Three isomers are known, 2-imidazolines, 3-imidazolines, and 4-imidazolines. The 2- and 3-imidazolines contain an imine center ... whereas the 4-imidazolines contain an alkene group. The 2-Imidazoline group occurs in several drugs. Liu, H. and Du, D.-M. ( ... Imidazoline is a class of heterocycles formally derived from imidazoles by the reduction of one of the two double bonds. ... 2009), Recent Advances in the Synthesis of 2-Imidazolines and Their Applications in Homogeneous Catalysis. Adv. Synth. Catal., ...

The 2-imidazolines are the most common imidazolines commercially, as the ring exists in some natural products and some ... Imidazoline receptor Imidazolidine Liu H, Du DM (March 2009). "Recent Advances in the Synthesis of 2-Imidazolines and Their ... 2-Imidazolines Clonidine Biimidazoline ligands and a complex. Second generation Grubbs' catalyst Spongotine B Cis-imidazolines ... Imidazoles can be prepared from dehydrogenation of imidazolines. As a structural analogue of 2-oxazolines, 2-imidazolines have ...

Imidazoline+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) imidazoline receptor 2 at the U. ... Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three main classes of ... imidazoline NISCH Head GA, Mayorov DN (January 2006). "Imidazoline receptors, novel agents and therapeutic potential". ... As of 2017, there are three known subtypes of imidazoline receptors: I1, I2, and I3. The I1 receptor appears to be a G protein- ...

Ruffolo, R. R. Jr.; Waddell, J. E. (1982). "Receptor interactions of imidazolines. IX. Cirazoline is an α1 adrenergic agonist ... Retrieved 2015-01-24.. Horie, K; Obika, K; Foglar, R (1995). "Selectivity of the imidazoline α-adrenoceptor agonists ( ... most selective agonist for alpha2-adrenergic as opposed to imidazoline-I1) Guanoxabenz (metabolite of guanabenz) Guanethidine ( ... mixed alpha2-adrenergic and imidazoline-I1 receptor agonist) Dexmedetomidine Fadolmidine Guanfacine, (preference for alpha2A- ...

Ruffolo, R. R. Jr.; Waddell, J. E. (1982). "Receptor interactions of imidazolines. IX. Cirazoline is an α1 adrenergic agonist ... Horie, K; Obika, K; Foglar, R. (1995). "Selectivity of the imidazoline α-adrenoceptor agonists (oxymetazoline and cirazoline) ... Imidazolines, Phenol ethers, All stub articles, Biochemistry stubs). ...

Imidazolines contain a cyclic amidine. A. W. Dox (1928). "Acetamidine Hydrochloride". Organic Syntheses. 8: 1. doi:10.15227/ ...

Mujić, M.; van Rossum, J. M. (June 1965). "Comparative pharmacodynamics of sympathomimetic imidazolines; studies on intestinal ... known for his contributions to classification of sympathomimetic drugs and comparative pharmacodynamics of imidazolines. He is ... interests included basic research in classification of sympathomimetic drugs and comparative pharmacodynamics of imidazolines. ...

... is a guanidine that activates presynaptic imidazoline receptors. Through its agonism at imidazoline receptors, ... Göthert, M.; Brüss, M.; Bönisch, H.; Molderings, G.J. (1999). "Presynaptic Imidazoline Receptors". Annals of the New York ... Molderings, GJ; Likungu, J; Jakschik, J; Göthert, M (1997). "Presynaptic imidazoline receptors and non-adrenoceptor 3H-idazoxan ...

It can reduce nasal airway resistance (NAR) up to 35.7% and reduce nasal mucosal blood flow up to 50%. Since imidazolines are ... Like other imidazolines, Oxymetazoline is readily absorbed orally. Effects on α receptors from systemically absorbed ... DE 1117588, Fruhstorfer W, Müller-Calgan H, "2-(2,6-dimethyl-3-hydroxy-4-tert-butyl-benzyl)-2-imidazoline,and acid addition ... Imidazolines, Merck & Co. brands, Phenols, Schering-Plough brands, Tert-butyl compounds, Topical decongestants, ...

October 2001). "beta-carboline binding to imidazoline receptors". Drug and Alcohol Dependence. 64 (2): 203-8. doi:10.1016/S0376 ... and imidazoline receptors. Beta-carboline Harmala alkaloid Tryptamine Shulgin A, Shulgin A (September 1997). TiHKAL: The ...

Imidazoline receptors occur in the nucleus tractus solitarii and also the centrolateral medulla. Clonidine is now thought to ... However, it is now known that clonidine binds to imidazoline receptors with a much greater affinity than α2 receptors, which ... Khan, ZP; Ferguson, CN; Jones, RM (February 1999). "alpha-2 and imidazoline receptor agonists. Their pharmacology and ...

