... strains are discussed in detail in Lee Silver's online book Mouse Genetics: Concepts and Applications: "Mouse Genetics ... Congenic strains are generated in the laboratory by mating two inbred strains (usually rats or mice), and back-crossing the ... Congenic mice or rats can then be compared to the pure recipient strain to determine whether they are phenotypically different ... November 1997). "Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains". Nat. Genet. 17 (3): ...

"Multiparameter analyses of spontaneous nonthymic lymphomas occurring in NFS/N mice congenic for ecotropic murine leukemia ... Rowe and his colleagues showed that retroviruses can cause leukemia in mice. He was among the first "to recognize the role of ... ISBN 978-0-323-14218-2. Rowe, W. P. (1961). "The Epidemiology of Mouse Polyoma Virus Infection". Bacteriological Reviews. 25 (1 ... Rowe, W. (1983). "Deformed whiskers in mice infected with certain exogenous murine leukemia viruses". Science. 221 (4610): 562- ...

1995). "T cell response to Borrelia garinii, Borrelia afzelii, and Borrelia japonica in various congenic mouse strains". ... It is known to cause experimental disease in mouse models, suggesting that some strains could also be connected with human Lyme ...

1995). "T cell response to Borrelia garinii, Borrelia afzelii, and Borrelia japonica in various congenic mouse strains". ...

2003). "A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density". Mamm. Genome. 13 (7): 335-40. ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Hahn GV, Cohen RB, ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...

Selective breeding - Organisms, often mice, may be bred selectively among inbred strains to create a recombinant congenic ... most commonly mice. The recent sequencing of the genome of many species, most notably mice, has facilitated this technique. ... Genetic engineering - The genome may also be experimentally-manipulated; for example, knockout mice can be engineered to lack a ... mice, and monkeys. As a result, a critical assumption in behavioral neuroscience is that organisms share biological and ...

Evidence from the use of a Y-maze differentially scented by congenic mice of different major histocompatibility types". Journal ... In a study, researchers discovered that mice heterozygous at all MHC loci were less resistant than mice homozygous at all loci ... Yamazaki, K.; Yamaguchi, M.; Baranoski, L.; Bard, J.; Boyse, E. A.; Thomas, L. (1979). "Recognition among mice. ... such as mice, assess a mate's genetic compatibility based on their urine odor. In an experiment studying three-spined ...

"Recognition among mice. Evidence from the use of a Y-maze differentially scented by congenic mice of different major ...

1985 - Started producing BALB/c mice. 1991 - Became the first commercial provider of the C.B-17 SCID mouse model. 1994 - ... Contracted with National Institute for Allergy and Infectious Disease to maintain a repository of inbred, congenic, and ... "Mice in microgravity: how rodent research in space accelerates study timelines". outsourcing-pharma.com. Retrieved 9 June 2017 ... They continue to supply NCI with BDF1 mice. 1975 - Began offering the SHR hypertensive rat and the WKY control strain. 1980 - ...

November 2004). "Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered ... The images and graph demonstrate that BMAT is higher in obese compared with lean mice. B6 mice were fed HFD from age 4 wk until ... August 2015). "Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice". ... August 2017). "Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice". Journal of Bone and Mineral ...

"Know thy mouse." Science Direct. Vol. 22, No. 12, Dec. 2006, pp. 649-653. Trends in Genetics. doi:10.1016/j.tig.2006.09.010 ... inbreeding guarantees a consistent and uniform animal model for experimental purposes and enables genetic studies in congenic ... The mice that are inbred typically show considerably lower survival rates. Inbreeding increases homozygosity, which can ... In order to achieve a mouse strain that is considered inbred, a minimum of 20 sequential generations of sibling matings must ...

Stanford, Lianne; Brown, Richard E. (September 2003). "MHC-congenic mice (C57BL/6J and B6-H-2K) show differences in speed but ... The Hebb-Williams maze is a maze used in comparative psychology to assess the cognitive ability of small animals such as mice ... The maze has been used to investigate strain and sex differences in mice. A 2018 study argued that the maze is potentially ... "Age and sex differences in motivation and spatial working memory in 3xTg-AD mice in the Hebb-Williams maze". Behavioural Brain ...

