Multiple endocrine neoplasia type 1
People with multiple endocrine neoplasia type 1 are born with one mutated copy of the MEN1 gene in each cell. Then, during ... Multiple endocrine neoplasia type 1 (MEN-1) is one of a group of disorders, the multiple endocrine neoplasias, that affect the ... In a diagnostic workup individuals with a combination of endocrine neoplasias suggestive of the MEN1 syndrome are recommended ... Individuals suffering from this disorder are prone to developing multiple endocrine and nonendocrine tumors. It was first ...
Multiple endocrine neoplasia
"Multiple Endocrine Neoplasia". The Lecturio Medical Concept Library. Retrieved 4 July 2021. "Multiple Endocrine Neoplasia Type ... "Multiple Endocrine Neoplasia". The Lecturio Medical Concept Library. Retrieved 11 August 2021. "Multiple Endocrine Neoplasia ... "multiple endocrine neoplasia" at Dorland's Medical Dictionary Carney JA (Jun 1998). "Familial multiple endocrine neoplasia ... The term multiple endocrine neoplasias are used when two or more endocrine tumor types, known to occur as a part of one of the ...
Multiple endocrine neoplasia type 2B
Multiple endocrine neoplasia Multiple endocrine neoplasia type 1 Multiple endocrine neoplasia type 2a Rapini, Ronald P.; ... Multiple endocrine neoplasia type 2B (MEN 2B) is a genetic disease that causes multiple tumors on the mouth, eyes, and ... Sizemore GW, Carney JA, Gharib H, Capen CC (1992). "Multiple endocrine neoplasia type 2B: eighteen-year follow-up of a four- ... It is the most severe type of multiple endocrine neoplasia, differentiated by the presence of benign oral and submucosal tumors ...
Multiple endocrine neoplasia type 2
Multiple endocrine neoplasia Multiple endocrine neoplasia type 1 Multiple endocrine neoplasia type 2b Multiple mucosal ... MEN2 is a sub-type of MEN (multiple endocrine neoplasia) and itself has sub-types, as discussed below. Variants in MEN2A have ... "Multiple Endocrine Neoplasia Type 2". Cancer.Net. 2012-06-25. Retrieved 2018-01-15. Wray CJ, Rich TA, Waguespack SG, Lee JE, ... MEN2 can present with a sign or symptom related to a tumor or, in the case of multiple endocrine neoplasia type 2b, with ...
Zollinger-Ellison syndrome
Thakker, Rajesh V. (June 2010). "Multiple endocrine neoplasia type 1 (MEN1)". Best Practice & Research Clinical Endocrinology ... 25 percent of patients with gastrinomas have multiple tumors as part of a condition called multiple endocrine neoplasia type 1 ... of cases it occurs as part of an autosomal dominant syndrome called multiple endocrine neoplasia type 1 (MEN 1). Patients with ... Disorders of endocrine pancreas, Syndromes affecting the gastrointestinal tract, Diseases of oesophagus, stomach and duodenum, ...
Gastrinoma
One fourth of gastrinomas are related to multiple endocrine neoplasia type 1, Zollinger-Ellison syndrome, peptic ulcer disease ... are associated with multiple endocrine neoplasia type 1 (MEN-1). Over 50% of gastrinomas are malignant and can metastasize to ... "Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy". Medicine. 98 (50): e18275. doi:10.1097/MD. ... Pancreatic endocrine tumor Jensen, Robert T.; Niederle, Bruno; Mitry, Emmanuel; Ramage, John K.; Steinmüller, Thomas; Lewington ...
Rajesh Thakker
Loureiro de Lemos, Manuel C. (2007). Genetic and phenotypic studies of the multiple endocrine neoplasia type 1 syndrome (DPhil ... Javid, Mahsa (2012). Gene modifiers and novel therapies for multiple endocrine neoplasia type 1 (DPhil thesis). University of ... Leotlela, Poloko D. (2003). Molecular genetics of multiple endocrine neoplasia type 1 and related disorders (DPhil thesis). ... Thakker's research investigates neuroendocrine tumours such as multiple endocrine neoplasia type 1 (MEN1) and the molecular ...
VIPoma
They are sometimes associated with multiple endocrine neoplasia type 1. Roughly 50-75% of VIPomas are malignant, but even when ... Endocrine tumors of the pancreas and gastrointestinal tract. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and ... A VIPoma or vipoma (/vɪˈpoʊmə/) is a rare endocrine tumor that overproduces vasoactive intestinal peptide (thus VIP + -oma). ... "Pancreatic endocrine tumors". J Surg Res. 120 (1): 139-61. doi:10.1016/j.jss.2003.12.007. PMID 15172200. "VIPoma , Genetic and ...
