... human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor ...

... hydroxymethylglutaryl-coa reductase inhibitors MeSH D27.505.519.389.375 - integrase inhibitors MeSH D27.505.519.389.375.400 - ... hydroxymethylglutaryl-coa reductase inhibitors MeSH D27.505.519.186.071.601 - lipotropic agents MeSH D27.505.519.186.144 - ... hydroxymethylglutaryl-coa reductase inhibitors MeSH D27.505.954.230.601 - lipotropic agents MeSH D27.505.954.248 - ... enzyme inhibitors MeSH D27.505.519.389.099 - aromatase inhibitors MeSH D27.505.519.389.200 - carbonic anhydrase inhibitors MeSH ...

Hydroxymethylglutaryl-coenzyme A reductase inhibitors (HMG-CoA inhibitors or statins) Statins may sometimes cause myalgia and ...

... pravastatin inhibits the function of hydroxymethylglutaryl-CoA (HMG-CoA) reductase. As a reversible competitive inhibitor, ... Tobert JA (July 2003). "Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors". Nature Reviews. Drug Discovery ... Like all statins, pravastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver that plays a role in producing ... pravastatin sterically hinders the action of HMG-CoA reductase by occupying the active site of the enzyme. Taking place ...

The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the ... Moghadasian, Mohammed H. (May 1999). "Clinical pharmacology of 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors". Life ... Tobert, Jonathan A. (July 2003). "Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors". Nature Reviews Drug ... Endo, Akira (November 1, 1992). "The Discovery and development of HMG-CoA reductase inhibitors". Journal of Lipid Research. 33 ...

... is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the ... July 1980). "Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol- ... The first breakthrough in efforts to find a potent, specific, competitive inhibitor of HMG CoA reductase occurred in 1976, when ... Lovastatin was the first specific inhibitor of HMG CoA reductase to receive approval for the treatment of hypercholesterolemia ...

Statins competitively inhibit hydroxymethylglutaryl (HMG) CoA reductase which is used in the biosynthesis of cholesterol and ... Sabatine, Marc S. (March 2019). "PCSK9 inhibitors: clinical evidence and implementation". Nature Reviews Cardiology. 16 (3): ... Istvan, Eva S.; Deisenhofer, Johann (2001-05-11). "Structural Mechanism for Statin Inhibition of HMG-CoA Reductase". Science. ... PCSK9 inhibitors are monoclonal antibodies that target an important protein in the degradation of LDL called proprotein ...

... and mononuclear leukocyte hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA reductase), the rate-controlling enzyme in the ... In October 2002, a new cholesterol absorption inhibitor, ezetimibe, received US Food and Drug Administration (FDA) approval for ... recent data indicate that secondary effects of unknown regulators other than sitosterol can lead to reduced HMG-CoA reductase ...

"On the Inhibitor Effects of Bergamot Juice Flavonoids Binding to the 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGR) Enzyme". J ... Isolation of 3-Hydroxymethylglutaryl Flavonoid Glycosides". Journal of Natural Products. 72 (7): 1352-1354. doi:10.1021/ ...

"On the Inhibitor Effects of Bergamot Juice Flavonoids Binding to the 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGR) Enzyme". J ... Isolation of 3-Hydroxymethylglutaryl Flavonoid Glycosides". Journal of Natural Products. 72 (7): 1352-1354. doi:10.1021/ ...

Statins act by inhibiting the enzyme hydroxymethylglutaryl CoA reductase (HMG-CoA-reductase) in the liver. In response, the ... Lomitapide, an inhibitor of the microsomal triglyceride transfer protein, was approved by the US FDA in December 2012 as an ... Synthesis of cholesterol by the liver is suppressed in the HMG-CoA reductase pathway. In FH, LDL receptor function is reduced ... Initially, they found increased activity of HMG-CoA reductase, but studies showed that this did not explain the very abnormal ...