Histidine-tRNA ligase
... belongs to the family of ligase enzymes, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA ... In enzymology, a histidine-tRNA ligase (EC 6.1.1.21) is an enzyme that catalyzes the chemical reaction ATP + L-histidine + ... L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His). This enzyme participates in ... The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include ...
Anti-Jo1
It has histidine-tRNA ligase as a target. Gutiérrez-Ramos R; Gonzalez-Díaz V; Pacheco-Tovar MG; López-Luna A; Avalos-Díaz E; ...
HARS
Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene. ... Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this ... "Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on ... Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (2002). "Interaction network of human aminoacyl-tRNA synthetases and ...
Margalitia
... have been identified through genomic analysis as exclusive for this genus in the proteins histidine tRNA ligase and peptide ...
Morganellaceae
... histidine-tRNA ligase, and N-acetylmuramoyl-L-alanine amidase. These molecular signatures provide a novel and reliable means of ...
Dermatomyositis
... including antibodies against histidine-tRNA ligase (Anti-Jo1); antibodies to signal recognition particle (SRP); and anti-Mi-2 ... of people have myositis-specific autoantibodies which include antibodies to aminoacyl-tRNA synthetases (anti-synthetase ...
His-tag
The fluorinated analog is incorporated into peptides via the relaxed substrate specificity of histidine-tRNA ligase and lowers ... Histidine or histamine can also be used. Decrease in pH When the pH decreases, the histidine residue is protonated and can no ... It is also known as a hexa histidine-tag, 6xHis-tag, or His6 tag. The tag was invented by Roche, although the use of histidines ... Polyhistidine tags most commonly consist of six histidine residues. Tags with up to twelve histidine residues or dual tags ...
Erwiniaceae
... two-component sensor histidine kinase, RNA helicase, tRNA pseudouridine(13) synthase TruD, glycine/betaine ABC transporter ATP- ... were identified through genomic analyses as exclusive for this family in the proteins glutamate-cysteine ligase, DNA gyrase ( ...
List of EC numbers (EC 6)
... glutamine-tRNA ligase EC 6.1.1.19: arginine-tRNA ligase EC 6.1.1.20: phenylalanine-tRNA ligase EC 6.1.1.21: histidine-tRNA ... threonine-tRNA ligase EC 6.1.1.4: leucine-tRNA ligase EC 6.1.1.5: isoleucine-tRNA ligase EC 6.1.1.6: lysine-tRNA ligase EC 6.1. ... valine-tRNA ligase EC 6.1.1.10: methionine-tRNA ligase EC 6.1.1.11: serine-tRNA ligase EC 6.1.1.12: aspartate-tRNA ligase EC ... glycine-tRNA ligase EC 6.1.1.15: proline-tRNA ligase EC 6.1.1.16: cysteine-tRNA ligase EC 6.1.1.17: glutamate-tRNA ligase EC ...
List of MeSH codes (D08)
... glutamate-trna ligase MeSH D08.811.464.263.200.350 - glycine-trna ligase MeSH D08.811.464.263.200.400 - histidine-trna ligase ... alanine-tRNA ligase MeSH D08.811.464.263.200.100 - arginine-tRNA ligase MeSH D08.811.464.263.200.150 - aspartate-tRNA ligase ... isoleucine-trna ligase MeSH D08.811.464.263.200.500 - leucine-trna ligase MeSH D08.811.464.263.200.550 - lysine-trna ligase ... serine-trna ligase MeSH D08.811.464.263.200.800 - threonine-tRNA ligase MeSH D08.811.464.263.200.850 - tryptophan-tRNA ligase ...
Guanylyltransferase
The transfer RNA (tRNA) for histidine is unique among eukaryotic tRNAs in requiring the addition of a guanine nucleotide before ... similarity to the nucleotidyl attachment motif of DNA and RNA ligases. Proc Natl Acad Sci USA 91(14): 6624-6628. Jackman JE, ... being aminoacylated by the histidine tRNA synthetase. The yeast guanylyl transferase specific to tRNAHis is unique in being the ... only known non-tRNA synthetase enzyme that specifically recognizes the tRNA anticodon. Guanylyl transferases also exist for ...
