February 1987). "Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin ... "Myelin basic protein-diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly ... "Myelin basic protein-diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly ... "Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein ...
Other names in common use include myelin basic protein methylase I, protein methylase I, S-adenosyl-L-methionine:[myelin-basic- ... myelin basic protein]-arginine ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega- ... In enzymology, a [myelin basic protein]-arginine N-methyltransferase (EC 2.1.1.126) is an enzyme that catalyzes the chemical ... Myelin basic protein- and histone-specific enzyme". J. Biol. Chem. 263 (35): 19024-33. PMID 2461933. Portal: Biology v t e ( ...
Miskimins R, Srinivasan R, Marin-Husstege M, Miskimins WK, Casaccia-Bonnefil P. p27(Kip1) enhances myelin basic protein gene ... "p27Kip1 Enhances myelin basic protein gene promoter activity". Journal of Neuroscience Research. 67 (1): 100-105. doi:10.1002/ ... that p27 regulates the differentiation of oligodendrocytes by modulating transcription of the gene for myelin basic protein. ... myelin formation, and myelin loss. Through analysis of epigenetic changes and transcriptional changes in glial cells, mostly ...
Edwards, A M; Ross N W; Ulmer J B; Braun P E (Jan 1989). "Interaction of myelin basic protein and proteolipid protein". J. ... Proteolipid protein 1 has been shown to interact with Myelin basic protein. PLP2 GRCh38: Ensembl release 89: ENSG00000123560 - ... Edwards AM, Ross NW, Ulmer JB, Braun PE (1989). "Interaction of myelin basic protein and proteolipid protein". J. Neurosci. Res ... Wood, D D; Vella G J; Moscarello M A (Oct 1984). "Interaction between human myelin basic protein and lipophilin". Neurochem. ...
"Transport and localization elements in myelin basic protein mRNA". The Journal of Cell Biology. 138 (5): 1077-1087. doi:10.1083 ... binding protein. eIF-4E and eIF-4G block the decapping enzyme (DCP2), and poly(A)-binding protein blocks the exosome complex, ... Proteins that are needed in a particular region of the cell can also be translated there; in such a case, the 3' UTR may ... Proteins that bind to either the 3' or 5' UTR may affect translation by influencing the ribosome's ability to bind to the mRNA ...
Fontana, A; Fierz, W; Wekerle, H (1984). "Astrocytes present myelin basic protein to encephalitogenic T-cell lines". Nature. ... "Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination". Nature. 479 (7374): 538-41. Bibcode ...
His master's thesis was on fragments of myelin basic protein. In 1978, he received his MD degree from the University of Miami ... and for bringing clinical importance to basic science findings." In 2015, Hafler was appointed to the newly created Edgerly ...
One of PAD2's target substrates is myelin basic protein (MBP). In the normal retina, deimination is found in nearly all the ... Harauz, G; Mussee (February 2007). "A tale of two citrullines-structural and functional aspects of myelin basic protein ... This increases the hydrophobicity of the protein, which can lead to changes in protein folding, affecting the structure and ... autoantibodies often attack citrullinated proteins. The presence of anti-citrullinated protein antibody is a standard test for ...
"Antibodies to Myelin Basic Protein in Children with Autistic Behavior". Brain, Behavior, and Immunity. 7 (1): 97-103. doi: ... coauthored a paper in Clinical Immunology and Immunopathology reporting the presence of antibodies to myelin basic protein in ... "Circulating autoantibodies to neuronal and glial filament proteins in autism". Pediatric Neurology. 17 (1): 88-90. doi:10.1016/ ...
Traina, G; Federighi, G; Macchi, M; Bernardi, R; Durante, M; Brunelli, M (26 May 2011). "Modulation of Myelin Basic Protein ... "Effects of Cyclic Nucleotides and Calcium/Calmodulin on Protein Phosphorylation in the CNS of Hirudo medicinalis". Journal of ...
