Inositol trisphosphate receptor
Inositol Inositol phosphate Inositol monophosphate Inositol trisphosphate Inositol pentakisphosphate Inositol hexaphosphate ... Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol ... Inositol+Trisphosphate+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... Paknejad N, Hite RK (August 2018). "Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3". ...
Inositol-trisphosphate 3-kinase
... whose substrates are inositol lipids, not the soluble second messenger inositol trisphosphate. Scientific interest in the ... In biology, the enzyme ITP3K is abbreviated a number of different ways, including 1D-myo-inositol-trisphosphate 3-kinase, ITP3K ... Schell MJ (June 2010). "Inositol trisphosphate 3-kinases: focus on immune and neuronal signaling". Cellular and Molecular Life ... Berridge MJ (January 1993). "Inositol trisphosphate and calcium signalling". Nature. 361 (6410): 315-25. Bibcode:1993Natur.361 ...
Basal electrical rhythm
"Inositol 1,4,5-trisphosphate Receptors and Pacemaker Rhythms." Journal of Molecular and Cellular Cardiology 53.3 (2012): 375-81 ... 4 (7): 848-851. doi:10.1038/nm0798-848. ISSN 1078-8956. PMID 9662380. Ju, Yue-Kun, Elizabeth A. Woodcock, David G. Allen, and ... PPY - inhibition of upper GI tract motility GLP-1 - Functions as an "Ileal Brake" to inhibit upper GI tract motility when the ... Current Opinion In Pharmacology [serial online]. December 1, 2013;13(Gastrointestinal * Endocrine and metabolic diseases):928- ...
Second messenger system
The enzyme phospholipase C produces diacylglycerol and inositol trisphosphate, which increases calcium ion permeability into ... Yoshida Y, Imai S (June 1997). "Structure and function of inositol 1,4,5-trisphosphate receptor". Japanese Journal of ... Hughes AR, Putney JW (March 1990). "Inositol phosphate formation and its relationship to calcium signaling". Environmental ... Examples of second messenger molecules include cyclic AMP, cyclic GMP, inositol triphosphate, diacylglycerol, and calcium. ...
Glyceraldehyde 3-phosphate dehydrogenase
Inositol 1,4,5-trisphosphate receptor to regulate intracellular Ca2+ signaling; Oct-1 to form the coactivator complex OCA-S, ... 66 (5): 2052-2059. doi:10.1128/IAI.66.5.2052-2059.1998. PMC 108162. PMID 9573088. Deng Z, Dai T, Zhang W, Zhu J, Luo XM, Fu D, ... 23 (4-5): 603-609. doi:10.1016/s0161-813x(02)00062-1. PMID 12428732. Allen M, Cox C, Belbin O, Ma L, Bisceglio GD, Wilcox SL, ... 451 (1): 137-141. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746. Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, ...
Inositol
... from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate ... 2013). "The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes ... U.S. National Library of Medicine: Drug Information Portal - Inositol Inositol MS Spectrum Inositol bound to proteins in the ... only a small quantity of myo-inositol is converted into D-chiro-inositol and the conversion is irreversible. Inositol, ...
Inositol-tetrakisphosphate 5-kinase
In enzymology, an inositol-tetrakisphosphate 5-kinase (EC 2.7.1.140) is an enzyme that catalyzes the chemical reaction ATP + 1D ... Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4, ... The systematic name of this enzyme class is ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase. This enzyme is ... Stevenson-Paulik J, Odom AR, York JD (2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6 ...
ITPR2
The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel. Inositol trisphosphate ... Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. ... "Entrez Gene: inositol 1". Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 ... 2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other ...
Phospholipase C
There is the formation of a weakly enzyme-bound intermediate, inositol 1,2-cyclic phosphodiester, and release of diacylglycerol ... IP3 is the rate-limiting substrate for the synthesis of inositol polyphosphates, which stimulate multiple protein kinases, ... and inositol 1,4,5-trisphosphate (IP3). Thus PLC has a profound impact on the depletion of PIP2, which acts as a membrane ... and inositol 1,4,5-trisphosphate (IP3), which serve as second messengers. Activators of each PLC vary, but typically include ...
George J. Augustine
Finch, Elizabeth A.; Augustine, George J. (1998). "Local Calcium Signalling by Inositol-1,4,5-trisphosphate in Purkinje Cell ... ISBN 978-1-60535-380-7. Ang, Jolene (2018). "NTU Gets $11 Million Gift for Endowment Fund". Straits Times. "Grass Fellows". ... ISBN 978-1-60535-380-7. Augustine, George J.; Charlton, Milton P.; Smith, Stephen J. (1987). "Calcium Action in Synaptic ... February 4, 2019. Retrieved June 9, 2019. (Articles with short description, Short description matches Wikidata, Use mdy dates ...
