Moloney, Gerard P.; Kelly, David P.; Mack, P. (2001). "Synthesis of Acridine-based DNA Bis-intercalating Agents" (PDF). ... Acridine and related derivatives (such as amsacrine) bind to DNA and RNA due to their abilities to intercalate. Acridine orange ... "Acridine Derivatives as Chemotherapeutic Agents". Current Medicinal Chemistry. 9 (18): 1655-65. doi:10.2174/0929867023369277. ...
It is an antineoplastic antibiotic and an intercalating agent. Becatecarin (BMS-181176) is a synthetic analog of rebeccamycin. ... a novel antitumor agent". The Journal of Antibiotics. 40 (5): 668-78. doi:10.7164/antibiotics.40.668. PMID 3112080. Anizon F, ...
"Activation of cGAS-dependent antiviral responses by DNA intercalating agents". Nucleic Acids Research. 45 (1): 198-205. doi: ...
Ligands may interact with DNA by covalently binding, electrostatically binding, or intercalating. Intercalation occurs when ... "Synthetic metallomolecules as agents for the control of DNA structure" (PDF). Chemical Society Reviews. 36 (3): 471-83. doi: ... Anthracycline Intercalation (chemistry) Molecular tweezers Twisted intercalating nucleic acid Richards, A. D.; Rodgers, A. ( ... Development and Action of Anticancer Agents. pp. 387-435. doi:10.1515/9783110470734-020. PMID 29394033. {{cite book}}: ,journal ...
Another option is to use SYBR Green I, a DNA intercalating coloring agent. This method is specifically advantageous because it ...
Common guests are reducing agents such as alkali metals. Strong oxidants, such as arsenic pentafluoride also intercalate into ... These materials are prepared by treating graphite with a strong oxidant or a strong reducing agent: C + m X → CXm The reaction ... The bronze-colored material KC8 is one of the strongest reducing agents known. It has also been used as a catalyst in ... Reaction of graphite with [O2]+[AsF6]− affords the salt [C8]+[AsF6]−. A number of metal halides intercalate into graphite. The ...
Propidium iodide is a fluorescent intercalating agent that can be used to stain cells. Propidium iodide is used as a DNA stain ... Mordants are chemical agents which have power of making dyes to stain materials which otherwise are unstainable Mordants are ... Ethidium bromide intercalates and stains DNA, providing a fluorescent red-orange stain. Although it will not stain healthy ... It is a strong oxidizing agent as the osmium has an oxidation number of +8. It aggressively oxidizes many materials, leaving ...
Gatasheh MK, Kannan S, Hemalatha K, Imrana N (December 2017). "Proflavine an acridine DNA intercalating agent and strong ... Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acid base pairs. It differs from ... Denny WA (September 2002). "Acridine derivatives as chemotherapeutic agents". Current Medicinal Chemistry. 9 (18): 1655-1665. ...
DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision ...
... is a fluorescent intercalating agent that can be used to stain cells and nucleic acids. PI binds to DNA by intercalating ...
Its main entrance is intercalated between an estate agent and a restaurant. Will Champion described it as a bigger version of ...
Intercalating agents- Chemical compounds that place themselves between stacked nitrogenous bases in DNA, causing a frameshift ... Some intercalating agents, like daunorubicin, are capable of blocking replication and transcription, making them incredibly ... Alkylating agents- Compounds that attach an alkyl group to the four bases. When an alkyl group is added to guanine, it can lead ... Induced mutations are any lesions in DNA caused by an agent or mutagen. Mutagens often demonstrate mutational specificity, ...
... that can intercalate DNA, thereby preventing cell division. The addition of monoclonal antibodies like rituximab to ... an alkylating antineoplastic agent from the oxazafosforine group; Mitoxantrone - a synthetic anthracycline analogue ( ...
... as they can act as intercalating agents. Primogenic Effect Tris(bipyridine)iron(II) chloride Broomhead J. A.; Young C. G. (1990 ... In this conversion, Ru(III) is reduced to Ru(II), and hypophosphorous acid is typically added as a reducing agent. [Ru(bpy)3]2+ ...
Agbandje-McKenna performed biophysical characterization of DNA-intercalating anthroquinone anti-tumor agents. During her PhD, ... 10-diones as potential anticancer agents. 1992. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted ... 10-diones as Potential Anticancer Agents. Synthesis, DNA-binding, and Biological Studies on a Series of 2,6-disubstituted ...
