Nervi B, Link DC, DiPersio JF (October 2006). "Cytokines and hematopoietic stem cell mobilization". J. Cell. Biochem. 99 (3): ... SCF may serve as guidance cues that direct hematopoietic stem cells (HSCs) to their stem cell niche (the microenvironment in ... c-Kit is expressed in HSCs, mast cells, melanocytes, and germ cells. It is also expressed in hematopoietic progenitor cells ... promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division". Blood. 86 (5): 1757-64. doi: ...
"Nociceptive nerves regulate haematopoietic stem cell mobilization". Nature. 589 (7843): 591-596. Bibcode:2021Natur.589..591G. ... CGRP has a role in human stem cells mobilization. In investigations carried out during last five years, treatment with CGRP ... from hamster ovarian cells, from yeast cells or from humanized cell cultures. The antibodies are also made repeatedly to make ... "Calcitonin gene-related peptide enhances osteogenic differentiation and recruitment of bone marrow mesenchymal stem cells in ...
Mayack, S. R.; Wagers, A. J. (2 May 2008). "Osteolineage niche cells initiate hematopoietic stem cell mobilization". Blood. 112 ... She has also identified novel regulators (such as EGR1) of stem cell trafficking and stem cell number in bone marrow and during ... Wagers researches intrinsic and extrinsic regulators of stem cell function and how stem cells impact tissue regeneration and ... and principal faculty of the Harvard Stem Cell Institute. She is co-chair of the Department of Stem Cells and Regenerative ...
"Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced ... "Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell". Cell. 172 (1-2): 191-204.e10. doi:10.1016/j.cell. ... "Phase II Study of MGTA-145 in Combination With Plerixafor in the Mobilization of Hematopoietic Stem Cells for Autologous ... MGTA-145 in Combination With Plerixafor for the Mobilization and Transplantation of HLA-Matched Donor Hematopoietic Stem Cells ...
2005). "Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist". J. ... "Regulation of the HIF-1α level is essential for hematopoietic stem cells". Cell Stem Cell. 7 (3): 391-402. doi:10.1016/j.stem. ... 2010). "The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche". Cell Stem Cell ... immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). As these cells ...
Hematopoietic System G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the ... of hematopoietic stem cells in the blood of the donor before collection by leukapheresis for use in hematopoietic stem cell ... Tay J, Levesque JP, Winkler IG (December 2016). "Cellular players of hematopoietic stem cell mobilization in the bone marrow ... G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate for conditioning regimens. ...
... hematopoietic stem cells into the bloodstream as peripheral blood stem cells. Peripheral blood stem cell mobilization is very ... ligand SDF-1 is known to be important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell ... It is a very efficient inducer of hematopoietic stem cell mobilization in animal and human studies. In a small human clinical ... To LB, Levesque JP, Herbert KE (October 2011). "How I treat patients who mobilize hematopoietic stem cells poorly". Blood. 118 ...
"Current developments in mobilization of hematopoietic stem and progenitor cells and their interaction with nicehes in bone ... Lapidot T, Petit I (September 2012). "Current understanding of stem cell mobilization: the roles of chemokines, proteolytic ... Besides liver cells, A1PI is produced in bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth ... In addition to binding to neutrophil elastase released by inflammatory cells, A1AT also binds to elastase localized on the cell ...
"Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced ... with expression on most immature and mature hematopoietic cell types (e.g. neutrophils, monocytes, T and B cells, dendritic ... some B cells (B lymphocytes) and NK cells] and is highly induced following cell activation. There are two isoforms, CXCR3-A and ... Langerhans cells and macrophages). In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cells ...
Peripheral blood stem cell mobilization, which is important as a source of hematopoietic stem cells for transplantation, is ... are important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence. The in vivo ... inducer of mobilization of hematopoietic stem cells from the bone marrow to the bloodstream as peripheral blood stem cells. ... is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are ...
... cells. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to ... Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and ... April 1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by ... FLT3L functions as a cytokine and growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) ...
