Metallothioneins are rich in thiols, causing them to bind a number of trace metals. Metallothionein is one of the few ... Singh VK, Hanson J (June 2006). "Assessment of metallothionein and antibodies to metallothionein in normal and autistic ... but metallothioneins also protect against metal toxicity and oxidative stress. Metallothionein has been documented to bind a ... Metallothionein also carries zinc ions (signals) from one part of the cell to another. When zinc enters a cell, it can be ...
"Entrez Gene: MT1G metallothionein 1G". West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: ... 1987). "Structure and Expression of the Human Metallothionein Genes". Metallothionein II. Experientia Supplementum. Vol. 52. pp ... Metallothionein-1G is a protein that in humans is encoded by the MT1G gene. GRCh38: Ensembl release 89: ENSG00000125144 - ... Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome ...
"Entrez Gene: MT1A metallothionein 1A". Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, et al. (2007). "Metallothionein: ... Minami T, Kubo K, Ichida S (2003). "Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas ... Metallothionein-1A is a protein that in humans is encoded by the MT1A gene. GRCh38: Ensembl release 89: ENSG00000205362 - ... 2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate ...
Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene. The single-nucleotide polymorphism ... "Entrez Gene: MT2A metallothionein 2A". Sekovanić A, Jurasović J, Piasek M (2020). "Metallothionein 2A gene polymorphisms in ... Karin M, Richards RI (Dec 1982). "Human metallothionein genes--primary structure of the metallothionein-II gene and a related ... 1992). "Comparison of the solution conformations of human [Zn7]-metallothionein-2 and [Cd7]-metallothionein-2 using nuclear ...
... is a member of the metallothionein family of proteins. GRCh38: Ensembl release 89: ENSG00000087250 - Ensembl ... Metallothionein-3 (also known as Growth Inhibitory Factor) is a protein that in humans is encoded by the MT3 gene. It is a 68- ... "Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals ... You HJ, Oh DH, Choi CY, Lee DG, Hahm KS, Moon AR, Jeong HG (Oct 2002). "Protective effect of metallothionein-III on DNA damage ...
Excess copper (as well as other heavy metal ions like zinc or cadmium) may be bound by metallothionein and sequestered within ... Zinc produces a mucosal block by inducing metallothionein, which binds copper in mucosal cells until they slough off and are ... Cousins, RJ (1985). "Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ... Kaegi, Jeremias H. R.; Schaeffer, Andreas (1988). "Biochemistry of metallothionein". Biochemistry. 27 (23): 8509-15. doi: ...
Hamer, D.H.: Metallothionein. Annu. Rev. Biochem. 55: 913‑951, 1986. Furst P.; Hu S.; Hackett R.; Hamer D.H. (1988). "Copper ... At NIH, Hamerʻs lab initially focused on the metallothionein gene system. They elucidated the mechanism of induction of yeast ... metallothionein by copper ions, one of the first eukaryotic gene regulatory systems to be understood at the molecular level and ...
Funk AE, Day FA, Brady FO (1987). "Displacement of zinc and copper from copper-induced metallothionein by cadmium and by ... Maret W (May 2003). "Cellular zinc and redox states converge in the metallothionein/thionein pair". The Journal of Nutrition. ... Theocharis SE, Margeli AP, Koutselinis A (2003). "Metallothionein: a multifunctional protein from toxicity to cancer". Int J ... For example, zinc regulates the expression of metallothionein, which has multiple functions, such as intracellular zinc ...
"Entrez Gene: MT1F metallothionein 1F". West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: ... 1987). "Structure and expression of the human metallothionein genes". Metallothionein II. Experientia Supplementum. Vol. 52. pp ... "Structure and expression of the human metallothionein-IG gene Differential promoter activity of two linked metallothionein-I ... Metallothionein-1F is a protein that in humans is encoded by the MT1F gene. GRCh38: Ensembl release 89: ENSG00000198417 - ...
Metallothionein-1H is a protein that in humans is encoded by the MT1H gene. GRCh38: Ensembl release 89: ENSG00000205358 - ... "Entrez Gene: MT1H metallothionein 1H". Soumillion A, Van Damme J, De Ley M (1992). "Cloning and specific polymerised-chain- ... West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (Mar 1991). "Human metallothionein genes: structure of the ... Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood ...
"Entrez Gene: MT1E metallothionein 1E". West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: ... Metallothionein-1E is a protein that in humans is encoded by the MT1E gene. GRCh38: Ensembl release 89: ENSG00000169715 - ... 2003). "Metallothionein isoform 1 and 2 gene expression in a human urothelial cell line (UROtsa) exposed to CdCl2 and NaAsO2". ... 2003). "Activation of metallothioneins and alpha-crystallin/sHSPs in human lens epithelial cells by specific metals and the ...
Metallothionein-1B is a protein that in humans is encoded by the MT1B gene. GRCh38: Ensembl release 89: ENSG00000169688 - ... "Entrez Gene: MT1B metallothionein 1B". Lederer CW, Torrisi A, Pantelidou M, et al. (2007). "Pathways and genes differentially ... 1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513-8. doi:10.1016/0888-7543 ... Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome ...