In neurobiology, Hood and his colleagues were the first to clone and study the myelin basic protein (MBP) gene. The MBP is a ... Saxe DF, Takahashi N, Hood L, Simon MI (1985). "Localization of the human myelin basic protein gene (MBP) to region 18q22---- ... Kamholz, J; Spielman, R; Gogolin, K; Modi, W; O'Brien, S; Lazzarini, R (1987). "The human myelin-basic-protein gene: ... The amount of protein required for an analysis decreased, from 10-100 nanomoles for Edman and Begg's protein sequencer, to the ...
Becker, Kyra J.; Tanzi, Patricia; Zierath, Dannielle; Buckwalter, Marion S. (2016-06-15). "Antibodies to myelin basic protein ... colleagues measured autoantibodies in patients after stroke and found that increases in autoantibodies to myelin basic protein ... They found that the increased TFGb in addition to increases in amyloid precursor protein led to increased CD4+ T cell ...
Some, such as myelin basic protein, and spectrin have mainly structural roles. A number of water-soluble proteins can bind to ... Protein-lipid interaction is the influence of membrane proteins on the lipid physical state or vice versa. The questions which ... Many peripheral membrane proteins bind to the membrane primarily through interactions with integral membrane proteins. But ... YashRoy, Rakesh C. (1991). "13C-NMR studies of membrane lipid-protein interactions upon protein heat denaturation". Journal of ...
1992) Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 258:1491- ...
Li H, Lu Y, Smith HK, Richardson W (December 2007). "Olig1 and Sox10 Interact Synergistically to Drive Myelin Basic Protein ... The encoded protein acts as a transcriptional activator after forming a protein complex with other proteins. This protein acts ... SOX10 can influence the generation of Myelin Protein Zero (MPZ) transcription through its interactions with proteins such as ... LeBlanc S, Ward R, Svaren, J (May 2007). "Neuropathy-Associated Egr2 Mutants Disrupt Cooperative Activation of Myelin Protein ...
Molineaux SM, Engh H, de Ferra F, Hudson L, Lazzarini RA (1986). "Recombination within the myelin basic protein gene created ... They are also used to study myelin defects more generally in demyelinating diseases such as multiple sclerosis. The shiverer ... and myelin deficient (shi mld)". Behav Genet. 20 (2): 213-234. doi:10.1007/BF01067791. PMID 1693848. S2CID 686238. Baker M (12 ... resulting in the failure of oligodendrocytes to form compact myelin in the central nervous system. Axons in shiverer mice fail ...
Hemachudha T, Griffin DE, Giffels JJ, Johnson RT, Moser AB, Phanuphak P (February 1987). "Myelin basic protein as an ... Weber MS, Derfuss T, Brück W (August 2018). "Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Central Nervous ... Misu T, Fujihara K (February 2019). "Neuromyelitis optica spectrum and myelin oligodendrocyte glycoprotein antibody‐related ... Rivers TM, Schwentker FF (April 1935). "Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys ...
Siu, Caitlin R.; Jones, David G.; Balsor, Justin L.; Murphy, Kathryn M. (2015). "Classic and Golli Myelin Basic Protein have ... Pinto, Joshua G. A.; Williams, C. Kate; Jones, David G.; Murphy, Kathryn M. (2015). "Characterizing synaptic protein ... "Development of Glutamatergic Proteins in Human Visual Cortex across the Lifespan". Journal of Neuroscience. 37 (25): 6031-6042 ...
Georgios Tsekenis (2008). "Label-free immunosensor assay for myelin basic protein based upon an ac impedance protocol". ... Chatterjee; Sitaraman (2008). "Protein microarray on-demand: a novel protein microarray system". PLOS ONE. 3 (9): e3265. ... Protein microarrays are a type of immunoassay that often employ fluorogenic reporters. Some labels work via ... Gofflot; El (2004). "Immuno-quantitative polymerase chain reaction for detection and quantitation of prion protein". Journal of ...
