Growth factor receptor inhibitors (growth factor inhibitors, growth factor receptor blockers, growth factor blockers, growth ... growth factor receptor inhibitors have been used to target cancer cells. In cancer research, growth factor receptor inhibitors ... HER2 inhibitors at the Drugs.com website. VEGF/VEGFR inhibitors at the Drugs.com website. Cancer growth blockers at the Cancer ... They interfere with binding of the growth factor to the corresponding growth factor receptors, impeding cell growth and are ...

"Modulation of endothelial cell growth arrest and apoptosis by vascular endothelial growth inhibitor". Circulation Research. 89 ... Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), ... Yao JJ, Zhang M, Miao XH, Zhao P, Zhu SY, Ding H, Qi ZT (Apr 2006). "Isoform of vascular endothelial cell growth inhibitor ( ... is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo". FASEB Journal. 13 (1): 181-9. doi:10.1096 ...

Nerve growth factor (NGF) inhibitors are a class of compounds that inhibit the action of the neurotrophin nerve growth factor ... NGF inhibitors may take the form of monoclonal antibodies that bind to NGF, or small molecule inhibitors of NGF receptors. NGF ... Oo, Win Min; Hunter, David J. (2021-11-01). "Nerve Growth Factor (NGF) Inhibitors and Related Agents for Chronic ... Cao Z, Zhou J, Long Z, Li Y, Sun J, Luo Y, Wang W (December 2020). "Targeting nerve growth factor, a new option for treatment ...

Cell Growth Differ. 6 (3): 309-314. PMID 7794798. Alho H, Vaalasti A, Podkletnova I, Rechardt L (1994). "Expression of diazepam ... 1998). "Diazepam binding inhibitor (DBI) in the plasma of pediatric and adult epileptic patients". Epilepsy Res. 29 (2): 129- ... Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of ... This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and ...

They are also sometimes used to treat excess hair growth in women and as a component of hormone therapy for transgender women. ... List of 5α-reductase inhibitors Discovery and development of 5α-reductase inhibitors CYP17A1 inhibitor Neurosteroidogenesis ... Liu, L; Zhao, S; Li, F; Li, E; Kang, R; Luo, L; Luo, J; Wan, S; Zhao, Z (September 2016). "Effect of 5α-Reductase Inhibitors on ... inhibitor Ulrike Blume-Peytavi; David A. Whiting; Ralph M. Trüeb (26 June 2008). Hair Growth and Disorders. Springer Science & ...

These growth factors, in turn, promote the growth, survival, and proliferation of cancer cells. Aberrant Shh signaling has also ... Thus, Hedgehog pathway inhibitors are an important class of anti-cancer drugs. At least three Hedgehog pathway inhibitors have ... Hedgehog pathway inhibitors, also sometimes called hedgehog inhibitors, are small molecules that inhibit the activity of a ... Therefore, SMO has been a primary target in the development of Hedgehog pathway inhibitors. Two such inhibitors, Sonidegib and ...

"Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells". Nat Med. 2 (5): 561-6. ... Bcr-Abl tyrosine-kinase inhibitor Protein kinase inhibitor Yaish P, Gazit A, Gilon C, Levitzki A (1988). "Blocking of EGF- ... Sunitinib, an inhibitor of the receptors for FGF, PDGF and VEGF is also based on early studies on TKIs aiming at VEGF receptors ... A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes ...

Argos is a secreted protein that is an inhibitor of the epidermal growth factor receptor (EGFR) pathway in Drosophila ... EGFR inhibitor Freeman M, Klämbt C, Goodman CS, Rubin GM (June 1992). "The argos gene encodes a diffusible factor that ... Argos binds the epidermal growth factor domain of Spitz, preventing interaction between Spitz and EGFR. Argos does not directly ... Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA (August 2004). "Argos inhibits epidermal growth factor receptor ...

"Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and ... VEGFR-2 inhibitor, also known as kinase insert domain receptor(KDR) inhibitor, are tyrosine kinase receptor inhibitors that ... Strong inhibitors of CYP3A4 will increase the plasma concentration of axitinib, while weak inhibitors have less effect on the ... CYP3A4 inhibitors are unlikely to affect sorafenib. Sorafenib is a competitive inhibitor of CYP2C19, CYP2D6 and CYP3A4. It ...

March 2004). "Plasminogen activator inhibitor-I and tumour growth, invasion, and metastasis". Thrombosis and Haemostasis. 91 (3 ... Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor (serpin E1) is a protein ... In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen ... PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue-type plasminogen activator ( ...

