They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C ... Mitomycin C is used as a medicine for treating various disorders associated with the growth and spread of cells. In general, ... Mitomycin C is used to treat pancreatic and stomach cancer, and is under clinical research for its potential to treat ... "Mitomycin". Drugs.com. 2017. Retrieved 11 November 2017. Rustagi, T; Aslanian, H. R; Laine, L (2015). "Treatment of Refractory ...
... is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given ... Mitomycin is also used as a chemotherapeutic agent in glaucoma surgery. Pregnant women should not take mitomycin gel because it ... Subjects received mitomycin gel once a week (mitomycin gel 4 mg per mL instillations via ureteral catheter or nephrostomy tube ... Mitomycin was discovered in 1955 by Japanese scientists in cultures of the microorganism Streptomyces caespitosus. Mitomycin C ...
Allen, G.; Pidacks, C.; Weiss, M. (5 June 1996). "The Mitomycin Antibiotics. Synthetic Studies". J. Am. Chem. Soc. 88 (11): ...
The additional use of mitomycin C is of unclear effect. Radiotherapy has also been used in an attempt to reduce the risk of ... "Mitomycin C in pterygium treatment". International Journal of Ophthalmology. 9 (3): 465-8. doi:10.18240/ijo.2016.03.25. PMC ...
"Mitomycin-C in congenital glaucoma". Ophthalmic Surg Lasers. 28 (12): 979-85. doi:10.3928/1542-8877-19971201-03. PMID 9427984 ...
... and mitomycin". Chemical Reviews. 105 (2): 739-58. doi:10.1021/cr030117g. PMID 15700963. Zhang, C; Griffith, BR; Fu, Q; ...
... and mitomycin". Chemical Reviews. 105 (2): 739-58. doi:10.1021/cr030117g. PMID 15700963. Kametani, T.; Ogasawara, K. J. J. Chem ...
It produces chemotherapeutic drug mitomycin C. Sugawara R, Hata T (1956). ""Mitomycin, a new antibiotic from Streptomyces. II. ...
De Benito-Llopis, L; Teus, MA; Sánchez-Pina, JM (2008). "Comparison between LASEK with mitomycin C and LASIK for the correction ... "Long-term concerns linger on safety of Mitomycin-C". Archived from the original on November 3, 2013. Retrieved April 22, 2013 ... Mitomycin C worsens post-surgical dry eye. PRK may be performed on one eye at a time to assess the results of the procedure and ... Mitomycin-C, can be applied briefly at the completion of surgery to reduce risk of hazing, although with increased risk of ...
This occurs when bleomycin binds to a metal ion, becomes chemically reduced and reacts with oxygen.: 87 Mitomycin is a ... Verweij J, Pinedo HM (October 1990). "Mitomycin C: mechanism of action, usefulness and limitations". Anti-Cancer Drugs. 1 (1): ... The most important subgroup is the anthracyclines and the bleomycins; other prominent examples include mitomycin C and ... mitomycin C, anthracyclines, BCNU, melphalan) including CDDP could be reversed at least partially by the addition of heat. ...
... produces actinomycin X, antipain and mitomycin. Xue, Jinghua; Wu, Min (27 March 2015). "Cyclic ... Wolf, Gudrun; Wörth, Jürgen; Achenbach, Hans (1975). "Mitomycin und ein neues Phenoxazon-Pigment aus Streptomyces michiganensis ... "Mitomycin und ein neues Phenoxazon-Pigment aus Streptomyces michiganensis". Archives of Microbiology. 106 (3): 245-249. doi: ...
They are derived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity ... Iyengar, 1 Bhashyam S.; Remers, William A. (1985). "A comparison of mechanisms proposed for the conversion of mitomycins into ... of the mitomycins. Maliepaard, Marc; de Mol, Nico J.; Tomasz, Maria; Gargiulo, Dario; Janssen, Lambert H. M.; van Duynhoven, ...
Mitomycins and porfiromycin: chemical mechanism of activation and cross-linking of DNA. Science. 145:55-56. August PR, Rahn JA ... Inducible synthesis of Mitomycin C resistance gene product (MCRA) from Streptomyces lavendulae. Gene: An International Journal ... Mitomycin Resistance in Streptomyces lavendulae Includes a Novel Drug-Binding-Protein-Dependent Export System. Journal of ... Characterization of a Mitomycin-Binding Drug Resistance Mechanism from the Producing Organism, Streptomyces lavendulae. Journal ...
