... (MRF) are basic helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5 ... Myogenic+Regulatory+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... Hernández-Hernández J, García-González E, Brun C, Rudnicki M (2017). "The myogenic regulatory factors, determinants of muscle ... of an Independent Amphioxus Expansion and Two-Gene Ancestral Vertebrate State for MyoD-Related Myogenic Regulatory Factors ( ...
"Functional conservation of nematode and vertebrate myogenic regulatory factors". J Cell Sci Suppl. 16: 111-115. doi:10.1242/jcs ... "Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis". Nature. 341 (6240): 303-307. ... During the final years of his life, Weintraub's work used myoD to delve broadly and deeply into the areas of regulatory ... Thayer, MJ; Tapscott, SJ; Davis, RL; Wright, WE; Lassar, AB; Weintraub, H (1989). "Positive autoregulation of the myogenic ...
Lin CY, Yung RF, Lee HC, Chen WT, Chen YH, Tsai HJ (November 2006). "Myogenic regulatory factors Myf5 and Myod function ... Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription ... Summerbell D, Halai C, Rigby PW (September 2002). "Expression of the myogenic regulatory factor Mrf4 precedes or is ... Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. It is a protein with a key role in regulating muscle ...
... myogenic regulatory factor 5 MeSH D12.776.210.500.570.600 - myogenin MeSH D12.776.210.500.600.100 - myosin heavy chains MeSH ... vascular endothelial growth factor a MeSH D12.776.467.100.800.300 - vascular endothelial growth factor b MeSH D12.776.467.100. ... fibroblast growth factor 4 MeSH D12.776.624.664.700.112 - fibroblast growth factor 6 MeSH D12.776.624.664.700.114 - fms-like ... peptide elongation factor g MeSH D12.776.835.700.350.700 - peptide elongation factor tu MeSH D12.776.835.700.350.800 - peptide ...
... myogenic regulatory factor 5 MeSH D12.776.930.125.750.600 - myogenin MeSH D12.776.930.127.061.500 - activating transcription ... MeSH D12.776.930.125.500.500 - microphthalmia-associated transcription factor MeSH D12.776.930.125.500.750 - sterol regulatory ... sterol regulatory element binding protein 2 MeSH D12.776.930.127.124.249 - CCAAT-binding factor MeSH D12.776.930.127.124.500 - ... microphthalmia-associated transcription factor MeSH D12.776.930.127.092.750 - sterol regulatory element binding proteins MeSH ...
... myogenic regulatory factor 5 MeSH D12.776.260.103.750.600 - myogenin MeSH D12.776.260.108.061.500 - activating transcription ... MeSH D12.776.260.103.500.500 - microphthalmia-associated transcription factor MeSH D12.776.260.103.500.750 - sterol regulatory ... sterol regulatory element binding protein 2 MeSH D12.776.260.108.124.249 - ccaat-binding factor MeSH D12.776.260.108.124.500 - ... microphthalmia-associated transcription factor MeSH D12.776.260.108.092.750 - sterol regulatory element binding proteins MeSH ...
... a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors". ... "Entrez Gene: TCF12 transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)". Ganna A, Verweij KJ, Nivard MG, ... Transcription factor 12 is a protein that in humans is encoded by the TCF12 gene. The protein encoded by this gene is a member ... Bhandari RK, Sadler-Riggleman I, Clement TM, Skinner MK (2011-05-17). "Basic helix-loop-helix transcription factor TCF21 is a ...
... she and her lab went on to study the myogenic regulatory factors, showing that Myf5 is present before MyoD in the embryo and ... "Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis". Nature. 341 (6240): 303-307. ... The behaviour of these cells is controlled by gene regulatory networks and signalling pathways, exemplified by the FGF10 gene. ... From genetic screens, they identified other Pax3 targets, demonstrating the central role of Pax3 in the gene regulatory network ...
... is a myogenic regulatory factor (MRF) involved in the process known as myogenesis. MYF6/Mrf4 is a member of the myogenic ... Myogenic factors are basic helix-loop-helix (bHLH) transcription factors. MYF6 is a gene that encodes a protein involved in the ... Myogenic factor 6 (also known as Mrf4 or herculin) is a protein that in humans is encoded by the MYF6 gene. This gene is also ... "Entrez Gene: Myogenic factor 6 (herculin)". Retrieved 2013-08-19. Braun T, Bober E, Winter B, Rosenthal N, Arnold HH (March ...
