It's a member of T cell factor/lymphoid enhancer factor (TCF/LEF) family. Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD ... Lymphoid enhancer-binding factor 1 has been shown to interact with: ALX4, AML-1, Catenin beta-1/β-catenin/CTNNB1, including ... "Entrez Gene: LEF1 lymphoid enhancer-binding factor 1". Erdfelder F, Hertweck M, Filipovich A, Uhrmacher S, Kreuzer KA (January ... Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene. ...

These cells also express a protein located in the cell nucleus, lymphoid enhancer-binding factor 1, in ~80% of cases. The RS ... "Aberrant expression of lymphoid enhancer-binding factor 1 in Hodgkin lymphoma". Human Pathology. 125: 2-10. doi:10.1016/j. ... RS cells express CD30 cell surface protein (a member of the tumor necrosis factor receptor family) and CD15 (a blood group ... LORTHOLARY P, BOIRON M, RIPAULT P, LEVY JP, MANUS A, BERNARD J (1964). "Chronic Lymphoid Leukemia Secondarily Associated with a ...

... has been shown to interact with Lymphoid enhancer-binding factor 1. GRCh38: Ensembl release 89: ENSG00000052850 - Ensembl ... Boras K, Hamel PA (January 2002). "Alx4 binding to LEF-1 regulates N-CAM promoter activity". The Journal of Biological ... Boras K, Hamel PA (January 2002). "Alx4 binding to LEF-1 regulates N-CAM promoter activity". The Journal of Biological ... 27 (1): 17-8. doi:10.1038/83703. PMID 11137991. S2CID 484321. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001 ...

Mothers against decapentaplegic homolog 7 and Lymphoid enhancer-binding factor 1. GRCh38: Ensembl release 89: ENSG00000105229 ... "A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy ... Lee PS, Chang C, Liu D, Derynck R (2003). "Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta ... 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J ...

Labbé E, Letamendia A, Attisano L (July 2000). "Association of Smads with lymphoid enhancer binding factor 1/T cell-specific ... June 2006). "The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress- ... Once bound to the receptor complex, axin will be rendered incompetent for β-catenin binding and GSK3 activity. Importantly, the ... Bauer A, Huber O, Kemler R (December 1998). "Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding ...

Labbé E, Letamendia A, Attisano L (July 2000). "Association of Smads with lymphoid enhancer binding factor 1/T cell-specific ... superfamily of growth factors into the cell nucleus. Binding of a subgroup of TGFβ superfamily ligands to extracellular ... The association with SMAD4 is important for the translocation of this protein into the cell nucleus, where it binds to target ... Hocevar BA, Smine A, Xu XX, Howe PH (June 2001). "The adaptor molecule Disabled-2 links the transforming growth factor β ...

... activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 ... Specific markers of mesenchymal tissue include the additional expression of ECM factors such as fibronectin and vitronectin. ... The interaction with ectoderm and somite-forming morphogenic factors cause some primary mesenchyme to form neural mesenchyme, ... 148 (1): 173-88. doi:10.1083/jcb.148.1.173. PMC 3207144. PMID 10629227. Mohamed, O. A.; Clarke, H. J.; Dufort, D (2004). "Beta- ...

Expression of lymphoid enhancer-binding factor 1 (LEF-1) triggers the translocation of β-catenin to the nucleus, where it ... For example, the cadherin-α-catenin complex binds the actin cytoskeleton, though whether it binds via binding proteins or ... In homodimeric form, α-catenins do not bind β- catenins, but preferentially bind F-actin and other proteins promoting F-actin ... Dimerized cadherins readily bind to their presynaptic cadherin partners. Inhibition of N-cadherin binding via blocking ...

