Chung KT, Fulk GE, Andrews AW (October 1981). "Mutagenicity testing of some commonly used dyes". Applied and Environmental ...
... is not teratogenic and carcinogenicity and mutagenicity testing has proven inconclusive. King, Gregory S.; Smialek, John E.; ...
It influenced research direction, regulatory procedures and mutagenicity testing within industry. In 1970 the EMS established ... particularly the development of tests for genetic toxicology, through the establishment of a register of substances tested for ... Bruce N. Ames on the Salmonella (Ames) mutagenicity assay. In 1979, the EMS began publishing its own journal, Environmental ... "Genetic Toxicology Data Bank (GENE-TOX) - Peer-reviewed genetic toxicology test data for over 3,000 chemicals". US National ...
"Determination of halogenated organic compounds and mutagenicity testing of spent bleach liquors". Science of the Total ...
"Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test". Mutation Research. ... These genetic tools also led to a simple test for carcinogens, the Ames test. As a natural alternative to traditional ... such as is used in the triple sugar iron test. Most isolates exist in two phases, a motile phase and a non-motile phase. ... Butz Bismuth sulfite agar Food testing strips Host-pathogen interface List of foodborne illness outbreaks 2008-2009 peanut- ...
"Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test". Mutation Research/ ... Negative Ames test means the possible mutagen DID not cause increase in revertants and positive Ames test signifies that the ... The Salmonella Mutagenesis test (Ames test) uses multiple strains of Salmonella typhimurium that are auxotrophic to histidine ... However only few of the positive Ames Test resulting chemicals were considered insignificant when tested in larger organisms ...
In vitro mutagenicity tests have shown that demeton has a significant genotoxic potential. However, disulfoton, of which ...
He is an expert on mutagenicity and an inventor of the Ames test. Awarded the National Medal of Science John E. Amoore (1939- ...
To test a substance for mutagenicity, it is applied to these cells and fluorescence is measured. GADD45A has been shown to ... that expression of this gene is an indicator of DNA damage has been exploited to construct an in vitro test for mutagenicity, ...
No mutagenic potential was identified in microbiological mutagenicity tests including a fluctuation test with S9 activation. No ...
CdTe has low acute inhalation, oral, and aquatic toxicity, and is negative in the Ames mutagenicity test. Based on notification ... Current CdTe modules pass the U.S. EPA's Toxicity Characteristic Leaching Procedure (TCLP) test, designed to assess the ...
Despite its reputation as a mutagen, tests have shown it to have low mutagenicity without metabolic activation. As with most ... "Comparison of SYBR Green I nucleic acid gel stain mutagenicity and ethidium bromide mutagenicity in the Salmonella/mammalian ... Testing in humans and longer studies in a mammalian system would be required to fully understand the long-term risk ethidium ... This likely indicates a permanent loss of function in this area against the tested target, T. congolense isolated from Boran ...
It significantly influenced research direction, regulatory procedures and mutagenicity testing within industry within the ...
Structure-Activity Relationship and Artificial Intelligence Systems To Improve in Silico Prediction of Ames Test Mutagenicity ... "Data Mining and Machine Learning Techniques for the Identification of Mutagenicity Inducing Substructures and Structure ...
He is the inventor of the Ames test, a system for easily and cheaply testing the mutagenicity of compounds. Ames, raised in New ... The Ames test on the other hand uses the bacteria Salmonella typhimurium to test for mutagens, and is considerably cheaper and ... Previous carcinogenic testing used live animals, and the procedures are expensive and time-consuming. This made animal testing ... The Ames test became widely used as an initial screen for possible carcinogens and has been used to identify potential ...
In vitro mutagenicity tests have shown that TBPH can induce chromosomal aberrations, but does not give rise to point mutations ... Although carcinogenicity tests have not been assessed for TBPH, (Q)SAR predictions did show that TBPH, belonging to the ... At the same time, a testing proposal evaluation was performed in the European Union, which resulted in a request for a prenatal ... Owing to these concerns, Chemtura entered into a modified Consent Order with USEPA in 2008, which required further testing of ...
The mutagenicity of a substance is proportional to the number of colonies observed. Mutagens identified via Ames test are also ... Furylfuramide in fact had previously passed animal tests, but more vigorous tests after its identification in the Ames test ... The Ames test is a widely employed method that uses bacteria to test whether a given chemical can cause mutations in the DNA of ... Therefore, to more effectively test a chemical compound's mutagenicity in relation to larger organisms, rat liver enzymes can ...
The mutagenicity and genetic hazard has been evaluated with the Ames-test and animal experiments. Furthermore, it is suspected ... Due to the suspicion of genotoxicity and mutagenicity of Sudan 1, a daily intake was not tolerable. The European Commission ... The carcinogenicity is estimated by animal testing. The regulation of Sudan 1 in Europe started in 2003 after repeated ... Toxicology and toxicological testing of colorants. Review of Progress in Coloration and Related Topics 2005, 35 (1), 76-89 http ...