Inositol-polyphosphate multikinase
... (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ... Odom AR, Stahlberg A, Wente SR, York JD (March 2000). "A role for nuclear inositol 1,4,5-trisphosphate kinase in ... Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW (January 2005). "The pathway for the production of inositol ... Stevenson-Paulik J, Odom AR, York JD (November 2002). "Molecular and biochemical characterization of two plant inositol ...
ITPKA
Inositol-trisphosphate 3-kinase A is an enzyme that in humans is encoded by the ITPKA gene. ITPKA is one of three inositol- ... Ryu SH, Lee SY, Lee KY, Rhee SG (November 1987). "Catalytic properties of inositol trisphosphate kinase: activation by Ca2+ and ... ITP3K proteins regulate inositol phosphate metabolism by phosphorylation of the second messenger inositol 1,4,5-trisphosphate ... Structurally, ITPKA belongs to the inositol polyphosphate kinase (IPK) family. The activity of the inositol 1,4,5-trisphosphate ...
Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels
... family includes Ryanodine receptors and Inositol trisphosphate receptors. Members of this family are large proteins, some ... The 3-D structure (2.2 Å) of the inositol 1,3,5-triphosphate receptor of an IP3 receptor has been solved (PDB: 1N4K). ... The ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channel (RIR-CaC) ... sensitive and inositol 1,4,5-triphosphate (IP3)-sensitive Ca2+-release channels function in the release of Ca2+ from ...
Inositol polyphosphate kinase
Members of the family include inositol-polyphosphate multikinases, inositol-hexakisphosphate kinases, inositol-trisphosphate 3- ... Inositol polyphosphate kinase (IPK) is a family of enzymes that have a similar 3-dimensional structure. All members of the ... Odom AR, Stahlberg A, Wente SR, York JD (2000). "A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional ... González B, Schell MJ, Letcher AJ, Veprintsev DB, Irvine RF, Williams RL (2004). "Structure of a human inositol 1,4,5- ...
Cytochrome c
Boehning D, Patterson RL, Sedaghat L, Glebova NO, Kurosaki T, Snyder SH (December 2003). "Cytochrome c binds to inositol (1,4,5 ... trisphosphate receptors, amplifying calcium-dependent apoptosis". Nature Cell Biology. 5 (12): 1051-61. doi:10.1038/ncb1063. ... ISBN 978-1-4051-5089-7. Stryer L (1975). Biochemistry (1st ed.). San Francisco: W.H. Freeman and Company. p. 362. ISBN 978-0- ... 33 (5): 446-52. doi:10.1177/33.5.2580882. PMID 2580882. Tanaka Y, Ashikari T, Shibano Y, Amachi T, Yoshizumi H, Matsubara H ( ...
Vomeronasal organ
Wekesa KS, Anholt RR (August 1997). "Pheromone regulated production of inositol-(1, 4, 5)-trisphosphate in the mammalian ... 5 December 2007. Retrieved 26 September 2009. Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR, Saghatelian A, et al. ( ... 281 (1): 1201-1211. doi:10.1002/ar.a.20125. PMID 15470677. Bhatnagar KP, Kennedy RC, Baron G, Greenberg RA (May 1987). "Number ... 90 (4): 775-784. doi:10.1016/s0092-8674(00)80537-1. PMID 9288756. S2CID 14898961. Ryba NJ, Tirindelli R (August 1997). "A new ...
Metabotropic glutamate receptor
This leads to the formation of inositol 1,4,5-trisphosphate (IP3) and diacyl glycerol. Due to its hydrophilic character, IP3 ... Sugiyama H, Ito I, Hirono C (1987). "A new type of glutamate receptor linked to inositol phospholipid metabolism". Nature. 325 ... Sladeczek F, Pin JP, Récasens M, Bockaert J, Weiss S (1985). "Glutamate stimulates inositol phosphate formation in striatal ... when it was shown that it could stimulate the formation of inositol phosphates. This finding allowed in 1987 to yield an ...
Calcineurin
Cameron AM, Steiner JP, Roskams AJ, Ali SM, Ronnett GV, Snyder SH (1995). "Calcineurin associated with the inositol 1,4,5- ... trisphosphate receptor-FKBP12 complex modulates Ca2+ flux". Cell. 83 (3): 463-72. doi:10.1016/0092-8674(95)90124-8. PMID ... 1 March 2019. Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S (July 2000). "DSCR1, ... 181 (1): 252-8. doi:10.1016/S0006-291X(05)81410-X. PMID 1659808. Kincaid RL, Giri PR, Higuchi S, Tamura J, Dixon SC, Marietta ...
