R-type) calcium channels". Molecular Pharmacology. 71 (1): 284-93. doi:10.1124/mol.106.028530. PMID 17050807. S2CID 3106603. ... The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms ... 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents". European Journal of Pharmacology. 467 (1-3): 77-80. doi: ... This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 which in ...
... and R-type Ca2+ channels transiently expressed in human embryonic kidney 293 cells". Molecular Pharmacology. 62 (6): 1418-30. ... The alteration of N-type calcium channels in therapeutic processes occurs in four major ways; through the blockage of N-type ... In the kidneys, blocking of N-type calcium channels reduce glomerular pressure through dilation of arterioles. N-type calcium ... and this shows that only the N-type calcium channel, not the P/Q/L type calcium channels, are involved in the release of ...
Molecular Ecology. 18 (24): 5207-17. doi:10.1111/j.1365-294X.2009.04407.x. PMID 20050301. S2CID 331555. Archived (PDF) from the ... Type B1 or pack ice orcas are smaller than type A. It has a large white eye patch. Most of the dark parts of its body are ... Type B2 or Gerlache orcas are morphologically similar to Type B1, but smaller. This ecotype has been recorded feeding on ... Types B and C live close to the ice, and diatoms in these waters may be responsible for the yellowish colouring of both types. ...
"The role of melatonin in the onset and progression of type 3 diabetes". Molecular Brain. 10 (1): 35. doi:10.1186/s13041-017- ... type 3 diabetes is a condition which can follow after initially being diagnosed with type 2 diabetes. In type 3 diabetes, the ... Type 3 diabetes is a term proposed in 2016 to describe the interlinked association between type 1 and type 2 diabetes, and ... Diagnosis for this disease[clarification needed] is different between patients with type 1 and type 2 diabetes. Type 1 diabetes ...
March 1992). "Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor". ... Furuta H, Guo DF, Inagami T (February 1992). "Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 ... Curnow KM, Pascoe L, White PC (July 1992). "Genetic analysis of the human type-1 angiotensin II receptor". Molecular ... Angiotensin II receptor type 1 (AT1) is the best characterized angiotensin receptor. It is encoded in humans by the AGTR1 gene ...
August 2006). "Molecular model of a type III secretion system needle: Implications for host-cell sensing". Proceedings of the ... October 2012). "Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor". Journal of the ... type III secretion is used both for secreting infection-related proteins and flagellar components. However, the term "type III ... "Protein homology network families reveal step-wise diversification of Type III and Type IV secretion systems". PLOS ...
The type VI secretion system (T6SS) is molecular machine used by a wide range of Gram-negative bacterial species to transport ... "Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates". Molecular Cell. 51 (5): ... While most of the early studies of Type VI secretion focused on its role in the pathogenesis of higher organisms, it is now ... Cell Press:Type VI Secretion Counterattack During Bacterial Cell-Cell Interactions (CS1 maint: multiple names: authors list, ...
The European Molecular Quality Genetics Network (EMQN) recommends criteria for each type, which must be met before testing can ... Kang S, Hong S (June 2009). "Molecular pathogenesis of spinocerebellar ataxia type 1 disease". Molecules and Cells. 27 (6): 621 ... Pérez Ortiz J, Orr HT (2018). "Spinocerebellar Ataxia Type 1: Molecular Mechanisms of Neurodegeneration and Preclinical Studies ... Genetic testing is available for many SCA types, including the relatively common types SCA1, 2, 3, 6, and 7; and the less ...
VirB11 and VirB4 mediate early DNA transfer reactions required for bacterial type IV secretion". Molecular Microbiology. 54 (5 ... The type IV secretion system is divided into type IVA and type IVB based on genetic ancestry. Notable instances of the type IV ... The bacterial type IV secretion system, also known as the type IV secretion system or the T4SS, is a secretion protein complex ... Type IVA systems are similar to the VirB/D4 system of Agrobacterium tumefaciens. Type IVB systems are similar to the Dot/Icm ...
Martin MM, Su B, Elton TS (November 1994). "Molecular cloning of the human angiotensin II type 2 receptor cDNA". Biochemical ... Molecular Pharmacology. 43 (5): 677-83. PMID 8502225. Yamada T, Horiuchi M, Dzau VJ (January 1996). "Angiotensin II type 2 ... "Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor". Biochemical and Biophysical ... "The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 ...
Molecular Cell Research. Protein trafficking and secretion in bacteria. 1843 (8): 1707-1716. doi:10.1016/j.bbamcr.2013.11.003. ... Type VII secretion systems are necessary in Mycobacterium because of their impermeable membrane. The RD1 locus or Gene for Type ... Once this core machinery is assembled the Type VII secretion system exports alpha helical protein residues using ATP-ase. Type ... "Structure of Type VII Secretion System Revealed". www.cssb-hamburg.de. Retrieved 2022-10-22. Bunduc CM, Fahrenkamp D, Wald J, ...
