Hepatic stellate cells (HSC), also known as perisinusoidal cells or Ito cells (earlier lipocytes or fat-storing cells), are ... Pancreatic stellate cell Stellate cell List of human cell types derived from the germ layers List of distinct cell types in the ... Senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating interactions with NK cells. ... The lipid droplets in the cell body store vitamin A as retinol ester. The function and role of quiescent hepatic stellate cells ...
TGF-β1 have been implicated in the process of activating hepatic stellate cells (HSCs) with the magnitude of fibrosis being in ... Puche JE, Saiman Y, Friedman SL (October 2013). "Hepatic stellate cells and liver fibrosis". Comprehensive Physiology. 3 (4): ... and obstructs hepatic blood flow. In addition, stellate cells secrete TGF beta 1, which leads to a fibrotic response and ... Research has shown the pivotal role of the stellate cell, that normally stores vitamin A, in the development of cirrhosis. ...
Isolation of Hepatic stellate cells: Shang L, Hosseini M, Liu X, Kisseleva T, Brenner DA (January 2018). "Human hepatic ... Isolated cells can also be used for cell culture, in which a single cell multiplies to create a colony of cells. Cell isolation ... Circulating cells such as blood cells or some tumour cells can be isolated by taking a blood sample. As blood samples contain a ... Cell isolation is the process of separating individual living cells from a solid block of tissue or cell suspension. While some ...
Hepatic stellate cell Stellate cell List of distinct cell types in the adult human body Omary MB, Lugea A, Lowe AW, Pandol SJ ( ... Watari likened these cells to hepatic stellate cells. The publication of two seminal research papers in 1998 outlining the ... While the discovery of hepatic stellate cells is attributed to Karl Wilhelm von Kupffer in 1876, who had termed them "stellate ... PaSCs are mediated by paracrine and autocrine stimuli and share similarities with the hepatic stellate cell. Pancreatic ...
Marek CJ, Tucker SJ, Koruth M, Wallace K, Wright MC (February 2007). "Expression of CYP2S1 in human hepatic stellate cells". ... CYP2S1 has been suggested to be involved in the growth and/or spread of certain tumors of epithelial cell origin: its higher ... Molecular and Cell Biology of Lipids. 1851 (4): 356-65. doi:10.1016/j.bbalip.2014.07.020. PMC 4314516. PMID 25093613. Human ... which stimulate the growth of various types of cancer cells, including those of the colon (see epoxyeicosatrienoic acid#cancer ...
2019), SHED were differentiated into hepatic stellate cells. They found that when hepatic cells derived from SHED were ... Dental pulp stem cells (DPSCs) are stem cells present in the dental pulp, which is the soft living tissue within teeth. DPSCs ... DPSCs were found to be able to differentiate into adipocytes and neural-like cells. These cells can be obtained from postnatal ... Volponi, A. A. (2010). "Stem cell-based biological tooth repair and regeneration". Trends in Cell Biology. 20 (12): 715-722. ...
... hepatic stellate cells and myofibroblasts are activated. Increased endogenous vasodilators in turn promote more blood flow in ... Portal hypertension is defined as a hepatic venous pressure gradient greater than 5 mmHg. Cirrhosis (a form of chronic liver ... post-hepatic). The most common cause is cirrhosis (chronic liver failure). Other causes include: Prehepatic causes Portal vein ... Hepatic causes Cirrhosis of any cause. alcohol use disorder chronic viral hepatitis biliary atresia Primary biliary cirrhosis ...
... being occupied by Kupffer cells, hepatic stellate cells, endothelial cells and mesothelial cells, which are not exactly ... Main liver cells are hepatocytes, Kupffer cells, and hepatic stellate cells; each one with a specific function. Cytology is the ... These cells are characteristic of the liver, since they are not found in any other tissue. These hepatic stellate cells, also ... Hepatic stellate cells rest over the Remak trabecules, and they emit extensions to the sinusoids. Julio, Sepúlveda Saavedra ( ...
Zhang M, Serna-Salas S, Moshage H (2021). "Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and ... SASP can aid in signaling to immune cells for senescent cell clearance, with specific SASP factors secreted by senescent cells ... Although transient expression of SASP can recruit immune system cells to eliminate cancer cells as well as senescent cells, ... Although SASP from senescent cells can kill neighboring normal cells, the apoptosis-resistance of senescent cells protects ...
A Novel Marker for Human and Rat Hepatic Stellate Cells". Am. J. Pathol. 155 (6): 1831-9. doi:10.1016/S0002-9440(10)65501-0. ... Cell. Neurosci. 21 (3): 454-62. doi:10.1006/mcne.2002.1191. PMID 12498786. S2CID 54366866. Wheeler TC, Chin LS, Li Y, Roudabush ... Cell Biol. 2 (1): 42-9. doi:10.1038/71366. PMID 10620806. S2CID 2623757. Nag TC, Wadhwa S (2001). "Differential expression of ... It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic ...
