Wei XY, Zhao Y, Wong-Riley MT, Ju G, Liu YY (September 2012). "Synaptic relationship between somatostatin- and neurokinin-1 ... Hayes JA, Del Negro CA (June 2007). "Neurokinin receptor-expressing pre-botzinger complex neurons in neonatal mice studied in ... Guyenet PG, Sevigny CP, Weston MC, Stornetta RL (May 2002). "Neurokinin-1 receptor-expressing cells of the ventral respiratory ... Wang H, Stornetta RL, Rosin DL, Guyenet PG (May 2001). "Neurokinin-1 receptor-immunoreactive neurons of the ventral respiratory ...

Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. ... Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. ...

Other neurokinin subtypes and neurokinin receptors that interact with SP have been reported as well. Amino acid residues that ... In 1983, Neurokinin A (previously known as substance K or neuromedin L) was isolated from porcine spinal cord and was also ... Its receptor - the neurokinin type 1 - is distributed over cytoplasmic membranes of many cell types (neurons, glia, endothelia ... Gobbi G, Cassano T, Radja F, Morgese MG, Cuomo V, Santarelli L, Hen R, Blier P (Apr 2007). "Neurokinin 1 receptor antagonism ...

Cully, Megan (June 2017). "Neurokinin 3 receptor antagonist revival heats up with Astellas acquisition". Nature Reviews Drug ... and the role of neurokinin B in the hot flush symptoms of menopausal women. "Home - Professor Waljit Dhillo". www.imperial.ac. ...

Neurokinin B - endogenous peptide ligand, also interacts with other neurokinin receptors but has highest affinity for NK3 ... This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. A number of selective ligands ... "Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and ... Page NM, Dakour J, Morrish DW (Jul 2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre- ...

... s in the dorsal raphe nucleus are co-localized with neurokinin 1 (NK1) receptors and have been shown to inhibit ... April 2007). "Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function". European ...

... (VLY-686 or LY686017) is an experimental drug that is a neurokinin 1 antagonist. It works by blocking substance P, ... March 2008). "Neurokinin 1 receptor antagonism as a possible therapy for alcoholism". Science. 319 (5869): 1536-9. Bibcode: ... February 2010). "Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder". ...

Litman RE, Smith MA, Desai DG, Simpson T, Sweitzer D, Kanes SJ (2014). "The selective neurokinin 3 antagonist AZD2624 does not ... selective neurokinin-3 (NK3) receptor antagonist which was under development by AstraZeneca and Millendo Therapeutics for the ... "Tachykinin neurokinin 3 receptor antagonists: a patent review (2005 - 2010)". Expert Opin Ther Pat. 21 (5): 637-55. doi:10.1517 ...

Payton S (August 2010). "Urinary incontinence: Neurokinin receptor antagonist inferior to tolterodine for OAB". Nature Reviews ... placebo controlled trial of a neurokinin-1 receptor antagonist for overactive bladder". The Journal of Urology. 184 (2): 616-22 ...

... belongs to the class of neurokinin-1 receptor antagonists medications. It works by blocking substance P from ... August 2005). "Antiemetic efficacy of the neurokinin-1 antagonist, aprepitant, plus a 5HT3 antagonist and a corticosteroid in ... May 2013). "Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant ... May 2004). "Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant". Biological ...

Schwyzer, R., "Membrane-assisted molecular mechanism of neurokinin receptor subtype selection." EMBO J. 6:2255-2259, 1987 ( ...

Reddy GK, Gralla RJ, Hesketh PJ (April 2006). "Novel neurokinin-1 antagonists as antiemetics for the treatment of chemotherapy- ... December 2013). "Efficacy of vestipitant, a neurokinin-1 receptor antagonist, in primary insomnia". Sleep. 36 (12): 1823-30. ...

April 2010). "Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain". Pain. 149 (1): 64-70. doi ...

Neurokinin 1 (NK1) receptor antagonists prevent an emetic signal from being transmitted. Medications include aprepitant and ... and the more recently discovered neurokinin-1 (substance P). A 2008 study compared 121 Japanese patients who experienced PONV ...

Kisspeptin, neurokinin B, and dynorphin (KNDy) neurons are neurons in the hypothalamus of the brain that are central to the ... KNDy neurons in the hypothalamus coexpress kisspeptin, neurokinin B (NKB) and dynorphin. They are involved in the negative ... KNDy neurons control GnRH pulse generation by through release of three known peptides: neurokinin B (NKB), dynorphin and ... Hu, Guangfu; Lin, Chengyuan; He, Mulan; Wong, Anderson O.L. (2014-11-01). "Neurokinin B and reproductive functions: "KNDy ...

Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. ... 2003). "Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women". Am. J ... 2003). "Neurokinin B is a paracrine vasodilator in the human fetal placental circulation". J. Clin. Endocrinol. Metab. 88 (5): ... 2004). "Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1". J. ...

The role of beta-arrestins in endocytosis of the neurokinin-1 receptor". The Journal of Biological Chemistry. 274 (23): 16257- ...

"Nicotine Enhances Excitability of Medial Habenular Neurons via Facilitation of Neurokinin Signaling". Journal of Neuroscience. ...

Pawsey S, Mills EG, Ballantyne E, Donaldson K, Kerr M, Trower M, Dhillo WS (July 2021). "Elinzanetant (NT-814), a Neurokinin 1, ... Elinzanetant (developmental code names BAY-3427080 GSK-1144814, NT-814) is an orally active small-molecule neurokinin/ ... List of investigational sex-hormonal agents § Neurokinin/tachykinin receptor antagonists "Elinzanetant - Bayer". Adis Insight. ...

"Ablation of Least Shrew Central Neurokinin NK1 Receptors Reduces GR73632-Induced Vomiting". Behavioral Neuroscience. 123 (3): ...

Molecules such as substance P may be involved in potentiation via neurokinin receptors. NMDA activation also triggers a change ...

... and neurokinin B-immunoreactivity in the human brainstem". Brain Structure and Function. 218 (1): 131-149. doi:10.1007/s00429- ...

These neurons express estrogen receptors and also coexpress neurokinin B in female rats. GHRH neurons help to control growth ... neurokinin B (NKB), β-endorphin, melanocyte-stimulating hormone (MSH), and somatostatin. Proopiomelanocortin (POMC) is a ... "Immunofluorescent histochemical and ultrastructural studies on the innervation of kisspeptin/neurokinin B neurons to ...