The interaction of other signaling molecules, such as myogenic regulatory factors, with this gradient promotes the development ... These transcription factors then regulate the expression of segment polarity genes, which define the polarity of each segment. ... Arthropods such as the fruit fly form segments from a field of equivalent cells based on transcription factor gradients. ... The pair-rule genes are mostly transcription factors, expressed in regular stripes down the length of the embryo. ...
Myogenic regulatory factors (MRFs): MyoD, Myf5, Myf6 and Myogenin. There are a number of stages (listed below) of muscle ... proteins transcription factor family. Cells that make myogenic bHLH transcription factors (including MyoD or Myf5) are ... high-throughput sequencing and ChIP-chip analysis has been essential in elucidating the targets of myogenic regulatory factors ... 2005). "Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene". J Biol Chem ...
... are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 ... The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 ( ... nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor". Proc. Natl. Acad. Sci. U.S.A. 89 (20): 9484-8 ... Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor ...
... by increasing the protein expression of certain myogenic regulatory factors (e.g., myoD and myogenin) and gene transcription ... factors (e.g., MEF2). HMB-induced human myosatellite cell proliferation in vitro is mediated through the phosphorylation of the ... non-human animal species has been shown to increase the serum concentration of growth hormone and insulin-like growth factor 1 ... In healthy individuals, approximately 60% of dietary L-leucine is metabolized after several hours, with roughly 5% (2-10% range ...
The dynamics of activation and quiesence and the induction of the myogenic program through the myogenic regulatory factors, ... Greater activation also results in increased expression of myogenic basic helix-loop-helix transcription factors MyoD, myogenin ... Myocyte nuclear factor (MNF), and c-met proto-oncogene (receptor for hepatocyte growth factor (HGF)) are less commonly used ... It is thought that HGF activates satellite cells, while insulin-like growth factor-I (IGF-1) and fibroblast growth factor (FGF ...
... belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription ... to induce cells in somites that receive these Wnt signals to express Pax3 and Pax7 in addition to myogenic regulatory factors, ... Wnt4, Wnt5, and Wnt6 function to increase the expression of both of the regulatory factors but at a more subtle level. ... Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B (February 1993). "Interaction of myogenic factors and ...
Ma K, Chan JK, Zhu G, Wu Z (May 2005). "Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, ... Svensson M (2000). Evolution of a family of plant genes with regulatory functions in development; studies on Picea abies and ... transcriptional activity, and myogenic differentiation". Molecular and Cellular Biology. 25 (9): 3575-82. doi:10.1128/MCB.25.9. ... Gramzow L, Ritz MS, Theissen G (April 2010). "On the origin of MADS-domain transcription factors". Trends in Genetics. 26 (4): ...
Differentiation is regulated by myogenic regulatory factors, including MyoD, Myf5, myogenin, and MRF4. GATA4 and GATA6 also ... Through this analysis, it seems that the myogenic GRN is an ancestral GRN with actual changes in myogenic function and ... Thus, the usage of any of these structural or regulatory elements in determining whether or not the muscle cells of the ... In another take on the argument, Andrikou & Arnone (2015) use the newly available data on gene regulatory networks to look at ...
"A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding ... in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor ... nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor". Proceedings of the National Academy of ... Myogenin has been shown to interact with: MDFI, POLR2C, Serum response factor Sp1 transcription factor, and TCF3. GRCh38: ...
The introduction of myogenic regulatory factors, growth factors, or other gene products into muscle cells may increase ... Culture media can be supplemented with additives-for instance sera-that supply additional growth factors. Growth factors can be ... One factor is the nature of the animal from which the cells are sourced, whether it is a kosher or non-kosher species and ... Regulatory matters must also be sorted out. Prior to being available for sale, the European Union, Australia, New Zealand, the ...
