Recombinant Immunotoxin Collaborative Group: The Recombinant Immunotoxin Collaborative Group (RICG) is a group of scientists specialising in immunology, biochemistry and molecular biology from the United Kingdom and Italy. The group is working toward the development of genetically engineered immunotoxins made from monoclonal antibody fragments genetically fused to either saporin or Pseudomonas exotoxin (PE) for the treatment of human hematological malignancies such as leukaemia, lymphoma and multiple myeloma.Aritox: The term aritox occurs in names of monoclonal antibodies and indicates that they are linked to an A chain of the ricin protein.Gelonin: Gelonin is a protein toxin of approximately 30 kDa found in the seeds of the Himalayan plant Gelonium multiflorum. In cell-free systems gelonin exerts powerful N-glycosidase activity on the 28S rRNA unit of eukaryotic ribosomes by cleaving out adenine at the 4324 site.Exoenzyme: An exoenzyme, or extracellular enzyme, is an enzyme that is secreted by a cell and functions outside of that cell. Exoenzymes are produced by both prokaryotic and eukaryotic cells and have been shown to be a crucial component of many biological processes.Pseudomonas exotoxin: The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa.Momordin (saponin): Momordin is one of several saponins derived from oleanolic acid, a triterpenoid. These chemical compounds are found in some plants of the Momordica genus, which includes the bitter melon (M.Inotuzumab ozogamicinAbra (genus): Abra is a genus of saltwater clams, marine bivalve mollusks in the family Semelidae. Members of this genus are mostly under 1.Monoclonal antibody therapyAB toxin: The AB toxins are two-component protein complexes secreted by a number of pathogenic bacteria. They can be classified as Type III toxins because they interfere with internal cell function.Denileukin diftitoxTransferrin receptor: Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration.Trichosanthin: Trichosanthin is a ribosome-inactivating protein.Capillary leak syndrome: Capillary leak syndrome (also known as systemic capillary leak syndrome, SCLS, or Clarkson’s disease) is an extremely rare medical condition characterized by self-reversing episodes during which the endothelial cells which line the capillaries are thought to separate for a few days, allowing for a leakage of fluid from the circulatory system to the interstitial space, resulting in a dangerous hypotension (low blood pressure), hemoconcentration, and hypoalbuminemia. It is a life-threatening illness because each episode has the potential to cause damage to, or the failure of, vital organs due to limited perfusion.Single-chain variable fragment: A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide of ten to about 25 amino acids.Huston, J.DsbC protein family: DsbC (Disulfide bond C) is a prokaryotic disulfide bond isomerase. The formation of native disulfide bonds play an important role in the proper folding of proteins and stabilize tertiary structures of the protein.Sambucus ebulusMedian toxic dose: ==Introduction==CLIP (protein): CLIP or Class II-associated invariant chain peptide is the part of the invariant chain (Ii) that binds MHC class II groove and remains there until the MHC receptor is fully assembled. The purpose of CLIP is to prevent the binding of self-peptide fragments prior to MHC II localization within the endo/lysosome.IsoantibodiesZinc ammonium chloride: Zinc ammonium chloride, also known as diammonium tetrachlorozincate(2-) (IUPAC name), is a zinc salt commonly used as a flux in the process of hot-dip galvanizing. The CAS registry number is 14639-97-5.Fragment antigen-binding: The fragment antigen-binding (Fab fragment) is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain.Protein synthesis inhibitor: A protein synthesis inhibitor is a substance that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins.Escheriosome: Escheriosomes are liposomes prepared from polar lipids extracted from Escherichia coli. Such kinds of delivery vehicles have been shown to elicit high cytotoxic T lymphocyte (CTL) responses.Nude mouseBrentuximab vedotinMir-26 microRNA precursor familyFramework region: In molecular biology, a framework region is a region in the variable domain of a protein which belongs to the immunoglobulin superfamily, and which is less "variable" than the CDR.Cholesterol-dependent cytolysin: Cholesterol-dependent cytolysins (CDC) are a family of β-barrel pore-forming exotoxins that are secreted by Gram-positive bacteria. CDC are secreted as water-soluble monomers of 50-70 kDa, that once bound to the target cell, will form a circular homo-oligomeric complex containing up to 40 monomers, although it is possible that some may incorporate more monomers.ImmunotherapyCadaverineLeguminous lectin family: In molecular biology, the leguminous lectin family is a family of lectin proteins.