Deamidation
... asparagine is converted to aspartic acid or isoaspartic acid. Glutamine is converted to glutamic acid or pyroglutamic acid (5- ... or isoaspartic acid, which is a beta amino acid (in green at bottom right). However, there is a concern that aspartic acid can ... Asparagine Aspartic acid Peptide bond Post-translational modification Clarke, S (2003). "Aging as war between chemical and ... Deamidation is a chemical reaction in which an amide functional group in the side chain of the amino acids asparagine or ...
Peptidyl-Asp metalloendopeptidase
... and cysteic acid (Xaa-Cya) residues at the N-terminus however this enzyme is unable to cleave isoaspartic acid. Typically ... Isoaspartic acid (isoAsp) has also been shown to have involvement with aging, autoimmune disorders, cancer and ... ISBN 978-0-12-382219-2. Ni W, Dai S, Karger BL, Zhou ZS (September 2010). "Analysis of isoaspartic Acid by selective ... This acid is created when asparagine undergoes deamination or isomerization of aspartic acid occurs. This is concerning for the ...
Isoaspartate
... either aspartic acid (in black at left) or isoaspartic acid, which is a β-amino acid (in green at bottom right). The reaction ... Isoaspartic acid (isoaspartate, isoaspartyl, β-aspartate) is an aspartic acid residue isomeric to the typical α peptide linkage ... It is a β-amino acid, with the side chain carboxyl moved to the backbone. Such a change is caused by a chemical reaction in ... The ester rapidly and spontaneously turns into the succinimide (red), and randomly turns back into normal aspartic acid (black ...
Edman degradation
... by acetylation or formation of pyroglutamic acid). Sequencing will stop if a non-α-amino acid is encountered (e.g. isoaspartic ... The thiazolinone amino acid is then selectively extracted into an organic solvent and treated with acid to form the more stable ... It is able to accurately sequence up to 30 amino acids with modern machines capable of over 99% efficiency per amino acid. An ... This procedure can then be repeated again to identify the next amino acid. A major drawback to this technique is that the ...
Microcystin
D-Masp is D-erythro-β-methyl-isoaspartic acid, a derivative of aspartic acid in β-amino acid form; Adda is (all-S,all-E)-3- ... amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid, a β-amino acid exclusively found in microcystin and the related ... Once ingested, microcystin travels to the liver via the bile acid transport system, where most is stored, though some remains ... In nodularin it is replaced by Mdhb (N-methyldehydrobutyrine), another dehydroamino acid derivative. Microcystins covalently ...
List of MeSH codes (D12.125)
... aspartic acid MeSH D12.125.067.500.150 - d-aspartic acid MeSH D12.125.067.500.275 - isoaspartic acid MeSH D12.125.067.500.400 ... aspartic acid MeSH D12.125.119.170.150 - d-aspartic acid MeSH D12.125.119.170.275 - isoaspartic acid MeSH D12.125.119.170.400 ... aspartic acid MeSH D12.125.427.300 - glutamic acid MeSH D12.125.481.100 - allylglycine MeSH D12.125.481.700 - n-substituted ... imino acids MeSH D12.125.072.401.200 - azetidinecarboxylic acid MeSH D12.125.072.401.623 - proline MeSH D12.125.072.401.623.270 ...