It is ligand for epidermal growth factor (EGF) and it is related to transforming growth factor alpha (TGF-alpha). This protein ... Tissue resident regulatory T cells (Tregs) can also express amphiregulin to promote tissue repair. These cells have a distinct ... and the production of amphiregulin could enhance the colony-forming efficiency and myogenic differentiation of skeletal muscle ... a member of the epidermal growth factor family". Growth Factors. 7 (3): 195-205. doi:10.3109/08977199209046924. PMID 1333777. ...
These myogenic effects are caused by increased cell death of myogenic precursors in the dermomyotome and diminished migration ... PAX3 and FOXO1 encode transcription factors, and the translocation results in a fusion transcription factor containing the N- ... Therefore, wild-type PAX3 exerts a regulatory role in tumorigenesis and tumor progression, which may be related to its role in ... Interaction of PAX3 with other transcription factors (such as SOX10) or chromatin factors (such as PAX3/7BP) enables ...
Myogenic control, which originates from the wall of the blood vessel itself and consists of both muscle reflexes and products ... Both of these factors affect pH and, in turn, the balance between vasodilation versus vasoconstriction in the brain. So, the ... However, the local intrinsic regulatory system described here is completely independent of these other mechanisms. Many organs ... Skeletal muscle is influenced by multiple factors. First, metabolites that are produced by active muscle use can alter skeletal ...
2007). "Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and ... 2005). "The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling ... "Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor- ... Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is ...
The first regulatory approvals for MSCs were granted conditional approval in 2012 in Canada and New Zealand for treating Graft ... In contrast, the addition of transforming growth factor-beta (TGF-b) could induce chondrogenic markers.[citation needed] The ... Caplan identified certain conditions by which mesodermal cells differentiate into cartilage or myogenic (muscle) tissue and ... "Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB ...
... blocks cell migration and invasion through the degradation of metal regulatory transcription factor 1 (MTF1) and YY2 ... STAU1 regulates the stability and translation of myogenic mRNAs, which negatively affects myoblast differentiation. For example ... SMD of transcriptional factor retina and anterior neural fold homobox2 (RAX2) transcript has shown to be required for the ... STAU1 is associated with the regulation of mRNA stability by directly binding RBPs to the regulatory motifs of target mRNAs ...
Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B (February 1993). "Interaction of myogenic factors and ... Xia X, Cheng A, Akinmade D, Hamburger AW (March 2003). "The N-terminal 24 amino acids of the p55 gamma regulatory subunit of ... When E2F is free it activates factors like cyclins (e.g. cyclin E and cyclin A), which push the cell through the cell cycle by ... pRb is able to bind to transcription factors in the E2F family and thereby inhibit their function. When pRb is chronically ...
Myogenic mechanism List of distinct cell types in the adult human body Betts, J. Gordon; Young, Kelly A.; Wise, James A.; ... The MLC20 is also known as the regulatory light chain and actively participates in muscle contraction. Two MLC20 isoforms are ... The mechanism in which external factors stimulate growth and rearrangement is not yet fully understood. A number of growth ... Because of its myogenic nature, single-unit smooth muscle is usually active, even when it is not receiving any neural ...
Both have the intrinsic capacity to activate the myogenic factor 5 (Myf5) promoter, a trait only associated with myocytes and ... To some degree, all cells of endotherms give off heat, especially when body temperature is below a regulatory threshold. ... Numerous factors make infants more susceptible to cold than adults: A higher ratio of body surface area (proportional to heat ... Fibroblast Growth Factor 21 Production (FGF-21) has been documented as a pathway to longevity. BAT activation through cold ...
Helix-loop-helix factors (bHLH) 1.2.1 Family: Ubiquitous (class A) factors 1.2.2 Family: Myogenic transcription factors (MyoD) ... Interferon regulatory factors 3.6 Class: TEA ( transcriptional enhancer factor) domain 3.6.1 Family: TEA (TEAD1, TEAD2, TEAD3, ... DNA within nucleosomes is inaccessible to many transcription factors. Some transcription factors, so-called pioneer factors are ... a number of transcription factors must bind to DNA regulatory sequences. This collection of transcription factors, in turn, ...
... is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". ... Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV ... "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655-66. ... POLR2J has been shown to interact with: Apoptosis antagonizing transcription factor, POLR2C, and SATB1. GRCh38: Ensembl release ...