Mobilization is used clinically as a source of hematopoietic stem cells for hematopoietic stem cell transplantation (HSCT). ... KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of ... It is also a marker for mouse prostate stem cells. In addition, mast cells, melanocytes in the skin, and interstitial cells of ... the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells ...
"Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle". Cell Stem ... mobilization and senescence are detrimental elements. These detrimental effects will eventually cause apoptosis. There are also ... Stem cells will turn into certain cells as the body needs them. Stem cells divide more than non stem cells so the tendency of ... have reviewed evidence that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell ...
... of Combination Treatment of BL-8040 and G-GSF as Compared to Placebo and G-CSF for thE MobilizatioN of HematopoiEtic Stem Cells ... Motixafortide is a hematopoietic stem cell mobilizer and a CXCR4 antagonist. It is given by subcutaneous injection. ... April 2023). "Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: ... to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in people ...
Isolation of Haematopoetic stem cells: Rector K, Liu Y, Van Zant G (2013). "Comprehensive Hematopoietic Stem Cell Isolation ... Isolation of Mesenchymal stem cells: Yosupov N, Haimov H, Juodzbalys G (2017). "Mobilization, Isolation and Characterization of ... Isolated cells can also be used for cell culture, in which a single cell multiplies to create a colony of cells. Cell isolation ... Circulating cells such as blood cells or some tumour cells can be isolated by taking a blood sample. As blood samples contain a ...
... continual effort to replace the somatic cells may cause exhaustion of stem cells. Hematopoietic stem cell aging Hematopoietic ... mobilization and senescence are detrimental elements. These detrimental effects will eventually cause apoptosis. There are also ... Hematopoietic stem cell diversity aging A study showed that the clonal diversity of stem cells that produce blood cells gets ... "Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle". Cell Stem ...
... injection and is indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later ... mobilization in patients with a prior insufficient PBPC collection". Bone Marrow Transplant. 34 (8): 683-91. doi:10.1038/sj.bmt ... It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell ... Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to ...
... to mobilize hematopoietic stem cells). BL-8040 is a CXCR4 antagonist that has undergone clinical trials (e.g. in various ... June 2016 BL-8040, a Peptidic CXCR4 Antagonist, Induces Leukemia Cell Death and Specific Leukemia Cell Mobilization in Relapsed ... BL-8040 treatment enhanced anti-tumor immune response potentially by increasing the CD8+ T-cells in the tumor microenvironment ... to enhance antitumor effects by increasing tumor infiltration of antigen-specific effector T-cells". Journal of Clinical ...
... is a form of autologous hematopoietic stem cell therapy where stem cells are mobilized and collected ... The most common adverse effects during mobilization and conditioning include nausea (79%), vomiting (72%), anorexia (42%), ... which allows their modified stem cells to replace stem cells lacking a functional copy of the ABCD1 gene. Elivaldogene ... October 2017). "Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy". The New England Journal of Medicine. ...
... has proven key for activation of hematopoietic stem cells, thus supporting a role for CMA in stem cell function. CMA activity ... "Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation". ... More recently CMA has been implicated in the regeneration capacity of new blood cells by sustaining hematopoietic stem cell ... "Chaperone-mediated autophagy sustains haematopoietic stem-cell function". Nature. 591 (7848): 117-123. Bibcode:2021Natur.591.. ...
July 2013). "Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma ... improvement of heart function due to mobilization and redirection of epicardial progenitor cells toward cardiovascular cell ... Scientists develop 'game changing' stem cell repair system. Stem Cells Portal Could this new stem cell become the game changer ... June 2014). "Human somatic cell nuclear transfer using adult cells". Cell Stem Cell. 14 (6): 777-80. doi:10.1016/j.stem.2014.03 ...