Parkin (protein)
... p38 tRNA synthase, Pael-R, synaptotagmin XI, sp22 and parkin itself (see also ubiquitin ligase). Additionally, parkin contains ... Ub transfer is aided by neighbouring residues histidine His433, which accepts a proton from Cys431 to activate it, and ... "Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases". Nature Communications. 4: 1982 ... Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin ...
List of EC numbers (EC 2)
... glutamate-tRNA ligase, EC 1.2.1.70, glutamyl-tRNA reductase and EC 5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase EC 2.7.2.14 ... protein-histidine pros-kinase EC 2.7.13.2: protein-histidine tele-kinase EC 2.7.13.3: histidine kinase EC 2.7.14.1: protein ... tRNA (guanine46-N7)-methyltransferase EC 2.1.1.34: tRNA (guanosine18-2′-O)-methyltransferase EC 2.1.1.35: tRNA (uracil54-C5)- ... tRNA (guanine110-N2)-dimethyltransferase EC 2.1.1.214: tRNA (guanine10-N2)-methyltransferase EC 2.1.1.215: tRNA (guanine26-N2/ ...
List of biomolecules
... tRNA) Triacsin C Thyroid-stimulating hormone (TSH) Thyrotropin-releasing hormone (TRH) Thyroxine (T4) Tocopherol (Vitamin E) ... HDL Histamine Histidine Histone Histone methyltransferase HLA antigen Homocysteine Hormone human chorionic gonadotropin (hCG) ... Lactase Lactic acid Lactose Lanolin Lauric acid Lectin Leptin Leptomycin B Leucine Leukotriene Ligase Lignin Limonene Linalool ... Dextran Dextrin Dicer Dihydrotestosterone DNA DNA polymerase DNA ligase Dopamine Endonuclease Enzyme Ephedrine Epinephrine - ...
Chromosome 19
Gene map locus 19q13.2 FCGBP: Fc fragment of IgG binding protein SARS2: seryl-tRNA synthetase 2, mitochondrial. Gene map locus ... encoding enzyme Long-chain-fatty-acid-CoA ligase ANKRD24: encoding protein Ankyrin repeat domain-containing protein 24 ARMC6: ... encoding protein Sarcoplasmic reticulum histidine-rich calcium-binding protein IFI30: encoding enzyme Gamma-interferon- ... "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) ...
Ribozyme
... which is responsible for conversion of a precursor tRNA into the active tRNA. Much to their surprise, they found that RNase-P ... In comparison, RNase A, a protein that catalyzes the same reaction, uses a coordinating histidine and lysine to act as a base ... Mutagenesis and selection has been performed on an RNA ligase ribozyme from a large pool of random RNA sequences, resulting in ... At about the same time, Sidney Altman, a professor at Yale University, was studying the way tRNA molecules are processed in the ...
List of EC numbers (EC 4)
... histidine ammonia-lyase EC 4.3.1.4: formiminotetrahydrofolate cyclodeaminase EC 4.3.1.5: Now divided into EC 4.3.1.23 (tyrosine ... tRNA-intron lyase EC 4.6.1.17: cyclic pyranopterin monophosphate synthase * EC 4.6.1.18: pancreatic ribonuclease * EC 4.6.1.19 ... heme ligase EC 4.99.1.9:: coproporphyrin ferrochelatase * EC 4.99.1.10: magnesium dechelatase * EC 4.99.1.11: sirohydrochlorin ... tRNA 4-demethylwyosine synthase (AdoMet-dependent) * EC 4.1.3.45: 3-hydroxybenzoate synthase * EC 4.1.3.46: (R)-citramalyl-CoA ...