Binary ethylenimine, a dimeric form of aziridine Tomasz, Maria (September 1995). "Mitomycin C: small, fast and deadly (but very ... Several drugs feature aziridine rings, including mitomycin C, porfiromycin, and azinomycin B (carzinophilin). The bond angles ...
Other cytotoxic antibiotics are anthracyclines, mitomycin C, bleomycin, mithramycin. Antibodies are sometimes used as a quick ...
Other crosslinking agents include mustard gas, mitomycin, and psoralen. In proteins, crosslinks are important in generating ...
Nayak, D.P.; Rasmussen Jr., A.F. (1966). "Influence of mitomycin C on the replication of influenza viruses". Virology. 30 (4): ...
Marey, H M; S S Mandour; A F Ellakwa (Oct 2012). "Subscleral Trabeculectomy with Mitomycin-C Versus Ologen for Treatment of ... "A prospective randomised trial of trabeculectomy using mitomycin C vs an ologen implant in open angle glaucoma". Eye. 24 (9): ... "Biodegradable collagen matrix implant vs mitomycin-C as an adjuvant in trabeculectomy: a 24-month, randomized clinical trial". ... is created under the conjunctiva and Tenon's capsule and the wound bed is treated for several seconds to minutes with mitomycin ...
... average birth weight decreased significantly in mice exposed to caffeine or theophylline when coadministered with mitomycin C, ... but not for paraxanthine coadministered with mitomycin C. Paraxanthine was reported to be significantly less clastogenic ... "Potentiating effects of methylxanthines on teratogenicity of mitomycin C in mice". Teratology. 28 (2): 243-247. doi:10.1002/ ...
These polymorphisms may have differential effects on platinum and mitomycin damage. ERCC1 protein expression is reduced or ...
"Surgical outcome of mitomycin C-soaked collagen matrix implant in trabeculectomy". J Glaucoma. 22 (6): 456-62. doi:10.1097/IJG. ...
730-736 Yuan F, Li L, Chen X, Yan X, Wang L (2015). "Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C ... "Surgical outcome of mitomycin C-soaked collagen matrix implant in trabeculectomy". J Glaucoma. 22 (6): 456-62. doi:10.1097/ijg. ...
A Cochrane Review comparing aqueous shunt surgery with and without Mitomycin-C did not find benefit or harm associated with the ... 2014). "Using a collagen matrix implant (Ologen) versus mitomycin-C as a wound healing modulator in trabeculectomy with the Ex- ... Foo VH, Htoon HM, Welsbie DS, Perera SA (2019). "Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma". ... This may require preventive measures using anti-fibrotic medication like 5-fluorouracil (5FU) or Mitomycin-C (during the ...
Upon mitomycin C induction, large amounts of SNJ1 virions can be produced. SNJ1 genome replicates by the rolling-circle ...
Cabourne, Emily; Clarke, Jonathan C. K.; Schlottmann, Patricio G.; Evans, Jennifer R. (2015-11-06). "Mitomycin C versus 5- ...
Mitomycin C and oxaliplatin are the most commonly used agent for colorectal cancer, while cisplatin is used in ovarian cancer. ... The chemotherapeutic agents generally infused during IPHC are mitomycin-C and cisplatin. IPHC is generally used after surgical ...
Unerberg, W. J. M.; Lingeman, H. (1983). "Determination of pKa Values of Some Prototropic Function in Mitomycin and ...
... , involved in Fanconi anemia, confers resistance to both hygromycin B and mitomycin C. FANCG contains a 5-prime GC-rich ... Kruyt FA, Abou-Zahr F, Mok H, Youssoufian H (November 1999). "Resistance to mitomycin C requires direct interaction between the ... "Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice". Hum. Mol. Genet. 11 (3): 273-81. doi ...
Yuan F, Li L, Chen X, Yan X, Wang L (2015). "Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for ... Traditionally, chemotherapeutic adjuvants, such as mitomycin C (MMC) or 5-fluorouracil (5-FU), are applied with soaked sponges ... This may require preventive measures using antifibrotic medications, such as 5-fluorouracil or mitomycin-C (during the ... "Biodegradable collagen matrix implant versus mitomycin-C in trabeculectomy: five-year follow-up". BMC Ophthalmology. 16 (24): ...
1995). "Mitomycin C and menadione for the treatment of lung cancer: a phase II trial". Investigational New Drugs. 13 (2): 157- ... 1995). "Phase I study of mitomycin C and menadione in advanced solid tumors". Cancer Chemotherapy and Pharmacology. 36 (4): 293 ...