Heat Shock Protein 90 (Hsp90). 1823 (3): 689-697. doi:10.1016/j.bbamcr.2011.09.016. ISSN 0167-4889. PMID 22001401. (CS1 Polish- ... It is a scaffolding protein and is crucial for aggregating other proteins that form the inflammasome. NLRP1, 3, 6, 7, and 12 ... LRR and PYD domains-containing protein 1 NLRP2, a human gene that encodes the NACHT, LRR and PYD domains-containing protein 2 ... LRR and PYD domains-containing protein 4 NLRP7, a human gene that encodes the NACHT, LRR and PYD domains-containing protein 7 ...

Wikimedia Commons has media related to HSP90 heat-shock proteins. Hsp90+Heat-Shock+Proteins at the U.S. National Library of ... However, when cells are heated, the fraction of heat shock proteins increases to 4-6% of cellular proteins. Heat shock protein ... Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against ... Miyata Y, Yahara I (April 1992). "The 90-kDa heat shock protein, Hsp90, binds and protects casein kinase II from self- ...

A current target is Heat Shock Protein 90 (HSP90). HSP90 is key in protein folding and maturation. TopoTarget is currently ... A number of heat shock protein 90 (HSP90) small molecule inhibitors have been developed by TopoTarget, with several compounds ... This protein was derived from the pro-apoptotic human Fas ligand (FasL) protein. APO010 causes cell death of cancerous cells ... Zemab comprises an antibody-toxin for the treatment of specific types of cancers in the form of a protein product., pg 20 The ...

September 2003). "Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma". Cancer. 98 (5): 970-7. ... Heat shock protein 60, HSP-60, HuCHA60, Mitochondrial matrix protein P1, P60 lymphocyte protein, HSPD1 Heat shock protein 60 ( ... Heat shock proteins are primarily responsible for maintaining the integrity of cellular proteins particularly in response to ... Heat shock proteins are amongst the most evolutionarily conserved of proteins. The significant function, structural, and ...

... affects transcription and translation by regulating heat-shock protein 90 (Hsp90). HDAC6 is required in the formation of ... The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal ... HDAC6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) HDAC6 human gene location in the ... This protein possesses histone deacetylase activity and represses transcription. It retracts the cilium of the cell, which is ...

An Hsp90 inhibitor is a substance that inhibits that activity of the Hsp90 heat shock protein. Since Hsp90 stabilizes a variety ... Among heat shock proteins the focus on HSP90 has increased due to its involvement in several cellular phenomena and more ... "Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for ... Al Shaer L, Walsby E, Gilkes A, Tonks A, Walsh V, Mills K, Burnett A, Rowntree C (May 2008). "Heat shock protein 90 inhibition ...

Basu S, Binder RJ, Ramalingam T, Srivastava PK (Mar 2001). "CD91 is a common receptor for heat shock proteins gp96, hsp90, ... Heat shock proteins: gp96, hsp70, hsp90, heparin cofactor II, Hepatic lipase, ITGB1BP1, Lactoferrin, Lipoprotein lipase, LPL, ... Li Z, Dai J, Zheng H, Liu B, Caudill M (Mar 2002). "An integrated view of the roles and mechanisms of heat shock protein gp96- ... In humans, the LRP1 protein is encoded by the LRP1 gene. LRP1 is also a key signalling protein and, thus, involved in various ...

Heat shock protein HSP 90-beta also called HSP90beta is a protein that in humans is encoded by the HSP90AB1 gene. HSP90AB1 is a ... heat shock protein 90 kDa alpha, class B, member 1) (this protein) HSP90B1 (heat shock protein 90 kDA beta, member 1) TRAP1 ( ... heat shock protein 90 kDa alpha, class A, member 1) HSP90AA3P (heat shock protein 90 alpha family class A member 3, pseudogene ... HSP90AB1 heat shock protein 90 alpha family class B member 1". Retrieved 2019-08-30. Lindquist S (June 1986). "The heat-shock ...

