In cell biology, microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular ... Alzheimer's disease Cytoskeleton Microtubule Mohan, Renu; John, Annie (June 2015). "Microtubule-associated proteins as direct ... There are many other proteins which affect microtubule behavior, such as catastrophin, which destabilizes microtubules, katanin ... Mandelkow E, Mandelkow EM (February 1995). "Microtubules and microtubule-associated proteins". Curr. Opin. Cell Biol. 7 (1): 72 ...

... is a protein in humans that is encoded by the MAP2 gene. This gene encodes a protein that ... MAP2 microtubule-associated protein 2". Lim RW, Halpain S (July 2000). "Regulated association of microtubule-associated protein ... Herrmann H, Wiche G (1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 ... human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2 ...

EB Proteins EB1 and other proteins SxlP proteins APC MACF STIM1 TOG proteins XMAP215 CLASP Motor proteins Tea2 MCAK Dynein HC ... microtubules, kinetochores, cell cortex, and centrosomes. Biology portal Microtubules Microtubule associated protein Proteins ... Microtubule plus-end/positive-end tracking proteins or +TIPs are a type of microtubule associated protein (MAP) which ... The end-binding proteins (EB proteins), have a precise N-terminal domain which is accountable for microtubule binding. The C- ...

... is a protein that in humans is encoded by the MTUS2 gene. GRCh38: Ensembl release 89 ... "Entrez Gene: Microtubule associated scaffold protein 2". Retrieved 2017-09-18. Jiang K, Wang J, Liu J, Ward T, Wordeman L, ... "Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic p300/CBP- ... Du Puy L, Beqqali A, Monshouwer-Kloots J, Haagsman HP, Roelen BA, Passier R (2009). "CAZIP, a novel protein expressed in the ...

Microtubule-associated proteins (MAPs) are proteins that interact with microtubules by binding to their tubulin subunits and ... Microtubule plus end tracking proteins (+TIPs) are MAPs that accumulates in the plus end of microtubules. In neurotubules, + ... Microtubule Neurofilament Tubulin Microtubule associated protein Neuronal migration "Medical Definition of NEUROTUBULE". www. ... Mandelkow E, Mandelkow EM (February 1995). "Microtubules and microtubule-associated proteins". Curr. Opin. Cell Biol. 7 (1): 72 ...

A single microtubule consists of 13 linear microfilaments. Unlike microfilaments, microtubules are composed of a protein called ... Goodson HV, Jonasson EM (June 2018). "Microtubules and Microtubule-Associated Proteins". Cold Spring Harbor Perspectives in ... a protein filament is a long chain of protein monomers, such as those found in hair, muscle, or in flagella. Protein filaments ... These microtubules will attach to the kinetochore at their positive end. Ndc80 is a protein found at this binding point that ...

Alteration in a microtubule-associated protein". The Journal of Biological Chemistry. 257 (2): 1071-1078. doi:10.1016/S0021- ... Podophyllotoxin destabilizes microtubules by binding tubulin and thus preventing cell division. In contrast, some of its ... Jindal S, Dudani AK, Singh B, Harley CB, Gupta RS (May 1989). "Primary structure of a human mitochondrial protein homologous to ... Mutant Chinese hamster cells resistant to podophyllotoxin are affected in a protein P1 that was later identified as the ...

Tubulin protein polymers are the major component of microtubules. During mitosis, microtubules form the organizing structure ... Lodish, H; Berk, A; Zipursky, SL (2000). "Microtubule dynamics and motor proteins during mitosis". Molecular Cell Biology (4th ... Agents that disrupt microtubules therefore inhibit mitosis through activation of this checkpoint. Moroidin and its related ... Mukhtar, Eiman; Adhami, Vaqar M; Mukhtar, Hasan (2014). "Targeting microtubules by natural agents for cancer therapy". Mol ...

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene. This gene encodes a protein that ... Tögel M, Wiche G, Propst F (1998). "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule ... belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule ... "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112-6. doi: ...

Brain Microtubule Associated Proteins: Modifications in Disease. Amsterdam: Harwood Acad. Publ. pp. 185-241. ISBN 978-90-5702- ... The company's protein aggregation inhibitors target the underlying pathology of dementia, with the aim of modifying or halting ... Their lead compound, LMTX, targets aggregation of tau and is believed to act on synuclein, TDP-43 and huntingtin protein. Its ... Wischik CM, Lai RY, Harrington CR (1997). "Modelling prion-like processing of tau protein in Alzheimer's disease for ...

This protein complex has microtubule-binding domains. HEC is one of several proteins involved in spindle checkpoint signaling. ... Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene. Ndc80 is one of the proteins of ... "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model". ... Chen Y, Riley DJ, Chen PL, Lee WH (October 1997). "HEC, a novel nuclear protein rich in leucine heptad repeats specifically ...

Flatow, Evan Lloyd (1977). "The Comparative Biochemistry of Microtubule Accessory Proteins". {{cite journal}}: Cite journal ... "The Comparative Biochemistry of Microtubule Accessory Proteins." He earned his medical degree from the Columbia University ...

"Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family". J ... "Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein ... Microtubule-associated protein 1S is a protein that in humans is encoded by the MAP1S gene. MAP1S has been shown to interact ... "Microtubule-associated protein 8 contains two microtubule binding sites". Biochem. Biophys. Res. Commun. 339 (1): 172-9. doi: ...