January 2014). "Syncoilin is an intermediate filament protein in activated hepatic stellate cells". Histochemistry and Cell ... Hepatic stellate cells are a specialized tissue type in the body that require syncoilin intermediate filaments. When an injury ... In this study, syncoilin isoforms SYNC1 and SYNC2 were highly expressed during in vivo activation of hepatic stellate cells. ... is now used to help mark activated hepatic stellate cells after being identified in an experiment done on primary liver cells ...
Hendriks HF, Brouwer A, Knook DL (1987). "The role of hepatic fat-storing (stellate) cells in retinoid metabolism". Hepatology ... RBP mRNA was localized to epithelial cells of the chorion, allantois, and amnion at day 45 of pregnancy. Lastly, RBP mRNA was ... by liver parenchymal cells in vitro does not specifically depend on its binding to RBP". Biochemistry. 32 (7): 1727-33. doi: ... "Localization of cellular retinol-binding protein and retinol-binding protein in cells comprising the blood-brain barrier of rat ...
Zhang M, Serna-Salas S, Damba T, Borghesan M, Demaria M, Moshage H (October 2021). "Hepatic stellate cell senescence in liver ... PAI-1 is mainly produced by the endothelium (cells lining blood vessels), but is also secreted by other tissue types, such as ... Dellas C, Loskutoff DJ (April 2005). "Historical analysis of PAI-1 from its discovery to its potential role in cell motility ... Journal of Cell Communication and Signaling. 12 (1): 69-82. doi:10.1007/s12079-017-0434-2. PMC 5842195. PMID 29260442. Elokdah ...
"HNE interacts directly with JNK isoforms in human hepatic stellate cells". J. Clin. Invest. 102 (11): 1942-50. doi:10.1172/ ... Feng Z, Hu W, Tang MS (June 2004). "Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible ... In the case of lipid peroxidation, ROS react with polyunsaturated fatty acids situated in the lipid bilayer of the cell ... Leonarduzzi G, Arkan MC, Başağa H, Chiarpotto E, Sevanian A, Poli G (May 2000). "Lipid oxidation products in cell signaling". ...
Wu J, Zern MA (2000). "Hepatic stellate cells: a target for the treatment of liver fibrosis". Journal of Gastroenterology. 35 ( ... to decreased hepatic uptake of vitamin A and the leaking of esters into the bloodstream from saturated hepatic stellate cells. ... decreased hepatic uptake of vitamin A and the leaking of esters into the bloodstream from saturated hepatic stellate cells. ... of this amount being stored in hepatic stellate cells and the remaining 10-20% being stored in hepatocytes). Fat is another ...
A novel marker for human and rat hepatic stellate cells". American Journal of Pathology. 155 (6): 1831-9. doi:10.1016/S0002- ... participate in remodeling of the cell. The role of nestin in dynamic cells, particularly structural organization of the cell, ... serves to mark hair follicle stem cells. These cells can differentiate into neurons, glia, keratinocytes, smooth muscle cells ... Nestin, a protein marker for neural stem cells, is also expressed in follicle stem cells and their immediate, differentiated ...
Senescence of hepatic stellate cells could prevent progression of liver fibrosis, although this has not been implemented as a ... Zhang M, Serna-Salas S, Damba T, Borghesan M, Demaria M, Moshage H (October 2021). "Hepatic stellate cell senescence in liver ... and stellate cell activation". Naunyn-Schmiedeberg's Archives of Pharmacology. 391 (11): 1257-1274. doi:10.1007/s00210-018-1540 ... In response to injury, this is called scarring, and if fibrosis arises from a single cell line, this is called a fibroma. ...
Maubach G, Lim MC, Chen J, Yang H, Zhuo L (June 2011). "miRNA studies in in vitro and in vivo activated hepatic stellate cells ... Cell. 123 (4): 631-40. doi:10.1016/j.cell.2005.10.022. PMID 16271387. S2CID 16973870. Desvignes T, Contreras A, Postlethwait JH ... In human glioma cell line T98G expression of miR-214 has been shown to suppress expression of the ubiquitin-conjugating enzyme ... miR-214 has been shown to inhibit bone formation in human cell lines both by targeting ATF4, a gene encoding one of the ...
"Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells". Archives of Pharmacal Research. 31 ... Totarol decreases the plasma levels of estrogens and can also effectively reduce pathogenic hepatic cells in vitro. Totarol's ... Totarol also prevents cells from undergoing oxidative stress in vitro by acting as a hydrogen donor to peroxy radicals or ... which also results in bacterial cells unable to synthesize ATP. Motivation for totarol functioning via disruption of membrane ...
"Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production". Journal of Hepatology. 37 (5): 584- ... A number of cell-based studies have shown that pirfenidone reduces fibroblast proliferation, inhibits transforming growth ... Pirfenidone can increase hepatic enzyme levels, especially those of aspartate transaminase, alanine transaminase and gamma- ... doi:10.1378/chest.130.4_meetingabstracts.230s-a. Sulfab M (2007). "The effects of pirfenidone and IFN-inducible T-cell alpha ...
"The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells". ... Fatty acids in the beta cells activate FOXO1, resulting in apoptosis of the beta cells. FOXO1 activation plays a role in cell ... It suppresses survival of tumor cells by inducing apoptosis in prostate cancer cells and glioma cells by upregulating the ... In hepatic cells this transcription factor seems to increase the expression of PEPCK and glycogen-6-phosphatase (the same ...
June 2009). "Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells". Hepatology ... It was unclear at that time if any or all of these were responsible for the observed effects in cells and model organisms. The ... Its ability for varied interactions may be due to direct effects on cell membranes. As of 2015, many specific biological ... The bioavailability of resveratrol is about 0.5% due to extensive hepatic glucuronidation and sulfation. Glucuronidation occurs ...
"Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells". Journal of Natural Medicines ...
"Aggf1 attenuates hepatic inflammation and activation of hepatic stellate cells by repressing Ccl2 transcription". Journal of ... it also has activity in mast cells, cardiac cells, Kupffer cells and hematopoietic stem cells. AGGF1 mRNA has been detected in ... Additionally, it activates autophagy in specific cell types, such as endothelial cells, cardiac HL1 and H9C2 cells, and ... In vitro models have shown that AGGF1 localizes to cell periphery and directly outside of the cell. Depending on the mutation ...
2007). "Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells". Am. J. ... VEGF expression is detected surrounding the nurse cell immediately after nurse cell formation, and the continued secretion of ... The larvae gain access to the circulation and migrate around the body of the host, in search of a muscle cell in which to ... Nurse cell formation in skeletal muscle tissue is mediated by the hypoxic environment surrounding the new vessel formation. The ...
Zi Xi, Lian (2011). "Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: a possible ... "Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: A possible molecular mechanism". ... The proteins are characterized by seed longevity used for cell protection and repair under stress. There are also several ...
"Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells". Frontiers in ... compounds that activate γδT cells by binding to butyrophilins in target cells and this T cell activation led to tumor cell ... Y. Xia, N. Yeddula, M. Leblanc, E. Ke, Y. Zhang, E. Oldfield, R. J. Shaw and I. M. Verma, Nature Cell Biology, 14, 257-265 ( ... He also worked on investigating Pt/Ru direct methanol oxidation fuel cell catalysts using 13C and 195Pt NMR, in collaboration ...
PDGF-BB is the highest-affinity ligand for the PDGFR-beta; PDGFR-beta is a key marker of hepatic stellate cell activation in ... vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. ... PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells. In both ... "Cell Death and Control of Cell Survival in the Oligodendrocyte Lineage". Cell. 70 (1): 31-46. doi:10.1016/0092-8674(92)90531-G ...
Two liver cell types are responsible for storage and release: hepatocytes and hepatic stellate cells (HSCs). Hepatocytes take ... Lymphocytes include natural killer cells, which function in innate immunity, T cells for adaptive cellular immunity and B cells ... of these measures is that they are not good indicators of liver vitamin A stores as retinyl esters in hepatic stellate cells. ... Within the eye, 11-cis-retinal is bound to the protein opsin to form rhodopsin in rod cells and iodopsin in cone cells. As ...
"Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats". ... It is found on the surface of cells in the airways (such as the lungs) and kidneys. Scientists may be able to use this to their ... Tina Hesman Saey (March 13, 2013). "News in Brief: New virus uses protein handle to infect cells". ScienceNews. Archived from ... Sato K, Dang NH (March 2003). "CD26: a novel treatment target for T-cell lymphoid malignancies? (Review)". International ...
Acetaldehyde may be responsible for alcohol-induced fibrosis by stimulating collagen deposition by hepatic stellate cells. The ... and possible hepatic decompensation with hepatic encephalopathy, variceal bleeding, and ascites accumulation. Tender ... The Kupffer cells of the liver then phagocytose endotoxin, stimulating the release of TNF-α. TNF-α then triggers apoptotic ... Fatty change, or steatosis, is the accumulation of fatty acids in liver cells. This can be seen as fatty globules under the ...