Hepatocyte nuclear factor 4 alpha
... (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear ... Hepatocyte nuclear factor 4 Hepatocyte nuclear factors GRCh38: Ensembl release 89: ENSG00000101076 - Ensembl, May 2017 GRCm38: ... including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. ... "Entrez Gene: HNF4A hepatocyte nuclear factor 4, alpha". Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan ...
FOXA2
"Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes". ... "Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte". ... "The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific ... Lau HH, Ng NH, Loo LS, Jasmen JB, Teo AK (May 2018). "The molecular functions of hepatocyte nuclear factors - In and beyond the ...
MODY 1
This gene codes for hepatocyte nuclear factor 4-alpha (HNF4-α) protein also known as transcription factor 14 (TCF14). HNF4α ... Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE (2002). "Crystal structure of the HNF4 alpha ligand binding domain in ... controls function of HNF1α (see MODY 3; HNF1A) and perhaps HNF1β (MODY 5) as well. This transcription network plays a role in ...
FOXI1
... regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma". ... "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain ... This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The ... "The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, ...
FOXA3
... regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma". Mol ... "Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte- ... Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) ... 2005). "A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, ...
SUB1
Guo H, Cai CQ, Kuo PC (February 2002). "Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide ... Like SUB1, alpha-synuclein functions in regulating DNA repair including repair of DNA double-strand breaks. SUB1 has been shown ... July 2019). "Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders". ... Swietlicki E, Iordanov H, Fritsch C, Yi L, Levin MS, Rubin DC (2003). "Growth factor regulation of PC4/TIS7, an immediate early ...
HNF1A
"HNF1A - Hepatocyte nuclear factor 1-alpha - Homo sapiens (Human) - HNF1A gene & protein". www.uniprot.org. Retrieved 2016-10-11 ... "Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. It is ...
FOXA1
Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is ... Lee HJ, Chattopadhyay S, Yoon WH, Bahk JY, Kim TH, Kang HS, Lee K (March 2010). "Overexpression of hepatocyte nuclear factor- ... These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and ... Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3- ...
PCBD2
"Entrez Gene: PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 ... Pterin-4-alpha-carbinolamine dehydratase 2 is an enzyme that in humans is encoded by the PCBD2 gene. GRCh38: Ensembl release 89 ... 11 (3): 422-35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein- ... 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. v t e (Articles with short description, Short description ...
C2orf72
In a study of embryonic liver samples lacking hepatocyte nuclear factor 4 alpha (HNF4α), the expression of C2orf72 was ... miR-1271-5p is a microRNA that could bind to the 3′ untranslated region of the C2orf72 mRNA transcript at 5′-...GUGCCAA...-3′. ...
3α-Hydroxysteroid dehydrogenase
"Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ... Ozeki T, Takahashi Y, Nakayama K, Kamataki T (September 2002). "Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and ... 1C4 gene by hepatocyte nuclear factor (HNF)-4alpha/gamma and HNF-1alpha". The Biochemical Journal. 355 (Pt 2): 537-44. doi: ... 3α-Hydroxysteroid dehydrogenase (3α-HSD or aldo-keto reductase family 1 member C4) is an enzyme that in humans is encoded by ...
Chromosome 10
6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) PCDH15: protocadherin 15 ... nuclear receptor-binding factor 2 NSMCE4A: non-SMC element 4 homolog A OTUD1: encoding protein OTU deubiquitinase 1 PAPSS2: ... fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1 ... PI4K2A: phosphatidylinositol 4-kinase 2-alpha PIP4K2A: phosphatidylinositol 5 phosphate 4-kinase type-2 alpha PITRM1: ...
ISLR
Myeloid zinc finger 1 factor (MZF1) Nuclear factor of activated T-cells Hepatocyte nuclear factor 3 (alpha, beta) (FOXA1, FOXA2 ... Homeodomain factor Nkx-2.5/Csx Estrogen-related receptor alpha (secondary DNA binding preference) Early B-cell factor 1 (Neuron ... Of all the predicted alpha helices, three alpha helices at 5-15 aa, 189-195 aa, and 214-216 aa were identified with high ... two SMAD factors, sine oculis homeobox (SIX), heat shock factor (HSF), PRDM, Snail, and cell cycles gene homology region (CHR ...
List of MeSH codes (D12.776.930)
... hepatocyte nuclear factor 1-alpha MeSH D12.776.930.323.500.750 - hepatocyte nuclear factor 1-beta MeSH D12.776.930.354.249.500 ... core binding factor alpha 1 subunit MeSH D12.776.930.155.200.200 - core binding factor alpha 2 subunit MeSH D12.776.930.155. ... hepatocyte nuclear factor 3-beta MeSH D12.776.930.977.249.875 - hepatocyte nuclear factor 3-gamma The list continues at List of ... aryl hydrocarbon receptor nuclear translocator MeSH D12.776.930.125.625.750 - hypoxia-inducible factor 1, alpha subunit MeSH ...
RAC3
yes Soutoglou E, Papafotiou G, Katrakili N, Talianidis I (April 2000). "Transcriptional activation by hepatocyte nuclear factor ... "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion ... Soutoglou E, Papafotiou G, Katrakili N, Talianidis I (April 2000). "Transcriptional activation by hepatocyte nuclear factor-1 ... yes Kim JH, Yu S, Chen JD, Kong AN (January 2013). "The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting ...
