Indole-3-glycerol-phosphate synthase
Other names in common use include indoleglycerol phosphate synthetase, indoleglycerol phosphate synthase, indole-3- ... glycerophosphate synthase, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, and carboxy-lyase (cyclizing). This enzyme ... 1-deoxy-D-ribulose 5-phosphate ⇌ {\displaystyle \rightleftharpoons } 1-C-(indol-3-yl)-glycerol 3-phosphate + CO2 + H2O This ... The enzyme indole-3-glycerol-phosphate synthase (IGPS) (EC 4.1.1.48) catalyzes the chemical reaction 1-(2-carboxyphenylamino)- ...
Li Jiayang
Li, J; Chen, S; Zhu, L; Last, R. L. (1995). "Isolation of cDNAs encoding the tryptophan pathway enzyme indole-3-glycerol ... phosphate synthase from Arabidopsis thaliana". Plant Physiology. 108 (2): 877-8. doi:10.1104/pp.108.2.877. PMC 157433. PMID ... Li, J; Last, R. L. (1996). "The Arabidopsis thaliana trp5 mutant has a feedback-resistant anthranilate synthase and elevated ...
TIM barrel
... and imidazole glycerol phosphate synthase (HisF) of the Thermotoga maritima histidine biosynthesis pathway. They catalyze 2 ... In another study involving the S. solfataricus indole-3-glycerol phosphate synthase TIM barrel protein, a conserved βαβαβ ... An example of a large salt bridge network can be found in 2-deoxyribose-5-phosphate aldolase. This network was found to be ... The TIM barrel gets its name from the enzyme triose-phosphate isomerase (TIM), which was the first protein possessing the fold ...
Trp operon
1-deoxy-D-ribulose 5-phosphate. The Indole-3-glycerol-phosphate synthase on the same protein then turns the product into (1S,2R ... The roles of their products are: TrpE (P00895): Anthranilate synthase produces anthranilate. TrpD (P00904): Cooperates with ... glycerol 3-phosphate. TrpA (P0A877), TrpB (P0A879): two subunits of tryptophan synthetase. Combines TrpC's product with serine ... Sequence 2 is then free to hybridize with sequence 3 to form the 2-3 structure, which then prevents the formation of the 3-4 ...
List of EC numbers (EC 4)
... imidazole glycerol-phosphate synthase * *No Wikipedia article EC 4.3.3.1: 3-ketovalidoxylamine C-N-lyase EC 4.3.3.2: ... indole-salvaging) EC 4.2.1.123: tetrahymanol synthase EC 4.2.1.124: arabidiol synthase EC 4.2.1.125: dammarenediol II synthase ... methyl phosphate synthase EC 4.2.3.154: demethyl-4-deoxygadusol synthase EC 4.2.3.155: 2-epi-valiolone synthase EC 4.2.3.156: ... deacetylipecoside synthase EC 4.3.3.5: 4′-demethylrebeccamycin synthase EC 4.3.3.6: pyridoxal 5′-phosphate synthase (glutamine ...
List of MeSH codes (D08)
... argininosuccinate synthase MeSH D08.811.464.259.350 - carbamoyl-phosphate synthase (ammonia) MeSH D08.811.464.259.400 - carbon- ... synthase MeSH D08.811.913.050.387 - diacylglycerol o-acyltransferase MeSH D08.811.913.050.425 - glycerol-3-phosphate O- ... indole-3-glycerol-phosphate synthase MeSH D08.811.520.224.125.387 - methylmalonyl-coa decarboxylase MeSH D08.811.520.224. ... riboflavin synthase MeSH D08.811.913.225.825 - spermidine synthase MeSH D08.811.913.225.912 - spermine synthase MeSH D08.811. ...
Tryptophan synthase
The β subunits catalyze the irreversible condensation of indole and serine to form tryptophan in a pyridoxal phosphate (PLP) ... Lyase Synthase Tryptophan synthase (indole-salvaging) Dunn MF, Niks D, Ngo H, Barends TR, Schlichting I (June 2008). " ... The active sites of tryptophan synthase are allosterically coupled. Subunits: Tryptophan synthase typically exists as an α-ββ-α ... Tryptophan synthetase is also known to accept indole analogues, e.g., fluorinated or methylated indoles, as substrates, ...
Bx1 benzoxazin1
Melanson, D; Chilton, MD; Masters-Moore, D; Chilton, WS (Nov 25, 1997). "A deletion in an indole synthase gene is responsible ... 2016 ). Catalyzes the first step in the synthesis of DIMBOA, forming indole from indole-3-glycerol phosphate. The enzyme is ... One is encoded by the gene tsa1, tryptophan synthase alpha1(Frey et al. 1997, Melanson et al. 1997 ), on chromosome 7, another ... The X-ray structure of BX1 protein has been resolved and compared with bacterial TSA (tryptophan synthase alpha subunit, Kulik ...
Tryptophan
... is transformed into indole. In the last step, tryptophan synthase catalyzes the formation of tryptophan from indole and the ... Indole-3-propionic acid (IPA)] has previously been identified in the plasma and cerebrospinal fluid of humans, but its ... Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a ... convert tryptophan to indole-3-aldehyde (I3A) through unidentified enzymes [125]. Clostridium sporogenes convert tryptophan to ...
