... is caused by chronic use of hydroxyurea for chronic myelogenous leukemia, thrombocytosis, or psoriasis, ...
This method of hydroxyurea synthesis was patented by Hussain et al. (2015). Hydroxyurea is a monohydroxyl-substituted urea ( ... offering potential synergy between hydroxyurea and radiation or alkylating agents. Hydroxyurea has many pharmacological ... Hydroxyurea lay dormant for more than fifty years until it was studied as part of an investigation into the toxicity of protein ... "Hydroxyurea". PubChem. U.S. National Library of Medicine. Archived from the original on 2017-05-18. Koç A, Wheeler LJ, Mathews ...
Hydroxyurea (HU) is a small molecule drug that inhibits the enzyme ribonucleotide reductase (RNR), preventing the catalysis of ... Koç A, Wheeler LJ, Mathews CK, Merrill GF (January 2004). "Hydroxyurea arrests DNA replication by a mechanism that preserves ... Xu YJ, Singh A, Alter GM (November 2016). "Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α- ... Platt OS (March 2008). "Hydroxyurea for the treatment of sickle cell anemia". The New England Journal of Medicine. 358 (13): ...
He was prescribed an unusual combination therapy: didanosine, indinavir and hydroxyurea. Hydroxyurea was the most unusual of ... Gibbs MA, Sorensen SJ (January 2000). "Hydroxyurea in the treatment of HIV-1". The Annals of Pharmacotherapy. 34 (1): 89-93. ...
Newton HB (2007). "Hydroxyurea chemotherapy in the treatment of meningiomas". Neurosurgical Focus. 23 (4): E11. doi:10.3171/foc ... A 2007 study of whether hydroxyurea has the capacity to shrink unresectable or recurrent meningiomata is being further ...
Hydroxyurea is the only FDA approved drug for thalassemia. Patients who took 10 mg/kg of hydroxyurea every day for a year had ... Thalassemia patients who do not respond well to blood transfusions can take hydroxyurea or thalidomide, and sometimes a ... Keikhaei, Bijan (2015). "Clinical and Haematological Effects of Hydroxyurea in β -Thalassemia Intermedia Patients". Journal of ... The combination of thalidomide and hydroxyurea resulted in hemoglobin levels increasing significantly in transfusion-dependent ...
In the early 1980s a team led by Charache began testing a few patients at Hopkins to see if hydroxyurea, a cancer drug, would ... They found that hydroxyurea treatment could increase recipients' blood levels of hemoglobin F, a form of hemoglobin primarily ... Subsequent investigation of the beneficial effects hydroxyurea in people with sickle cell disease has revealed multiple ... Agrawal, Rohit Kumar; Patel, Rakesh Kantilal; Shah, Varsha; Nainiwal, Lalit; Trivedi, Bhadra (June 2014). "Hydroxyurea in ...
These include hydroxyurea and interferon therapy, among others. The tendency of some practitioners to avoid chemotherapy if ... While hydroxyurea is considered a safer chemotherapy in this aspect, there is still some debate about its long-term safety. ...
Hydroxyurea administration - Hydroxyurea is a drug that can be used as an alternative method of increasing fetal haemoglobin ... Hydroxyurea also provides the benefit of reducing inflammation. Haematopoetic stem cell transplantation - This process is more ...
Tripathi, K; Mor, V; Bairwa, NK; Del Poeta, M; Mohanty, BK (2012). "Hydroxyurea treatment inhibits proliferation of ...
The hydroxyurea arm had a lower likelihood of myelofibrosis, arterial thrombosis, and bleeding, but it had a slightly higher ... July 2005). "Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia". The New England Journal of Medicine ... Anagrelide can be useful in times when hydroxyurea proves ineffective. Common side effects are headache, diarrhea, unusual ... Stopping anagrelide (and switching patients to hydroxyurea) appeared to reverse the degree of marrow fibrosis. Thus, patients ...
July 2005). "Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia". The New England Journal of Medicine ... Extremely high platelet counts can be treated with hydroxyurea (a cytoreducing agent) or anagrelide (Agrylin). In Janus kinase ...
Inhibition of the enzyme by hydroxyurea, hydroxylamine, and acetohydroxamic acid". J Biol Chem. 240: 2407-2414. doi:10.1016/ ...