The protein encoded by this gene belongs to the Hsp90 family of heat shock proteins. Ozawa K, Murakami Y, Eki T, Soeda E, ... Heat shock protein 90kDa alpha (cytosolic), class A member 2, also known as HSP90AA2, is a human gene. ... Yokoyama K (February 1992). "Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14 ... v t e (Protein pages needing a picture, Genes on human chromosome 11, Human gene pages with Wikidata item, All stub articles, ...

... mainly heat shock proteins). It is one of the best studied co-chaperones of the Hsp70/Hsp90-complex. It was first discovered in ... "Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to ... "Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex ... Human Hop (STIP1) has been shown to interact with PRNP and Heat shock protein 90kDa alpha (cytosolic), member A1. GRCh38: ...

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90 ... Chen S, Smith DF (1999). "Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery". J. Biol. Chem ... 2005). "The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor". Mol. Endocrinol. ... Johnson BD, Schumacher RJ, Ross ED, Toft DO (1998). "Hop modulates Hsp70/Hsp90 interactions in protein folding". J. Biol. Chem ...

1997). "Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is ... 1998). "Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive ... 2000). "Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone". J. Biol. Chem. 275 (30): 23045- ... McLaughlin SH, Smith HW, Jackson SE (2002). "Stimulation of the weak ATPase activity of human hsp90 by a client protein". J. ...

... s mechanism of action is in part due to heat shock protein Hsp90 protein inhibition. Tanida S, Hasegawa T, Higashide E ... "Genetic and Biochemical Analysis of p23 and Ansamycin Antibiotics in the Function of Hsp90-Dependent Signaling Proteins". Mol. ...

... is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. Hsp90 ... Antibiotic Tan 420F Herbimycin A Herbimycin induces the degradation of proteins that are need to be mutated in tumor cells such ... This effect is mediated via Hsp90.[citation needed] Geldanamycin Satoshi Ōmura Shaaban, KA; Wang, X; Elshahawi, SI; Ponomareva ... client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis ...

Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene. The gene, HSP90AA1, encodes the ... Kang J, Kim T, Ko YG, Rho SB, Park SG, Kim MJ, Kwon HJ, Kim S (Oct 2000). "Heat shock protein 90 mediates protein-protein ... Ciocca DR, Arrigo AP, Calderwood SK (Jan 2013). "Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor ... Quanz M, Herbette A, Sayarath M, de Koning L, Dubois T, Sun JS, Dutreix M (Mar 2012). "Heat shock protein 90α (Hsp90α) is ...

The hypothesis that chaperones can act as evolutionary capacitors is closely associated with the heat shock protein Hsp90. When ... Chaperones assist in protein folding. The need to fold proteins correctly is a big restriction on the evolution of protein ... Similarly, binding proteins may spend some proportion of their time bound to off-target proteins. These reactions or ... Sup35p is a yeast protein involved in recognising stop codons and causing translation to stop correctly at the ends of proteins ...

Heat shock protein 90 (Hsp90) is a molecular chaperone essential for activating many signaling proteins in the eukaryotic cell ... Biological machines Chaperome Chaperonin Chemical chaperones Heat shock protein Heat shock factor 1 Molecular chaperone therapy ... thus heat shock protein chaperones are the most extensive. A variety of nomenclatures are in use for chaperones. As heat shock ... thus many chaperone proteins are classified as heat shock proteins, as the tendency for protein aggregation is increased by ...

This event occurs in the NuA4 protein complex. One more function of reptin is its interaction with heat shock protein 90 (HSP90 ... and regions for binding to other reptin proteins to form a hexamer ring as well as pontin and other proteins. The reptin ... where it assists regulation of polycomb group proteins (PcG). In turn, PcG proteins regulate chromatin structure to turn Hox ... "Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin". ...

Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle ... Radicicol, also known as monorden, is a natural product that binds to Hsp90 ( ... an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii". Chemistry & Biology. 15 (12): 1328-1338. doi:10.1016/j. ...

