Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments". Current Medicinal Chemistry. 12 (1 ... Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are ... Porter JC, Hogg N (October 1998). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends ... many integrins are known to facilitate signal transduction. In mammals the integrins that include alpha-V are : Overexpression ...

Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments". Curr. Med. Chem. 12 (1): 51-70. doi ... Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as ... The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha ... "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". J. Biol. Chem. 272 (23): ...

Chen Y, Lee H, Tong H, Schwartz M, Zhu C (July 2016). "Force regulated conformational change of integrin alphaVbeta3". Matrix ... integrin alpha 4 beta 1 with vascular adhesion molecule 1, integrin alpha M beta 2 with ICAM-1, integrin alpha V beta 3 with ... Chen Y, Ju LA, Zhou F, Liao J, Xue L, Su QP, Jin D, Yuan Y, Lu H, Jackson SP, Zhu C (July 2019). "An integrin αIIbβ3 ... CMR has been observed for interactions between integrin alpha 5 beta 1 and fibronectin and between G-actin and G-actin or F- ...

Bergh JJ, Lin HY, Lansing L, Mohamed SN, Davis FB, Mousa S, Davis PJ (July 2005). "Integrin alphaVbeta3 contains a cell surface ... Integrins are found in all animals while integrin-like receptors are found in plant cells. Integrins work alongside other ... The following are 16 of the ~24 integrins found in vertebrates: Beta-1 integrins interact with many alpha integrin chains. Gene ... integrins of the β2 family). This α-I domain is the binding site for ligands of such integrins. Those integrins that don't ...

"RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties". The Journal of Biological ... "RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties". The Journal of Biological ... Cathepsin Z has an exposed integrin-binding Arg-Gly-Asp motif within the propeptide of the enzyme, through which cathepsin Z ... Cathepsin Z has also been found to interact with: Integrin, PRLP0, and γ-Enolase. GRCh38: Ensembl release 89: ENSG00000101160 ...

November 2005). "Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced ... November 2008). "Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer". Neoplasia ... a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors". Investigational ...

"Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium". Dev Biol. 287 (2): 336- ...

"Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3". The Journal of Biological ...

Yokosaki Y, Monis H, Chen J, Sheppard D (September 1996). "Differential effects of the integrins alpha9beta1, alphavbeta3, and ... Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins ... One α and one β subunit associate non-covalently to form 24 unique integrins found in mammals. While some β integrin subunits ... "Entrez Gene: ITGB6 integrin, beta 6". Hynes RO (September 2002). "Integrins: bidirectional, allosteric signaling machines". ...

Sajid, M.; Zhao, R.; Pathak, A.; Smyth, S. S.; Stouffer, G. A. (November 23, 2003). "Alphavbeta3-integrin antagonists inhibit ... Estevez, Brian; Shen, Bo; Du, Xiaoping (January 23, 2015). "Targeting Integrin and Integrin Signaling in Treating Thrombosis". ... His studies have focused on identifying mechanisms whereby β3 integrins mediate responses to thrombin and other SMC agonists. ... Stouffer, G. A.; Smyth, S. S. (November 1, 2003). "Effects of thrombin on interactions between beta3-integrins and ...

"Identification of the alphavbeta3 integrin-interacting motif of betaig-h3 and its anti-angiogenic effect". Journal of ... Bladder tumor-targeting peptide and use thereof US 7745410 Use of a peptide that interacts with alphaV beta3 integrin of ... Lee, B. H.; Ruoslahti, E. (2005). "Α5β1 integrin stimulates Bcl-2 expression and cell survival through Akt, focal adhesion ... via v 3 Integrin". Cancer Research. 65 (10): 4153-4161. doi:10.1158/0008-5472.CAN-04-2705. PMID 15899806. Lee, S. J.; Jeon, H. ...

Yokosaki Y, Monis H, Chen J, Sheppard D (1996). "Differential effects of the integrins alpha9beta1, alphavbeta3, and ... Høye AM, Couchman JR, Wewer UM, Fukami K, Yoneda A (May 2012). "The newcomer in the integrin family: integrin α9 in biology and ... The α9 subunit forms a heterodimeric complex with a β1 subunit to form the α9β1 integrin. This integrin participates in cell ... Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins ...