The tau proteins were identified in 1975 as heat-stable proteins essential for microtubule assembly, and since then they have ... Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways ... Hyperphosphorylated tau disassembles microtubules and sequesters normal tau, MAPT 1 (microtubule associated protein tau 1), ... human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2 ...

The severing of microtubules by katanin is regulated by protective microtubule-associated proteins (MAPs), and the p80 subunit ... Katanin is a microtubule-severing AAA protein. It is named after the Japanese sword called a katana. Katanin is a heterodimeric ... Using antibodies, these two proteins were found to localize at the ends of microtubules in the meiotic spindle, and, when ... This regulation is indirect: MAP proteins, which protect the microtubules from being severed during interphase, dissociate and ...

2006). "RGS14 is a microtubule-associated protein". Cell Cycle. 4 (7): 953-60. doi:10.4161/cc.4.7.1787. PMID 15917656. S2CID ... Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene. RGS14 is a member of the ... This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco motif. The protein attenuates the ... Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis ...

At Princeton, his early work on microtubules established their unusual molecular assembly from tubulin proteins and identified ... The first step in spindle formation is the nucleation of microtubules by microtubule-organizing centers, which then grow in all ... "A protein factor essential for microtubule assembly". Proceedings of the National Academy of Sciences of the United States of ... of the dynamic instability of microtubules, In mitosis, for example, microtubules form the spindle that separates the ...

... is a protein that in humans is encoded by the MAP7 gene. The product of this gene is a microtubule-associated protein ... This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of ... Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization ... "Entrez Gene: MAP7 microtubule-associated protein 7". Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes GJ, Peeters CA, Katrukha ...

"Entrez Gene: CKAP2 cytoskeleton associated protein 2". Alternative titles: tumor- and microtubule-associated protein; TMAP, LB1 ... Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene. Human CKAP2 gene, the cDNA of which ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... Seki A, Fang G (2007). "CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit". J. Biol. Chem. 282 ( ...

Microtubule-associated protein 6 (MAP6) or stable tubule-only polypeptide (STOP or STOP protein) is a protein that in humans is ... This gene encodes a microtubule-associated protein (MAP). The encoded protein is a calmodulin binding, and calmodulin-regulated ... "Entrez Gene: MAP6 microtubule-associated protein 6". Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC ( ... Wei H, Sun S, Li Y, Yu S (November 2016). "Reduced plasma levels of microtubule-associated STOP/MAP6 protein in autistic ...

2006). "HIV-1 Tat protein enhances microtubule polymerization". Retrovirology. 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. ... Tubulin beta-4A chain is a protein that in humans is encoded by the TUBB4A gene. Two tubulin beta-4 chain proteins are encoded ... 2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel ... Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro- ...

2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology. 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. ... Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro- ... 2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197-204 ... TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans. GRCh38: Ensembl release 89: ENSG00000101162 - ...

2006). "HIV-1 Tat protein enhances microtubule polymerization". Retrovirology. 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. ... Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro- ... 2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197- ... Tubulin alpha-1C chain is a protein that in humans is encoded by the TUBA1C gene. GRCh38: Ensembl release 89: ENSG00000167553 ...

2006). "HIV-1 Tat protein enhances microtubule polymerization". Retrovirology. 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. ... 2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". J ... Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro- ... 1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro". Mol. Cell. Biol. ...

... translationally controlled protein P23 has properties of a tubulin binding protein and associates transiently with microtubules ... TCTP has properties of a tubulin binding protein that associates with microtubules in a cell cycle-dependent manner. The ... Translationally controlled tumor protein (TCTP) is a protein that in humans is encoded by the TPT1 gene. TPT1 is mapped to ... Yarm FR (September 2002). "Plk phosphorylation regulates the microtubule-stabilizing protein TCTP". Molecular and Cellular ...

Carlier MF, Simon C, Cassoly R, Pradel LA (April 1984). "Interaction between microtubule-associated protein tau and spectrin". ... Wolfe LC, John KM, Falcone JC, Byrne AM, Lux SE (November 1982). "A genetic defect in the binding of protein 4.1 to spectrin in ... Spectrin beta chain, erythrocyte is a protein that in humans is encoded by the SPTB gene. GRCh38: Ensembl release 89: ... "Defining of the minimal domain of protein 4.1 involved in spectrin-actin binding". The Journal of Biological Chemistry. 270 (36 ...

"MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule ... 2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology. 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. ... Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene. GRCh38 ... Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro- ...

... has been found to bind with high, nanomolar affinity to microtubule-associated protein 2 (MAP2) in the brain. In ... Fontaine-Lenoir V, Chambraud B, Fellous A, David S, Duchossoy Y, Baulieu EE, Robel P (2006). "Microtubule-associated protein 2 ... As such, pregnenolone may control formation and stabilization of microtubules in neurons and may affect both neural development ... contrast to pregnenolone, pregnenolone sulfate did not bind to microtubules. However, progesterone did and with similar ...

It is a negative allosteric modulator of the CB1 receptor, a ligand of the microtubule-associated protein 2 (MAP2), and an ... Fontaine-Lenoir V, Chambraud B, Fellous A, David S, Duchossoy Y, Baulieu EE, Robel P (2006). "Microtubule-associated protein 2 ...

Microtubule-associated protein 1A is a protein that in humans is encoded by the MAP1A gene. This gene encodes a protein that ... "Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins". J. ... "Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics ... Pedrotti B, Colombo R, Islam K (1994). "Microtubule associated protein MAP1A is an actin-binding and crosslinking protein". ...