Another receptor that can be bound is heat shock protein 90 (HSP90) on the surface of the DF-1 cell membrane. Although, this ... which is cleaved into three proteins . Segment B encodes a single viral protein, VP1. Viral protein 1 is an RNA-dependent RNA ... Viral protein 4 is a serine protease, which catalyzes the hydrolysis of polyprotein pVP2-VP4-VP3 to release the viral proteins ... Viral protein 3 is an immunogenic protein that interacts with VP1. Its helps to regulate VP2 apoptosis by inhibiting ...

The N-terminal domain binds to protein kinases. The central domain is the Hsp90 chaperone (heat shock protein 90) binding ... "Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 ... Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene. This protein is highly similar to Cdc 37, a ... Boudeau J, Deak M, Lawlor MA, Morrice NA, Alessi DR (March 2003). "Heat-shock protein 90 and Cdc37 interact with LKB1 and ...

... resides in the cytosol complexed with a variety of proteins including heat shock protein 90 (hsp90), the heat shock protein 70 ... March 1999). "Delimitation of two regions in the 90-kDa heat shock protein (Hsp90) able to interact with the ... resulting in release of the heat shock proteins. The resulting activated form GR has two principal mechanisms of action, ... Hulkko SM, Wakui H, Zilliacus J (August 2000). "The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the ...

... heat shock protein 90 (Hsp90) inhibitors and epothilones. Their technology platform was based on manipulation of the genetic ...

... when high temperatures cause the dissociation of inactive HSF1 from complexes with heat shock proteins Hsp40/Hsp70 and Hsp90. ... Most commonly, protein phosphorylation is catalyzed by protein kinases, ultimately resulting in a cellular response. Proteins ... Other activated proteins interact with adaptor proteins that facilitate signaling protein interactions and coordination of ... Shamovsky I, Ivannikov M, Kandel ES, Gershon D, Nudler E (March 2006). "RNA-mediated response to heat shock in mammalian cells ...

The mechanism of action of pimitespib involves inhibition of heat shock protein 90 (Hsp90). In June 2022, it received approval ... "Taiho Pharmaceutical Obtains Approval to Manufacture and Market HSP90 inhibitor Jeselhy® Tablets 40 mg (Pimitespib) for ...

"Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for ... Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a protein that in humans is encoded by the BIRC2 gene. ... a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". Cell. 102 (1): 43-53. doi:10.1016/ ... a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". Cell. 102 (1): 43-53. doi:10.1016/ ...

"Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for ... The promoter of the UBC gene contains putative heat shock elements (HSEs), which mediates UBC induction upon stress. UBC gene ... Polyubiquitin-C doesn't activate the heat-shock response, but it plays a key role in sustaining the response. UBC gene ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ...

... heat shock proteins (hsp70, hsp90) and immunophilins. Upon activation, due to hormone binding to ligand binding pocket, the ... Smith DF, Stensgard BA, Welch WJ, Toft DO (Jan 1992). "Assembly of progesterone receptor with heat shock proteins and receptor ... Oñate SA, Estes PA, Welch WJ, Nordeen SK, Edwards DP (Dec 1991). "Evidence that heat shock protein-70 associated with ... of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90-kDa heat shock protein ...

... functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and ... TSC1 has been shown to interact with: AKT1, HSP70 HSP90 NEFL, PLK1, and TSC2. Tuberous sclerosis protein GRCh38: Ensembl ... Two proteins involved in tuberous sclerosis". The Journal of Biological Chemistry. 276 (24): 21017-21. doi:10.1074/jbc. ... TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC complex. This complex negatively regulates mTORC1 ...

PPID in particular helps chaperone the assembly of heat shock protein Hsp90, as well as the nuclear localization of ... "Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock". Cell ... have been observed to be activated by heat shock and hypoxia-reoxygenation as well as complex with heat shock proteins. Thus, ... "Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90". The Journal of Biological ...