MAP kinase kinase kinase
MAP kinase MAP kinase kinase MAP kinase kinase kinase kinase List of unusual biological names "Global Identification, ... is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP ... These MAP kinases include the extracellular regulated kinases (ERKs), the c-Jun N-terminal Kinases (JNKs), and the p38 MAP ... MAP+Kinase+Kinase+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 2.7.11.25 Portal: Biology ...
Mitogen-activated protein kinase
Signal transduction MAP kinase kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 ... Similarly, both dual-specificity MAP kinase phosphatases and MAP-specific tyrosine phosphatases bind to MAP kinases through the ... Nemo-like kinase: atypical MAPK) ERK1/2 kinases ERK1/2 pathway JNK kinases p38 MAP kinases MEKK2 (MAP3K2) ASK1 (MAP3K5) Pearson ... A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine ...
Extracellular signal-regulated kinases
"MAP kinase-kinase", thus qualifying as a "MAP kinase kinase kinase". The MAP kinase-kinase, which activates ERK, was named " ... MAP) kinase through MAP kinase kinase". Proceedings of the National Academy of Sciences of the United States of America. 90 (3 ... Kyriakis JM, App H, Zhang XF, Banerjee P, Brautigan DL, Rapp UR, Avruch J (July 1992). "Raf-1 activates MAP kinase-kinase". ... In molecular biology, extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein ...
Wall-associated kinase
Kohorn BD, Johansen S, Shishido A, Todorova T, Martinez R, Defeo E, Obregon P (December 2009). "Pectin activation of MAP kinase ... Kohorn BD, Johansen S, Shishido A, Todorova T, Martinez R, Defeo E, Obregon P (December 2009). "Pectin activation of MAP kinase ... Cell wall associated kinases are receptor-like protein kinases, found in plant cell walls, that have the capability to transmit ... Wall-Associated Kinases (WAKs) are a subfamily of receptor-like kinases (RLKs) associated with the cell wall. They were ...
Janus kinase 1
1992). "Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24". Mamm. Genome. 3 (1): 36- ... Janus kinase 1 has been shown to interact with: ELP2, GNB2L1 IL6ST, Grb2, IL2RB, IRS1, IL10RA, PTPN11, STAM2, STAT3, STAT5A, ... Janus+Kinase+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (Genes on human ... JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the ...
MAPK phosphatase
Kondoh, Kunio; Nishida, Eisuke (1 August 2007). "Regulation of MAP kinases by MAP kinase phosphatases". Biochimica et ... Kondoh, Kunio; Nishida, Eisuke (1 August 2007). "Regulation of MAP kinases by MAP kinase phosphatases". Biochimica et ... Kondoh, Kunio; Nishida, Eisuke (1 August 2007). "Regulation of MAP kinases by MAP kinase phosphatases". Biochimica et ... Kondoh, Kunio; Nishida, Eisuke (1 August 2007). "Regulation of MAP kinases by MAP kinase phosphatases". Biochimica et ...
Signaling Gateway (website)
Rousseau, Simon (2011). "P38 alpha MAP kinase". AfCS-Nature Molecule Pages. doi:10.1038/mp.a001717.01. Katoh, Masaru (2008). " ... "Frizzled 7". AfCS-Nature Molecule Pages. doi:10.1038/mp.a000965.01. Alison Abbott (2002). "Alliance for cellular signaling: ...
HSP90AB1
"A human MAP kinase interactome". Nature Methods. 7 (10): 801-5. doi:10.1038/nmeth.1506. PMC 2967489. PMID 20936779. Erazo T, ... extracellular regulated kinase 5), or the checkpoint kinase Wee1. Cystic fibrosis (CF, mucoviscidosis) is a genetic disease ... "Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation ... Sato S, Fujita N, Tsuruo T (Sep 2000). "Modulation of Akt kinase activity by binding to Hsp90". Proceedings of the National ...
KIAA0232
"A human MAP kinase interactome". Nature Methods. 7 (10): 801-805. doi:10.1038/nmeth.1506. PMC 2967489. PMID 20936779. Varjosalo ... DYRK1A/B are dual-specificity tyrosine kinases. This corroborates the post-translational modification predictions. "KIAA0232 ... "The Protein Interaction Landscape of the Human CMGC Kinase Group". Cell Reports. 3 (4): 1306-1320. doi:10.1016/j.celrep.2013.03 ...
