They also developed advanced proteomic methods to interrogate mitochondria (Mitoplex) and to image mitochondrial turnover ( ... a novel tool for monitoring mitochondrial turnover". Autophagy. 9 (11): 1852-1861. doi:10.4161/auto.26501. PMC 4028337. PMID ... Her current work is focused on mitophagy and mitochondrial biogenesis as linked processes that are tightly controlled in the ... At Cedars-Sinai Medical Center, she serves as the Director of Metabolism and Mitochondrial Research Core, as Curriculum ...

During his Ph.D. thesis research, Israel isolated the mitochondrial enzymes that catalyze the first step in the synthesis of ... Cholesterol and adrenodoxin interactions at equilibrium and during turnover". The Journal of Biological Chemistry. 256 (9): ... He examined this issue and showed that indeed, electrons that leak during the action mitochondrial P450 systems generate ... Rapoport R, Sklan D, Hanukoglu I (10 March 1995). "Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 ...

P450scc is a mitochondrial enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the ... Cholesterol and adrenodoxin interactions at equilibrium and during turnover". The Journal of Biological Chemistry. 256 (9): ... The supplying of cholesterol to this membrane (from the outer mitochondrial membrane) is, thus, considered the true rate- ... Topological studies of cytochromes P-450scc and P-45011 beta in bovine adrenocortical inner mitochondrial membranes. Effects of ...

"Regulation of mitochondrial protein turnover by thyroid hormone(s)". Biochem. J. 152 (2): 379-387. doi:10.1042/bj1520379. PMC ...

The mitochondrial matrix protein p32 stabilizes smARF. This protein binds various cellular and viral proteins, but its exact ... Knocking down p32 dramatically decreases smARF levels by increasing its turnover. The levels of p19Arf are not affected by p32 ... The function of ARF involving p53-independent death, has now been attributed to the small mitochondrial isoform of ARF, smARF. ... May 2006). "A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death". Mol. Cell. 22 (4): 463- ...

"The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover". Molecular Biology of the Cell. 22 (3): 291- ...

"Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics". The EMBO Journal. 33 ... Deshwal S, Fiedler KU, Langer T (June 2020). "Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity". ... Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene. OMA1 is a Zn2+-dependent ... March 2020). "Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway". Nature. 579 (7799): 427-432. ...

"Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2". Molecular and Cellular ... It is a member of the Mitochondrial carrier (MC) Superfamily, however, its metal cargo makes it distinct from other members of ... Mfrn1 plays a key role in mitochondrial iron homeostasis as an iron transporter, importing ferrous iron from the intermembrane ... Hung HI, Schwartz JM, Maldonado EN, Lemasters JJ, Nieminen AL (January 2013). "Mitoferrin-2-dependent mitochondrial iron uptake ...

"TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III". Molecular Cell. ... "UQCRFS1 - Cytochrome b-c1 complex subunit Rieske, mitochondrial". The UniProt Consortium. Zong NC, Li H, Li H, Lam MP, Jimenez ... Shimomura Y, Nishikimi M, Ozawa T (December 1985). "Novel purification of cytochrome c1 from mitochondrial Complex III. ... mitochondrial cytochrome b) and ten nuclear genes UQCRC1, UQCRC2, Cytochrome C1, UQCRFS1 (this protein, a type of Rieske ...

Gospodarska E, Nowialis P, Kozak LP (March 2015). "Mitochondrial turnover: a phenotype distinguishing brown adipocytes from ... Azzu V, Brand MD (May 2010). "The on-off switches of the mitochondrial uncoupling proteins". Trends in Biochemical Sciences. 35 ... Busiello RA, Savarese S, Lombardi A (2015). "Mitochondrial uncoupling proteins and energy metabolism". Frontiers in Physiology ...

"TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III". Molecular Cell. ... This protein is embedded in the inner mitochondrial membrane and is involved in the formation of the mitochondrial respiratory ... Mitochondrial complex III deficiency, nuclear (type 2) is a diverse group of neuromuscular and multi-systemic disorders caused ... Variants of TTC19 have been associated with mitochondrial complex III deficiency, nuclear 2 (MC3DN2). TTC19 is known to cause ...

