IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin ... Thus, the insulin receptor binds IRS. IRS1 (see also Insulin receptor substrate 1) IRS2 (see also Insulin receptor substrate 2 ... Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells. ... "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene. 18 (20 ...

Insulin receptor substrate 1 (IRS-1). Regulators of small G-proteins: 64 RhoGEFs of the Dbl-like family., and several GTPase ... G protein receptor kinases (GRK) of GRK2 subfamily (beta-adrenergic receptor kinases): GRK2 and GRK3. Spectrin/pleckstrin-like ... ARAP proteins contain five PH domains. Serine/threonine-specific protein kinases such as the Akt/Rac family, protein kinase D1 ... the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. Pleckstrin contains ...

In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of ... Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". ... It is a scaffold protein related to Sorting nexins and it regulates protein cargo traffic. The orthologous mouse protein has ... Nischarin is a protein that in humans is encoded by the NISCH gene. This gene encodes a nonadrenergic imidazoline-1 receptor ...

2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. 277 (22): 19439-47. doi:10.1074/jbc. ... WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene. This gene encodes a member of the WD ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... Xie X, Wang Z, Chen Y (2007). "Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27( ...

These domains can be found in the insulin receptor substrate. LIM domain LIM domains were initially identified in three ... complex Protein domain dynamics Protein flexibility Protein structure Protein-protein interaction prediction Protein-protein ... Protein-Protein Interaction Databases Library of Modulators of Protein-Protein Interactions (PPI) Proteins and Enzymes at ... To test protein-protein interaction, the targeted protein cDNA and query protein cDNA were immobilized in a same coated slide. ...

"IRS4 - Insulin receptor substrate 4 - Homo sapiens (Human) - IRS4 gene & protein". Uniprot.org. Retrieved 2016-05-05. (All ... IRS4 functions as interface between growth factor receptors consisting of tyrosine kinase activity, such as insulin receptors. ... OCC-1 contains an "opioid growth factor receptor repeat" (OGFr) motif from residue 8 to 27. OCC-1 is an acidic protein with an ... "overexpressed in colon carcinoma 1 protein [Homo sapiens] - Protein - NCBI". Ncbi.nlm.nih.gov. 2015-09-28. Retrieved 2016-05-05 ...

Moodie SA, Alleman-Sposeto J, Gustafson TA (1999). "Identification of the APS protein as a novel insulin receptor substrate". J ... SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene. The protein encoded by this gene is expressed ... "Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin ... Qian X, Riccio A, Zhang Y, Ginty DD (1999). "Identification and characterization of novel substrates of Trk receptors in ...

"The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Molecular and Cellular ... Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion ... and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role ... "Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched ...

This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous ... Abbott MA, Wells DG, Fallon JR (1999). "The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are ... 2003). "Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein". J. Hum ... Proteins Are Localized to Purkinje Cell Dendritic Spines and Bind the SH3 Adapter Protein Insulin Receptor Substrate p53". J. ...

"The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575 ... "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575 ... Tobaben S, Südhof TC, Stahl B (2000). "The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family ... "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J ...

April 6, 2001). "Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein". Science. 292 (5514 ...

"The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Molecular and Cellular ... Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg ... Kreienkamp HJ, Zitzer H, Richter D (2001). "Identification of proteins interacting with the rat somatostatin receptor subtype 2 ... This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds ...

"Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction". The Journal ... A family of proteins that inhibits signaling through tyrosine kinase receptors. Nature 386:181-6 (1997) doi:10.1038/386181a0. ... "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181-186. Bibcode:1997Natur ... "Protein-Tyrosine Phosphatases: Linking Metabolism and Cancer", Protein Tyrosine Phosphatases in Cancer, New York, NY: Springer ...

Insulin receptors activate insulin-like receptor substrates. These substrates activate phosphoinositide 3-kinases (PI-3K) which ... Catecholamines bind to 7TM receptors (G protein-coupled receptors) on the adipocyte cell membrane, which activate adenylate ... Insulin counter-regulates this increase in lipolysis when it binds to insulin receptors on the adipocyte cell membrane. ... The regulation of this process involves interactions between insulin receptors and gangliosides present in the neuronal cell ...

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene. IRS4 encodes the insulin receptor ... 2003). "Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor". ... "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II". Endocrinology. ... "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II". Endocrinology. 142 ( ...

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene. This gene encodes the insulin receptor ... 1995). "4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice". J ... 1996). "Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. ... 1997). "Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor". J. Biol. Chem. ...

