Allen LB, Cochran KW (November 1972). "Target-Organ Treatment of Neurotropic Virus Disease with Interferon Inducers". Infection ... Other experimental antivirals of that period included: heparin, trifluorothymidine (TFT), Ribivarin, interferon, Virazole, and ...

1988). "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes". Eur. J. Biochem. 169 ... Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene. GRCm38: ... 1983). "Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA". ... Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G (Jul 1992). "The interferon- and virus-inducible IFI-56K and IFI- ...

2005). "HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration ... Interferon alpha-16, also known as IFN-alpha-16, is a protein that in humans is encoded by theIFNA16 gene. GRCh38: Ensembl ... "Entrez Gene: interferon". Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (October 1992). " ... 1996). "Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids". Virology. 221 (1 ...

1992). "Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer". AIDS Res. Hum. ... "Entrez Gene: IFNA7 interferon, alpha 7". Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV- ... 1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. ... Interferon alpha-7 is a protein that in humans is encoded by the IFNA7 gene. GRCh38: Ensembl release 89: ENSG00000214042 - ...

The cytokine family of glial scar inducers include interferon-γ (IFNγ) and fibroblast growth factor 2 (FGF2). IFNγ has been ... 1991). "γ-Interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in ... 1995). "A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system ...

In the early 1970s, she successfully synthesized tilorone, an interferon inducer which helps to protect cells. Since then, much ...

Ohno, S; Taniguchi, T (1982). "Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into ... Ohno, S; Taniguchi, T (1983). "The 5'-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of ... Shigeo Ohno, CDB Symposium 2009 Speaker Ohno, S; Taniguchi, T (1981). "Structure of a chromosomal gene for human interferon ... Japanese Foundation for Cancer Research to investigate Interferons with Tadatsugu Taniguchi. From 1983 to 1991, he was a ...

... a potent interferon inducer". The Journal of Infectious Diseases. 142 (3): 394-9. doi:10.1093/infdis/142.3.394. PMID 6255036. ... The contribution of type I interferons (IFN) in recovery from infection with viruses has been demonstrated in vivo by the ... A 2006 study suggests mosquito saliva can also decrease expression of interferon−α/β during early mosquito-borne virus ... therapeutic and prophylactic effects of administration of IFN inducers or IFN itself, and different research suggests mosquito ...

IFN-γ is an important activator of macrophages and inducer of major histocompatibility complex class II molecule expression. ... Interferon-γ has been shown to interact with Interferon gamma receptor 1 and Interferon gamma receptor 2. Interferon-γ has been ... "The heparan sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma ... Interferon gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The ...

Universal inducer of endogenous interferon amizon in the prevention and treatment of influenza]. m-l.com.ua (in Ukrainian). ... "Modern Non-Steroidal Anti-Inflammatory Drug and Interferon Inductor Amizon: Prospects of Application" (PDF). Institute of ...

... small molecular weight compound that is an orally active interferon inducer. It is used as an antiviral drug in some countries ... Tilorone activates the production of interferon. "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in ... Stringfellow D, Glasgow L (1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrob Agents Chemother. 2 ( ...

... a mycobacteria that is a potent inducer of interferon (IFN)-gamma. Using this model, they found both BCG and IFN-gamma activate ... Interferon-ϒ inhibits macrophage insulin-like growth factor-I synthesis at the transcriptional level. Molecular Endocrinology 9 ...

... and interferon inducers," and "elucidated the mechanism by which the biosynthesis of cephalosporin in Cephalsporium acremonium ...

... interferon inducers MeSH D27.505.696.477.656 - immunosuppressive agents MeSH D27.505.696.477.656.500 - complement inactivating ...

The PD-L1 gene promoter region has a response element to IRF-1, the interferon regulatory factor. Type I interferons can also ... Whereas the Epstein-Barr viral (EBV) latent membrane protein-1 (LMP1) is a known potent inducer of PD-L1, the EBV miRNA miR- ... Upon treatment with interferon-gamma, miR-513 was down-regulated, thereby lifting suppression of PD-L1 protein. In this way, ... February 2006). "Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced ...

... is the inducer of interferon, and that just one molecule of dsRNA is enough to induce interferon production in a cell, thus ... Three highlights included: the discovery of the world's most efficient inducer of interferon -a single molecule of double- ... The primary focus of his research from 1966 until his death was in the field of interferon research. 'His Virus and Interferon ... Serving eighteen years as editor-in-chief of the Journal of Interferon Research (later renamed the Journal of Interferon and ...

... and acting as an interferon-inducer [97]. ... A large, multicenter, Phase 3 randomized-controlled trial comparing nitazoxanide ... The similar mechanism of action of interferon and nitazoxanide suggest that stand-alone nitazoxanide therapy or nitazoxanide in ...