1985). "Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella ... In Ames test, where the varying concentrations of the chemical are used in the test, the dose response curve obtained is nearly ... Ames test - This is the most commonly used test, and Salmonella typhimurium strains deficient in histidine biosynthesis are ... Sex-Linked Recessive Lethal Test - Males from a strain with yellow bodies are used in this test. The gene for the yellow body ...
Only 21 companies (or 3% of the 830 companies) have all SIDS tests available for their chemicals. The basic set of test data ... mutagenicity, ecotoxicity and environmental fate. Using SIDS and detailed exposure data OECD's High Production Volume Chemicals ... of TRI chemicals have had full SIDS testing, while only 7% of other chemicals have full test data". They wrote "...of the 830 ... In 2011, the EPA announced, but as of 2013 had yet to finalize, plans to require testing for 23 additional chemicals, so ...
In consequence, only 40 percent of acute toxicity and mutagenicity testing is ever completed, even less data on long-term ... 140 of those chemicals were tested by regulatory order and 60 were tested after voluntary consent by the manufacturer. ... Second, producers should test their chemicals and report data to officials on the quantities, uses, physical and biological ... 2603 - Testing of Chemical Substances and Mixtures. 15 U.S.C. § 2603 "About Sustainable Futures". EPA. April 25, 2018. Chemical ...
The high correlation between the Umu Chromotest and traditional Ames test for mutagenicity supports it as a reasonable ... The umu test, using only a single Salmonella strain, could potentially test a greater range of new chemicals with the same ... A simple colorimetric test is possible by adding a lactose analog which is degraded by β-galactosidase, producing a colored ... This test uses an operon fusion placing the lac operon (responsible for producing β-galactosidase, a protein which degrades ...
... inventor of the Ames test for mutagenicity (sometimes regarded as a test for carcinogenicity) John E. Amoore (1939-1998), ... Discovered prostate-specific antigen (PSA) which led to the development of the PSA test Erik Acharius (1757-1819), Swedish ... He currently works on DNA paternity testing. Jean Cabanis (1816-1906), German ornithologist, founder of the Journal für ... with work that led to the first test tube baby Jean-Pierre Changeux (born 1936), French biochemist and neuroscientist, ...
Genotoxicity and Mutagenicity - Mechanisms and Test Methods, IntechOpen, doi:10.5772/intechopen.91630, ISBN 978-1-83880-041-3, ... These fruit fly tests are a short-term test and a non-mammalian approach for in vivo testing of putative genotoxins found in ... Graf, U.; Frei, H.; Kägi, A.; Katz, A.J.; Würgler, F.E. (April 1989). "Thirty compounds tested in the Drosophila wing spot test ... Graf, U.; Frei, H.; Kägi, A.; Katz, A.J.; Würgler, F.E. (April 1989). "Thirty compounds tested in the Drosophila wing spot test ...
This was the exciting era of environmental toxicology with predictive mutagenicity and carcinogenicity testing of thousands of ... IRI Ltd were a contract research organisation providing safety testing facilities for new chemicals. They later merged with the ... and developed an ELISA based test for the environmental monitoring of Legionella pneumophila, marketed by Boots Microcheck. ...
Positive results from mutagenicity analysis via the Ames test of compounds commonly found in preparations labelled "pangamic ... Herbert V, Gardner A, Colman N (June 1980). "Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic ... Gelernt MD, Herbert V (1982). "Mutagenicity of diisopropylamine dichloroacetate, the "active constituent" of vitamin B15 ( ...
... it showed the potential for mutagenicity. The results show two different paths and until further testing has been performed it ... When the same test was performed with metabolic activation or when the C-Test was performed, ... When testing ambazone via AMES with no metabolic activation, it was found there are no mutagenic or carcinogenic properties. ... Through experimental testing ambazone has shown antiseptic properties, along with anti-tumor properties. Ambazone has the ...
... created Ames test to screen chemicals for mutagenicity D. Bernard Amos (1923-2003), UK-US immunologist who studied the genetics ... US geneticist known for the McDonald-Kreitman test that is used to infer adaptive evolution in population genetic studies Eric ...
"Comparison of SYBR Green I nucleic acid gel stain mutagenicity and ethidium bromide mutagenicity in the Salmonella/mammalian ... In a study using the Ames test, which measures the ability of chemicals to cause mutations, when assayed at the same ... microsome reverse mutation assay (Ames test)". Mutation Research. 439 (1): 37-47. doi:10.1016/s1383-5718(98)00172-7. PMID ...
"Comparison of SYBR Green I nucleic acid gel stain mutagenicity and ethidium bromide mutagenicity in the Salmonella/mammalian ... microsome reverse mutation assay (Ames test)". Mutat. Res. 439 (1): 37-47. doi:10.1016/s1383-5718(98)00172-7. PMID 10029672. ...