This leads to the induction of myeloid differentiation factor 88 (MYD88) and the release of zonulin into the lumen. Zonulin ... then binds to epidermal growth factor receptor (EGFR) and protease-activated receptor 2 (PAR2) in the intestinal epithelium. ...
They are called the myeloid differentiation primary response gene 88 (MYD88) and interleukin-1 receptor-activated protein ... IRAK2 and tumor necrosis factor receptor-associated factor (TRAF) 6. TRAF6 is a ubiquitin E3 ligase, that in association with ... IL-1F7 has also been found in the nucleus where it can function as a nuclear factor. This cytokine may bind or may itself be a ... IL-18 is known as a factor that induces the production of interferon gamma (IFN-γ). It is a pro-inflammatory cytokine that ...
The product of this gene, myeloid differentiation primary response 88, continuously activates NF-κB as well as the STAT3 and ... Another key factor in the initiation of many EMZL cases is chronic inflammation caused by a chronic infection or autoimmune ... This gene's product, tumor necrosis factor, alpha-induced protein 3, functions to impair the activation of NF-κB. 2) Gain-of- ... This chimeric protein promotes the continuous activation of a transcription factor, NF-κB. NF-κB controls the expression of ...
... most notably the adaptor protein myeloid differentiation factor 88, MyD88. The proST domain contains serine, proline, and ... divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 ( ... March 2001). "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity". The Journal of Biological ... March 2001). "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity". The Journal of Biological ...
May 2010). "Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers ... The MyD88-dependent pathway is regulated by two adaptor-associated proteins: Myeloid Differentiation Primary Response Gene 88 ( ... June 2010). "Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 ... TRAM-TRIF signals activate the transcription factor Interferon Regulatory Factor-3 (IRF3) via TRAF3. IRF3 activation induces ...
TLR8 binding to the viral RNA recruits the myeloid differentiation primary response protein 88 (MyD88) and leads to activation ... TLR8 is also involved in the activation of dendritic cells to produce inflammatory factors to help regulate tumor growth, so ... TLR8 has also been designated as CD288 (cluster of differentiation 288). It is a member of the toll-like receptor (TLR) family ... of the transcription factor NF-κB and an antiviral response that leads to proinflammatory cytokine synthesis. TLR8 recognizes ...
... myeloid differentiation primary response 88, tumor suppressorp14/p19ARF, tyrosine hydroxylase, clock gene CRY1, SUMO2, and Wnt1 ... MTA1 expression is regulated by growth factors, growth factor receptors, oncogenes, environmental stress, ionizing radiation, ... The transcription of MTA1 is stimulated by transcriptional factors including, c-Myc, SP1, CUTL1 homeodomain, NF-ḵB, HSF1, HIF- ... Yoo YG, Kong G, Lee MO (Mar 2006). "Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha ...
MYD88 Myeloid differentiation primary response gene (88)". Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE (January ... Fibroblast growth factor receptor substrate 2 GAB2 - GRB2-associated binding protein 2 GRAP - GRB2-related adaptor protein ... Myeloid differentiation primary response gene 88 NCDN - Neurochondrin NCK1 - NCK adaptor protein 1 NCK2 - NCK adaptor protein 2 ... kinases and G-protein GTPases into short-lived active complexes in response to an activating signal such as a growth factor ...
... a novel myeloid differentiation primary response gene induced by multiple cytokines". Oncogene. 6 (1): 165-7. PMID 1899477. ... including brain-derived neurotrophic factor and fibroblast growth factor. Hence GADD45B is implicated in affecting synaptic ... a novel myeloid differentiation primary response gene induced by multiple cytokines". Oncogene. 6 (1): 165-7. PMID 1899477. ... Vairapandi M, Balliet AG, Fornace AJ, Hoffman B, Liebermann DA (Jun 1996). "The differentiation primary response gene MyD118, ...
Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the MYD88 gene. Model organisms ... to activate the transcription factor NF-κB. Mal (also known as TIRAP) is necessary to recruit Myd88 to TLR 2 and TLR 4, and ... "Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)". Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, ... a novel myeloid differentiation primary response gene induced by IL6". Oncogene. 5 (7): 1095-7. PMID 2374694. Arancibia SA, ...
"Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal ... In the case of a viral factor, the infected cell may shut off its protein synthesis and may undergo programmed cell death ( ... If the ligand is a bacterial factor, the pathogen might be phagocytosed and digested, and its antigens presented to CD4+ T ... TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR3 does not use the MyD88 dependent pathway. Its ...
Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth ... Autonomous multi-lineage differentiation in vitro of primitive CD34+ cells from patients with chronic myeloid leukemia. ... Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proc Natl Acad ... Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proc Natl ...
Park GS, Kim JH (Mar 2015). "Myeloid differentiation primary response gene 88-leukotriene B4 receptor 2 cascade mediates ... differentiation, adherence to extracellular matrix, and motility as well as factors that are released to promote new blood ... Kim H, Choi JA, Kim JH (Aug 2014). "Ras promotes transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition ... by inducing the proteolytic cleavage and release of a ligand for the Epidermal growth factor receptor [EGFR] receptor from HB- ...
IL-1 impairs insulin-like growth factor I-induced differentiation and downstream activation signals of the insulin-like I ... is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid ... Differentiation of promyeloid cells into both neutrophils and macrophages is also promoted by IGF-I. Differentiation of ... is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid ...
The granulocyte-macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a ... "Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid ... "Regulation of myeloid development and function by colony stimulating factors". Developmental and Comparative Immunology. 28 (5 ... Kinetics of the receptor in immature and mature myeloid cells in response to GM-CSF is readily regulated by internalization or ...
Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Mol. Cell ... positive myeloid malignancies". Oncogene. 21 (43): 6703-12. doi:10.1038/sj.onc.1205882. PMID 12242670. Amann JM, Nip J, Strom ... "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176-84. doi:10.1038/sj.onc. ... Histone deacetylases can be regulated by endogenous factors, dietary components, synthetic inhibitors and bacteria-derived ...
MLL OMIM Entry: MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA GENE; MLL MLL+protein,+human at the U.S. National Library of ... Goto NK, Zor T, Martinez-Yamout M, Dyson HJ, Wright PE (November 2002). "Cooperativity in transcription factor binding to the ... a protein involved in neuronal differentiation. Multiple chromosomal translocations involving this gene are the cause of ... Goto NK, Zor T, Martinez-Yamout M, Dyson HJ, Wright PE (November 2002). "Cooperativity in transcription factor binding to the ...
The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, ... induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050-8. PMID 12460926. McGhee L, Bryan ... Ferrara F, Del Vecchio L (2002). "Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity". ... Erickson PF, Robinson M, Owens G, Drabkin HA (1994). "The ETO portion of acute myeloid leukemia t(8;21) fusion transcript ...
May 2016). "Comprehensive mutational profiling of core binding factor acute myeloid leukemia". Blood. 127 (20): 2451-9. doi: ... August 2011). "A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation". Nature. 476 (7361): 467-71. ... August 2013). "Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites". Cell. ... February 2015). "Acute myeloid leukemia ontogeny is defined by distinct somatic mutations". Blood. 125 (9): 1367-76. doi: ...
In chronic myeloid leukemia (CML), NOV is downregulated as a consequence of the kinase activity of BCR-ABL, a chimeric protein ... Nov is regulated by the hematopoietic transcription factor MZF-1. NOV can bind BMP2 and inhibit its functions in promoting ... NOV regulates multiple cellular activities including cell adhesion, migration, proliferation, differentiation, and survival. It ... Piszczatowski RT, Rafferty BJ, Rozado A, Parziale JV, Lents NH (November 2015). "Myeloid Zinc Finger 1 (MZF-1) Regulates ...
"Ligation of TLR5 promotes myeloid cell infiltration and differentiation into mature osteoclasts in rheumatoid arthritis and ... The activation of this receptor mobilizes the nuclear factor NF-κB and stimulates tumor necrosis factor-alpha production. TLR5 ... This suggests that an unknown H. pylori factor is responsible for this response In addition to inflammation induction, TLR5 is ... Gohda J, Matsumura T, Inoue J (September 2004). "Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent ...
"The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation ... "TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro". ... Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene. Kruppel-like factors GRCh38: Ensembl release ... Gunther M, Laithier M, Brison O (2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid ...
... which control cell growth and differentiation. LOX expression is regulated by hypoxia-inducible factors (HIFs), and, hence, LOX ... LOX secreted by hypoxic breast tumor cells crosslinks collagen in the basement membrane and is essential for CD11b+ myeloid ... Subcutaneous tumor-derived LOX was shown to increase vascular endothelial growth factor (VEGF) expression and secretion, which ... Clinically relevant LOX inhibitors may help slow cancer progression by downregulating crucial growth factors that promote solid ...
2008). "Histone deacetylase inhibitor romidepsin has differential activity in core binding factor acute myeloid leukemia". ... "C/EBPa and DEF coordinately regulation myeloid differentiation". Blood. 119 (21): 4878-88. doi:10.1182/blood-2011-10-383083. ... Acute myeloid leukemia is more lethal than chronic myeloid leukemia, a disease that affects the same myeloid cells, but at a ... Myeloid refers to the type of white blood cells that are affected by the condition. Acute myeloid leukemia is the most common ...
... of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia ... This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene ... induced differentiation of myeloid leukemia cell lines". The Journal of Biological Chemistry. 275 (26): 20117-26. doi:10.1074/ ... In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C ...
... is expressed in the hematopoietic progenitors and down-regulated during myeloid differentiation of HL60 cells". Genomics. 70 (3 ... chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding ... During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since ... Saiki Y, Yamazaki Y, Yoshida M, Katoh O, Nakamura T (December 2000). "Human EVI9, a homologue of the mouse myeloid leukemia ...
Immune Factor Seen to Control T-Cell Checkpoints Involved in Spread of Cancers and Infections. June 2016 Nature. 2019 Oct;574( ... Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene. SELPLG codes for PSGL-1, ... the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical ... In mice it seems to be an immune factor regulating T-cell checkpoints, and it could be a target for future checkpoint inhibitor ...
... , also known as "Myeloid Differentiation factor 2 (MD-2)," is a protein that in humans is encoded by the ... 194 (1): 79-88. doi:10.1084/jem.194.1.79. PMC 2193443. PMID 11435474. Visintin A, Mazzoni A, Spitzer JA, Segal DM (October 2001 ...
Both ligands regulate myeloid cell survival, proliferation, and differentiation, but CSF-1 and IL-34 differ in their structure ... Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 ( ... and differentiation of many myeloid cell types in vivo and in vitro. CSF1R signaling is involved in many diseases and is ... colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34). CSF1R is highly expressed in myeloid cells, and CSF1R signaling ...
It is also characterized by an impaired lymphoid maturation and early differentiation arrest in the myeloid lineage. AK2 ... Common factors that influence adenine nucleotide levels, and therefore ADK activity are exercise, stress, changes in hormone ... "Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation". PLOS ... "Structural and catalytic role of arginine 88 in Escherichia coli adenylate kinase as evidenced by chemical modification and ...