Angioblasts are believed to be a form of early progenitor or stem cell which gives rise to the endothelium alone. More recently ... or circulating angiogenic cells (CAC) instead (depending on the method of isolation), highlighting their role as hematopoietic ... the miRNAs miR-10b and miR-196b led to significant defects in angiogenesis-mediated tumor growth by decreasing the mobilization ... Endothelial progenitor cell (or EPC) is a term that has been applied to multiple different cell types that play roles in the ...
... a multipotent hematopoietic stem cell, becomes a common myeloid progenitor or a multipotent stem cell, then a unipotent stem ... It appears that this links erythropoietin-driven eyrthropoiesis with the iron mobilization needed for hemoglobin synthesis. ... The production of all blood cells begins with the haemocytoblast, a multipotent haematopoietic stem cell. Haemocytoblasts have ... Erythropoiesis is the development of mature red blood cells from erythropoietic stem cells. The first cell that is ...
Hematopoietic stem cells were cultured (see cell culture) on a so-called semisolid matrix, which prevents cells from moving ... Promegapoietin Bone marrow stimulation Stem cell mobilization Kumar, Vinay; Abbas, Abul K.; Aster, Jon C.; Turner, Jerrold R.; ... These are referred to as "colonies". Therefore, it was possible to add various substances to cultures of hemopoietic stem cells ... all of the cells derived from it will remain clustered around the spot in the matrix where the first cell was originally ...
SDF-1α secreted from Mesenchymal Stem Cells (MSCs) has important role in homing and maintenance of Hematopoietic Stem Cell (HSC ... is also certain degree of similarity in homing-mobilization of normal stem cells and metastasis-invasion of cancer stem cells. ... cell-cell interactions between stem cells, as well as interactions between stem cells and neighbouring differentiated cells, ... The CSC niche is very similar to normal stem cells niche (embryonic stem cell (ESC), Adult Stem Cell ASC) in function ( ...
The adipocytes in this depot are derived from mesenchymal stem cells (MSC) which can give rise to fat cells, bone cells as well ... is a poorly understood adipose depot that resides in the bone and is interspersed with hematopoietic cells as well as bony ... Ross R, Rissanen J (November 1994). "Mobilization of visceral and subcutaneous adipose tissue in response to energy restriction ... February 2010). "Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells". ...
The only prospect for a permanent cure is the high-risk option of an allogeneic hematopoietic stem cell transplantation (SCT). ... Martino R, Sureda A, Brunet S (1997). "Peripheral blood stem cell mobilization in refractory autoimmune Evans syndrome: a ... Oyama Y, Papadopoulos EB, Miranda M, Traynor AE, Burt RK (2001). "Allogeneic stem cell transplantation for Evans syndrome". ... The symptoms of Evans syndrome vary between patients depending on which blood cells are affected. If red blood cells are ...
Bone marrow or hematopoietic stem cell transplant (41.1) Puncture of spleen (41.2) Splenotomy (41.3) Diagnostic procedures on ... Stapes mobilization (19.1) Stapedectomy (19.2) Revision of stapedectomy (19.3) Other operations on ossicular chain (19.4) ... Magnetic resonance imaging of brain and brain stem (88.92) Magnetic resonance imaging of chest and myocardium (88.93) Magnetic ... 1 bacterial smear 2 culture 3 culture and sensitivity 4 parasitology 5 toxicology 6 cell block and Papanicolaou smear 9 other ...
... growth factors and mobilization of peripheral blood derived stem cells for blood and marrow transplant. Her professional ... Granulocyte-macrophage colony stimulating factor expands the circulating hematopoietic progenitor cell compartment in humans, ... Mobilization of peripheral blood progenitor cells by chemotherapy and GM-CSF for hematologic support after high dose ... hematopoietins and stem cells (three editions), Molecular Targeting in Oncology). Antman's publications also include reviews ...
Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells ... "Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand". Cell. 109 ( ... "Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization". Leukemia & Lymphoma. 43 (2): 233-41. doi: ... Lastly, there is significant evidence that Gelatinase B is required for the recruitment of endothelial stem cells, a critical ...