HMG-CoA reductase: HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, ; NADPH-dependent, ) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol.StatinLovastatinHMG-CoAList of important publications in medicine: The definitive bibliographic source of books and articles demonstrating the history of medicine and identifying the first publications in the field is "Garrison and Morton". (Morton, Leslie T.CholesterolPyrroleNitrate reductase (NADPH): Nitrate reductase (NADPH) (, assimilatory nitrate reductase, assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase, NADPH-nitrate reductase, assimilatory NADPH-nitrate reductase, triphosphopyridine nucleotide-nitrate reductase, NADPH:nitrate reductase, nitrate reductase (NADPH2), NADPH2:nitrate oxidoreductase) is an enzyme with system name nitrite:NADP+ oxidoreductase. This enzyme catalises the following chemical reactionCholestyramineRibonucleotide: In biochemistry, a ribonucleotide or ribotide is a nucleotide containing ribose as its pentose component. It is considered a molecular precursor of nucleic acids.PravastatinSterol carrier protein: A:437-540 A:437-540 A:628-731Cytochrome b5 reductaseUndecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase: Undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase (, PglC) is an enzyme with system name UDP-N,N'-diacetylbacillosamine:tritrans,heptacis-undecaprenyl-phosphate N,N'-diacetylbacillosamine transferase. This enzyme catalyses the following chemical reactionFMN reductase (NADPH): FMN reductase (NADPH) (, FRP, flavin reductase P, SsuE) is an enzyme with system name FMNH2:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction:Thioredoxin reductaseDolichol kinase deficiency: Dolichol kinase deficiency is a cutaneous condition caused by a mutation in the dolichol kinase gene.Glucose-methanol-choline oxidoreductase family: In molecular biology, the glucose-methanol-choline oxidoreductase family (GMC oxidoreductase) is a family of enzymes with oxidoreductase activity.FnrS RNA: FnrS RNA is a family of Hfq-binding small RNA whose expression is upregulated in response to anaerobic conditions. It is named FnrS because its expression is strongly dependent on fumarate and nitrate reductase regulator (FNR), a direct oxygen availability sensor.Butyric anhydrideFlavoprotein pyridine nucleotide cytochrome reductases: A:229-424 A:229-424 A:985-1214Microsome: In cell biology, microsomes are vesicle-like artifacts re-formed from pieces of the endoplasmic reticulum (ER) when eukaryotic cells are broken-up in the laboratory; microsomes are not present in healthy, living cells.Liver sinusoid: A liver sinusoid is a type of sinusoidal blood vessel (with fenestrated, discontinuous endothelium) that serves as a location for the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.SIU SOM Histology GIHMG-CoA synthase: In molecular biology, HMG-CoA synthase is an enzyme which catalyzes the reaction in which Acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). It is the second reaction in the mevalonate-dependent isoprenoid biosynthesis pathway.Prenylation: Prenylation (also known as isoprenylation or lipidation) is the addition of hydrophobic molecules to a protein or chemical compound. It is usually assumed that prenyl groups (3-methyl-but-2-en-1-yl) facilitate attachment to cell membranes, similar to lipid anchors like the GPI anchor, though direct evidence is missing.Lipokine: A lipokine is a lipid-controlling hormone. The term "lipokine" was first used by Haiming Cao in 2008 to classify fatty acids which modulate lipid metabolism by what he called a "chaperone effect".Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".Dihydrofolate reductaseCholesterol 7 alpha-hydroxylase: Cholesterol 7 alpha-hydroxylase also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1) is an enzyme that in humans is encoded by the CYP7A1 gene which has an important role in cholesterol metabolism .It is a cytochrome P450 enzyme, which belongs to the oxidoreductase class, and converts cholesterol to 7-alpha-hydroxycholesterol, the first and rate limiting step in bile acid synthesis.Plant stanols: Plant stanols are like cholesterol but for plants. They are commonly found in plant related foods.Methylenetetrahydrofolate reductase: Methylene tetrahydrofolate reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene. Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine.Coles PhillipsMethionine sulfoxideGeranylgeranyl diphosphate reductase: Geranylgeranyl diphosphate reductase (, geranylgeranyl reductase, CHL P) is an enzyme with system name geranylgeranyl-diphosphate:NADP+ oxidoreductase. This enzyme catalises the following chemical reactionYWTD domain of low-density lipoprotein receptor: The low-density lipoprotein receptor (LDLR) regulates cholesterol homeostasis in mammalian cells. LDLR binds cholesterol-carrying LDL, associates with clathrin-coated pits, and is internalized into acidic endosomes where it separates from its ligand.Bile acid malabsorptionSulfide:quinone reductase: Sulfide:quinone reductase () is an enzyme with system name sulfide:quinone oxidoreductase. This enzyme catalyses the following chemical reaction