ARHGAP31
2010). "A human MAP kinase interactome". Nat. Methods. 7 (10): 801-5. doi:10.1038/nmeth.1506. PMC 2967489. PMID 20936779. Jenna ... 2007). "Glycogen synthase kinase-3 phosphorylates CdGAP at a consensus ERK 1 regulatory site". J. Biol. Chem. 282 (6): 3624-31 ... 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621-5. Bibcode: ... 273 (44): 29172-7. doi:10.1074/jbc.273.44.29172. PMID 9786927. Horne BD, Hauser ER, Wang L, et al. (2009). "Validation study of ...
HER2
Huang YZ, Zang M, Xiong WC, Luo Z, Mei L (January 2003). "Erbin suppresses the MAP kinase pathway". The Journal of Biological ... Signaling pathways activated by HER2 include: mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K/Akt) ... Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ... One of which is erbB-2, and the other members being erbB-1, erbB-3 (neuregulin-binding; lacks kinase domain), and erbB-4. All ...
Erbin (protein)
Huang YZ, Zang M, Xiong WC, Luo Z, Mei L (January 2003). "Erbin suppresses the MAP kinase pathway". J. Biol. Chem. 278 (2): ... Huang YZ, Zang M, Xiong WC, Luo Z, Mei L (2003). "Erbin suppresses the MAP kinase pathway". J. Biol. Chem. 278 (2): 1108-14. ... Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis ... 7 (5): 475-85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. S2CID 12598418. Jaulin-Bastard F, Arsanto JP, Le Bivic A, ...
KSR1
Roy F, Therrien M (2002). "MAP kinase module: the Ksr connection". Curr. Biol. 12 (9): R325-7. doi:10.1016/S0960-9822(02)00831- ... 2005). "Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and ... Xing HR, Lozano J, Kolesnick R (2000). "Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of ... "Entrez Gene: KSR1 kinase suppressor of ras 1". Goettel JA, Liang D, Hilliard VC, et al. (2011). "KSR1 is a functional protein ...
Mitogen-activated protein kinase 9
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple ... MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine. This article incorporates text from the United States National ... Davis RJ (2000). "Signal transduction by the JNK group of MAP kinases". Cell. 103 (2): 239-52. doi:10.1016/S0092-8674(00)00116- ... This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, ...
MARK2
"Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2". Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, ... Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene. EMK (ELKL Motif Kinase) is a ... "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833-43. doi: ... Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT (2001). "PAR-1 is a Dishevelled-associated kinase and a ...
PLA2G4A
1993). "cPLA2 is phosphorylated and activated by MAP kinase". Cell. 72 (2): 269-78. doi:10.1016/0092-8674(93)90666-E. PMID ... 15 (7): 1566-1571. doi:10.1002/j.1460-2075.1996.tb00501.x. PMC 450066. PMID 8612580. de Carvalho MG, McCormack AL, Olson E, et ... doi:10.1016/S0021-9258(17)36794-7. PMID 8175726. "Entrez Gene: PLA2G4A phospholipase A2, group IVA (cytosolic, calcium- ...
WRKY transcription factor
2008) Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus. EMBO J. 27(16). ... 2002) MAP kinase signalling cascade in Arabidopsis innate immunity. Nature. 415(6875). 977-983 Deslandes, Olivier, Peeters, ... 2005) Tobacco Transcription Factor WRKY1 Is Phosphorylated by the MAP Kinase SIPK and Mediates HR-Like Cell Death in Tobacco. ... While kinases phosphorylating WRKY transcription factors are known, phosphatases removing phosphate groups have yet to be ...
MAPK7
... is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are ... This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the ... MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine. Portal: Biology (Articles with short description, Short ... Purandare SM, Lee JD, Patel PI (March 1999). "Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with ...
MAPK4
MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine Portal: Biology v t e (Articles with short description, Short ... Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor ... December 2000). "Arabidopsis map kinase 4 negatively regulates systemic acquired resistance". Cell. 103 (7): 1111-20. doi: ... Gonzalez FA, Raden DL, Rigby MR, Davis RJ (June 1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues ...
