Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress- ... Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal ... "Entrez Gene: mitogen-activated protein kinase 12". Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2006). "Uncovering ... 2008). "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection ...

Signal transduction MAP kinase kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 ... MAP Kinase Resource . Table of names for mitogen-activated kinases. MAPK cascade picture Mitogen-Activated+Protein+Kinases at ... A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine ... Extracellular signal-regulated kinases (ERKs) c-Jun N-terminal kinases (JNKs) p38 mitogen-activated protein kinases (p38s) ...

... is an enzyme that in humans is encoded by the MAPK9 gene. The protein encoded by this gene ... "The JIP group of mitogen-activated protein kinase scaffold proteins". Molecular and Cellular Biology. 19 (10): 7245-54. doi: ... "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Molecular and Cellular ... "Entrez Gene: MAPK9 mitogen-activated protein kinase 9". Saleem A, Datta R, Yuan ZM, Kharbanda S, Kufe D (Dec 1995). " ...

... are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress ... p38+Mitogen-Activated+Protein+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) P38mapkPathway ... MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to ... a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". The Journal of ...

"The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of ... "Entrez Gene: MAP3K12 mitogen-activated protein kinase kinase kinase 12". Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ ... "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10. ... Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene. The protein encoded by this ...

Signal transduction MAP kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase Dérijard B, et al. (1995). "Independent ... Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which ... Mitogen-Activated+Protein+Kinase+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... phosphorylates mitogen-activated protein kinase (MAPK). MAP2K is classified as EC 2.7.12.2. There are seven genes: MAP2K1 (a.k. ...

... , the protein encoded by this gene, is located on the Golgi apparatus, the cell membrane, and in the cytosol. It contains ... There is a region of 79 amino acids from p. 1686 - 1764 that is required for PLCE1 to be activated by RHOA, RHOB, GNA12, GNA13 ... Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L (August 2003). "Identification of Tyr900 in the kinase domain ... "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158-D169. January 2017. doi:10.1093/nar/ ...

The protein encoded by this gene is a member of the MAP (mitogen-activated protein) kinase family. MAP kinases are also known ... including cyclin-dependent kinase 2 (CDK2), mitogen-activated protein kinase 12 (MAPK12), and lactotransferrin (LTF), among ... Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 ... "Entrez Gene: MAPK15 mitogen-activated protein kinase 15". Chia J, Tham KM, Gill DJ, Bard-Chapeau EA, Bard FA (2014). "ERK8 is a ...

"Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2". Molecular Biology of ... Golgi reassembly-stacking protein of 55 kDa (GRASP55) also known as golgi reassembly-stacking protein 2 (GORASP2) is a protein ... thus linking the cisternae together through multiple protein-protein interactions. GRASP55 is attached to the membrane in two ... It is a peripheral membrane protein located on the Golgi cisterna, and it can bind to another GRASP55 located on an adjacent ...

... lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway ... protein. Dimerization of NPM constitutively activates the ALK kinase domain. The full-length protein ALK was identified in 1997 ... Lee HH, Norris A, Weiss JB, Frasch M (October 2003). "Jelly belly protein activates the receptor tyrosine kinase Alk to specify ... September 2011). "The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to ...

"Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade". ... "Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation". The Journal of Biological ... In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA. TIAM1 is found in virtually all tumor cell lines ... Rho guanine nucleotide exchange factor TIAM1 is a protein that in humans is encoded by the TIAM1 gene. TIAM1 is tightly ...

"SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons". Proceedings of the National ... "SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons". Proceedings of the National ... "Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II". The ... Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded ...

... not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases ... 5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene. The protein encoded ... 2004). "The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy ... 2004). "AMP-activated protein kinase plays a role in the control of food intake" (PDF). J. Biol. Chem. 279 (13): 12005-8. doi: ...

1999). "KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation ... Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene. G ... 2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B ... "Entrez Gene: GNG3 guanine nucleotide binding protein (G protein), gamma 3". Wedegaertner PB, Wilson PT, Bourne HR (1995). " ...