1999). "Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells". J. ... with integrin alphavbeta3". J Biol Chem. 273 (13): 7345-50. doi:10.1074/jbc.273.13.7345. PMID 9516430. "Entrez Gene: ADAM15 ... 2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for ... Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also ...

"Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1". Journal of Vascular Research. ... It functions by direct binding to integrin receptors, as well as other receptors such as NOTCH1 and fibulin 1c (FBLN1). NOV is ... Lin CG, Chen CC, Leu SJ, Grzeszkiewicz TM, Lau LF (Mar 2005). "Integrin-dependent functions of the angiogenic inducer NOV (CCN3 ... "CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma ...

AlphaV-beta3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts Chong YH, Soh CC (1966). "The protein ... ". "The way in of HSV: Routing by Integrins and Targeting to Cancer Receptors". Herpes Virus Workshop. Archived from the ...

Ludbrook SB, Barry ST, Delves CJ, Horgan CM (2003). "The integrin alphavbeta3 is a receptor for the latency-associated peptides ...

Ludbrook SB, Barry ST, Delves CJ, Horgan CM (2003). "The integrin alphavbeta3 is a receptor for the latency-associated peptides ...

Yokosaki Y, Monis H, Chen J, Sheppard D (1996). "Differential effects of the integrins alpha9beta1, alphavbeta3, and ... 1994). "The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of ... An example of this interaction is the adhesion of SW80 carcinoma cells to the third FN-III repeat of TN-C via the αvβ3 integrin ... 1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human ...

2007). "Necl-5/poliovirus receptor interacts in cis with integrin alphaVbeta3 and regulates its clustering and focal complex ...

... involvement of integrin alphavbeta3, PI 3-kinase, and the proteasome". Biochem. Cell Biol. 84 (5): 684-94. doi:10.1139/o06-055 ...

... inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-alphaVbeta3 integrin ...

... a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent ... This gene is highly expressed in the brain and may function as an integrin ligand in the brain. GRCh38: Ensembl release 89: ...

Ling Y, Maile LA, Badley-Clarke J, Clemmons DR (February 2005). "DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and ... "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation". Mol. Cell. Biol. 20 (5 ...

integrin+alphaVbeta3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Integrins, All stub ... αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin ... Integrin αVβ3 is a potential drug target because abnormal expression of v3 is linked to the development and progression of ... "Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin". Nature Structural & Molecular ...

November 2005). "Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced ... Vitaxin (MEDI-523) is a humanized monoclonal antibody against the vascular integrin alpha-v beta-3. It is shown to be a ... ISBN 978-0-12-006679-7. Wilder RL (November 2002). "Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis ...

... integrin alpha5beta1 MeSH D12.776.395.550.625.419 - integrin alpha6beta1 MeSH D12.776.395.550.625.439 - integrin alphavbeta3 ... integrin alpha4beta1 MeSH D12.776.395.550.200.625.550 - lymphocyte function-associated antigen-1 MeSH D12.776.395.550.200.625. ... integrin alphaxbeta2 MeSH D12.776.395.550.200.450 - intercellular adhesion molecule-1 MeSH D12.776.395.550.200.625 - receptors ...

... integrin alpha5beta1 MeSH D12.776.543.550.625.419 - integrin alpha6beta1 MeSH D12.776.543.550.625.439 - integrin alphavbeta3 ... integrin alpha6beta1 MeSH D12.776.543.750.705.675.541 - integrin alphavbeta3 MeSH D12.776.543.750.705.675.554 - lysosomal- ... integrin alpha1 MeSH D12.776.543.750.705.408.100.350 - integrin alpha2 MeSH D12.776.543.750.705.408.100.400 - integrin alpha3 ... integrin alpha5 MeSH D12.776.543.750.705.408.100.550 - integrin alpha6 MeSH D12.776.543.750.705.408.100.900 - integrin alphav ...