The insulin-like growth factor-binding protein (IGFBP) serves as a transport protein for insulin-like growth factor 1 (IGF-1). ... "Role of insulin-like growth factor binding proteins in the control of IGF actions". Prog. Growth Factor Res. 6 (2-4): 357-66. ... November 1998). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): ... Hwa V, Oh Y, Rosenfeld RG (December 1999). "The insulin-like growth factor-binding protein (IGFBP) superfamily". Endocr. Rev. ...

Jones JI, Clemmons DR (February 1995). "Insulin-like growth factors and their binding proteins: biological actions". Endocrine ... "Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor". Growth ... "Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase ... insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a ...

Firth SM, Baxter RC (December 2002). "Cellular actions of the insulin-like growth factor binding proteins". Endocrine Reviews. ... Activated protein C inactivates factors Va and VIIIa. Binding of activated protein C to protein S leads to a modest increase in ... Thrombin bound to thrombomodulin activates protein C, an inhibitor of the coagulation cascade. The activation of protein C is ... The activity of factor Xa is greatly enhanced by binding to activated Factor V (Va), termed the prothrombinase complex. ...

... a novel insulin-like growth factor-binding protein-5 proteinase". J Biol Chem. 276 (24): 21849-53. doi:10.1074/jbc.M102191200. ... "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824-54. doi:10.1210/er.2001-0033. ... "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5 ... Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (Nov 2000). "Pregnancy-associated plasma protein-E (PAPP-E)". ...

Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene. An IGFBP5 gene ... 1999). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF ... Nam TJ, Busby W, Clemmons DR (1997). "Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I ... Kiefer MC, Ioh RS, Bauer DM, Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein". ...

IGF2R is a multifunctional protein receptor that binds insulin-like growth factor 2 (IGF2) at the cell surface and mannose-6- ... Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell ... Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development". Endocrinology. 131 ( ... growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II ...

2000). "H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein". J. Biol. Chem. 275 (38): 29562-9. ... 2005). "Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II- ... 2004). "Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice". Mol. ... "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol. 19 ( ...

"The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation ... UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late ... "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 ( ... Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene. The protein ...

"Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor ... "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 ( ... It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. ... Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene. This gene ...

1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol ... 1999). "Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, ... "Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6". Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor ... 2001). "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". J. Clin. Endocrinol. Metab. 86 (4): ...

... insulin-like growth factor binding protein 1". Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor- ... Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is ... The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein ... 1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by ...

"Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3". The American Journal of ... The exposure of this receptor binding domain allows the α2-macroglobulin protease complex to bind to clearance receptors and be ... These movements expose the KR5 lysine-binding site to potential binding partners, and suggest a requirement for spatially ... and factor XII (Hageman factor). Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator. Urokinase ...

Bach LA, Rechler MM (1996). "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: ... Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene. GRCh38: Ensembl release ... 1991). "Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of ... Chesik D, De Keyser J, Wilczak N (2007). "Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: ...

2007). "N-Acetylgalactosaminyltransferase 14, a novel insulin-like growth factor binding protein-3 binding partner". Biochem. ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine ( ... 357 (2): 360-5. doi:10.1016/j.bbrc.2007.03.153. PMID 17434446. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, ...

"Expression of growth hormone-releasing factor, growth hormone, insulin-like growth factor-1 and its binding proteins in human ... Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene. The major function of ... Wilson HM, Birnbaum RS, Poot M, Quinn LS, Swisshelm K (2002). "Insulin-like growth factor binding protein-related protein 1 ... dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)". J. Mol. Biol ...

"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3". ... It is believed to be a major fetal growth factor in contrast to insulin-like growth factor 1 (IGF-1), which is a major growth ... "Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3". The Journal of ... Twigg SM, Baxter RC (Mar 1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with ...

"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3". ... "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". The Journal of Clinical Endocrinology and ... Transferrin has been shown to interact with insulin-like growth factor 2 and IGFBP3. Transcriptional regulation of transferrin ... Some invertebrates have proteins that act like transferrin found in the hemolymph. When not bound to iron, transferrin is known ...

"Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect ... IGFALS insulin-like growth factor binding protein, acid labile subunit". Twigg SM, Baxter RC (March 1998). "Insulin-like growth ... Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded ... The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and ...