Ahlquist RP, Huggins RA, Woodbury RA (March 1947). "The pharmacology of benzyl-imidazoline (Priscol)". The Journal of ...

There is no antidote for tetryzoline or other similar imidazoline analogue poisoning, but the symptoms can be alleviated and ... Chemically, tetryzoline is a derivative of imidazoline. It has two enantiomers. Tetryzoline is the INN. An urban legend ... US 2731471, Synerholm M, Jules LH, Sahyun M, "Imidazoline Derivatives", issued 17 January 1956, assigned to Sahyun Laboratories ...

Lysidine is a derivative of 2-imidazoline. It is a colorless solid with basic properties and soluble in organic solvents. It is ...

"Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-like drugs ... Imidazoline antagonists, Benzodioxans, Imidazolines, All stub articles, Nervous system drug stubs). ... It acts as both a selective α2 adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. Idazoxan has ... US 2979511, Krapcho J, Lott WA, "Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process", issued 11 ...

All of them are related imidazoline guanidinium derivatives. NSTX, and other PSTs, are produced by several species of marine ...

Some imidazoline-containing fungicides are derived from ethylenediamine. Ethylenediamine is an ingredient in the common ...

Schäfer SG, Kaan EC, Christen MO, Löw-Kröger A, Mest HJ, Molderings GJ (July 1995). "Why imidazoline receptor modulator in the ...

"Relationship between platelet imidazoline receptor-binding peptides and candidate imidazoline-1 receptor, IRAS". Annals of the ... June 2000). "Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization". DNA and Cell Biology. 19 (6): ... This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the inner layer of the plasma membrane as ... Imidazoline receptor GRCh38: Ensembl release 89: ENSG00000010322 - Ensembl, May 2017 "Human PubMed Reference:". National Center ...

... s are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumor suppressor p53, and which were ... Imidazoline core based on the methoxyphenyl substituents also stabilizes p53. Vassilev LT, Vu BT, Graves B, Carvajal D, ... imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological ... "Synthetic Design and Biological Evaluation of New p53-MDM2 Interaction Inhibitors Based on Imidazoline Core". Pharmaceuticals. ...

Imidazolones (also called imidazolinones) are oxo derivatives of imidazoline (dihydroimidazoles). Examples include imidazol-4- ...

Nicotinic, imidazoline I1 and I2, α2-adrenergic (no intrinsic activity-neither agonist nor antagonist), glutamate NMDAr, and ... Agmatine binds to α2-adrenergic receptor and imidazoline receptor binding sites, and blocks NMDA receptors and other cation ... imidazoline receptors subtypes, norepinephrine release and NO production. Agmatine hypoglycemic effects are the result of ... an endogenous ligand at imidazoline binding sites". British Journal of Pharmacology. 133 (6): 755-80. doi:10.1038/sj.bjp. ...

ISBN 978-0-12-376350-1. Piletz JE, Halaris A, Ernsberger PR (1994). "Psychopharmacology of imidazoline and alpha 2-adrenergic ... and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM). Clorgiline is also a multidrug efflux pump inhibitor. ...

... is a selective agonist at the imidazoline receptor subtype 1 (I1). This receptor subtype is found in both the ... Moxonidine (INN) is a new-generation alpha-2/imidazoline receptor agonist antihypertensive drug licensed for the treatment of ... Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1- ... Fairbanks CA, Wilcox GL (July 1999). "Moxonidine, a selective alpha2-adrenergic and imidazoline receptor agonist, produces ...

Both contain an imidazoline ring and a 2,6-dichlorinated phenyl ring. The differences in structure are shown in red, while the ...

Inhibitors of the MDM2-p53 interaction include the cis-imidazoline analog nutlin. Levels and stability of Mdm2 are also ...

Ishihara, Midori; Togo, Hideo (2007). "Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines ...

... is an α2-adrenergic receptor antagonist and antagonist of the imidazoline receptor. The Darzens reaction between 2- ... Imidazolines, Alpha-2 blockers, All stub articles, Pharmacology stubs). ...

ISBN 978-0-85404-182-4. Ferm, R. J.; Riebsomer, J. L. From "The chemistry of the 2-imidazolines and imidazolidines" Chemical ... The intermediate, resulting from the addition of only two hydrogen atoms is called imidazoline (dihydroimidazole). The ...

Additionally, her study of PCET in Iron Bi-imidazoline complexes has refined common comprehension of PCET, having proven her ... and Proton-Coupled Electron Transfer in Iron Bi-imidazoline Complexes". Journal of the American Chemical Society. 123 (16): ...