... a Drosophila insulin receptor substrate protein"". Science. "Selman, Colin, Lingard, Steven, Gems, David; Partridge, Linda; ... Withers, Dominic J. (2008) "Extended lifespan with reduced age-related pathology in insulin receptor substrate 1 null mice"". ... From 1993 to 2014, much of Gems's work related to long-lived C. elegans daf-2 mutants and the defects in insulin/IGF-1 ... During the 2000s his work also focused on identifying the processes of aging itself that insulin/IGF-1 signaling controls, in ...

Sun, Xiao Jian, "Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein." Nature 352, ... 53, No.3 Colin S et al "The antiangiogenic insulin receptor substrate-1 antisense oligonucleotide aganirsen impairs AU-rich ... Aganirsen (previously GS-101) is a 25 mer DNA antisense oligonucleotide therapeutic inhibiting insulin receptor substrate-1 ( ... an antisense oligonucleotide to insulin receptor substrate-1: a first in man phase I investigation", British Journal of ...

Insulin receptor substrate-1 proteins contain both a pleckstrin homology domain and a phosphotyrosine binding (PTB) domain. The ... The phosphotyrosine-binding domain of insulin receptor substrate-1 is not related to the phosphotyrosine-binding domain of ... Protein domains, Protein families, Membrane proteins, All stub articles, Membrane protein stubs). ... "Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor". Cell. 85 (5): 695-705. doi: ...

"SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates". Biochemical and Biophysical ... inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation". The ... "Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor". ... the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors ...

"Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic ... These pro-apoptotic proteins are in turn activated by BH3-only proteins, and are inhibited by the function of BCL-2 and its ... "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341-51. doi:10.1016/ ... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". The ...

The SHC and its adaptor proteins transmit signaling of the cell surface receptors such as EGFR, erbV-2 and insulin receptors. ... "The functional significance of Shc in insulin signaling as a substrate of the insulin receptor". Endocrine Journal. 47 (4): 373 ... The protein SHC1 also acts as a scaffold protein which is used in cell surface receptors. The three proteins that SHC1 codes ... It has been proposed that SHC1 modulates the life span and stress response through the DAF-2 insulin- like receptor of the IIS ...

PI3Ks interact with the insulin receptor substrate (IRS) to regulate glucose uptake through a series of phosphorylation events ... The PI3K is activated by G protein-coupled receptors and tyrosine kinase receptors. Class I PI3Ks are heterodimeric molecules ... Many of these functions relate to the ability of class I PI3Ks to activate protein kinase B (PKB, aka Akt) as in the PI3K/AKT/ ... Many other proteins have been identified that are regulated by PtdIns(3,4,5)P3, including Bruton's tyrosine kinase (BTK), ...

"Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require ... GTPase activating protein and VPS9 domains 1, also known as GAPVD1, Gapex-5 and RME-6 is a protein which in humans is encoded ... 2006). "Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis". Biochem. Biophys. Res. Commun. 340 (3 ... "Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis". Biochem. Biophys. Res. Commun. 340 (3): 967- ...

"Par14 Protein Associates with Insulin Receptor Substrate 1 (IRS-1), Thereby Enhancing Insulin-induced IRS-1 Phosphorylation and ... Cytoplasm: Par14 interacts with the insulin receptor substrate (IRS-1) and enhances insulin-induced tyrosine-phosphorylation of ... Par14 requires phosphorylation of Ser7 and Ser9 by protein kinase B (Akt) (or protein kinase C) for nuclear export. This export ... The protein is primarily active within the nucleus/nucleolus of the cell, but also found within the cytoplasm. ...

"Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes". ... AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene. GRCh38: Ensembl release 89: ... Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (March 1997). "AP-3: an adaptor-like protein complex ... "Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit". Human AP3S1 genome location and AP3S1 gene details page ...

"Insulin Receptor Substrate and p55 Orthologous Adaptor Proteins Function in the Caenorhabditis elegans daf-2/Insulin-like ... Binding causes dimerization and phosphorylation of the receptor, which induces recruitment of the DAF-2 receptor substrate IST- ... Ogg, Scott; Ruvkun, Gary (December 1998). "The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic ... This pathway gets activated upon binding of an insulin-like peptide to the DAF-2/IGF1R receptor. ...

"Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase ... Braun L, Ghebrehiwet B, Cossart P (2000). "gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of ... GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. The protein encoded by this gene is ... "Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors". Blood ...

BAI1-associated protein 2) or insulin receptor tyrosine kinase substrate p53 (IRSp53), a multifunctional adaptor protein that ... forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein". J. Biol. Chem. ... is a BAR-like domain of approximately 250 amino acids found at the N-terminus in the insulin receptor tyrosine kinase substrate ... Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2-like proteins 1 and 2 (BAI1-associated protein 2-like ...

Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR (1997). "Insulin receptor substrate proteins create a link between the tyrosine ...