According to some researches, decreased body weight of the child, intrauterine growth retardation, neonatal adaptive syndrome, ... Selective Serotonin Reuptake Inhibitors (SSRIs) are a class of drugs that are typically employed as antidepressants in the ... Taking monoamine oxidase inhibitors (MAOIs) in combination with SSRIs can be fatal, since MAOIs disrupt monoamine oxidase, an ... Eom CS, Lee HK, Ye S, Park SM, Cho KH (May 2012). "Use of selective serotonin reuptake inhibitors and risk of fracture: a ...

"The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three- ... mainly a PIK3CD inhibitor) AEZS-136 (dual PI3K and ERK inhibitor) B591 (pan-class I PI3K inhibitor) GNE-477 (dual PIK3CA and ... PI3K inhibitors block the PI3K/AKT/mTOR pathway and thus slow down cancer growth. They are examples of a targeted therapy. ... irreversible PI3K inhibitor) IC87114 (mainly a PIK3CD inhibitor) LY294002 (reversible PI3K inhibitor), mainly used as a ...

... basic fibroblast growth factor (bFGF), ephrin-B2, vascular endothelial growth factor (VEGF), and members of the tumor growth ... The second generation of mTOR inhibitors is known as ATP-competitive mTOR kinase inhibitors. mTORC1/mTORC2 dual inhibitors such ... Rapamycin inhibitors and rapalogs can target tumor growth both directly and indirectly. Direct impact of them on cancer cells ... human epidermal growth factor receptor 2) and IGFR (insulin-like growth factor receptor), mutations in PI3K and mutations/ ...

Loss-of-function mutations in this gene have also been shown associated to the IMAGe syndrome (Intrauterine growth restriction ... Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator ... Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C ... It encodes a cell cycle inhibitor that binds to G1 cyclin-CDK complexes. Thus p57KIP2 causes arrest of the cell cycle in G1 ...

"Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis". Clinical Cancer Research. 18 (13 ... Src inhibitor is a class of inhibitors[jargon] that targets the Src kinase family of tyrosine kinase, which is transcribed by ... PP1, PP2 (kinase inhibitor) are both inhibitors of Lck and FynT. Dasatinib Rivera-Torres J, José ES (2019). "Src Tyrosine ... breast cancer and stomach cancer KX2-391 is an oral src inhibitor and the first clinical inhibitor with GI50 of 9-60 nM in ...

Liao S, Lin J, Dang MT, Zhang H, Kao YH, Fukuchi J, Hiipakka RA (April 2001). "Growth suppression of hamster flank organs by ... This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase. This ... Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ, Yoon YK (October 2002). "The hair growth promoting effect of Sophora flavescens ... Cabeza M, Bratoeff E, Heuze I, Ramírez E, Sánchez M, Flores E (2003). "Effect of beta-sitosterol as inhibitor of 5 alpha- ...

Claassen DA, Desler MM, Rizzino A (August 2009). "ROCK inhibition enhances the recovery and growth of cryopreserved human ... Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho ... Rho kinase inhibitor also functions by blocking rho-mediated dephosphorylation of MLC20. A number of Rho kinase inhibitors are ... Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential. 2016 (Protein kinase inhibitors). ...

Similar inhibition of growth can be seen in pathogens that interact with these inhibitors. In order to discover how the ... The proteinase inhibitors work to disrupt the enzymatic ability of the digestive or microbial enzymes that are present in the ... Once the proteinase inhibitor has been ingested by the insect, it presents itself as a normal substrate for the digestive ... While proteinase inhibitors are present in plants naturally, production of these proteins for defense is often induced by ...

The chain contains both GLA domain and two epidermal growth factor domains (EGF like domains). The active site of FXa is ... In 2008 the first direct Xa inhibitor was approved for clinical use. Direct Xa inhibitors are just as efficacious as LMWH and ... It works as an antidote to all direct and indirect FXa inhibitors. Andexxa acts as a decoy receptor for Xa inhibitors. " ... Antistasin is a polypeptide and a potent Xa inhibitor. In 1990 another naturally occurring Xa inhibitor was isolated, tick ...

4-Hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors (HPPD inhibitors) are a class of herbicides that prevent growth in plants ... Bayer CropScience has also been active in developing new HPPD inhibitors. The mechanism of action for HPPD inhibitors was ... crops that are resistant to HPPD inhibitors and glufosinate. The collaboration to develop the stacked HPPD inhibitor/glyphosate ... HPPD inhibitors were first brought to market in 1980, although their mechanism of action was not understood until the late ...