"The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells". Frontiers in Immunology. 3: 30 ... Type 1 regulatory cells or Tr1 (TR1) cells are a class of regulatory T cells participating in peripheral immunity as a subsets ... Gregori et al.: Type 1 regulatory T (Tr1) cells: from the bench to the bedside. Journal of Translational Medicine 2012 10(Suppl ... Zeng, Hanyu; Zhang, Rong; Jin, Boquan; Chen, Lihua (September 2015). "Type 1 regulatory T cells: a new mechanism of peripheral ...
In order to confirm this the most practical measures to take next are: to perform a normal SMN1 molecular genetic testing to ... X-linked spinal muscular atrophy type 2 (SMAX2, XLSMA), also known as arthrogryposis multiplex congenita X-linked type 1 (AMCX1 ... SMA type 0 (SMA0) and SMA type I (SMA1). In SMA0, prenatal onset of weakness and poor intrauterine movement results in ... The types of evaluations that are recommended are categorized in nutrition/feeding and respiratory function.[citation needed] ...
"The molecular structure of human tissue type XV presents a unique conformation among the collagens". The Biochemical Journal. ... Type XV collagen is known to be a tumor suppressor that can be used to understand tumor cells environment. Type XV collagen ... This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with ... Hägg PM, Hägg PO, Peltonen S, Autio-Harmainen H, Pihlajaniemi T (June 1997). "Location of type XV collagen in human tissues and ...
Human Molecular Genetics. 11 (25): 3231-3236. doi:10.1093/hmg/11.25.3231. PMID 12444107. Zhang, Hua; Luo, Hunjin; Chen, ... Type 2D is distinguished from other types through the absence of dystopia canthorum, meaning that the wide distance between the ... It also results in heterochromia, where the eyes are different colors, in about half of those affected by Type 2. Type 2 also ... There is often misdiagnosis between Type 1 and Type 2 of the Waardenburg syndrome due to such close similarities between the ...
Ogawa Y, Nakao K, Arai H, Nakagawa O, Hosoda K, Suga S, Nakanishi S, Imura H (Jul 1991). "Molecular cloning of a non-isopeptide ... Endothelin receptor type B, (ET-B) is a protein that in humans is encoded by the EDNRB gene. Endothelin receptor type B is a G ... The multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. In horses, a ... Endothelin receptor type B has been shown to interact with Caveolin 1. Agonists IRL-1620 Antagonists A-192,621 BQ-788 Bosentan ...
"The 1.6 A structure of Kunitz-type domain from the alpha 3 chain of human type VI collagen". Journal of Molecular Biology. 246 ... This protein is an alpha chain of type VI collagen that aids in microfibril formation. As part of type VI collagen, this ... "Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution ( ... "Structure and multiple conformations of the kunitz-type domain from human type VI collagen alpha3(VI) chain in solution". ...
Wakabayashi, K.; Gustafson, A. M.; Sidransky, E.; Goldin, E. (2011). "Mucolipidosis type IV: An update". Molecular Genetics and ... "Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel". Human Molecular ... Mucolipidosis type IV is severely under-diagnosed. It is often misdiagnosed as cerebral palsy. In the Ashkenazi Jewish ... Mucolipidosis type IV (ML IV, ganglioside sialidase deficiency, or ML4) is an autosomal recessive lysosomal storage disorder. ...
... locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease". Human Molecular Genetics. 27 (17): 3079- ... Niemann-Pick type C is biochemically, genetically and clinically distinct from Niemann-Pick Types A or and B. In Types A and B ... referred to as type C2. The clinical manifestations of types Niemann-Pick types C1 and C2 are similar because the respective ... Approximately 95% of Niemann-Pick type C cases are caused by genetic mutations in the NPC1 gene, referred to as type C1; 5% are ...
Costa, R. M.; Silva, A. J. (2002). "Molecular and cellular mechanisms underlying the cognitive deficits associated with ... proximal NF1-REP-a and distal NF1-REP-c for the 1.4 Mb type-1 microdeletion, and SUZ12 and SUZ12P for the 1.2 Mb type-2 ... Neurofibromatosis type I (NF-1), or von Recklinghausen syndrome, is a complex multi-system human disorder caused by the ... Living with Neurofibromatosis Type 1: A Guide for Adults. New York, NY: The National Neurofibromatosis Foundation, Inc. Print. ...