Indole-3-glycerol-phosphate lyase
... indole glycerol phosphate hydrolase, indole synthase, indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase, indole-3- ... glycerol phosphate lyase, IGL, BX1, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate, and D-glyceraldehyde-3-phosphate-lyase. This ... Melanson D, Chilton MD, Masters-Moore D, Chilton WS (1997). "A deletion in an indole synthase gene is responsible for the ... indole-forming). Other names in common use include tryptophan synthase alpha, TSA, indoleglycerolphosphate aldolase, ...
Phosphoribosylanthranilate isomerase
... is given in the table below for PRAI and indole-glycerol-phosphate synthase (IGPS, EC 4.1.1.48). Depending on the microorganism ... 1-deoxy-D-ribulose 5-phosphate [5, 6,8); Indoleglycerol phosphate (8); Indolepropanol phosphate (8); MnCI2 CoCI2 [16); CuS04 ( ... Eberhard M, Tsai-Pflugfelder M, Bolewska K, Hommel U, Kirschner K (April 1995). "Indoleglycerol phosphate synthase- ... Sterner R, Merz A, Thoma R, Kirschner K (2001). Phosphoribosylanthranilate isomerase and indoleglycerol-phosphate synthase: ...
Camptothecin
Then this intermediate is converted to indole glycerol phosphate, which interacts with the alpha-subunit of tryptophan (TSA) ... synthase to yield indole. The beta-subunit of tryptophan synthase (TSB) catalyzes condensation of indole with serine, leading ... First, chorismate is converted to anthranilate by the alpha-subunit of anthranilate synthase (ASA). Anthranilate reacts with 5- ... Condensation of IPP and dimethylallyl diphosphate (DMAPP) yields geranyl diphosphate (GPP). The geraniol synthase (GS) then ...
List of EC numbers (EC 1)
... sn-glycerol-1-phosphate dehydrogenase EC 1.1.1.262: 4-hydroxythreonine-4-phosphate dehydrogenase EC 1.1.1.263: 1,5-anhydro-D- ... 2-hydroxyisoflavanone synthase EC 1.14.13.137: Now EC 1.14.14.153, indole-2-monooxygenase EC 1.14.13.138: Now EC 1.14.14.157, ... glycerol dehydrogenase EC 1.1.1.7: propanediol-phosphate dehydrogenase EC 1.1.1.8: glycerol-3-phosphate dehydrogenase (NAD+) EC ... pyruvate synthase EC 1.2.7.2: Now included with EC 1.2.7.1, pyruvate synthase. EC 1.2.7.3: 2-oxoglutarate synthase EC 1.2.7.4: ...
List of EC numbers (EC 3)
... lipid-phosphate phosphatase EC 3.1.3.77: acireductone synthase EC 3.1.3.78: phosphatidylinositol-4,5-bisphosphate 4-phosphatase ... glycerol-1,2-cyclic-phosphate 2-phosphodiesterase EC 3.1.4.43: glycerophosphoinositol inositolphosphodiesterase EC 3.1.4.44: ... indol-3-yl)acetyl-L-aspartate hydrolase * EC 3.5.1.135: N 4-acetylcytidine amidohydrolase * EC 3.5.1.136: N,N′- ... glycerol-2-phosphatase EC 3.1.3.20: phosphoglycerate phosphatase EC 3.1.3.21: glycerol-1-phosphatase EC 3.1.3.22: mannitol-1- ...
List of EC numbers (EC 2)
... sucrose-phosphate synthase EC 2.4.1.15: α,α-trehalose-phosphate synthase (UDP-forming) EC 2.4.1.16: chitin synthase EC 2.4.1.17 ... teichoic acid glycerol-phosphate primase (*) EC 2.7.8.45: teichoic acid glycerol-phosphate transferase (*) EC 2.7.8.46: ... indole synthase EC 2.5.1.147: 5-amino-6-(D-ribitylamino)uracil-L-tyrosine 4-hydroxyphenyl transferase EC 2.5.1.148: ... synthase EC 2.3.3.2: decylcitrate synthase EC 2.3.3.3: citrate (Re)-synthase EC 2.3.3.4: decylhomocitrate synthase EC 2.3.3.5: ...
1-Aminocyclopropane-1-carboxylate synthase
They are natural toxins that cause slow binding inhibition by interfering with the coenzyme pyridoxal phosphate. ACC synthase ... Lin, E. C. C.; Kistler, W. S.; Zwaig, N. (June 1970). "Glycerol Kinase, the Pacemaker for the Dissimilation of Glycerol in ... Stresses such as wounding, noxious chemicals, auxin, flooding, and indole-3-acetic acid (IAA) promote ethylene synthesis, ... aminocyclopropanecarboxylic acid synthase, aminocyclopropanecarboxylate synthase, ACC synthase, and S-adenosyl-L-methionine ...
Natural product
In animals, the three carbon precursors lactate or glycerol can be converted into pyruvate which in turn can be converted into ... Corsello MA, Kim J, Garg NK (September 2017). "Indole diterpenoid natural products as the inspiration for new synthetic methods ... Vitamin B6 (pyridoxol, pyridoxal, and pyridoxamine) as pyridoxal 5′-phosphate is a cofactor for many enzymes especially ... are condensed by fatty acid synthase to produce fatty acids.: Ch. 3 Fatty acid are essential components of lipid bilayers that ...