Melphalan
"Alkeran- melphalan tablet, film coated". DailyMed. 18 November 2019. Retrieved 23 April 2022. "Evomela- melphalan injection, ... Melphalan was approved for medical use in the United States in 1964. It is on the World Health Organization's List of Essential ... Melphalan belongs to the class of nitrogen mustard alkylating agents. It works by interfering with the creation of DNA and RNA ... The applicant for this medicinal product is Adienne S.r.l. S.U. Melphalan was approved for medical use in the European Union in ...
Melphalan flufenamide
... is a peptidase enhanced cytotoxic (PEnC) with a targeted delivery within tumor cells of melphalan, a ... Compared to melphalan, melphalan flufenamide exhibits significantly higher in vitro and in vivo activity in several models of ... This suggests that melphalan flufenamide is rapidly and widely distributed to extravasal tissues, in which melphalan is formed ... Melphalan flufenamide was approved for medical use in the European Union in August 2022. Melphalan flufenamide is the ...
Alkylating antineoplastic agent
Examples include melphalan and chlorambucil. The following three groups are almost always considered "classical". Nitrogen ... Uramustine or uracil mustard Melphalan Chlorambucil Ifosfamide Bendamustine Nitrosoureas Carmustine Lomustine Streptozocin ...
Buthionine sulfoximine
Defty, CL; Marsden, JR (2012). "Melphalan in regional chemotherapy for locally recurrent metastatic melanoma". Current Topics ...
Chemotherapy
Most chemotherapy is delivered intravenously, although a number of agents can be administered orally (e.g., melphalan, busulfan ... Dexamethasone along with either bortezomib or melphalan is commonly used as a treatment for AL amyloidosis. Recently, ... Nitrogen mustards include mechlorethamine, cyclophosphamide, melphalan, chlorambucil, ifosfamide and busulfan. Nitrosoureas ... melphalan) including CDDP could be reversed at least partially by the addition of heat. Chemotherapy is used in veterinary ...
Nitrogen mustard
Other nitrogen mustards developed include cyclophosphamide, chlorambucil, uramustine, melphalan, and bendamustine. Bendamustine ...
Multiple myeloma
Treatment with bortezomib, melphalan, and prednisone had an estimated overall survival of 83% at 30 months, lenalidomide plus ... For these people, the standard of care has been chemotherapy with melphalan and prednisone. Recent studies among this ... August 2008). "Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma". The New England Journal of ... such as melphalan, cyclophosphamide, thalidomide, or dexamethasone, alone or in combination), and a second ASCT. Later in the ...
Chromosome abnormality
Meiotic inter-strand DNA damages caused by melphalan can escape paternal repair and cause chromosomal aberrations in the zygote ... Melphalan is a bifunctional alkylating agent frequently used in chemotherapy. ...
Ligand Pharmaceuticals
The drugs for which it receives royalties include Kyprolis, Promacta, Melphalan and Baxdela. As of 2015, Ligand Pharmaceuticals ...
Takeda Oncology
"VELCADE as Initial Standard Therapy in multiple myeloma: Assessment with melphalan and prednisone". Millennium Corporate ...
Juvenile myelomonocytic leukemia
The EWOG-MDS study also involves cyclophosphamide and melphalan in its conditioning regimen. Post transplant management: ...
Sporadic late-onset nemaline myopathy
Improvement has also been noted with autologous stem cell transplantation, and chemotherapy with melphalan. Chahin N, Selcen D ...
Specialty drugs in the United States
"Melphalan granted FDA Orphan Drug Designation for treatment of cholangiocarcinoma", News-Medical.Net, 20 July 2015, retrieved 6 ... NASDAQ: DCTH) a specialty pharmaceutical and medical device company manufactures melphalan. By 2011 the oral medications for ... melphalan (trade name Alkeran), busulfan, capecitabine). Delcath Systems, Inc. ( ...
Immunomodulatory imide drug
EMA has also approved it to treat MM in combination with prednisone and/or melphalan. Orphan indications by the FDA include ...
Light chain deposition disease
High-dose melphalan in conjunction with autologous stem cell transplantation has been used in some patients. A regimen of ...
Suppression of tumorigenicity 8 (ovarian)
The four-drug combination helped in the increased overall remission rate, but was more toxigenic than melphalan. The four-drug ... regimen is more effective than melphalan in the management of advanced ovarian adenocarcinoma. ST8 suppression of ...
Intraperitoneal injection
... and melphalan. There needs to be more research done to determine appropriate dosing and combinations of these drugs to advance ...
Aspen Pharmacare
In 2009, Aspen purchased the rights to market Melphalan and several other cancer drugs from GSK, such as levothyroxine, ... The investigation was conducted due to rising prices for five drugs (chlorambucil, melphalan, mercaptopurine, tioguanine and ...
Thalidomide
... is used as a first-line treatment for multiple myeloma in combination with dexamethasone or with melphalan and ... It was also evaluated whether thalidomide can be combined with melphalan and prednisone for patients with multiple myeloma. ... including doxorubicin and melphalan) concurrently. Thalidomide may interfere with various contraceptives, and hence it is ...
Fertility preservation
... melphalan, chlorambucil and chlormethine. Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and ...
List of Ig Nobel Prize winners
"Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic ...
CFU-GEMM
... with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high-dose melphalan ...
Bortezomib
People were randomized to receive either nine cycles of oral melphalan (M) plus prednisone (P) or MP plus bortezomib. People ... It was seen that bortezomib plus lenalidomide plus dexamethasone as well as bortezomib plus melphalan and prednisone may result ...
POEMS syndrome
Hematological response rates to the dexamethasone/melphalan regimens have been reported to be in the 80% range with ... a corticosteroid such as dexamethasone plus an alkylating agents such as melphalan. Dosage regimens are selected on the basis ... neurological response rates approaching 100%. Patients successfully treated with the high-dose dexamethasone/melphalan regimen ...
Female infertility
... melphalan, chlorambucil and chlormethine. Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and ...
Large neutral amino acids transporter small subunit 2
... polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". ...
Large neutral amino acids transporter small subunit 1
... polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". ...
Papular mucinosis
It has been reported that clearance of lesions can be done with melphalan and cyclophosphamide alone or in combination with ...
Carmustine
Use under this protocol, usually with fludarabine and melphalan, was developed by oncologists at the University of Texas MD ...
Institute of Cancer Research
... and melphalan (Alkeran). In 1952 the ICR's Eric Boyland had proposed that certain chemicals that cause cancer (carcinogens) ...