Incerti, Barbara (2000). "Oa1 knock-out: New insights on the pathogenesis of ocular albinism type 1". Human Molecular Genetics ... Ocular albinism type 1 (OA1) is the most common type of ocular albinism, with a prevalence rate of 1:50,000. It is an ... Localization patterns of wild type OA1-GFP and mutated OA1-GFP were compared. The wild type OA1 localized to late endosomal or ... Defective intracellular transport and processing of OA1 is a major cause of ocular albinism type 1. Human Molecular Genetics 9( ...
Domenico, I.; Ward, D.M.; Nemeth, E.; Vaughan, M.B.; Musci, G.; Ganz, T.; Kaplan, J.; Kornfeld, S.A. (2005). "The molecular ... Type 4A hemochromatosis typically has milder symptoms than other types of hemochromatosis. Individuals with type 4A ... The symptoms of type 4B hemochromatosis tend to be more severe. They resemble the symptoms of hemochromatosis types 1, 2, and 3 ... Liver iron deposition tends to be greater in type 4B than in type 4A. Liver damage occurs more frequently in this form of ...
Human Molecular Genetics. 15 Spec No 2: R124-30. doi:10.1093/hmg/ddl215. PMID 16987875. "Can Diabetes Type II be inherited?". ... Most cases of type 2 diabetes involved many genes contributing small amount to the overall condition. As of 2011 more than 36 ... Genetic risk for type 2 diabetes changes as humans first began migrating around the world, implying a strong environmental ... While obesity is an independent risk factor for type 2 diabetes that may be linked to lifestyle, obesity is also a trait that ...
Molecular Brain Research. 26 (1-2): 47-54. doi:10.1016/0169-328x(94)90072-8. PMID 7854065. (Human proteins, Neurotransmitter ...
Molecular and Therapeutic Approaches". Current Pharmaceutical Design. 20 (35): 5619-5633. doi:10.2174/1381612820666140306095106 ... which was similar to the increased histone lysine acetylation at these gene promoters in type 1 diabetes and type 2 diabetes ... increased histone lysine acetylation at these promoters in monocytes obtained from Diabetes mellitus type 1 and Diabetes type 2 ... hypomethylation leads to increased susceptibility to Type 2 Diabetes. Type 2 diabetes associated sequence polymorphisms have ...
Advances in molecular genetics have enabled identification of most genes associated with HSAN I. However, the molecular ... HSAN I is the most common type among the five types of HSAN. As a heterogeneous group of diseases, HSAN I can be divided into ... Hereditary sensory and autonomic neuropathy type I (HSAN I) or hereditary sensory neuropathy type I (HSN I) is a group of ... However, the unique molecular signature of the mutations or the functional domains of the ATL1 gene that are affected in ...
Molecular and Cell Biology of Lipids. 1801 (4): 455-461. doi:10.1016/j.bbalip.2009.12.005. PMID 20045079. Hiroyama M, Takenawa ... Lysophosphatidic acid phosphatase type 6 is an acid phosphatase enzyme that is encoded in humans by the ACP6 gene. It acts as a ... Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. (Articles with short description, ... "Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6". Protein & Cell. 4 (7): 548-61. ...
Tanaka T, Takahashi K, Furukawa F, Imamura S (March 1992). "Molecular cloning and characterization of type VII collagen cDNA". ... This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha ... in the collagen type VII alpha 1 chain (COL7A1) gene. Collagen, type VII, alpha 1 forms a complex network with several other ... "Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin". The ...
Molecular and Cellular Biology. 20 (17): 6587-6599. doi:10.1128/mcb.20.17.6587-6599.2000. PMC 86141. PMID 10938133. "Bare ... Bare lymphocyte syndrome type II (BLS II) is a rare recessive genetic condition in which a group of genes called major ... "bare lymphocyte syndrome type II". Genetics Home Reference. Retrieved 2017-07-13. "SCID due to absent class II HLA antigens ( ... One of the several proteins that are required to switch on MHC II genes in various cells types is absent. The diagnosis for ...
Journal of Molecular and Cellular Cardiology. 38 (1): 213-8. doi:10.1016/j.yjmcc.2004.10.014. PMID 15623438. Rieck DC, Li KL, ... "Entrez Gene: TNNC1 troponin C type 1 (slow)". "Troponin C, slow skeletal and cardiac muscles". Cardiac Organellar Protein Atlas ... In contrast, levosimendan inhibits type 3 phosphodiesterase with nanomolar affinity, so its biological target is controversial ... Journal of Molecular and Cellular Cardiology. 75: 181-7. doi:10.1016/j.yjmcc.2014.07.015. PMC 4169182. PMID 25101951. Bers DM ( ...