Phosphatidylinositol 4,5-bisphosphate
1990). "Evidence that the inositol phospholipids are necessary for exocytosis. Loss of inositol phospholipids and inhibition of ... trisphosphate (PtdIns(3,4,5)P3) and PtdIns(4,5)P2 can be converted from PtdIns4P. PtdIns4P, PtdIns(3,4,5)P3 and PtdIns(4,5)P2 ... The products of the PLC catalyzation of PIP2 are inositol 1,4,5-trisphosphate (InsP3; IP3) and diacylglycerol (DAG), both of ... and over-expression of membrane-tethered inositol 5-phosphatase domain of synaptojanin 1 , all suggested vesicle (synaptic ...
Catenin beta-1
... trisphosphate. Soluble inositol-(1,4,5)-trisphosphate triggers calcium to be released from the endoplasmic reticulum. This ... Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. β-Catenin is ... 5 (9): e366. doi:10.1038/mtna.2016.66. PMC 5056990. PMID 27673562. Cao Z, Hao Z, Xin M, Yu L, Wang L, Zhang Y, et al. (December ... 5 (1): 137. doi:10.1038/s42003-022-03079-4. PMC 8854631. PMID 35177769. Tian X, Liu Z, Niu B, Zhang J, Tan TK, Lee SR, et al. ( ...
Calcium-binding protein 1
... superfamily which modulates Ca2+-dependent activity of inositol trisphosphate receptors (InsP3RS). L-CaBP1 is also associated ... CaBP1 interacts with inositol 1,4,5-triphosphate (InsP3) receptors to elicit channel activation when InsP3 is absent. In ... This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium ... "Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1". The Journal of ...
PRKG1
Komalavilas P, Lincoln TM (Mar 1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent ... "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate ( ... 96 (5): 2467-72. Bibcode:1999PNAS...96.2467E. doi:10.1073/pnas.96.5.2467. PMC 26808. PMID 10051666. Wang X, Bruderer S, Rafi Z ... cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene. PRKG1 has been shown ...
B cell scaffold protein with ankyrin repeats 1
This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in ... 10 (5): 531-8. doi:10.1038/gene.2009.18. PMC 2736873. PMID 19339986. Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW, Lee KW ... 10 (5): 414-20. doi:10.1038/gene.2009.16. PMC 2834352. PMID 19357697. Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW, Lee ... 10 (5): 531-8. doi:10.1038/gene.2009.18. PMC 2736873. PMID 19339986. Guo L, Deshmukh H, Lu R, Vidal GS, Kelly JA, Kaufman KM, ...
Metabotropic glutamate receptor 5
11 (5): 655-65. PMID 18729017. Hu Y, Dong L, Sun B, Guillon MA, Burbach LR, Nunn PA, Liu X, Vilenski O, Ford AP, Zhong Y, Rong ... 147 (Suppl 1): S100-8. doi:10.1038/sj.bjp.0706444. PMC 1760733. PMID 16402093. Gass JT, Osborne MP, Watson NL, Brown JL, Olive ... 71 (5): 1389-98. doi:10.1124/mol.106.032425. PMID 17303702. S2CID 7004830. de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, ... 17 (5): 1386-91. doi:10.1016/j.bmcl.2006.11.081. PMID 17210250. O'Brien JA, Lemaire W, Wittmann M, Jacobson MA, Ha SN, Wisnoski ...
Phyllis Gardner (clinical pharmacologist)
Gardner, Phyllis (1987). "Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes". ...
LIN7C
"The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria". J. Biol ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano ... Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs ...
ITPK1
Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene. It is involved in inositol ... "Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase". Saiardi A, Cockcroft S (2008). "Human ITPK1: a reversible inositol ... Wilson MP, Sun Y, Cao L, Majerus PW (2001). "Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates ... Wilson MP, Majerus PW (Aug 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the ...
ITPR3
Inositol trisphosphate receptor GRCh38: Ensembl release 89: ENSG00000096433 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Ogasawara H (2008). "The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of ... Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. ... "Entrez Gene: inositol 1". Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 ...
COPS8
Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding ... 82 (3): 353-4. doi:10.1016/0092-8674(95)90423-9. PMID 7634324. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin ... 86 (1): 115-21. doi:10.1016/S0092-8674(00)80082-3. PMID 8689678. Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and ... 5 (12): 1029-33. doi:10.1038/ncb1203-1029. PMID 14647295. S2CID 37458780. Chamovitz DA, Wei N, Osterlund MT, et al. (1996). " ...
EPB41L1
... trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271-83. doi:10.1016/s1044-7431(02)00027-1. ... "Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain ... trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271-83. doi:10.1016/S1044-7431(02)00027-1. ... 4 (2): 141-50. doi:10.1093/dnares/4.2.141. PMID 9205841. Walensky LD, Blackshaw S, Liao D, Watkins CC, Weier HU, Parra M, ...