Hepatocyte nuclear factors Hepatocyte nuclear factor 4A Chartier FL, Bossu JP, Laudet V, Fruchart JC, Laine B (1994). "Cloning ... Hepatocyte+Nuclear+Factor+4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic ... "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure. 10 (9): 1225-34. doi: ...
... including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. ... "The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms ... dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4". ... "Entrez Gene: HNF4A hepatocyte nuclear factor 4, alpha". Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan ...
... is a nuclear receptor that in humans is encoded by the HNF4G gene. Hepatocyte nuclear factor 4 Hepatocyte nuclear factors ... "Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma". Drewes T, Senkel S, Holewa B, Ryffel GU (March 1996). "Human hepatocyte ... Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) ... Ozeki T, Takahashi Y, Nakayama K, Funayama M, Nagashima K, Kodama T, Kamataki T (January 2003). "Hepatocyte nuclear factor-4 ...
Wang JC, Stafford JM, Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4". J. Biol. ... GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1). Nuclear ... "Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of ... The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is ...
Wang JC, Stafford JM, Granner DK (1998). "SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4". J. Biol. ... The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is ... nuclear receptor coactivator 3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) NURSA C91 Liao L, Kuang ... Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression. The ratio of PAX2 to AIB-1 protein expression ...
PAK1 Hepatocyte nuclear factor 4 alpha India portal Biology portal Irudayaraj (16 January 2019). "Indian Institute of ... a potent inhibitor of the transcription factor HNF4A, suppresses tumorigenicity of head and neck squamous cell carcinoma in ...
Li X, Jiang H, Qu L, Yao W, Cai H, Chen L, Peng T (January 2014). "Hepatocyte nuclear factor 4α and downstream secreted ... Guan M, Qu L, Tan W, Chen L, Wong CW (February 2011). "Hepatocyte nuclear factor-4 α regulates liver triglyceride metabolism in ... also known as platelet activating factor acetylhydrolase (PAF-AH). The extracellular forms of phospholipases A2 have been ... 76 (4): 471-474. doi:10.1016/j.ijporl.2011.12.026. PMID 22297210. Henderson WR, Oslund RC, Bollinger JG, Ye X, Tien YT, Xue J, ...
The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1). Mutations of the ... Milatovich A, Mendel DB, Crabtree GR, Francke U (April 1993). "Genes for the dimerization cofactor of hepatocyte nuclear factor ... "Studies on the enzymatic and transcriptional activity of the dimerization cofactor for hepatocyte nuclear factor 1". ... Pterin-4-alpha-carbinolamine dehydratase is an enzyme that in humans is encoded by the PCBD1 gene. This gene encodes pterin-4 ...
Pterin-4-alpha-carbinolamine dehydratase 2 is an enzyme that in humans is encoded by the PCBD2 gene. GRCh38: Ensembl release 89 ... "Entrez Gene: PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 ...
This gene codes for hepatocyte nuclear factor 4-alpha (HNF4-α) protein also known as transcription factor 14 (TCF14). HNF4α ...
... dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4". ... Hepatocyte nuclear factor 4 alpha, P53, PPARGC1A, PPARG, TGS1, and Thyroid hormone receptor alpha. This entry represents ... These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The mediator of ... Maeda Y, Rachez C, Hawel L, Byus CV, Freedman LP, Sladek FM (July 2002). "Polyamines modulate the interaction between nuclear ...
"The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms ... "The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms ... SHP is a member of the nuclear receptor family of intracellular transcription factors. SHP is unusual for a nuclear receptor in ... Hepatocyte nuclear factor 4 alpha, Liver receptor homolog-1, Liver X receptor alpha, Peroxisome proliferator-activated receptor ...
"The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms ... Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ...
"The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms ... Baes, M; Gulick, T; Choi, H S; Martinoli, M G; Simha, D; Moore, D D (March 1994). "A new orphan member of the nuclear hormone ... There, he identified the bile acid and xenobiotic ligands of farnesoid X-receptor, an orphan nuclear receptor he had first ... The discovery of bile acid ligands for FXR led Moore and colleagues to demonstrate a strong link between nuclear hormone ...
... dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4". ... dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4". ... Glucocorticoid receptor and Hepatocyte nuclear factor 4 alpha. GRCh38: Ensembl release 89: ENSG00000180182 - Ensembl, May 2017 ... These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein ...
... and Hepatocyte nuclear factor 4 alpha. Testicular receptor GRCh38: Ensembl release 89: ENSG00000177463 - Ensembl, May 2017 ... Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (Jul 1996). "New variants of the human and rat nuclear hormone receptor, ... Young WJ, Smith SM, Chang C (Jan 1997). "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor ( ... Lee CH, Chinpaisal C, Wei LN (Sep 1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 ...