Metallothionein 1X, also known as MT1X, is a protein which in humans is encoded by the gene. Metallothionein GRCh38: Ensembl ... "Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein ... "Entrez Gene: MT1X metallothionein 1X". West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (November 1990). " ... 2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate ...
Metallothionein-1M is a protein that in humans is encoded by the MT1M gene. GRCh38: Ensembl release 89: ENSG00000205364 - ... "Entrez Gene: MT1M metallothionein 1M". Lederer CW, Torrisi A, Pantelidou M, et al. (2007). "Pathways and genes differentially ... West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (Mar 1991). "Human metallothionein genes: structure of the ... 2000). "Metallothioneins in human kidneys and associated tumors". Nephron. 83 (4): 331-40. doi:10.1159/000045425. PMID 10575295 ...
267: 573-582 Dallinger R., Berger B., Hunziker P.E., Kägi J.H.R. (1997) Metallothionein in snail Cd and Cu metabolism. In: ... 4:97-109 Dallinger R., Egg M., Köck G., Hofer R. (1997) The role of metallothionein in cadmium accumulation of Arctic Char ( ... Dallinger was also involved in the elucidation of the three-dimensional structure of a metallothionein with three Cadmium- ... 85: 135-145 Gruber C., Stürzenbaum S., Gehrig P., Sack R., Hunziker P., Berger B., Dallinger R. (2000) (Cd)-Metallothionein ...
Metallothionein maintains copper levels in yeast. The copper fist domain is similar in structure to metallothionein itself, and ... These proteins activate the transcription of the metallothionein gene in response to copper. ...
Freisinger EF, Vasac M (2013). "Cadmium in Metallothioneins". In Sigel A, Sigel H, Sigel RK (eds.). Cadmium: From Toxicity to ...
Vasken Aposhian, H.; Bruce, D. C. (1991). "Binding of Polonium-210 to Liver Metallothionein". Radiation Research. 126 (3): 379- ...
Isolation of Metallothionein from Cadmium-contaminated Isopods. Richard Greco, Donald Clarke, Grace Vernon, & Ruth Witkus. 1991 ...
Metallothioneins and related chelators. Sigel, Astrid., Sigel, Helmut., Sigel, Roland K. O. Cambridge: Royal Society of ... Maret, Wolfgang (2008-05-01). "Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc". ...
Chemical Mimicking of Metallothioneins". Journal of the American Chemical Society. 133 (16): 6403-6410. doi:10.1021/ja200792m. ... renders the reaction catalytic in copper and uses only one equivalent of boronic acid by mimicking the metallothionein (MT) ...
Goyer, R.A.; Haust, M.D.; Cherian, M.G. (1992). "Cellular localization of metallothionein in human term placenta". Placenta. 13 ...
"Developing pineapple fruit has a small transcriptome dominated by metallothionein". Journal of Experimental Botany. 56 (409): ...
Zinc may be held in metallothionein reserves within microorganisms or in the intestines or liver of animals. Metallothionein in ... and is stored and transferred in metallothioneins. It is the second most abundant trace metal in humans after iron and it is ... excess zinc particularly impairs copper absorption because metallothionein absorbs both metals. The human dopamine transporter ...
... and metallothionein act as a redox pair, and much of the antioxidant functions of attributed to metallothionein are ... The binding of heavy metal ions to both thionein and metallothionein is due to their high cysteine content. Wolfgang m (2003 ... Palacios O, Atrian S, Capdevila, M (2011). "Zn- and Cu-thioneins: a functional classification for metallothioneins?". Journal ... Thionein is a cysteine-rich coenzyme associated with metallothioneins. ...
... may be held in metallothionein reserves within microorganisms or in the intestines or liver of animals. Metallothionein in ... Aydemir, T. B.; Blanchard, R. K.; Cousins, R. J. (2006). "Zinc supplementation of young men alters metallothionein, zinc ... and is stored and transferred in metallothioneins. It is the second most abundant trace metal in humans after iron and it is ... excess zinc particularly impairs copper absorption because metallothionein absorbs both metals. The human dopamine transporter ...
Mocchegiani E, Muzzioli M, Cipriano C, Giacconi R (1998). "Zinc, T-cell pathways, aging: role of metallothioneins". Mechanisms ...
"Pentavalent vanadium induces hepatic metallothionein through interleukin-6-dependent and -independent mechanisms". Toxicology. ...
Her dissertation was titled Control of hepatic metallothionein synthesis by zinc and cadmium. She was a postdoctoral researcher ... Squibb, Katherine Sprague (1977). Control of hepatic metallothionein synthesis by zinc and cadmium (Ph.D. thesis). Rutgers ...
"Pentavalent vanadium induces hepatic metallothionein through interleukin-6-dependent and -independent mechanisms". Toxicology. ...