TRNA-intron endonuclease
Active sites of tRNA-intron lyase are composed of tyrosine, histidine and lysine. Eukaryotes and archaea function similarly and ... Popow J, Schleiffer A, Martinez J (August 2012). "Diversity and roles of (t)RNA ligases". Cellular and Molecular Life Sciences ... The use of tRNA-intron endonuclease in pre-tRNA intron excision is just one of the steps for tRNA maturation. pre-tRNAs undergo ... tRNA-intron lyase (EC 4.6.1.16, tRNA intron endonuclease, transfer ribonucleate intron endoribonuclease, tRNA splicing ...
Glyceraldehyde 3-phosphate dehydrogenase
... tRNA, Hepatitis A viral RNA, Hepatitis B viral RNA, Hepatitis C viral RNA, HPIV3, lymphokine mRNA, IFN-γ mRNA, JEV mRNA, and ... a ubiquitin ligase. The complex moves into the nucleus where Siah1 targets nuclear proteins for degradation, thus initiating ... The hemithioacetal is deprotonated by a histidine residue in the enzyme's active site (general base catalysis). Deprotonation ... nuclear tRNA transport, DNA replication, and DNA repair. In addition, nuclear translocation of GAPDH has been reported in ...
Translocase
This entry comprises bacterial enzymes that import Histidine, Arginine, Lysine, Glutamine, Glutamate, Aspartate, ornithine, ... and ligases (EC 6). However, it became apparent that none of these could describe the important group of enzymes that catalyse ... tRNA) and messenger RNA (mRNA) through the ribosome. The enzyme classification and nomenclature list was first approved by the ...
Biosynthesis
... tRNA ↽ − − ⇀ aminoacyl − tRNA + AMP {\displaystyle {\ce {{Aminoacyl-AMP}+ tRNA <=> {aminoacyl-tRNA}+ AMP}}} The combination of ... Okazaki fragments are covalently joined by DNA ligase to form a continuous strand. Then, to complete DNA replication, RNA ... threonine and tryptophan for adults and histidine, and arginine for babies are obtained through diet. The general structure of ... This reaction, called tRNA charging, is catalyzed by aminoacyl tRNA synthetase. A specific tRNA synthetase is responsible for ...
Metalysinibacillus
... cysteine-tRNA ligase, coproporphyrinogen III oxidase, and PBP1A family penicillin-binding protein. These molecular signatures ... sensor histidine kinase YycG, hypothetical proteins, ribonuclease Y, cell division protein FtsA, ABC transporter ATP- binding ... tRNA preQ1(34)S-adenosylmethionine ribosyltransferase-isomerase QueA, DNA primase, FMN reductase (NADPH), UvrABC system protein ...
RTCB
The bacterial RtcB acts as a tRNA ligase, rejoining broken stem-loops in case of damage. It is also able to catalyse RNA ... "Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation". Biochemistry. 52 (15): 2518-25 ... Tanaka N, Meineke B, Shuman S (September 2011). "RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in ... The eukaryotic homologs of RtcB, including the human RTCB protein, participates in the tRNA-splicing ligase complex. GRCh38: ...
Karelsulcia muelleri
... the phenylalanine-tRNA ligase beta-subunit, VARS, elongation factor Tu, the RNA polymerase beta-subunit, and the ribosomal ... It receives its other two amino acids - methionine and histidine from either its host or its co-symbiont. Sulcia muelleri is ... K. muelleri" lacks a full set of Aminoacyl tRNA synthetases; surprisingly, however, it possesses all of the genes necessary to ... The proteins used were the DNA polymerase III beta-subunit, initiation factor IF-2, leucyl-tRNA synthetase, ...
Enzyme
For instance, two ligases of the same EC number that catalyze exactly the same reaction can have completely different sequences ... Ibba M, Soll D (2000). "Aminoacyl-tRNA synthesis". Annual Review of Biochemistry. 69: 617-650. doi:10.1146/annurev.biochem.69.1 ... February 2005). "Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human ... Rodnina MV, Wintermeyer W (2001). "Fidelity of aminoacyl-tRNA selection on the ribosome: kinetic and structural mechanisms". ...