5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
... roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha". Biochimica et Biophysica Acta (BBA) - ... 1634 (3): 86-96. doi:10.1016/j.bbalip.2003.09.002. PMID 14643796. Lukacin R, Matern U, Junghanns KT, Heskamp ML, Britsch L, ... whereas its 3 products are 5beta-cholestane-3alpha,7alpha,12alpha-triol, NADP+, and H2O. This enzyme belongs to the family of ...
Small heterodimer partner
Hepatocyte nuclear factor 4 alpha, Liver receptor homolog-1, Liver X receptor alpha, Peroxisome proliferator-activated receptor ... "The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms ... "The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms ... SHP is a member of the nuclear receptor family of intracellular transcription factors. SHP is unusual for a nuclear receptor in ...
PCBD1
"Entrez Gene: PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1 ... The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1). Mutations of the ... "Genes for the dimerization cofactor of hepatocyte nuclear factor-1 alpha (DCOH) are on human and murine chromosomes 10". ... "Studies on the enzymatic and transcriptional activity of the dimerization cofactor for hepatocyte nuclear factor 1". ...
HNF1B
HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene ... Mendel DB, Hansen LP, Graves MK, Conley PB, Crabtree GR (1991). "HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and ... "Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta ... HNF1B encodes hepatocyte nuclear factor 1-beta, a protein of the homeobox-containing basic helix-turn-helix family. The HNF1B ...
PPRC1
2004). "SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic ... by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators". Mol. Cell. Biol. 25 (4): 1354-66. doi:10.1128/ ... a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 ( ... Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells". Mol Cell Biol. 21 (11 ...
List of MeSH codes (D12.776.260)
... hepatocyte nuclear factor 1-alpha MeSH D12.776.260.262.500.750 - hepatocyte nuclear factor 1-beta MeSH D12.776.260.400.249.249 ... serum response factor MeSH D12.776.260.400.624.500 - hepatocyte nuclear factor 6 MeSH D12.776.260.522.750.249 - sp1 ... hepatocyte nuclear factor 3-beta MeSH D12.776.260.950.249.875 - hepatocyte nuclear factor 3-gamma The list continues at List of ... aryl hydrocarbon receptor nuclear translocator MeSH D12.776.260.103.625.750 - hypoxia-inducible factor 1, alpha subunit MeSH ...
Hepatocyte nuclear factor 4 gamma
"Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ... is a nuclear receptor that in humans is encoded by the HNF4G gene. Hepatocyte nuclear factor 4 Hepatocyte nuclear factors ... HNF4G hepatocyte nuclear factor 4, gamma". Drewes T, Senkel S, Holewa B, Ryffel GU (March 1996). "Human hepatocyte nuclear ... Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) ...
ADH1A
... gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/ ... Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. This gene is ... This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. Members ... Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high ...
Retinoid X receptor alpha
"The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms ... Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear ... "Entrez Gene: RXRA retinoid X receptor, alpha". "Retinoic acid receptor RXR-alpha - Homo sapiens (Human)". UniProt. Na SY, Choi ... "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR ...
Sex hormone-binding globulin
The mechanism of activating the promoter for SHBG in the liver involves hepatocyte nuclear factor 4 alpha (HNF4A) binding to a ... hepatocyte nuclear factor 4. Reference ranges for blood tests for SHBG have been developed: SHBG levels are decreased by ... "Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor- ... As an example anti-psoriatic drugs that inhibit TNF-alpha cause an increase in SHBG. The common downstream mechanism for all of ...
Suresh Kumar Rayala
PAK1 Hepatocyte nuclear factor 4 alpha India portal Biology portal Irudayaraj (16 January 2019). "Indian Institute of ... a potent inhibitor of the transcription factor HNF4A, suppresses tumorigenicity of head and neck squamous cell carcinoma in ... 233 (3): 2613-2628. doi:10.1002/jcp.26139. ISSN 1097-4652. PMID 28782802. Kanakaveti, Vishnupriya; Sakthivel, Ramasamy; Rayala ...
C14orf119
... hepatocyte nuclear factor 4, alpha (HNF4A), leukocyte receptor cluster member 1 (LENG1), and ubiquitin C (UBC). Expression of ... The specific makeup of the secondary structure is as follows, alpha helices make up 38.57% of the protein (54 amino acids), ... It has evolved faster than both hemoglobin and cytochrome c, but slower than fibrinogen alpha chain. The table below reveals ... However, the protein has a 7.9% basic residue content and a nuclear localization signal (NLS) score of -0.47. Additionally, ...
Thyroid hormone receptor alpha
... nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ... "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells". Proteomics. 8 (14): 2885-96. ... Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear ... nuclear factor kappa B, Sp1, and Tat". Transactions of the Association of American Physicians. 106: 13-32. PMID 8036737. This ...
Liver receptor homolog-1
LRH-1 is a member of the nuclear receptor family of intracellular transcription factors. LRH-1 plays a critical role in the ... "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of ... developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha ... Brendel C, Gelman L, Auwerx J (Jun 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that ...
Glucokinase
Hepatic nuclear factor-4-alpha (HNF4α) is an orphan nuclear receptor important in the transcription of many genes for enzymes ... Levels of F2,6P 2 play other amplifying roles in glycolysis in hepatocytes. Other transacting factors suspected of playing a ... Upstream stimulatory factor 1 (USF1) is another basic helix-loop-helix zipper (bHLHZ) transactivator. Hepatic nuclear factor 6 ... Pdx-1 is a homeodomain transcription factor involved in the differentiation of the pancreas. PPARγ is a nuclear receptor that ...