This protein is a member of Ikaros family of transcription factors. This gene encodes a member of the Ikaros family of zinc- ... Since Ikaros family members can interact with each other, it is probable that when one transcription factor is defected, others ... This family of transcription factors consists of five members: Ikaros (Ikzf1), Helios (Ikzf2), Aiolos (Ikzf3), Eos (Ikzf4), and ... Because of this, it is rather difficult to assess precise function to each transcription factor. Ikaros family members are ...

Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in ... a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". The EMBO Journal ... Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by ... Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by ...

... is a novel gene target of the hemolymphopoietic transcription factor Ikaros". The Journal of Biological Chemistry. 277 (16): ...

Ikaros is a transcription factor that is encoded by the IKZF genes of the Ikaros family zinc finger group. Zinc finger is a ... The Ikaros Zinc Finger (IkZF) family of transcription factors are known regulators of hematopoietic cell development and many ... The mutation in the IKZF1 gene can cause dysfunction of the Ikaros transcription factor. The dysfunction affects expression in ... Georgopoulos K, Moore DD, Derfler B (October 1992). "Ikaros, an early lymphoid-specific transcription factor and a putative ...

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes ... "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)". Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein ... Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with ... 2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos". Nat. Neurosci. 7 (11): 1250-8. doi: ...

Other transcription factors include Ikaros (B cell development), and Gfi1 (promotes Th2 development and inhibits Th1) or IRF8 ( ... Growth factors initiate signal transduction pathways, which lead to activation of transcription factors. Growth factors elicit ... Mutations in transcription factors are tightly connected to blood cancers, as acute myeloid leukemia (AML) or acute ... Recently, it was reported that transcription factors such as NF-κB can be regulated by microRNAs (e.g., miR-125b) in ...

... cohesion function in gene expression and genome organisation with Ikaros family transcription factors (TFs). She uses current ... Fisher's group published an important paper on the DNA-binding factor Ikaros, that at the time was presumed to be a ... For example, studies showed that Ikaros- target genes in T and B cells were recruited to pericentric heterochromatin domains ... suggesting that important developmental regulator genes might be poised for transcription in ES cells, yet repressed by the ...

SMAD3.01 Smad3 is a transcription factor involved in TGF-beta signaling. V$EBF1.01 Early B-cell factor 1 regulates B cell gene ... V$IK2.01 Ikaros 2 is a potential regulator for lymphocyte differentiation. Several other proteins have been predicted to ... There are three notable transcription factors that are known to be involved in the regulation of cell growth or immune ... There are several high quality transcription factor binding sites. There are also several stem-loop structures that are ...

... a figure in Greek mythology Ikaros, a character in Heaven's Lost Property Ikaros, a transcription factor encoded by the human ... Ikaros may refer to: IKAROS, a Japanese satellite Ikaros (island), an island in the Aegean Sea Ikaros (Failaka Island), an ... IKZF1 gene This disambiguation page lists articles associated with the title Ikaros. If an internal link led you here, you may ... ancient Greek city in the Persian Gulf Ikaros (mythology), ...

... been shown to interact with the ubiquitin E3 ligase cereblon and target this enzyme to degrade the Ikaros transcription factors ...

... functions alongside IRF8 to induce the expression of the Ikaros and Aiolos transcription factors, which decrease ... IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast ... IRF4 can function either as an activating or an inhibitory transcription factor depending on its transcription cofactors. IRF4 ... April 1996). "A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the ...

Possible transcription factors for human SOGA2 include: Modulator recognition factor 2 cAMP-responsive element binding protein ... 1 alternative splicing variant of FOXP1 MDS1/EVI1-like gene 1 Ikaros 2, possible regulator of lymphocyte differentiation ...

... the Busslinger group investigated the role of other important transcription factors, such as E2A, EBF1, Ikaros, and Blimp1, in ... Here, he discovered a new set of histone genes of the sea urchin and identified a tissue-specific transcription factor (TSAP) ... "Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis". Retrieved ... "Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development ...

... transcription factor". Molecular and Cellular Biology. 20 (6): 2248-59. doi:10.1128/MCB.20.6.2248-2259.2000. PMC 110841. PMID ... Koipally J, Georgopoulos K (June 2002). "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in ... transcription factor". Molecular and Cellular Biology. 20 (6): 2248-59. doi:10.1128/MCB.20.6.2248-2259.2000. PMC 110841. PMID ... a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". ...

... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ... Koipally J, Georgopoulos K (June 2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of ... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ... CtBP also binds the Kruppel-like factors family of zinc finger proteins KLF3, KLF8 and KLF12. In addition, CtBP complexes with ...