... tcf transcription factors MeSH D12.776.660.235.400.800.500 - lymphoid enhancer-binding factor 1 MeSH D12.776.660.235.400.800. ... telomeric repeat binding protein 2 MeSH D12.776.660.352.500.500 - hepatocyte nuclear factor 1-alpha MeSH D12.776.660.352. ... hepatocyte nuclear factor 1-beta MeSH D12.776.660.650.875.500 - lamin type a MeSH D12.776.660.650.875.750 - lamin type b The ... t cell transcription factor 1 MeSH D12.776.660.235.700.500 - heterogeneous-nuclear ribonucleoprotein group a-b MeSH D12.776. ...

TCF/LEF family (T cell factor/lymphoid enhancer factor family) LEF1 (Lymphoid enhancer-binding factor 1) TCF7 (TCF-1) TCF7L1 ( ... Furthermore, these HMG-box DNA-binding proteins increase the flexibility of the DNA upon binding. In mammalian cells, the HMG ... Gene regulatory network HMG-box Transcription factors Rajeswari MR, Jain A (2002). "High-mobility-group chromosomal proteins, ... The high-mobility group protein such as HMO1 alters DNA architecture by binding, bending and looping. ...

Ccaat-enhancer-binding proteins, and Lymphoid enhancer-binding factor 1 are all related to immunity. This gene is found in all ... Ccaat/Enhancer Binding Proteins, and Lymphoid enhancer-binding factor 1. ETS1, ... Several of the most common and most conserved transcription factor binding sites families that are predicted to be found in ... Shortage In Chiasmata 1, also known as SHOC1, is a protein that in humans is encoded by the SHOC1 gene. The chromosomal locus ...

"Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 ... Transcription factor 7 is the gene that in humans encodes for the TCF1 protein. GRCh38: Ensembl release 89: ENSG00000081059 - ... "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)". van de Wetering M, Oosterwegel M, Holstege F, et al. ( ... Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related ...

... the Lymphoid enhancer-binding factor 1 L.E.F., a 2006 album by Ferry Corsten LEF (journal), a journal of aesthetics published ...

... tcf transcription factors MeSH D12.776.664.235.400.800.500 - lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800. ... cleavage stimulation factor MeSH D12.776.664.962.452.249 - poly(a)-binding protein i MeSH D12.776.664.962.452.500 - poly(a)- ... eukaryotic initiation factor-4f MeSH D12.776.664.962.750.750 - nuclear cap-binding protein complex MeSH D12.776.765.678.968.900 ... rheumatoid factor MeSH D12.776.377.715.548.114.345 - binding sites, antibody MeSH D12.776.377.715.548.114.345.180 - ...

T-cell factor/lymphoid enhancer-binding factor (TCF/LEF), GATA2/3, retinoic acid receptor α, and SMAD6/7 don't affect the ... Transcription factors, peroxis proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding proteins (C/EBPs) are main ... Other pro-adipogenic factors like C/EBPs and Krüppel-like factors (KLFs) have been shown to induce the PPARγ promoter. Moreover ... C/EBPs, transcription factors, are members of the basic-leucine zipper class. cAMP, an inducer of adipogenesis, can promote ...

The nuclear protein binds to a purine-rich sequence known as the PU-box found on enhancers of target genes, and regulates their ... This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell ... The ETS domain is the DNA-binding module of PU.1 and other ETS-family transcription factors. SPI1 has been shown to interact ... Hallier M, Tavitian A, Moreau-Gachelin F (May 1996). "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA ...

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription ... The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle ... Castrop J, van Norren K, Clevers H (Feb 1992). "A gene family of HMG-box transcription factors with homology to TCF-1". Nucleic ... "TCF7L1 transcription factor 7 like 1 [ Homo sapiens (human) ]". Retrieved 2021-05-29. "Salmonella infection data for Tcf7l1". ...

... is transcription factor CCAAT-enhancer binding protein α (C/EBPα). Mutations in C/EBPα are associated with acute myeloid ... They are derived from common lymphoid progenitors. The lymphoid lineage is composed of T-cells, B-cells and natural killer ... Growth factors initiate signal transduction pathways, which lead to activation of transcription factors. Growth factors elicit ... One of the key players in self-renewal and development of haematopoietic cells is stem cell factor (SCF), which binds to the c- ...

"Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers". Mol Cell ... and these tissue specific enhancers enable the binding of lymphoid or erythroid regulatory proteins, therefore the gene ... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). ...

"A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is ... The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions ... CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. ... "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is ...

... "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled ... Warner DR, Pisano MM, Roberts EA, Greene RM (Mar 2003). "Identification of three novel Smad binding proteins involved in cell ... a novel Dvl-binding protein". Mol. Cell. Biol. 21 (1): 330-42. doi:10.1128/MCB.21.1.330-342.2001. PMC 88806. PMID 11113207. ... 8 (1): 118-30. doi:10.1101/gad.8.1.118. PMID 8288125. Pizzuti A, Novelli G, Mari A, Ratti A, Colosimo A, Amati F, Penso D, ...

... "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled ... March 2001). "Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor". Journal of ... Beta-arrestin has been shown to play a role as a scaffold that binds intermediates and may direct G-protein signaling by ... Bennett TA, Maestas DC, Prossnitz ER (August 2000). "Arrestin binding to the G protein-coupled N-formyl peptide receptor is ...

... a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected ... 1998). "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino ... 1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): ... Chilson OP, Kelly-Chilson AE (1989). "Mitogenic lectins bind to the antigen receptor on human lymphocytes". Eur. J. Immunol. 19 ...

"Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible ... IRF8 and IRF4 function redundantly to drive common lymphoid progenitors (CLPs) to B-cell lineage. IRF8 and IRF4 are also ... Media related to Interferon regulatory factors at Wikimedia Commons Interferon+regulatory+factors at the U.S. National Library ... Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression ...

Rao S, Karray S, Gackstetter ER, Koshland ME (October 1998). "Myocyte enhancer factor-related B-MEF2 is developmentally ... The binding between the secretory component and secretory Ig is facilitated by the antibody's J chain which makes physical ... J chain expression is believed to occur in the early stages of lymphoid cell differentiation as it is expressed in both B and T ... Hajdu I, Moldoveanu Z, Cooper MD, Mestecky J (December 1983). "Ultrastructural studies of human lymphoid cells. mu and J chain ...

Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans ... Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also ... Kamps MP, Murre C, Sun XH, Baltimore D (Feb 1990). "A new homeobox gene contributes the DNA binding domain of the t(1;19) ... Huggins GS, Chin MT, Sibinga NE, Lee SL, Haber E, Lee ME (Oct 1999). "Characterization of the mUBC9-binding sites required for ...

The encoded protein is primarily expressed in lymphoid cells and can act as both an enhancer and a repressor to regulate ... "cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1". Molecular ... E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene. This gene encodes ... "Entrez Gene: E74-like factor 1 (ets domain transcription factor)". Xiang P, Lo C, Argiropoulos B, Lai CB, Rouhi A, Imren S, ...

... or GATA-binding factor 2 is a transcription factor, i.e. a nuclear protein which regulates the expression of genes. It ... GATA2 binds to a specific nucleic acid sequence viz., (T/A(GATA)A/G), on the promoter and enhancer sites of its target genes ... and rarely a lymphoid leukemia. Overexpression of the GATA2 transcription factor that is not due to mutations in the GATA2 gene ... For example, in hematological stem cells, GATA2 transcription factor itself binds to one of these sites and in doing so is part ...

... factor binding site is required for the deregulation of c-myc expression by the immunoglobulin heavy chain gene enhancers in ... "c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma". Oncol. Rep ... The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA ... MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the ...

"The transcriptional regulator Aire binds to and activates super-enhancers". Nature Immunology. 18 (3): 263-273. doi:10.1038/ni. ... Except the thymus, Aire is expressed also in the periphery, namely in the secondary lymphoid organs. However, the search for ... Aire is not classical transcription factor, because instead of recognition of specific consensus sequences, Aire seeks after ... Among these molecules further rank acetylase Creb-binding protein (CBP), which enhances stability of Aire, however dampens its ...