The cytosolic isoform has a higher turnover rate, approximately 2-5 times faster than the mitochondrial isoform. BCATc has been ... Human BCATc is encoded by BCAT1 Mitochondrial branched-chain amino acid aminotransferases are the more ubiquitous of the two ... Yennawar N, Dunbar J, Conway M, Hutson S, Farber G (April 2001). "The structure of human mitochondrial branched-chain ... Mammalian BCATs come in two isoforms: cytosolic (BCATc) and mitochondrial (BCATm). The isoforms share 58% homology, but vary in ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... 4 July 2017). "Deeply divergent archaic mitochondrial genome provides lower time boundary for African gene flow into ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... Ranaweera L, Kaewsutthi S, Win Tun A, Boonyarit H, Poolsuwan S, Lertrit P (January 2014). "Mitochondrial DNA history of Sri ... According to Van Driem (2007), the mitochondrial picture indicates that the Munda maternal lineage derives from the earliest ... Derenko M, Malyarchuk B, Bahmanimehr A, Denisova G, Perkova M, Farjadian S, Yepiskoposyan L (2013). "Complete mitochondrial DNA ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... The theory proposes that early modern humans, some of the bearers of mitochondrial haplogroup L3, arrived in the Arabian ... 13 May 2005), "Single, Rapid Coastal Settlement of Asia Revealed by Analysis of Complete Mitochondrial Genomes; Vol. 308. no. ... 1034-36, doi:10.1126/science.1109792, PMID 15890885, S2CID 31243109, ... mitochondrial DNA variation in isolated "relict" ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... There have, however, been no reports of the survival of Y-chromosomal or mitochondrial DNA clearly deriving from archaic humans ... Mitochondrial Eve and Y-chromosomal Adam). Estimates of the age of Y-chromosomal Adam have been pushed back significantly with ... "Ancestral mitochondrial N lineage from the Neolithic 'green' Sahara". Sci Rep. 9 (1): 3530. Bibcode:2019NatSR...9.3530V. doi: ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... "Ancestral mitochondrial N lineage from the Neolithic 'green' Sahara". Sci Rep. 9 (1): 3530. Bibcode:2019NatSR...9.3530V. doi: ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... "Ancestral mitochondrial N lineage from the Neolithic 'green' Sahara". Sci Rep. 9 (1): 3530. Bibcode:2019NatSR...9.3530V. doi: ...

... mitochondrial DNA analyses of ancient and modern grey wolf specimens supports a pattern of population reduction and turnover. ... Mitochondrial DNA sequences have a higher mutation rate than the mutation rate of nuclear genes and for mammals this rate is 5- ... The abundance of mitochondrial DNA (mDNA) is useful for the genetic analysis of ancient remains where the DNA has degraded. ... The mitochondrial protein-coding genes evolve much faster and are powerful markers for inferring evolution history at category ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... 4 July 2017). "Deeply divergent archaic mitochondrial genome provides lower time boundary for African gene flow into ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... 19 October 2017). "Mitochondrial pseudogenes suggest repeated inter-species hybridization among direct human ancestors". ... July 2017). "Deeply divergent archaic mitochondrial genome provides lower time boundary for African gene flow into Neanderthals ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... "Ancestral mitochondrial N lineage from the Neolithic 'green' Sahara". Sci Rep. 9 (1): 3530. Bibcode:2019NatSR...9.3530V. doi: ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... "Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... By some 50-70,000 years ago, a subset of the bearers of mitochondrial haplogroup L3 migrated from East Africa into the Near ... From 2000 to 2003, there was controversy about the mitochondrial DNA of "Mungo Man 3" (LM3) and its possible bearing on the ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... By comparing mitochondrial DNA, which is inherited only from the mother, geneticists have concluded that the last female common ... Cann RL, Stoneking M, Wilson AC (1987). "Mitochondrial DNA and human evolution". Nature. 325 (6099): 31-36. Bibcode:1987Natur. ... June 2009). "Correcting for purifying selection: an improved human mitochondrial molecular clock". American Journal of Human ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ...

"Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in ... Mitochondrial DNA studies of Sami people, haplogroup U5 are consistent with multiple migrations to Scandinavia from Volga-Ural ... There have been a number of studies about the mitochondrial DNA haplogroups (mtDNA) in Europe. In contrast to Y DNA haplogroups ... March 2019). "Ancestral mitochondrial N lineage from the Neolithic 'green' Sahara". Scientific Reports. 9 (1): 3530. Bibcode: ...