... (PLP or lipophilin) is the major myelin protein from the central nervous system (CNS). It plays an ... Weimbs T, Sto ffel W (1992). "Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid ... GPM6A; GPM6B; PLP1; PLP2 Dautigny A, Popot JL, Pham Dinh D (1991). "Major Myelin proteolipid: the 4-alpha-helix topology". J. ... Stoffel W, Schliess F (1991). "Evolution of the myelin integral membrane proteins of the central nervous system". Biol. Chem. ...

Other names in common use include myelin PLP acyltransferase, acyl-protein synthetase, and myelin-proteolipid O- ... myelin proteolipid] Thus, the two substrates of this enzyme are palmitoyl-CoA and myelin proteolipid, whereas its two products ... Bizzozero OA, McGarry JF, Lees MB (1987). "Acylation of endogenous myelin proteolipid protein with different acyl-CoAs". J. ... In enzymology, a [myelin-proteolipid] O-palmitoyltransferase (EC 2.3.1.100) is an enzyme that catalyzes the chemical reaction ...

... and proteolipid protein (PLP), which is the most abundant protein in CNS myelin, but only a minor component of PNS myelin. In ... protein. Protein content includes myelin basic protein (MBP), which is abundant in the CNS where it plays a critical, non- ... Greer JM, Lees MB (March 2002). "Myelin proteolipid protein--the first 50 years". The International Journal of Biochemistry & ... Cholesterol is an essential lipid component of myelin, without which myelin fails to form. The main purpose of myelin is to ...

... (PLP1) is a form of myelin proteolipid protein (PLP). Mutations in PLP1 are associated with Pelizaeus- ... Edwards, A M; Ross N W; Ulmer J B; Braun P E (Jan 1989). "Interaction of myelin basic protein and proteolipid protein". J. ... Proteolipid protein 1 has been shown to interact with Myelin basic protein. PLP2 GRCh38: Ensembl release 89: ENSG00000123560 - ... Edwards AM, Ross NW, Ulmer JB, Braun PE (1989). "Interaction of myelin basic protein and proteolipid protein". J. Neurosci. Res ...

Edwards AM, Ross NW, Ulmer JB, Braun PE (January 1989). "Interaction of myelin basic protein and proteolipid protein". Journal ... Edwards AM, Ross NW, Ulmer JB, Braun PE (January 1989). "Interaction of myelin basic protein and proteolipid protein". Journal ... February 1987). "Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin ... Myelin basic protein has been shown to interact in vivo with proteolipid protein 1, and in vitro with calmodulin, actin, ...

It is caused by mutations in proteolipid protein 1 (PLP1), a major myelin protein. It is characterized by a decrease in the ... Pelizaeus-Merzbacher disease is caused by X-linked recessive mutations in the major myelin protein proteolipid protein 1 (PLP1 ... "Therapeutic suppression of proteolipid protein rescues Pelizaeus-Merzbacher Disease in mice". bioRxiv: 508192. doi:10.1101/ ... "Suppression of proteolipid protein rescues Pelizaeus-Merzbacher Disease". Nature. 585 (7825): 397-403. Bibcode:2020Natur.585.. ...

... protein and RNA, leading to apoptosis. Myelin proteolipid protein This article incorporates text by Jessica Hutchinson ... "Proteolipids - proteins modified by covalent attachment to lipids - N-myristoylated, S-palmitoylated, prenylated proteins, ... A proteolipid is a protein covalently linked to lipid molecules, which can be fatty acids, isoprenoids or sterols. The process ... These proteins are also potent antigens, and are in fact the main immunogens of these two species. Proteolipids include ...

... low expression of MBP and proteolipid protein and the decrease in the number of myelinated axons indicate the lack of myelin ... "Per2 - Period circadian protein homolog 2 - Mus musculus (Mouse) - Per2 gene & protein". www.uniprot.org. Retrieved 2020-10-31 ... "CABLES2 protein expression summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2020-11-01. "AATK Gene - ... Cdk5 belongs to the eukaryotic protein kinases (ePKs). A crystal structure of the catalytic domain of cAMP-dependent protein ...

In the CNS the major myelin protein is proteolipid protein, and in the PNS it is myelin basic protein. Nodes of Ranvier (also ... The myelin membrane is unique in its relatively high lipid to protein ratio. In the peripheral nervous system axons are ... It also includes the myelin sheath. The Nissl bodies that produce the neuronal proteins are absent in the axonal region. ... As a consequence protein accumulations such as amyloid-beta precursor protein can build up in a swelling resulting in a number ...

... myelin proteolipid protein MeSH D10.570.877.360 - glycosphingolipids MeSH D10.570.877.360.025 - acidic glycosphingolipids MeSH ...

have placed the transcription unit under the control of the regulatory sequences of the myelin proteolipid protein (PLP) gene, ... "Myelin Gene Regulatory Factor is Required for Maintenance of Myelin and Mature Oligodendrocyte Identity in the Adult CNS". ... Annotation of the human and mouse genomes has led to the identification of >20 000 protein-coding genes and >3 000 noncoding ... with the ultimate goal to have all protein genes mutated via gene trapping and -targeting in murine ES cells. These efforts ...

... a process characterized by the emergence of the expression of myelin basic protein (MBP), proteolipid protein (PLP), or myelin- ... Spontaneous myelin repair does not result in morphologically normal oligodendrocytes and is associated with thinner myelin ... Spontaneous myelin repair was first observed in cat models. It was later discovered to occur in the human CNS as well, ... Peru RL, Mandrycky N, Nait-Oumesmar B, Lu QR (2008). "Paving the axonal highway: from stem cells to myelin repair". Stem Cell ...