DBA mice were nearly lost in 1918, when the main stocks were wiped out by murine paratyphoid, and only three un-pedigreed mice ... Backcrossing Congenic strain Inbreeding Linebreeding Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing MF, ... "The period before World War I led to the initiation of inbreeding in rats by Dr Helen King in about 1909 and in mice by Dr C. C ... Soon after World War I, inbreeding in mice was started on a much larger scale by Dr L. C. Strong, leading in particular to the ...

In 2016 a new knock-in mouse was generated on the C57BL/6 background to be a perfect congenic strain. This mouse, dubbed the ... For instance, leukocytes can be transferred from a CD45.1 donor mouse, into a CD45.2 host mouse, and can be subsequently ... "Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/ ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Kaplan R, Morse B, ...

... associated with susceptibility to IDDM have been identified in the NOD mouse strain through the development of congenic mouse ... The mice (as well as C57BL/6 and SJL) are known to carry IgG2c allele. Non-obese diabetic (NOD) mice exhibit a susceptibility ... Loss of IL-2 can thereby contribute to the development of autoimmunity in NOD mice. NOD mice have a mutation in exon 2 of the ... NOD mice have polymorphisms in the Idd3 locus which are linked to IL-2 production. IL-2 promotes either immunity or tolerance ...

MeSH B01.050.157.040 - animals, congenic MeSH B01.050.157.040.500 - mice, congenic MeSH B01.050.157.520 - mice, inbred strains ... mice, congenic MeSH B01.050.199.520.520 - mice, inbred strains MeSH B01.050.199.520.520.300 - mice, inbred a MeSH B01.050. ... mice MeSH B01.150.900.649.865.635.505.500.150 - mice, congenic MeSH B01.150.900.649.865.635.505.500.400 - mice, inbred strains ... congenic MeSH B01.050.199.040.500 - mice, congenic MeSH B01.050.199.520 - animals, inbred strains MeSH B01.050.199.520.040 - ...

The karyotype of the house mouse normally consists of 40 telocentric chromosomes, but in certain regions in Europe, mice with ... The associations were demonstrated by testing the responses of congenic strains differing at the H2 complex and mapping the ... Genetic mapping of the loci controlling the class I and class II antigens of the mouse showed them to be part of a cluster, ... Klein group's combined t and H2 studies on wild mice from all over the world led to the identification and characterization of ...

... "congenic", or deliberately inbred mouse strains which are histocompatible.[citation needed] An individual's immune response of ...

... rat electronic annotations from UniProt and mouse phenotype annotations from the Mouse Genome Database/Mouse Genome Informatics ... For congenic and mutant strains, genomic positions are assigned for the introgressed region (congenic strains) or the location ... Mouse QTL records, including Mammalian Phenotype (MP) ontology assignments, are imported directly from MGI. For rat and human ... Although the largest numbers of these are human and mouse cell lines, records are also available for rat, bonobo, dog, squirrel ...

Using a number of recombinant and congenic rat strains, the work mapped susceptibility genes in the BB rat to the class II MHC ... Arlotta P; Tai AK; Manfioletti G; Clifford C; Jay G; Ono SJ (May 2000). "Transgenic mice expressing a truncated form of the ... Using transgenic mouse technology, they also showed (concurrently and independently of Alfredo Fusco), that fusion proteins ... can drive the development of lipomas and generate obese mice. Further contributions in the field include the mapping of the ...

In mice, ZIP12 mRNA is not detected in pancreas. In mouse Neuro-2a cells and primary mouse neurons, ZIP12 is necessary for ... identified ZIP12 as the responsible gene through congenic breeding between Fisher 344 (F344) rats, which are resistant to ... ZIP12 mRNA is more abundant in mouse oocytes compared to cumulus cells, which indicates that ZIP12 may play a role in ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: ...

They had previously described the development, manufacture, and efficacy in mice of an A/Anhui/1/13 (H7N9) viruslike particle ( ... the national avian flu reference laboratory concluded that the strain of the H7N9 virus found on pigeons was highly congenic ... vaccine against H7N9 influenza is immunogenic in mice". Emerging Microbes & Infections. 2 (8): e52. doi:10.1038/emi.2013.54. ...