MEN1
"Entrez Gene: MEN1 multiple endocrine neoplasia I". Thakker RV (June 2010). "Multiple endocrine neoplasia type 1 (MEN1)". Best ... GeneReviews/NIH/NCBI/UW entry on Multiple Endocrine Neoplasia Type 1 MEN1 gene variant database MEN1+protein,+human at the U.S ... Kong C, Ellard S, Johnston C, Farid NR (November 2001). "Multiple endocrine neoplasia type 1Burin from Mauritius: a novel MEN1 ... Yaguchi H, Ohkura N, Tsukada T, Yamaguchi K (2002). "Menin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP- ...
Penetrance
For example, multiple endocrine neoplasia type 1, a hereditary disorder characterized by parathyroid hyperplasia and pancreatic ... Feb 1998). "Characterization of mutations in patients with multiple endocrine neoplasia type 1". American Journal of Human ... A condition which shows complete penetrance is neurofibromatosis type 1 - every person who has a mutation in the gene will show ... Nature Education 1(1):64. Retrieved 2023-01-24. Evans, D.G., Shenton, A., Woodward, E. et al. Penetrance estimates for BRCA1 ...
Francis Collins
They included isolation of the genes for Huntington's disease, neurofibromatosis, multiple endocrine neoplasia type 1, inv(16) ... "Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1". Science. 276 (5311): 404-7. doi:10.1126/science. ... but has continued to lead an active lab there with a research focus on progeria and type 2 diabetes. On July 8, 2009, President ... and multiple non-profit organizations.[citation needed] In 2014, Collins worked with the larger biomedical research community ...
Angiofibroma
Fibrous papules also occur in individuals with multiple endocrine neoplasia type 1 (a study done in Japan found that 43% of ... List of cutaneous conditions Tuberous sclerosis Multiple endocrine neoplasia type 1 Birt-Hogg-Dube syndrome "Picture of ... multiple endocrine neoplasia type 1, and Birt-Hogg-Dube syndrome. The following are examples of these cutaneous angiofibromas ... "Frequency of facial angiofibromas in Japanese patients with multiple endocrine neoplasia type 1". Endocrine Journal. 47 (5): ...
Glucagon
It may occur alone or in the context of multiple endocrine neoplasia type 1. Elevated glucagon is the main contributor to ... Glucagon induces lipolysis in humans under conditions of insulin suppression (such as diabetes mellitus type 1). Glucagon ... Oberg K (December 2010). "Pancreatic endocrine tumors". Seminars in Oncology. 37 (6): 594-618. doi:10.1053/j.seminoncol.2010.10 ... It was found that a subset of adults with type 1 diabetes took 4 times longer on average to approach ketoacidosis when given ...
Glucagonoma
A family history of multiple endocrine neoplasia type 1 (MEN1) is a risk factor. Additionally, those with Mahvash disease have ... However, about 10% of cases are associated with multiple endocrine neoplasia type 1 (MEN-1) syndrome. Although the cause of ... CS1 errors: missing periodical, Articles with short description, Short description matches Wikidata, Endocrine neoplasia, Rare ... 16 (1): 1-7. doi:10.17305/bjbms.2015.794. ISSN 1840-4812. PMC 4765933. PMID 26773171. van Beek AP, de Haas ER, van Vloten WA, ...
Pancreatic cancer
PanNETs have been associated with multiple endocrine neoplasia type 1 (MEN1) and von Hippel Lindau syndromes. Chronic ... A fourth type of cancer that arises in the pancreas is the intraductal tubulopapillary neoplasm. This type was recognised by ... The first case of hyperinsulinism due to a tumor of this type was reported in 1927. Recognition of a non-insulin-secreting type ... though survival considerably varies depending on the type of tumor. The many types of pancreatic cancer can be divided into two ...
MALAT1
"A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Research. 7 (7): 725- ... MALAT1 was identified in multiple types of physiological processes, such as alternative splicing, nuclear organization, ... In so far as MALAT1 has been identified to be involved in tumorigenesis of various types of cancer such as lung cancer, ... Elevated MALAT1 expression is correlated with poor overall survival in various types of cancer, suggesting that this gene is a ...
CDC42EP2
"A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Research. 7 (7): 725- ...
FOXN3
2007). "Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response". Cancer ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression ... 33 (1): 1-8. doi:10.1006/geno.1996.0153. PMID 8617492. Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Field LL, Tobias R, Thomson G, Plon S (1996). "Susceptibility ...