One famous intercalation host is graphite, which intercalates potassium as a guest. Intercalation expands the van der Waals gap ... Treating graphite with strong acids in the presence of oxidizing agents causes the graphite to oxidise. Graphite bisulfate, [ ... The bond between the carbon and fluorine atoms is covalent, thus fluorine is not intercalated.[clarification needed] Such ...
... s can be induced using a variety of mutagens, including DNA intercalating agents, as well as chemicals that can ... They also found that treatment of wild-type S. cerevisiae with DNA-intercalating agents would more rapidly produce this ... and other intercalating agents. Their mechanisms work to break down and cause the eventual loss of mitochondrial DNA: if the ... mutation by chemical and physical agents in Saccharomyces cerevisiae". Mutation Research. 265 (1): 103-148. doi:10.1016/0027- ...
Investigation of possible mechanisms revealed that the compounds bind to DNA and act as intercalating agents, besides ... Anti-Cancer Agents. 5 (2): 173-182. doi:10.2174/1568011053174864. hdl:2078.1/10136. PMID 15777224. Oliver-Bever B (January 1983 ...
This agent also intercalates into DNA and inhibits RNA synthesis in vitro and shows potential antineoplastic activity. ... Hycanthone is shown to intercalates into DNA and inhibit RNA synthesis in vitro. A growing body of evidence has shown that ...
The accumulated damage may arise from reactive oxygen species (ROS), chemical reactions (e.g. with intercalating agents), ... of prelamin A show increased DNA damage and chromosome aberrations and have increased sensitivity to DNA damaging agents. In ...
... that is able to intercalate DNA and thus prevent cell division (mitosis); Etoposide - a topoisomerase inhibitor. A phase II ... an alkylating antineoplastic agent from oxazafosforine group; Mitoxantrone - a synthetic anthracycline analogue (anthraquinone ...
Alkylating agents such as cyclophosphamide and cisplatin, as well as intercalating agent such as daunorubicin and doxorubicin ... Infectious agents have been suggested to cause cancer as early as 1908 by Vilhelm Ellermann and Oluf Bang, and 1911 by Peyton ... Alkylating agents such as ethylnitrosourea. The compounds transfer methyl or ethyl group to bases or the backbone phosphate ... Deaminating agents, for example nitrous acid which can cause transition mutations by converting cytosine to uracil. Polycyclic ...
These agents most preferentially form a 1,3 5'-d(GNC) interstrand crosslink. The introduction of this agent slightly bends the ... These compounds intercalate into DNA at 5'-AT sequence sites and form thymidine adducts when activated in the presence of Ultra ... These cross-linking agents have the ability to act as single-agent therapies by targeting and destroying specific nucleotides ... are further exogenous agents that may induce DNA crosslinks. Unlike other crosslinking agents, aldehyde-induced crosslinking is ...
Graphite was first intercalated in 1841 using a strong oxidizing or reducing agent that damaged the material's desirable ... but without oxidizing agents. The new method has yet to achieve output sufficient for commercialization. Applying a layer of ... which then intercalate into the graphite structure, peeling graphite to produce graphene. The graphene nanosheets produced ...
This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. Miller AA ... Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA ...
... an alkylating antineoplastic agent; Hydroxydaunorubicin, also known as doxorubicin: an anthracycline antibiotic that is able to ... intercalate DNA, damaging it and preventing cell division. This regimen requires the use of prophylactic antibiotics to prevent ...
Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove ... Amsacrine (synonyms: m-AMSA, acridinyl anisidide) is an antineoplastic agent. It has been used in acute lymphoblastic leukemia ...
... (or homidium bromide, chloride salt homidium chloride) is an intercalating agent commonly used as a ... It is added to running buffer and binds by intercalating between DNA base pairs. When the agarose gel is illuminated using UV ... In the laboratory the intercalating properties have long been used to minimize chromosomal condensation when a culture is ... because the phenyl ring has been shown to project outside the intercalated bases. In fact, the phenyl group is found to be ...
These compounds are DNA intercalating agents and as such can impact a wide range of cellular DNA processes in addition to ... Specifically, they intercalate into the DNA and prevent the DNA religation step of the topoisomerase reaction (Fig. 5). This is ... Prospects for the Development of New Antibacterial Agents". Journal of Molecular Biology. 431 (18): 3400-3426. doi:10.1016/j. ...
These polymers can selectively bind specific sequences of double-stranded DNA by intercalating in a sequence dependent manner. ... Depending on the alkylating agent and the counteranion, various ionic liquids result, e.g. 1-butyl-3-methylimidazolium ...