Mitogen-Activated Protein Kinase Signaling, and Caspase Activation". Chemical Research in Toxicology. 34 (12): 2579-2591. doi: ... Interaction with cellular proteins, particularly HMG domain proteins, has also been advanced as a mechanism of interfering with ... Since this was only demonstrated for colon carcinoma cells, it remains an open question whether the Omi/Htra2 protein ... Santi M, Mapanao AK, Cassano D, Vlamidis Y, Cappello V, Voliani V (April 2020). "Endogenously-Activated Ultrasmall-in-Nano ...

Receptor Potential Ankyrin 1 Is Up-Regulated in Response to Lipopolysaccharide via P38/Mitogen-Activated Protein Kinase in ... 190 (12): 2417-2426. doi:10.1016/j.ajpath.2020.08.016. PMID 32919979. S2CID 221674768. (Articles without InChI source, Articles ...

... to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1 ... In response to upregulation of tumor suppressor protein p53, C16-ceramide levels were increased in leukemia and colon cancer ... Articles with short description, Short description matches Wikidata, Protein pages needing a picture, Genes on human chromosome ... 5 (8): 801-12. doi:10.1158/1541-7786.MCR-07-0100. PMID 17699106. van Hall T, Wolpert EZ, van Veelen P, Laban S, van der Veer M ...

"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proceedings of the National ... Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene. MAP2K4 ... mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes". The Journal of Experimental Medicine. 186 (6): 941- ... Chen Z, Cobb MH (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". The ...

This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the ... "Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases". The ... Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene. MAPK7 ... "Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein". The ...

It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle ... A specific method for activating AMP-activated protein kinase in intact cells?". European Journal of Biochemistry. 229 (2): 558 ... Kim JE, Kim YW, Lee IK, Kim JY, Kang YJ, Park SY (March 2008). "AMP-activated protein kinase activation by 5-aminoimidazole-4- ... Lemieux K, Konrad D, Klip A, Marette A (September 2003). "The AMP-activated protein kinase activator AICAR does not induce ...

"Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver". Proc. Natl. ... "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions". Mol. Cell. Biol. 17 (6): 3094-102 ... JUNB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their ...

... factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase- ... receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation". ... "Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase". The Journal of ... 92 (12): 5361-5. Bibcode:1995PNAS...92.5361S. doi:10.1073/pnas.92.12.5361. PMC 41694. PMID 7777512. Gearing DP, Druck T, ...

Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases ... "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909-20. doi: ... "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high ... "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Mol. Cell. Biol. ...

... role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by ... Saito Y, Hojo Y, Tanimoto T, Abe J, Berk BC (June 2002). "Protein kinase C-alpha and protein kinase C-epsilon are required for ... GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. The protein encoded by this gene is ... Braun L, Ghebrehiwet B, Cossart P (2000). "gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of ...

... "p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR". Human Molecular Genetics. 18 (21): ... Survival of motor neuron 2 (SMN2) is a gene that encodes the SMN protein (full and truncated) in humans. The SMN2 gene is part ... Chen HH, Chang JG, Lu RM, Peng TY, Tarn WY (November 2008). "The RNA binding protein hnRNP Q modulates the utilization of exon ... Yong J, Wan L, Dreyfuss G (May 2004). "Why do cells need an assembly machine for RNA-protein complexes?". Trends in Cell ...

"Entrez Gene: MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2". Giza J, et al. (2010). "Behavioral and ... "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol Cell Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10. ... "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. 20 (3): ... "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. 20 (3): ...

"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase ... Fibronectin domain-containing protein 5 is a membrane protein comprising a short cytoplasmic domain, a transmembrane segment, ... potentially generating a protein that begins at methionine-76 (Met-76). A protein initiated at Met-76 would be missing the ... In mice, this causes production of the FNDC5 protein which is cleaved to give a new product irisin. Due to its production ...

"Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation". ... Dubois T, Howell S, Zemlickova E, Aitken A (April 2002). "Identification of casein kinase Ialpha interacting protein partners ... ERF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene. GRCh38: Ensembl release ...

"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6". J. Biol. ... Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene. The protein encoded by this gene ... Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated ... MAPK11 has been shown to interact with HDAC3 and Promyelocytic leukemia protein. p38 mitogen-activated protein kinases GRCh38: ...

This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a serine/threonine protein-kinase. This ... "Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase". Mol. Cell ... Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is ... "Entrez Gene: MAP3K14 mitogen-activated protein ki kinase kinase 14". Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E (May ...