July 1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and ... Perdomo, J; Holmes, M; Chong, B; Crossley, M (December 2000). "Eos and pegasus, two members of the Ikaros family of proteins ... "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics. 87 (4): 474-82. doi:10.1016/j.ygeno. ... Crossley, M; Brownlee, GG (May 1990). "Disruption of a C/EBP binding site in the factor IX promoter is associated with ...

Nuclear factor of activated T-cells Hepatocyte nuclear factor 3 (alpha, beta) (FOXA1, FOXA2) E2F transcription factor 1 ... Early B-cell factor 1 (Neuron specific olfactory factor) Nascent polypeptide-associated complex subunit alpha 1 IKAROS family ... ETS1, an oncogenic transcription factor in stromal cells, induced the expression of ISLR protein which inhibited Hippo ... There are six distinct transcription factors that bind onto the promoter region of ISLR from Genomatix predictions: two SMAD ...

... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ... Koipally J, Georgopoulos K (June 2002). "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in ... Shen J, Han Q, Li W, Chen X, Lu J, Zheng J, Xue S (August 2022). "miR-383-5p Regulated by the Transcription Factor CTCF Affects ... Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein ...

Meloni AR, Smith EJ, Nevins JR (1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the ... Koipally J, Georgopoulos K (2002). "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a ... "The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling". Blood. 97 (9): 2815-22. doi: ... Meloni AR, Smith EJ, Nevins JR (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment ...

... which are transcription factors with the ability to modulate cytokine receptors and growth factors. JAK2 phosphorylates the BCR ... Another factor preventing cell cycle progression and apoptosis is the deletion of the IKAROS gene, which presents in >80% of Ph ... The Ras/MAPK/ERK pathway relays signals to nuclear transcription factors and plays a role in governing cell cycle control and ... Interactions with the IL-3 receptor also induce the Ras/RAF/MEK/ERK pathway to phosphorylate transcription factors which play a ...

Bryant H, Farrell PJ (October 2002). "Signal Transduction and Transcription Factor Modification during Reactivation of Epstein- ... Koipally J, Georgopoulos K (August 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of ... Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein ... This study also showed that signaling via the insulin/Insulin-like growth factor 1 receptor led to increased levels of HDAC7 in ...

"Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of ... Koipally J, Renold A, Kim J, Georgopoulos K (June 1999). "Repression by Ikaros and Aiolos is mediated through histone ... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ... "The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase ...

After conducting in vitro transcription experiments, Kingston found that there is a heat-shock transcription factor (HSTF) that ... He discovered that the Ikaros-NURD complex is able to target chromatin remodeling and histone deacetylation complexes in vivo. ... He was also able to conclude that different domains of transcription factors target SWI/SNF complexes to chromatin in a gene- ... and that the HSP70 gene promoter also depends on a CCAAT-box-binding transcription factor (CTF) for CCAAT-box-dependent ...

Sp1 transcription factor, Sp3 transcription factor, TOP2B, and YY1. Histone deacetylase GRCh38: Ensembl release 89: ... Koipally J, Renold A, Kim J, Georgopoulos K (June 1999). "Repression by Ikaros and Aiolos is mediated through histone ... Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Molecular ... a transcription factor in Saccharomyces cerevisiae". Cytogenetics and Cell Genetics. 73 (1-2): 130-133. doi:10.1159/000134323. ...

McKinsey TA, Zhang CL, Olson EN (December 2000). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/ ... Koipally J, Georgopoulos K (August 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of ... and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor ... October 2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood. 98 (7): 2116-23. ...

"Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)". Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, ... Xu Y, Sengupta PK, Seto E, Smith BD (Apr 2006). "Regulatory factor for X-box family proteins differentially interact with ... Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone ... Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone ...

Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZN1 and IKZN3 transcription factors, which are ... "The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins". Science. 343 (6168): 305-9. ... CUL4B binds to the beta-propeller of the DDB1 adaptor protein which interacts with numerous DDB1-CUL4-Associated Factors (DCAFs ... Both CRL4 complexes utilize Cdt2 and the DNA processivity factor PCNA to induce the ubiquitination and degradation of ...

Recent reports show that IMiDs bind to CRL4CRBN and promote the degradation of IKZF1 and IKZF3 transcription factors, which are ... "The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins". Science. 343 (6168): 305-9. ... accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1". ... In addition to the "global" type of NER, the CRL4A complex also appears to play a role in "transcription-coupled" NER in ...

Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in ... "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes". Immunity. 10 (3): 345-55. doi: ... "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3 ... "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3 ...