2004). "SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic ... by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators". Mol. Cell. Biol. 25 (4): 1354-66. doi:10.1128/ ... a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 ( ... Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells". Mol Cell Biol. 21 (11 ...
In a study of embryonic liver samples lacking hepatocyte nuclear factor 4 alpha (HNF4α), the expression of C2orf72 was ... 73 (4): 830-844.e12. doi:10.1016/j.molcel.2018.12.001. PMC 6386588. PMID 30639242. Bruening J, Lasswitz L, Banse P, Kahl S, ...
1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth ... Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein ... "Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like)". Han S, Stuart LA, Degen SJ (1991). " ... identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein". DNA Seq. 8 (6): 409-13. doi:10.3109/ ...
The mechanism of activating the promoter for SHBG in the liver involves hepatocyte nuclear factor 4 alpha (HNF4A) binding to a ... hepatocyte nuclear factor 4. Reference ranges for blood tests for SHBG have been developed: SHBG levels are decreased by ... "Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor- ... Simó R, Barbosa-Desongles A, Lecube A, Hernandez C, Selva DM (February 2012). "Potential role of tumor necrosis factor-α in ...
"Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP ... COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that ... "The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral ... "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1". Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson ...
HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene ... "Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta ... HNF1B encodes hepatocyte nuclear factor 1-beta, a protein of the homeobox-containing basic helix-turn-helix family. The HNF1B ... 1999). "Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification". Development. 126 (21): 4795-4805 ...
In the liver, AMPK inhibits gluconeogenesis by inhibiting transcription factors including hepatocyte nuclear factor 4 (HNF4) ... it enhances the activity of transcription factors like nuclear respiratory factor 1 (NRF-1), myocyte enhancer factor 2 (MEF2), ... myocyte enhancer factor 2 (MEF2) and GLUT4 enhancer factor (GEF). Mutations in the DNA binding regions for either of these ... It is also regulated by several protein-protein interactions, and may either be activated or inhibited by oxidative factors; ...
Song KH, Li T, Chiang JY (2006). "A prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4 ... "The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes ... 2002). "The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues". FASEB ... 2002). "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor". EMBO J ...
... and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells". Mol. Cell. Biol. ... Sato Y, Suzuki T, Hidaka K, Sato H, Ito K, Ito S, Sasano H (2003). "Immunolocalization of nuclear transcription factors, DAX-1 ... COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein ... "The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis ...
Ozeki T, Takahashi Y, Nakayama K, Kamataki T (September 2002). "Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and ... Ozeki T, Takahashi Y, Nakayama K, Funayama M, Nagashima K, Kodama T, Kamataki T (January 2003). "Hepatocyte nuclear factor-4 ... alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human ... 1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha". The Biochemical Journal. 355 (Pt 2): 537-44. doi: ...
"Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain ... Murphy DB, Seemann S, Wiese S, Kirschner R, Grzeschik KH, Thies U (March 1997). "The human hepatocyte nuclear factor 3/fork ... Hackett BP, Brody SL, Liang M, Zeitz ID, Bruns LA, Gitlin JD (May 1995). "Primary structure of hepatocyte nuclear factor/ ... You Y, Huang T, Richer EJ, Schmidt JE, Zabner J, Borok Z, Brody SL (April 2004). "Role of f-box factor foxj1 in differentiation ...
... hepatocyte nuclear factor 4, alpha (HNF4A), leukocyte receptor cluster member 1 (LENG1), and ubiquitin C (UBC). Expression of ... However, the protein has a 7.9% basic residue content and a nuclear localization signal (NLS) score of -0.47. Additionally, ... SUMOylation is involved in transcriptional regulation, protein stability, apoptosis, nuclear-cytosolic transport, progression ... there are a number of transcription factor binding sites associated with this promoter sequence, such as RB1, HNF4A, ETS1, and ...
6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) PCDH15: protocadherin 15 ... nuclear receptor-binding factor 2 NSMCE4A: non-SMC element 4 homolog A OTUD1: encoding protein OTU deubiquitinase 1 PAPSS2: ... fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1 ... eukaryotic translation initiation factor 5A-like 1 EPC1: Enhancer of polycomb homolog 1 ERCC6: excision repair cross- ...
"Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. It is ... Luo Z, Li Y, Wang H, Fleming J, Li M, Kang Y, Zhang R, Li D (2015-01-01). "Hepatocyte nuclear factor 1A (HNF1A) as a possible ...