Tropomyosin receptor kinase C
Valent A, Danglot G, Bernheim A (1997). "Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to ... Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, ... The TrkC receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable ... The TrkC locus encodes at least eight isoforms including forms without the kinase domain or with kinase insertions adjacent to ...
Osmotic shock
One example of a calcium activated second messenger molecule is MAP Kinase Hog-1. It is activated under hyper-osmotic stress ... Kültz D, Burg M (November 1998). "Evolution of osmotic stress signaling via MAP kinase cascades". The Journal of Experimental ... Kim, Jiyoung; Oh, Junsang; Sung, Gi-Ho (2016). "MAP Kinase Hog1 Regulates Metabolic Changes Induced by Hyperosmotic Stress". ... 7: 732. doi:10.3389/fmicb.2016.00732. PMC 4870262. PMID 27242748. Pierce, Sidney K.; Politis, Alexander D.; Smith, Laurens H.; ...
Dialkylbiaryl phosphine ligands
"Process Research and Development for Heterocyclic p38 MAP Kinase Inhibitors". Synlett. 23 (11): 1564-1574. doi:10.1055/s-0031- ... 7 (18): 3965-3968. doi:10.1021/ol0514754. ISSN 1523-7060. PMID 16119943. Fors, Brett P.; Watson, Donald A.; Biscoe, Mark R.; ... 346 (7): 717-722. doi:10.1002/adsc.200404011. ISSN 1615-4150. Dhondi, Pawan K.; Chisholm, John D. (2006-01-01). "Rhodium- ... 122 (7): 1360-1370. doi:10.1021/ja993912d. ISSN 0002-7863. Moradi, Wahed A.; Buchwald, Stephen L. (2001). "Palladium-Catalyzedα ...
DUSP1
... binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase ... binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase ... kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation". The ... MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34". Human Genetics. 93 (5): 513-6. doi:10.1007/ ...
MAPK8IP1
... and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions ... 1999). "Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun -amino-terminal kinase ... 1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science. 281 (5383): 1671-4. doi:10.1126 ... "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science. 281 (5383): 1671-4. doi:10.1126/science ...
Neuronal memory allocation
When activated by the second messengers such as cAMP and calcium ions, enzymes such as PKA and MAP kinase can translocate to ... Treisman, R. (1996). Regulation of transcription by MAP kinase cascades. Current Opinion in Cell Biology, 8(2), 205-215. Nguyen ... roles for the ERK MAP kinase cascade in memory. Annual Review of Pharmacology and Toxicology, 42(1), 135-163. ... For example, the cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) pathways appear to participate in neuronal ...
ELK4
Janknecht R, Hunter T (1997). "Convergence of MAP kinase pathways on the ternary complex factor Sap-1a". EMBO J. 16 (7): 1620-7 ... Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling ... Kamakura S, Moriguchi T, Nishida E (1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. ... Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and ...
Vascular endothelial growth factor A
"Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation". Cell. 93 (4): 605-615. doi: ... leading to the activation of protein kinase C (PKC). PKC phosphorylates the mitogen-activated protein kinase (MAPK) ERK which ... The tyrosine kinase activity of VEGFR1 is less efficient than that of VEGFR2 and its activation alone is insufficient to bring ... Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K (February 2006). "MAPKAPK-2-mediated LIM-kinase activation is critical ...
Cyclin-dependent kinase 4
Demetrick DJ; Zhang H; Beach DH (1994). "Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes". Cytogenet ... Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene ... This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Ser/Thr-kinase component ... Kato JY; Matsuoka M; Strom DK; Sherr CJ (1994). "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase". ...
PTPN7
The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was ... Saxena M, Williams S, Taskén K, Mustelin T (September 1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a ... Saxena M, Williams S, Taskén K, Mustelin T (1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein ... Pettiford SM, Herbst R (2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". ...
RAP1GAP
"MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases". The Journal of Biological Chemistry. 277 (36): ... "The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35". Cytogenetics and Cell Genetics. ... 32490-7. doi:10.1074/jbc.M200556200. PMID 12082090. Liu L, Schwartz BR, Tupper J, Lin N, Winn RK, Harlan JM (October 2002). " ...