"Association of insulin-like growth factor I and insulin-like growth factor-binding protein-3 with intelligence quotient among 8 ... "Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in ... The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system ... Growth factors, Hormones of the somatotropic axis, Insulin-like growth factor receptor agonists, Peptide hormones). ...

"Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. ... Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene. This gene is a member ... "Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein". ... The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non- ...

In the extracellular space, tTG binds to proteins of the extracellular matrix (ECM), binding particularly tightly to ... Heat Shock Factor 1) and thus the body's response to heat shock. In the absence of tTG, the response to heat shock is impaired ... Multiple Ca2+ can bind to a single tTG molecule. Specifically, tTG binds up to 6 calcium ions at 5 different binding sites. ... Endoplasmic reticulum (ER)-resident protein 57 (ERp57), a protein in the ER that promotes folding of nascent proteins and is ...

... has two paralogs in humans: TMEM219 and insulin-like growth factor binding protein 3 (IGFBP3) receptor isoform 2 ... TMEM248 is a multi-pass component of the membrane and functions in protein binding and vesicular transport. TMEM248 has both ... Transmembrane protein 248, also known as C7orf42, is a gene that in humans encodes the TMEM248 protein. This gene contains ... cite journal}}: Cite journal requires ,journal= (help) "transmembrane protein 248 isoform X1 [Homo sapiens] - Protein - NCBI". ...

"The heparin binding domain of insulin-like growth factor binding protein (IGFBP)-3 increases susceptibility of IGFBP-3 to ... factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: ... Thompson RE, Mandle R, Kaplan AP (1980). "Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen ... Fujikawa K, Chung DW, Hendrickson LE, Davie EW (1986). "Amino acid sequence of human factor XI, a blood coagulation factor with ...

"Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1". Mol ... Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene. The protein ... "Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein". J. ... "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF- ...

"DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in ... FOXO transcription factors have been shown to be the down downstream effector molecules of insulin-like growth factor (IGF) ... The fusion proteins formed by these translocations lack the DNA-binding domain, causing the protein to lose function. In ... FOXO4 can bind with p53 protein to induce cellular senescence. A peptide competing with FOXO4 can act as a senolytic by ...

"Genotype of Brahman and Brahman Cross Cattle based on SNP in Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) gene ... 18 (2): 820. doi:10.13057/biodiv/d180255. ISSN 2085-4722. "«Մենք մեր մասին» ամսագիր: "We about ourselves" magazine". Issuu. Nov ...

... and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length ... The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in ... CDK9 CREB-binding protein Cyclin A1 Cyclin-dependent kinase inhibitor 1C EP300 PARP1 Retinoblastoma-like protein 1 GRCh38: ... Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene. ...

"Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)". J. Biol. Chem. ... "Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2)". J. Biol. Chem. ... The Four-and-a-half LIM (FHL)-only protein subfamily is one of the members of the LIM-only protein family. Protein members ... towards the functional role of FHL2 in supporting protein-protein interactions of LIM-containing proteins and its binding ...

... p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Molecular ... Tyrosine phosphorylation of IRS-1 by insulin receptor (IR) introduces multiple binding sites for proteins bearing SH2 homology ... IRS-1 integrates signalling from insulin receptor (InsR), insulin-like growth factor-1 receptor (IGF1R) and many other cytokine ... Insulin receptor substrate 1 plays a key role in transmitting signals from the insulin receptor (IR) and insulin-like growth ...

2004). "ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3". Biochem. Biophys ... implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3". Cancer Res. 66 ... The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript ... 2007). "Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial ...

... insulin-like growth factor 2) mRNA. Lin28 binds to the let-7 pre-microRNA and blocks production of the mature let-7 microRNA in ... Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene. LIN28 encodes an RNA-binding protein that binds to ... LIN28 can regulate glucose homeostasis in mammals by increasing insulin-PI3K-mTOR signaling and insulin sensitivity, thereby ... Moss EG, Lee RC, Ambros V (Mar 1997). "The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is ...

... have been characterized as direct m6A readers and have a conserved m6A-binding pocket. Insulin-like growth factor-2 mRNA- ... These binding proteins are named m6A readers. The YT521-B homology (YTH) domain family of proteins (YTHDF1, YTHDF2, YTHDF3 and ... The biological functions of m6A are mediated through a group of RNA binding proteins that specifically recognize the methylated ... January 2018). "Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers". Cell Reports. 22 (1): 286 ...