ARL2
"A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7): 725-35. ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano ... 13 (1): 71-83. doi:10.1091/mbc.01-05-0245. PMC 65073. PMID 11809823. Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, ... 534 (1-3): 26-32. doi:10.1016/S0014-5793(02)03766-3. PMID 12527357. S2CID 22603052. Shern JF, Sharer JD, Pallas DC, Bartolini F ...
MAP4K2
"A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Research. 7 (7): 725- ... 30 (1): 1-17. doi:10.1101/gad.274027.115. ISSN 0890-9369. PMC 4701972. PMID 26728553. Meng, Zhipeng; Moroishi, Toshiro; Mottier ... Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor ... Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor ...
EHD1
1997). "A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus". Genome Res. 7 (7): ... 240 (1): 227-32. doi:10.1016/S0378-1119(99)00395-9. PMID 10564830. Pohl U, Smith JS, Tachibana I, et al. (2000). "EHD2, EHD3, ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Naslavsky N, Boehm M, Backlund PS, Caplan S (2005). "Rabenosyn-5 and EHD1 ... 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474. Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale ...
Medical Top Team
Later she was diagnosed with Multiple endocrine neoplasia type 1 (MEN1) and was involved in clinical trials. Choi Min-ho as Kim ... It aired in the Philippines on GMA Network from June 1 to July 1, 2016, under the title I Heart You Doc. It is also available ... Retrieved August 1, 2013. "Jo Woo-ri becomes a lovely nurse". Hancinema. September 26, 2013. Retrieved September 27, 2013. " ... The series repeated again from October 25 - December 3, 2018, every Monday to Friday, 1:00pm - 2:00pm. Lee, Sun-min (September ...
DPF2
1997). "A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus". Genome Res. 7 (7): ... This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional ... 36 (1): 174-7. doi:10.1006/geno.1996.0440. PMID 8812431. Guru SC, Agarwal SK, Manickam P, et al. ( ...
NEAT1
1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7): ... It is transcribed from the multiple endocrine neoplasia locus. Expression of NEAT1 is induced in mouse brains during infection ... 13 (1): 95-101. doi:10.1038/ncb2140. PMC 3007124. PMID 21170033. Peyman JA (2001). "Mammalian expression cloning of two human ... 60 (1): 23-31. doi:10.1095/biolreprod60.1.23. PMID 9858482. (Genes on human chromosome 11, RNA, Non-coding RNA). ...
SNX15
1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7): ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Phillips SA, Barr VA, Haft DH, et al. (2001). " ... 1 (11): 904-16. doi:10.1034/j.1600-0854.2000.011109.x. PMID 11208079. S2CID 31092568. "Entrez Gene: SNX15 sorting nexin 15". ...
Cushing's syndrome
Some of these are associated with inherited disorders such as multiple endocrine neoplasia type 1 and Carney complex. Diagnosis ... Cushing's disease is a specific type of Cushing's syndrome caused by a pituitary tumor leading to excessive production of ACTH ... "Cushing's Syndrome". National Endocrine and Metabolic Diseases Information Service (NEMDIS). July 2008. Archived from the ... The excess cortisol may also affect other endocrine systems and cause, for example, insomnia, inhibited aromatase, reduced ...
Pancreatic neuroendocrine tumor
Pancreatic neuroendocrine tumors may arise in the context of multiple endocrine neoplasia type 1, Von Hippel-Lindau disease, ... 69 PanNETs in Multiple endocrine neoplasia type 1 are often multiple, and thus require different treatment and surveillance ... "pancreatic endocrine tumours" are neuroendocrine neoplasms that arise from cells of the endocrine (hormonal) and nervous system ... PanNETs are a type of neuroendocrine tumor, representing about one-third of gastroenteropancreatic neuroendocrine tumors (GEP- ...
TM7SF2
"Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) ... 269 (1): 283-90. doi:10.1046/j.0014-2956.2001.02646.x. PMID 11784322. Holmer L, Pezhman A, Worman HJ (1999). "The human lamin B ... 44 (1): 94-100. doi:10.1006/geno.1997.4872. PMID 9286704. "Entrez Gene: TM7SF2 transmembrane 7 superfamily member 2". Bennati ...
Angiopoietin-related protein 1
"Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) ... Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene ... Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and ...
Birt-Hogg-Dubé syndrome
... and multiple endocrine neoplasia type 1. Tuberous sclerosis must be distinguished because both disorders can present with ... Renal tumors can manifest as multiple types of renal cell carcinoma, but certain pathological subtypes (including chromophobe, ... When a wild-type FLCN gene was added, the phenotype was rescued. Knockout mice have been created for a kidney-cancer causing ... Though the types of tumors typically associated with BHD are considered less aggressive, cases of advanced or metastatic kidney ...