As the myelin organoid matures, the OPC cells differentiate into oligodendrocytes that express proteolipid protein 1 (PLP1), ... Proteolipid protein 1 (PLP1) show perinuclear retention in oligodendrocytes. Perinuclear retention of misfolded proteins is a ... PMD is a rare monogenic disease caused by various mutations of the X-linked proteolipid protein 1 gene (PLP1). PLP1 is a ... In a myelinoid model of PMD caused by point mutations in Proteolipid protein 1 (PLP1), a CRISPR correction to the wildtype ...

DHHC domain Myristoylation Myelin proteolipid protein Palmitoleoylation Prenylation Dejanovic B, Semtner M, Ebert S, Lamkemeyer ... protein-protein interactions, or binding capacities of a protein. An example of a protein that undergoes palmitoylation is ... "Proteolipids - proteins modified by covalent attachment to lipids - N-myristoylated, S-palmitoylated, prenylated proteins, ... A major mediator of protein clustering in the synapse is the postsynaptic density (95kD) protein PSD-95. When this protein is ...

These involve the hepatitis B virus mimicking the human proteolipid protein (myelin protein) and the Epstein-Barr virus ... proteolipid protein) 139-151 epitope) with that of a human myelin-specific epitope. Bystander myelin damage is caused by virus ... To determine which epitopes are shared between pathogen and human, large protein databases are used. The largest protein ... It has been hypothesized that these virulent proteins display their mimicry through molecular surfaces that mimic host protein ...

... multilamellar myelin sheaths that contain myelin basic protein (MBP) and myelin proteolipid protein (PLP). Myelinogenesis thus ... In the process of regeneration, Schwann cells re-synthesize proteins associated with myelin-specific proteins when axonal ... Synthesis of myelin-specific proteins only occurs in Schwann cells associated with axons. Furthermore, membrane-membrane ... 2014). "Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue". Cell. 156 (1-2): ...

"Rafts in adult peripheral nerve myelin contain major structural myelin proteins and myelin and lymphocyte protein (MAL) and ... In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin ... Myelin and lymphocyte protein is a protein that in humans is encoded by the MAL gene. The protein encoded by this gene is a ... The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal ...

She studied myelin proteins, and identified Na⁺/K⁺-ATPase as a myelin protein. At Harvard Medical School, Lees developed ... The protein later became known as the Folch-Lees proteolipid. Lees started her independent academic career at the Geisel School ... Alongside her work on proteolipids, Lees studied myelin, the fatty substance that surrounds the axons of nerves. She argued ... M. B. Lees; S. Paxman (1 May 1972). "Modification of the lowry procedure for the analysis of proteolipid protein". Analytical ...

"Therapeutic suppression of proteolipid protein rescues Pelizaeus-Merzbacher Disease in mice". bioRxiv: 508192. doi:10.1101/ ... Tesar identified drugs that stimulate myelin regeneration and reverse paralysis in mice with multiple sclerosis. Tesar also ... "Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease". Nature. 585 (7825): 397-403. Bibcode:2020Natur.585.. ... "Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease". Nature. 585 (7825): 397-403. Bibcode:2020Natur.585.. ...

... myelin basic protein, and proteolipid protein, causing an autoimmune response. This sets off a cascade of signaling molecules ... Amyloid beta is a fragment from a larger protein called amyloid precursor protein (APP), a transmembrane protein that ... protein ubiquitin along with enzymes is key for the degradation of many proteins that cause proteopathies including polyQ ... "Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein". Biochemical Society ...

His method led to the identification of myelin proteolipid (defined as a new type of lipoproteins) in white matter and water- ... He then devised a procedure that involved precipitation of lipids and proteins with colloidal iron and removal of most of the ... Until the end of his career, the characterization of proteolipids was a major focus of Folch's work and interest. The Folch's ... One of its uses is in separating polar from nonpolar compounds, for example separating nonpolar lipids from polar proteins and ...

... zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central ... Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene. The protein encoded by this gene is a ... "Entrez Gene: MYT1 myelin transcription factor 1". Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (October ... MYT1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ...

Hills, BA (1994). "Release of surfactant and a myelin proteolipid apoprotein in spinal tissue by decompression". Undersea & ... hydrophobic protein and lamellar bodies in spinal tissue". Undersea & Hyperbaric Medicine. Undersea and Hyperbaric Medical ...

The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched ... Magyar JP, Ebensperger C, Schaeren-Wiemers N, Suter U (1997). "Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin ... MAL-like protein is a protein that in humans is encoded by the MALL gene. This gene encodes an element of the machinery for ... 2001). "BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial- ...

... myelin-proteolipid] O-palmitoyltransferase EC 2.3.1.101: formyl,methanofuran-tetrahydromethanopterin N-formyltransferase EC 2.3 ... cAMP-dependent protein kinase EC 2.7.11.12: cGMP-dependent protein kinase EC 2.7.11.13: protein kinase C EC 2.7.11.14: ... protein-histidine pros-kinase EC 2.7.13.2: protein-histidine tele-kinase EC 2.7.13.3: histidine kinase EC 2.7.14.1: protein ... mitogen-activated protein kinase EC 2.7.11.25: mitogen-activated protein kinase kinase kinase EC 2.7.11.26: tau-protein kinase ...

... encoding protein Placenta-specific protein 1 PLP2: encoding protein Proteolipid protein 2 PRR32: encoding protein PRR32 RPA4: ... It affects only boys between the ages of 5 and 10 and destroys the protective cell surrounding the nerves, myelin, in the brain ... encoding protein ZFP92 zinc finger protein ZMYM3: encoding protein Zinc finger MYM-type protein 3 ZNF157: encoding protein Zinc ... encoding protein Integral membrane protein 2A LAS1L: encoding protein LAS1-like protein LINC01420: encoding protein Nucleosome ...