In response to the oral administration of the inflammation-inducer dextran sodium sulfate, Blt2 receptor knockout mice, ... enhanced accumulation of interferon-producing macrophages in affected colon tissues; d) increased phosphorylation of signal ... increased mRNA expression for the pro-inflammatory cytokines interferon-γ, IL1B, and Interleukin 6, two pro-inflammatory ...

eccDNA significantly induces type I interferons (IFNα, IFNβ), interleukin-6 (IL-6), and tumor necrosis factor (TNF), even more ... so than linear DNA and other generally potent cytokine inducers at their highest concentration levels. Similar patterns are ...

... which itself is a weak IFN-I inducer in human cells. SARS-CoV-2 limits the IFN-III response as well. Reduced numbers of ... PEGylated interferon-alpha-2b (Pegintron), polyethylene glycol is linked to the interferon molecule to make the interferon last ... The type I interferons present in humans are IFN-α, IFN-β, IFN-ε, IFN-κ and IFN-ω. In general, type I interferons are produced ... Interferon type II (IFN-γ in humans): This is also known as immune interferon and is activated by Interleukin-12. Type II ...

... it is an inducer of interferon and is considered to be antiviral and immunomodulatory. One RCT evaluated rintatolimod and found ... A systematic review found two small RCTs that evaluated interferon. One RCT found an overall beneficial effect and the other ... A 2007 review of research needs for CFS concluded that trials for interferon beta are an important priority. A systematic ...

1988). "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes". Eur. J. Biochem. 169 ... 1988). "Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene". Mol. Cell. Biol ... Benech P, Mory Y, Revel M, Chebath J (1986). "Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of ... 1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal ...

Most drug-drug interactions with Harvoni involve Pgp-inducers such as St. John's wort or rifampicin. Concomitant use will ... without interferon and ribavirin. On 10 October 2014 the FDA approved the combination product ledipasvir/sofosbuvir called ... agent that interferes with HCV replication and can be used to treat patients with genotypes 1a or 1b without PEG-interferon or ...

Most side effects are more common in interferon-containing regimens as compared to interferon-free regimens. For example, ... Therefore, inducers of intestinal P-glycoprotein, such as rifampicin and St. John's wort, could reduce the absorption of ... the end of the pegylated interferon era and the emergence of all-oral interferon-free antiviral regimens: a concise review". ... On one hand, this agent offers up to a 95% response rate as part of an interferon-free treatment regimen for hepatitis C. ...

Transcription factor 'Signal inducer and activator of transcription 3' (STAT3) is continuously activated in cancer cells. It ... It also inhibits the release of nitric oxide from lipopolysaccharide- and interferon-γ-stimulated RAW264.7 cells. Lastly. it ...

2008). "Tpl2 kinase regulates T cell interferon- production and host resistance to Toxoplasma gondii". Journal of Experimental ... "Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22". Journal of Experimental Medicine. 206 (1): 35-41. ...

Concomitant use of drugs that are strong inducers of the cytochrome P450 CYP3A is contraindicated due to decreased therapeutic ... Daclatasvir has been tested in combination regimens with pegylated interferon and ribavirin, as well as with other direct- ... Daclatasvir is a CYP3A and p-glycoprotein substrate, therefore, drugs that are strong inducers or inhibitors of these enzyme ... Some common drugs that are strong CYP3A inducers include dexamethasone, phenytoin, carbamazepine, rifampin and St. John's Wort ...

The trait was mapped to mutations in the STAT1 gene, which were associated with lower production of interferon-γ, IL-17, and IL ... It promotes the development of Th1 responses and is a powerful inducer of IFNγ production by T and NK cells. A child with ... It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural ... It does this by increasing production of interferon gamma, which in turn increases the production of a chemokine called ...

ACIN1: encoding protein Apoptotic chromatin condensation inducer in the nucleus AHNAK2: encoding protein Ahnak nucleoprotein 2 ... encoding protein Interferon regulatory factor 2 binding protein like ITPK1: encoding enzyme Inositol-tetrakisphosphate 1-kinase ... encoding protein Interferon alpha-inducible protein 27 IFT43: intraflagellar transport 43 IGH@: immunoglobulin heavy chain ...

... has been tested in combination regimens with pegylated interferon alfa-2a and ribavirin, and in interferon-free ... and will significantly decrease if taken with strong CYP3A4 inducers (i.e. efavirenz, rifampin, Saint John's wort). Simeprevir ... Simeprevir is administered as one capsule once daily with pegylated interferon and ribavirin for the treatment of genotype 1 or ... "Phase 3 Studies Show Simeprevir plus Interferon/Ribavirin Cures Most Patients in 24 Weeks". hivandhepatitis.com. 27 December ...