It is hypothesized that myostatin inhibitors have an ergogenic effect due to promoting muscle growth. Myostatin inhibitors are ... Myostatin inhibitors are a class of drugs that work by blocking the effects of myostatin, which inhibits muscle growth. In ... Myostatin, a member of the transforming growth factor superfamily, is a negative regulator of bone and muscle growth. It may ... Myostatin inhibitors were generally able to increase lean body mass and reduce body fat in people with sarcopenia, but the ...

"Use of aromatase inhibitors in children and adolescents with disorders of growth and adolescent development". Pediatrics. 121 ( ... There are two types of aromatase inhibitors approved to treat breast cancer: Irreversible steroidal inhibitors, such as ... Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, and ... Aromatase inhibitors are generally not used to treat breast cancer in premenopausal women because, prior to menopause, the ...

COX inhibitors have been shown to reduce the occurrence of cancers and precancerous growths. The National Cancer Institute has ... of NSAID expenditures were for COX-2 inhibitors. Over the period of the study, COX-2 inhibitors rose from 10.03% of total ... Some COX-2 inhibitors are used in a single dose to treat pain after surgery. In this role etoricoxib appears as good as, if not ... COX-2 inhibitors appear to work as well as nonselective NSAIDs, such as aspirin. They have not been compared to other treatment ...

... its product also has retinal pigment epithelial cell growth-promoting properties. TFPI has a relative molecular mass of 34,000 ... TFPI exhibits significant homology with human inter-alpha-trypsin inhibitor and bovine basic pancreatic trypsin inhibitor. ... Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa ... Tissue factor pathway inhibitor has been shown to interact with Factor X. Hemostasis GRCh38: Ensembl release 89: ...

Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors". J. ... Some research has shown that protease inhibitors can cause irreversible suppressive effect on carcinogenic cell growth. However ... Kunitz soybean trypsin inhibitor is a type of protein contained in legume seeds which functions as a protease inhibitor. Kunitz ... "Kunitz STI inhibitors". A web/HMMer based tool to study Kunitz protease inhibitors. Federal University of São Paulo. Retrieved ...

It was thought that by inhibiting FT, ras will not be activated, therefore preventing cancer growth. The problem was that ras ... or farnesyl-transferase inhibitors). As with mTOR inhibitors, many companies developed them to treat cancers, where they were ... When FFTase is blocked by FFTase inhibitors this pathway comes into operation - both K and N-Ras are able to be activated ... The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with ...

... NVP-BEP800 has been described to affect stability of SRC kinases clients and growth of T-cell and B-cell acute ... The first HSP90 inhibitors were developed from geldanamycin and radicicol which are the natural product inhibitors and are ... Furthermore, a number of Hsp90 inhibitors are currently undergoing clinical trials for a variety of cancers. Hsp90 inhibitors ... "HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias". ...

In many cases, expression of the growth promoting transcription factor Myc is blocked by BET inhibitors. BRD2 and BRD3 are ... Examples include use of BET inhibitors in combination with γ-secretase inhibitors for T cell acute lymphoblastic leukemia and ... BRAF-inhibitor (vemurafenib) for BRAF-inhibitor resistant melanomas carrying the BRAFV600E mutation. BET inhibitors have been ... Notable BET inhibitors include: I-BET 151 (GSK1210151A) I-BET 762 (GSK525762) OTX-015 TEN-010 CPI-203 CPI-0610 olinone, e.g. to ...

The role of PAI-2 in cancer growth and metastasis is complex, as PAI-2 may have tumor-promoting and tumor-inhibiting effects. ... Plasminogen activator inhibitor-2 (placental PAI, SerpinB2, PAI-2), a serine protease inhibitor of the serpin superfamily, is a ... The MEROPS online database for peptidases and their inhibitors: I04.007 Plasminogen+Activator+Inhibitor+2 at the U.S. National ... Notably, it is high expression of PAI-2 by tumor cells, not the host organism, which influences cancer growth. Cancer cells may ...

"Host protein C inhibitor inhibits tumor growth, but promotes tumor metastasis, which is closely correlated with ... Protein C inhibitor is activated by heparin against thrombin. Protein C inhibitor (PCI) is serine protease inhibitor of serpin ... Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) that limits the activity of protein C (an ... In the beginning protein C Inhibitor (PCI) was identified as an inhibitor of activated protein C (APC), it is currently clear ...