Inhibition of the Enzyme by Hydroxyurea, Hydroxylamine, and Acetohydroxamic Acid". The Journal of Biological Chemistry. 240: ...
Hydroxycarbamide (hydroxyurea) was shown effective in mouse models and subsequently commercially researched by Novo Nordisk, ... Grzeschik SM, Ganta M, Prior TW, Heavlin WD, Wang CH (August 2005). "Hydroxyurea enhances SMN2 gene expression in spinal ... placebo-controlled trial of hydroxyurea in spinal muscular atrophy". Neurology. 75 (24): 2190-7. doi:10.1212/WNL. ...
For example, it is used to prepare the drug hydroxyurea. It is also used for the heat treatment of metals (e.g., Ferritic ...
Brawley, Otis W. (2008-06-17). "National Institutes of Health Consensus Development Conference Statement: Hydroxyurea Treatment ... hydroxyurea treatment for sickle cell disease." "Introduction to special issue: advancing the ethics of community-based ... "NIH consensus development statement on hydroxyurea treatment for sickle cell disease". NIH Consensus and State-of-the-science ... "NIH consensus development statement on hydroxyurea treatment for sickle cell disease." "National Institutes of Health Consensus ...
Examples of substances under this schedule: Testolactone, Hydroxyurea, Carbutamide, Primidone etc. Schedule H: The drug label ...
Hydroxyurea had previously been used as a chemotherapy agent, and some concern exists that long-term use may be harmful, but ... Hydroxyurea and phlebotomy combined may be more effective than transfusion and chelation combined in terms of pain, life- ... Hydroxyurea, also known as hydroxycarbamide, probably reduces the frequency of painful episodes and the risk of life- ... Guidelines from NIH published in 2014 state that all children and adolescents should take hydroxyurea, as should adults with ...
The primary treatment consists of anagrelide or hydroxyurea to lower platelet levels. Congenital amegakaryocytic ...
The starting dose was lower for participants who were transitioning from hydroxyurea. The trial was conducted at six sites ...
Rodgers G. "Hydroxyurea and other disease-modifying therapies in sickle cell disease". UpToDate. Archived from the original on ...
"1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea". chemspider.com. Retrieved 24 December 2015. Marr KA, Lees P, ...
Cytokinetic analysis of L1210 leukemia after continuous infusion of hydroxyurea in vivo Straus, Marc J., Vivian Sege, and Sung ... "Synchronization of L1210 leukemia with hydroxyurea infusion and the effect of subsequent pulse dose chemotherapy." Cancer Treat ... "Cytokinetic analysis of L1210 leukemia after continuous infusion of hydroxyurea in vivo." Cancer research 39.5 (1979): 1616- ...
Hydroxyurea is also used to treat certain types of cancer and blood disorders. Aphidocolin is a fungus-derived tetracyclic ... Hydroxyurea decreases the production of dNTPs by inhibiting the enzyme ribonucleotide reductase. This serves to halt DNA ... "Hydroxyurea Arrests DNA Replication by a Mechanism That Preserves Basal dNTP Pools". Journal of Biological Chemistry. 279 (1): ...
Hydroxyurea is used to increase the amount of fetal hemoglobin in an adult. The fetal hemoglobin levels drop within 6 months of ...
Najean Y, Rain JD (November 1997). "Treatment of polycythemia vera: the use of hydroxyurea and pipobroman in 292 patients under ... Dexamethasone, alpha-interferon and hydroxyurea (also known as hydroxycarbamide) may play a role. Lenalidomide and thalidomide ... the development of myelofibrosis following these disorders may be accelerated by the oral chemotherapy drug hydroxyurea. The ...
The drugs hydroxyurea and Motexafin gadolinium interfere with the action of this enzyme. Elledge SJ, Zhou Z, Allen JB (March ... "Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea". The Journal of Biological ...
Patients may receive hydroxyurea to induce the protective effects of increased fetal hemoglobin production. They may also ...
Noguchi has studied hydroxyurea and hemoglobin, showing that hydroxyurea can increase a form of fetal hemoglobin in sickle cell ... "Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase". Journal of Clinical ...