Howard L, Glynn P (1995). Membrane-associated metalloproteinase recognized by characteristic cleavage of myelin basic protein: ... Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway, which ... Notch-2 (Neurogenic locus notch homolog protein 2) is a protein that in humans is encoded by the NOTCH2 gene. NOTCH2 is ... These type 1 single pass transmembrane proteins fall into the Delta/Serrate/Lag-2 (DSL) family of proteins which is named after ...
... protein. Protein content includes myelin basic protein (MBP), which is abundant in the CNS where it plays a critical, non- ... which is the most abundant protein in CNS myelin, but only a minor component of PNS myelin. In the PNS, myelin protein zero ( ... Cholesterol is an essential lipid component of myelin, without which myelin fails to form. The main purpose of myelin is to ... Lesional demyelinations of the central nervous system Myelin-associated glycoprotein Myelin incisure The Myelin Project, ...
... rats injected with activated T cells which are specific for myelin basic protein (MBP, a common protein in the CNS) retained 3- ... 2000). "Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion". Journal of ... for example peptides derived from myelin proteins) is problematic, because it carries the risk of inducing, in individuals ... 2003). "Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells ...
"Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit". ...
The molecular mimicry hypothesis, in which T cells are essentially confusing an HHV-6 viral protein with myelin basic protein, ... Levels of myelin basic protein were elevated in his cerebrospinal fluid, suggesting that demyelination was occurring. This link ... Italian researchers used the HHV-6a variant along with bovine myelin basic protein to generate cross-reactive T cell lines. ... A study of t cell cross-reactivity to viral and myelin basic protein antigens". Journal of Medical Virology. 68 (2): 268-72. ...
The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the ... Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene. The protein encoded by this gene is ... Creasy CL, Chernoff J (1995). "Cloning and characterization of a human protein kinase with homology to Ste20". J. Biol. Chem. ... Schultz SJ, Nigg EA (1993). "Identification of 21 novel human protein kinases, including 3 members of a family related to the ...
Myelination is arrested at the promyelinating stage and in fish no myelin basic protein can be detected. In fish this can be ... which rescues myelin basic protein expression. GPR56 may play a role in the interactions between bone marrow and hematopoietic ... Since many of these domains have been demonstrated to mediate protein-protein interactions within other proteins, they are ... Adhesion G protein-coupled receptors (adhesion GPCRs) are a class of 33 human protein receptors with a broad distribution in ...
2008). "Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis". Annals of Neurology. 63 (5): 611- ... Peptide microarrays can be used to study different kinds of protein-protein interactions, specially those involving modular ... protein interaction domains. The reason for this is that such protein substructures recognize short linear motifs often exposed ... medicine and pharmacology to study binding properties and functionality and kinetics of protein-protein interactions in general ...
Kakeya, H.; Onose, R.; Osada, H. "Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug- ... and p36 myelin basic protein (MBP) kinase. Cytotrienin A is an ansamycin with a macrocyclic, twenty-one carbon, lactam, ... Cyt A is thought to induce apoptosis by activating c-Jun N-terminal Kinase (JNK), p38 mitogen-activated protein kinase (MAPK), ... The apoptosis pathway was shown to involve the proteolytic activation of MST/Krs proteins by caspase-3 which results in the ...
... myelin basic protein (Golli-MBP; or "golli"), an expression of MBP, myelin basic protein Ramesh Golli, a sprint kayaker ...
Exposure to methylmercury causes increased levels of antibodies sent to myelin basic protein (MBP), which is involved in the ... "Methylmercury Causes Neurodegeneration and Downregulation of Myelin Basic Protein in the Spinal Cord of Offspring Rats after ... This causes an autoimmmune response against MBP and GFAP and results in the degradation of neural myelin and general decline in ... "Exposure to methyl mercury results in serum autoantibodies to neurotypic and gliotypic proteins". Neurotoxicology. 17 (1): 267- ...